JPWO2018221620A1 - Dentifrice composition - Google Patents

Abstract

(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide 0.00001 to 0.01% by mass, (B) xanthan gum 1.4 to 2.5% by mass, and ( C) A dentifrice composition containing at least one selected from sodium polyacrylate and sodium alginate, and (B) / (C) having a mass ratio of 6 to 20. Further, the above dentifrice composition containing (D) thickening silica or (E) surfactant. According to the present invention, it is possible to provide a dentifrice composition which gives a continuous and high feeling of cleansing in the oral cavity and has good usability.

Description

  TECHNICAL FIELD The present invention relates to a dentifrice composition that provides a sustained and high oral cleansing feeling and has good usability.

The act of brushing teeth using a dentifrice composition is often performed in the hope of a clear and clean feeling in the oral cavity, in addition to the purpose of preventing oral diseases such as tooth decay, periodontal disease and bad breath. .
The dentifrice composition may be blended with a cooling agent such as fragrance such as menthol or mint oil and a cooling sensation agent such as menthyl lactate so that a cool feeling can be obtained when brushing the teeth. In recent years, the development of a cooling sensation agent exhibiting a strong cooling sensation has been active, and N-substituted-p-menthane-carboxamide and the like are widely known. It has been recognized that the above-mentioned cooling agents and cooling sensates are effective in imparting a cooling sensation immediately after rinsing during tooth brushing.

  Patent Documents 1 to 6 (Japanese Patent Application Laid-Open No. 2014-125440, Japanese Patent Application Laid-Open No. 2015-182983, Japanese Patent Application Laid-Open No. 2006-102076, Japanese Patent Application No. 2014-507440, Japanese Patent Application No. No. 520925) proposes a composition for the oral cavity in which the cooling and refreshing feeling is improved by N-substituted-p-menthane-carboxamide as a cooling or cooling agent.

JP 2014-125440 A JP-A-2015-182983 JP-A-2006-102076 JP 2014-507440 A JP-T-2012-508741 JP 2011-520925 A JP 2012-97057 A JP 2009-149540 A

  However, there is still room for improvement in order to satisfy the neat and clean feeling in the oral cavity, and there is a problem in the sense of sustainability, and it cannot be said that it is sufficient. Increasing the amount of the cooling agent or cooling sensation agent can improve the cooling sensation to a certain extent, but the irritation in the oral cavity and the unpleasant sensation due to taste, etc. become strong, and the clean feeling may not be good. Was.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that gives a continuous and high feeling of cleansing in the oral cavity and has good usability.

  The present inventors have conducted intensive studies to achieve the above object. As a result, a specific amount of xanthan gum and sodium polyacrylate were added to a dentifrice composition containing a specific amount of a specific N-substituted-p-menthane-carboxamide. And one or more selected from sodium alginate in combination at a specific ratio to enhance the effect of imparting a feeling of cleansing in the oral cavity and improve its persistence, and also found that the usability can be maintained. . That is, in the present invention, (A) 0.00001 to 0.01% by mass of N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide and (B) xanthan gum of 1.4 to 2. 5% by mass and (C) a dentifrice composition containing one or more selected from sodium polyacrylate and sodium alginate, wherein (B) / (C) has a mass ratio of 6 to 20 by a dentifrice composition, which is sustained and The present inventors have found that a high feeling of cleansing in the oral cavity can be provided, and that the composition can be easily placed on a toothbrush and maintain good usability without any uncomfortable feeling, and the present invention has been accomplished.

