JPWO2018199136A1 - Ａｂｌ１ ｔ３１５ｉ変異の発現レベルの測定方法 - Google Patents

Ａｂｌ１ ｔ３１５ｉ変異の発現レベルの測定方法 Download PDF

Info

Publication number
JPWO2018199136A1
JPWO2018199136A1 JP2019514562A JP2019514562A JPWO2018199136A1 JP WO2018199136 A1 JPWO2018199136 A1 JP WO2018199136A1 JP 2019514562 A JP2019514562 A JP 2019514562A JP 2019514562 A JP2019514562 A JP 2019514562A JP WO2018199136 A1 JPWO2018199136 A1 JP WO2018199136A1
Authority
JP
Japan
Prior art keywords
abl1
mutation
primer
mrna
reverse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019514562A
Other languages
English (en)
Japanese (ja)
Inventor
粛典 葛城
粛典 葛城
田中　秀明
秀明 田中
隆太 伊藤
隆太 伊藤
古賀　大輔
大輔 古賀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of JPWO2018199136A1 publication Critical patent/JPWO2018199136A1/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
JP2019514562A 2017-04-26 2018-04-25 Ａｂｌ１ ｔ３１５ｉ変異の発現レベルの測定方法 Pending JPWO2018199136A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017087578 2017-04-26
JP2017087578 2017-04-26
PCT/JP2018/016748 WO2018199136A1 (fr) 2017-04-26 2018-04-25 Procédé de mesure du niveau d'expression d'une mutation t315i d'abl1

Publications (1)

Publication Number Publication Date
JPWO2018199136A1 true JPWO2018199136A1 (ja) 2020-05-14

Family

ID=63919184

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019514562A Pending JPWO2018199136A1 (ja) 2017-04-26 2018-04-25 Ａｂｌ１ ｔ３１５ｉ変異の発現レベルの測定方法

Country Status (6)

Country Link
JP (1) JPWO2018199136A1 (fr)
KR (1) KR20200002933A (fr)
CN (1) CN110997938A (fr)
PH (1) PH12019502417A1 (fr)
SG (2) SG10201912849TA (fr)
WO (1) WO2018199136A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111321200A (zh) * 2020-02-28 2020-06-23 广州安镝声生物医药科技有限公司 一种细胞外abl1激酶活性检测试剂盒及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211483A1 (en) * 2002-05-09 2003-11-13 Schroeder Benjamin G. Methods for the enrichment of low-abundance polynucleotides
JP5221248B2 (ja) * 2008-08-26 2013-06-26 株式会社日立ハイテクノロジーズ 高発現遺伝子由来のｃＤＮＡクローンの含有率を低減させたｃＤＮＡライブラリーの作製方法
WO2011029899A1 (fr) * 2009-09-11 2011-03-17 The Chinese University Of Hong Kong Procédés d'évaluation des pathologies hépatiques
KR101875199B1 (ko) * 2010-11-11 2018-07-06 주식회사 파나진 Ｐｎａ 기반의 실시간 ｐｃｒ 클램핑을 이용한 ｂｃｒ-ａｂｌ 융합 유전자의 돌연변이 검출 방법 및 키트
CN102676638B (zh) * 2011-03-08 2014-06-04 苏州大学附属第一医院 检测bcr/abl融合基因abl激酶区耐药突变位点的方法及试剂盒
JP6531312B2 (ja) * 2014-10-17 2019-06-19 東洋鋼鈑株式会社 Ｂｃｒ−ａｂｌ阻害剤耐性関連変異の検出方法及びこれを用いたｂｃｒ−ａｂｌ阻害剤耐性を予測するためのデータ取得方法
RU2609641C1 (ru) * 2015-12-07 2017-02-02 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Способ анализа соматических мутаций в химерном гене BCR/ABL с использованием ОТ-ПЦР и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом)
CN105349681A (zh) * 2015-12-07 2016-02-24 湖南圣维基因科技有限公司 一种bcr-abl融合基因t315i突变荧光pcr检测试剂盒
CN105441568B (zh) * 2016-01-06 2019-01-08 武汉海吉力生物科技有限公司 用于检测人类bcr-abl融合基因t315i突变的引物、探针及试剂盒

Also Published As

Publication number Publication date
SG10201912849TA (en) 2020-02-27
SG11201909983QA (en) 2019-11-28
WO2018199136A1 (fr) 2018-11-01
KR20200002933A (ko) 2020-01-08
CN110997938A (zh) 2020-04-10
PH12019502417A1 (en) 2020-10-19

Similar Documents

Publication Publication Date Title
US11773388B2 (en) Target enrichment by unidirectional dual probe primer extension
CN108251522B (zh) 人类mthfr和mtrr基因检测试剂盒及其用途
CN110719957B (zh) 用于核酸靶向富集的方法和试剂盒
EP2691775B1 (fr) Mesure de la longueur de télomère dans des échantillons fixés à la formaline inclus dans la paraffine (ffip) par pcr quantitative
JP7389551B2 (ja) Ｍｅｔエキソン１４欠失の検出と、関連する治療法
CN106536735B (zh) 分析dna样品的探针集合和使用所述探针集合的方法
KR102648647B1 (ko) 짧은 호모폴리머릭 반복서열의 개선된 검출법
CN111670254A (zh) 微卫星不稳定性的改进检测
JP2022189882A (ja) ｍｉｎｏｒ ＢＣＲ－ＡＢＬ１遺伝子を検出する方法
EP3653730A1 (fr) Kit d'isolement d'adn acellulaire mutant et procédé d'isolement d'adn acellulaire mutant l'utilisant
US20170253932A1 (en) Method for detecting bcr-abl inhibitor resistance-related mutation and data acquisition method for predicting bcr-abl inhibitor resistance using the same
KR20160106041A (ko) Ｎｒａｓ 및 ｂｒａｆ 핵산의 멀티플렉스 분석을 위한 조성물 및 방법
WO2018199136A1 (fr) Procédé de mesure du niveau d'expression d'une mutation t315i d'abl1
JP7335871B2 (ja) 短い核酸の多重検出
JPWO2013157625A1 (ja) Ｈｌａ−ａ＊２４：０２を検出する方法、及び検出キット
EP4317455A1 (fr) Procédé d'amplification d'acide nucléique cible utilisant une sonde de guidage et sonde de serrage et composition pour amplifier un acide nucléique cible le comprenant
JP2006325446A (ja) 薬剤に対する感受性を決定する方法
JP2024086170A (ja) 分析方法、キット及び検出用デバイス