CN111527204B - 靶基因改造用组合物 - Google Patents

靶基因改造用组合物 Download PDF

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Publication number
CN111527204B
CN111527204B CN201880084068.9A CN201880084068A CN111527204B CN 111527204 B CN111527204 B CN 111527204B CN 201880084068 A CN201880084068 A CN 201880084068A CN 111527204 B CN111527204 B CN 111527204B
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rna
seq
composition
nucleic acid
cas9
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CN111527204A (zh
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堀田秋津
井福正隆
藤本直子
岩渕久美子
见城江利也
莳田幸正
落合留美子
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Kyoto University NUC
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Takeda Pharmaceutical Co Ltd
Kyoto University NUC
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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CN201880084068.9A 2017-12-28 2018-12-27 靶基因改造用组合物 Active CN111527204B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017254798 2017-12-28
JP2017-254798 2017-12-28
PCT/JP2018/048034 WO2019131829A1 (ja) 2017-12-28 2018-12-27 標的遺伝子改変用組成物

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CN111527204A CN111527204A (zh) 2020-08-11
CN111527204B true CN111527204B (zh) 2023-09-01

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US (1) US12031130B2 (https=)
EP (1) EP3733844B1 (https=)
JP (1) JP7288282B2 (https=)
KR (1) KR102799255B1 (https=)
CN (1) CN111527204B (https=)
AU (1) AU2018397951B2 (https=)
CA (1) CA3086885A1 (https=)
TW (1) TWI825057B (https=)
WO (1) WO2019131829A1 (https=)

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WO2016130600A2 (en) 2015-02-09 2016-08-18 Duke University Compositions and methods for epigenome editing
KR102787119B1 (ko) 2015-11-30 2025-03-27 듀크 유니버시티 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
US20190127713A1 (en) 2016-04-13 2019-05-02 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
JP7490211B2 (ja) 2016-07-19 2024-05-27 デューク ユニバーシティ Ｃｐｆ１に基づくゲノム編集の治療適用
US20200331841A1 (en) 2017-12-28 2020-10-22 Takeda Pharmaceutical Company Limited Cationic lipids
EP3740580A4 (en) 2018-01-19 2021-10-20 Duke University GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS
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Title
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo;Hao Yin et al.;Nat Biotechnol;第34卷(第34期);摘要，图1-3 *

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TW201938202A (zh) 2019-10-01
KR20200104318A (ko) 2020-09-03
EP3733844A4 (en) 2021-11-03
AU2018397951A1 (en) 2020-07-09
JP7288282B2 (ja) 2023-06-07
EP3733844A1 (en) 2020-11-04
TWI825057B (zh) 2023-12-11
US12031130B2 (en) 2024-07-09
CA3086885A1 (en) 2019-07-04
JPWO2019131829A1 (ja) 2021-02-04
EP3733844B1 (en) 2025-04-02
KR102799255B1 (ko) 2025-04-24

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