The effect of N-substituted-p-menthane-carboxamide to impart a feeling of cleanliness to the oral cavity is not sufficient, but in the present invention, when component (B) and component (C) are combined with component (A), (B) / ( When the mass ratio of (C) is within a specific range, excellent useability as a dentifrice is maintained, and an excellent effect of imparting an oral cleanliness is exhibited. The operation and effect of the present invention is a special operation and effect obtained only by combining the combination system of the component (A) with the component (B) and the component (C), and the component (A), (B) or (C) In the case of lacking, or containing the components (A), (B) and (C), the content of the components (A) and (B) is inappropriate, or the mass ratio of (B) / (C) Is inappropriate, the effect is inferior.
As shown in a comparative example described later, when the component (C) is contained together with the component (A) and the component (B) is absent, it is known as an organic binder component similarly to the component (B) or the component (C). However, even when sodium carboxymethylcellulose was contained, the feeling of cleansing in the oral cavity was inferior (Comparative Examples 1 and 5). Further, when an inappropriate N-substituted-p-menthancarboxamide or menthyl lactate is used in place of the component (A) even if it is a cooling agent, even if it contains the components (B) and (C), the mouth is cleaned. The feeling was not maintained (Comparative Examples 8 and 9). In addition, when the composition contains the components (A) and (B) and lacks the component (C), even if it contains an inorganic binder thickening silica, it is difficult to put it on a toothbrush and keeps usability and improves a feeling of cleansing in the oral cavity. No (Comparative Example 10).
More specifically, the present invention provides an excellent cleansing sensation in the oral cavity after toothbrushing, particularly from the viewpoint that the maintenance of the cleansing sensation is not only related to the selection of an appropriate cleansing imparting component but also closely related to the dentifrice composition. Study was carried out. As a result, the component (A) is used in a specific amount as a cleanliness imparting agent, the component (B) as a binder is used as a dentifrice component in a specific amount or more, and the component (C) is used in a specific ratio. By combining the binder systems used in the above, the above-mentioned specific and special effects could be obtained. In this case, the foaming quality caused by blending the component (B) with the component (A) in a specific amount enhances the cooling sensation of the component (A), thereby giving a sustained and excellent oral cleansing sensation. It is presumed that by further blending the component (C), the combined use of the components (A) and (B) could also maintain good usability, which is easy to put on a toothbrush.

  Patent Documents 7 and 8 (Japanese Patent Application Laid-Open Nos. 2012-97057 and 2009-149540) are directed to improving foam performance and dispersibility in the oral cavity during use of the dentifrice composition by using xanthan gum. No mention is made of the later feeling of cleansing in the oral cavity. From Patent Literatures 1 to 6, and further from Patent Literatures 7 and 8, a sustained and excellent oral cleansing feeling is obtained by combining the component (A) of the present invention with the component (B) and the component (C) in a specific amount and ratio. The grant is unpredictable.

Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) 0.00001 to 0.01% by mass of N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide;
(B) Xanthan gum 1.4-2.5% by mass
And (C) a dentifrice composition containing one or more selected from sodium polyacrylate and sodium alginate, wherein (B) / (C) has a mass ratio of 6 to 20.
[2]
The dentifrice composition according to [1], containing the component (C) in an amount of 0.1 to 0.3% by mass.
[3]
The dentifrice composition according to [1] or [2], further comprising (D) 0.1 to 10% by mass of a thickening silica.
[4]
The dentifrice composition according to any one of [1] to [3], further comprising (E) 0.1 to 5% by mass of a surfactant.
[5]
(E) The dentifrice composition according to [4], wherein the surfactant is an anionic surfactant containing a sulfonic acid group.
[6]
The dentifrice composition according to any one of [1] to [5], wherein the content of the organic binder other than the components (B) and (C) is 0 to 0.5% by mass.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition which gives a sustained and high feeling of cleansing in the oral cavity and has good usability can be provided.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is selected from (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, (B) xanthan gum, and (C) sodium polyacrylate and sodium alginate. And (B) / (C) are in a specific ratio by mass.

(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide has an effect of imparting a feeling of cleansing in the oral cavity.
(A) The compounding quantity of a component is 0.00001-0.01% (mass%, same hereafter) of the whole composition, Preferably it is 0.0001-0.005%. If the amount is less than 0.00001%, the feeling of oral cleanliness is inferior. If it exceeds 0.01%, the feeling of discomfort and irritation in the oral cavity may be increased.

  (B) The compounding amount of xanthan gum is 1.4 to 2.5% of the whole composition, and preferably 1.6 to 2.0%. When the amount is less than 1.4%, the feeling of cleansing in the oral cavity is inferior. When it exceeds 2.5%, the feeling of cleansing in the oral cavity decreases.

The component (C) is sodium polyacrylate or sodium alginate, either of which may be used alone or both may be used in view of the effect.
The blending amount of the component (C) is set so that (B) / (C) described below is appropriate, but is preferably 0.1 to 0.3% of the entire composition. When the content is 0.1% or more, the ease of placement on the toothbrush is sufficiently good, and when the content is 0.3% or less, spinnability can be sufficiently maintained.

In the present invention, when the ratio of the components (B) and (C) is within the specific range, it is possible to maintain a good and easy to clean oral cavity while maintaining good ease of placement on the toothbrush.
In this case, (B) / (C) indicating the blending ratio of the component (B) and the component (C) is 6 to 20, preferably 6 to 15, and more preferably 6 to 10 as a mass ratio. . If the mass ratio of (B) / (C) is less than 6, the ease of placing on the toothbrush may be poor, and the feeling of cleansing in the oral cavity may be reduced. Is inferior.

  In the present invention, it is preferable to further blend (D) a thickening silica as an inorganic binder. When (D) the viscosity-increasing silica is blended, the deterioration of the spinnability due to the increase in the amount of (B) xanthan gum is further suppressed, and the ease of placing on the toothbrush is further improved.

  (D) When compounding a thickening silica, the compounding quantity is preferably 0.1 to 10% of the whole composition, more preferably 0.5 to 8%, further more preferably 1 to 8%. If the amount is too large, it may be difficult to put on a toothbrush.

In the present invention, an organic binder other than the components (B) and (C) (xanthan gum, sodium polyacrylate and sodium alginate) may not be blended, but as long as the effects of the present invention are not impaired. It can be blended if necessary.
Specifically, examples of the organic binder other than the components (B) and (C) include sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, karaya gum, arabia gum, locust bean gum, polyvinyl alcohol, and carboxy. Vinyl polymer, carbopol, propylene glycol alginate and the like. When blending these organic binders, the blending amount is preferably 0.5% or less. It may be 0% without blending.

  In the present invention, it is preferable to further blend (E) a surfactant. When the (E) surfactant is blended, the foaming property is appropriately increased, so that the feeling of cleansing in the oral cavity is further improved.

As the surfactant (E), an anionic surfactant is particularly preferable.
Examples of the anionic surfactant include alkyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-acyl taurine salts such as N-methyl-N-acyl taurine salt, Acyl amino acid salts such as acyl sarcosine salts and N-acyl-L-glutamic acid salts. These can be used alone or in combination of two or more. Above all, anionic surfactants containing a sulfonic acid group are preferred in terms of foaming and good foam quality, and alkyl sulfates and α-olefin sulfonates are more preferred. Examples of the salt include a sodium salt, a potassium salt, an ammonium salt and the like, and a sodium salt is particularly preferable.

The alkyl sulfate preferably has 12 to 14 carbon atoms in the alkyl group. Specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.
As the α-olefin sulfonate, alkali metal salts of α-olefin sulfonic acid having 14 to 16 carbon atoms such as sodium and potassium can be used, and among them, α-olefin sulfonate having 14 carbon atoms, particularly sodium Salt (common name; sodium tetradecenesulfonate) is preferred. These can be obtained from commercial products that can be used for oral preparations, and for example, “K Liporan PJ-400CJ” (trade name, manufactured by Lion Specialty Chemicals Co., Ltd.) can be used.

(E) The amount of the surfactant, particularly the anionic surfactant, is preferably from 0.1 to 5%, more preferably from 0.5 to 2.5%, even more preferably from 1.0 to 5% of the whole composition. 2.0%.
As the surfactant (E), a nonionic surfactant, an amphoteric surfactant, or the like may be blended in an amount of 5% or less of the whole composition. When combined with an anionic surfactant and a surfactant other than the anionic surfactant, it is preferable to use the surfactant within a range that does not hinder the effects of the present invention, and the surfactant other than the anionic surfactant is used. Is preferably not more than 4.5%, particularly preferably not more than 3% of the whole composition, and may be 0% without being added.

  The dentifrice composition of the present invention can be in various forms such as paste, liquid dentifrice, liquid dentifrice, liquid dentifrice, lubricating dentifrice, etc. Is toothpaste and can be prepared by a usual method. Further, in addition to the above-mentioned components, known components usually used in dentifrice compositions can be blended as necessary within a range not to impair the effects of the present invention. Examples of optional components that can be blended include an abrasive, a wetting agent, a sweetening agent, a preservative, a pH adjuster, a flavor, and a medicinal ingredient.

  Examples of the abrasive include calcium phosphate-based abrasives such as dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, and calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, and titanium-binding silica. Silica-based abrasives such as calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; Two or more can be blended. Among these, precipitated silica, aluminosilicate, zirconosilicate, silica-based abrasives mainly containing silicates such as titanium-binding silica and calcium carbonate-based abrasives, especially silica-based abrasives such as precipitated silica Abrasives are preferred.

The abrasive, particularly the precipitated silica, is preferably abrasive particles having a particle size of 1 to 40 μm, and more preferably has a BET specific surface area of 80 to 250 square meters per gram. The particle size is a value measured by a particle size distribution measuring device (Microtrac particle size distribution meter, dispersion medium; water, manufactured by Nikkiso Co., Ltd.).
Commercially available products can be used as such a silica-based polishing agent. For example, Zeodent 124 and Zeodent 113 manufactured by HUBER, TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia, Sident 3 and Sident 20 manufactured by Degussa, and Taki Chemical ( Zircono silicate, alumino silicate, etc. manufactured by K.K.

The abrasive may be in the form of granules, and granules can be blended as a component having abrasiveness. The granules are particles obtained by forming a water-insoluble powder into granules, and may be granules obtained by crushing silica gel or granules using a binder for granulation.
The compounding amount of the abrasive is preferably 8 to 70%, particularly preferably 10 to 50% of the whole composition.

  Examples of the wetting agent include sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as propylene glycol and glycerin. The compounding amount is usually 5 to 50%, especially 20 to 45% of the whole composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, glycyrrhizin, thaumatin, and asparatyl phenylalanine methyl ester.
Examples of preservatives include paraoxybenzoate, sodium benzoate and the like.
Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

  Examples of the flavor include known oral flavors such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, Examples include peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, laurel oil, perilla oil, winter green oil, clove oil, and eucalyptus oil.

  Pharmaceutical components include enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, and glycyrrhetinate; sodium chloride, vitamins, allantoin, and the like. Cell activator; bactericide such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; water-soluble copper compound such as copper chlorophyll, copper gluconate; tartar preventive such as zeolite; Blood circulation promoters; amino acids such as alanine, glycine, proline and the like can be added. The compounding amount of the medicinal component can be an effective amount as long as the effect of the present invention is not impaired.

  Further, as an optional component, inorganic compounds such as mica titanium, titanium oxide, bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, glucomannan; polyvinyl acetate, acrylic resin , Polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, and other synthetic high molecular compounds or copolymers thereof; carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax, and other waxes; Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, natural rubber and the like can be blended as long as the effects of the present invention are not impaired.

  Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and filled in ordinary laminated tube containers. These were used as samples and evaluated by the following method. The results are shown in Tables 1 to 3.

Evaluation method Evaluation was performed by four subjects.
1 g of the sample dentifrice composition was placed on a toothbrush (Clinica Advantage toothbrush, 4 rows compact normal type, manufactured by Lion Corporation), and the teeth were brushed for 3 minutes.
With respect to the feeling of cleansing in the oral cavity, the feeling of cleansing in the oral cavity was determined immediately after the toothbrush was rinsed with water, and immediately after and 30 minutes after the rinsing, according to the following criteria. Here, the intra-oral clean feeling is a refreshing sensation that the dirt in the oral cavity is removed.
The discomfort in the oral cavity during brushing (discomfort due to poor taste and irritation) was determined according to the following criteria.
Regarding the ease of placing on the toothbrush, the ease of placing when the sample was extruded from the tube container onto the toothbrush was determined based on the following evaluation criteria. It was determined whether the sample was torn or the shape retention of the sample was too high and the sample was likely to fall off from the toothbrush, depending on the physical properties of the sample.
These determination results were evaluated based on the following evaluation criteria by obtaining an average value.

<Mouth cleansing feeling (immediately after rinsing, 30 minutes after rinsing)>
Rating criteria 5: Very felt 4: Felt 3: Somewhat felt 2: Neither 1: Not felt Evaluation criteria ◎: Average score of 4 people is 4 or more ○: Average score of 4 people is 3 Not less than 4 and less than 4 points: Average score of 4 people is 2 or more and less than 3 points ×: Average score of 4 people is less than 2 points

<Discomfort in the oral cavity>
Rating criteria 5: Did not feel 4: Neither can be felt 3: Felt somewhat 2: Felt 1: Strong feeling Evaluation criteria ◎: Average score of four people is 4.5 or more ○: Average score of four people 4 or more and less than 4.5 points Δ: The average score of 4 people is 2 or more and less than 4 points ×: The average score of 4 people is less than 2 points

<Easy to put on toothbrush>
Rating criteria 5: Very easy to put 4: Easy to put 3: Neither can be 2: Neither hard to put 1: Very hard to put Evaluation criteria ◎: Average score of 4 people is 4 or more ○: Average score of 4 people is 3 Not less than 4 and less than 4 points: Average score of 4 people is 2 or more and less than 3 points ×: Average score of 4 people is less than 2 points

Details of the raw materials used are shown below.
(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide: Evacool 180 (manufactured by Dibodan Japan)
Menthyl lactate (comparative product): Fresco rat ML (Simrise Co., Ltd.)
N-ethyl-p-menthancarboxamide (comparative product): WS-3 (registered trademark, manufactured by Givaudan Japan KK)
(B) Xanthan gum: Monate gum DA (manufactured by CP Kelco)
(C) Sodium polyacrylate: Rheogic 260H (Toagosei Co., Ltd.)
(C) Sodium alginate: Kimika Algin (Kimika Co., Ltd.)
Sodium carboxymethylcellulose (comparative product): CMC1260 (manufactured by Daicel Finechem)
Polyvinylpyrrolidone (comparative product): Rubiscol K30 (manufactured by BASF)
(D) Thickening silica: Carplex # 67 (manufactured by DSL Japan)
(E) Sodium lauryl sulfate: Texapon (manufactured by BASF)

Claims (6)

(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide
0.00001 to 0.01% by mass,
(B) Xanthan gum 1.4-2.5% by mass
And (C) a dentifrice composition containing one or more selected from sodium polyacrylate and sodium alginate, wherein (B) / (C) has a mass ratio of 6 to 20.   The dentifrice composition according to claim 1, which comprises (C) component in an amount of 0.1 to 0.3% by mass.   3. The dentifrice composition according to claim 1, further comprising (D) 0.1 to 10% by mass of a thickening silica.   The dentifrice composition according to any one of claims 1 to 3, further comprising (E) 0.1 to 5% by mass of a surfactant.   The dentifrice composition according to claim 4, wherein (E) the surfactant is an anionic surfactant containing a sulfonic acid group.   The dentifrice composition according to any one of claims 1 to 5, wherein the content of the organic binder other than the components (B) and (C) is 0 to 0.5% by mass.