PH12019502417A1 - Method of determining expression level ot t315i variant of abl1 - Google Patents

Method of determining expression level ot t315i variant of abl1

Info

Publication number
PH12019502417A1
PH12019502417A1 PH12019502417A PH12019502417A PH12019502417A1 PH 12019502417 A1 PH12019502417 A1 PH 12019502417A1 PH 12019502417 A PH12019502417 A PH 12019502417A PH 12019502417 A PH12019502417 A PH 12019502417A PH 12019502417 A1 PH12019502417 A1 PH 12019502417A1
Authority
PH
Philippines
Prior art keywords
abl1
primer
reverse
expression level
variant
Prior art date
Application number
PH12019502417A
Other languages
English (en)
Inventor
Kiyonori Katsuragi
Hideaki Tanaka
Ryuta Ito
Daisuke Koga
Original Assignee
Otsuka Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceuticals Co Ltd filed Critical Otsuka Pharmaceuticals Co Ltd
Publication of PH12019502417A1 publication Critical patent/PH12019502417A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
PH12019502417A 2017-04-26 2019-10-25 Method of determining expression level ot t315i variant of abl1 PH12019502417A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017087578 2017-04-26
PCT/JP2018/016748 WO2018199136A1 (fr) 2017-04-26 2018-04-25 Procédé de mesure du niveau d'expression d'une mutation t315i d'abl1

Publications (1)

Publication Number Publication Date
PH12019502417A1 true PH12019502417A1 (en) 2020-10-19

Family

ID=63919184

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12019502417A PH12019502417A1 (en) 2017-04-26 2019-10-25 Method of determining expression level ot t315i variant of abl1

Country Status (6)

Country Link
JP (1) JPWO2018199136A1 (fr)
KR (1) KR20200002933A (fr)
CN (1) CN110997938A (fr)
PH (1) PH12019502417A1 (fr)
SG (2) SG10201912849TA (fr)
WO (1) WO2018199136A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111321200A (zh) * 2020-02-28 2020-06-23 广州安镝声生物医药科技有限公司 一种细胞外abl1激酶活性检测试剂盒及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211483A1 (en) * 2002-05-09 2003-11-13 Schroeder Benjamin G. Methods for the enrichment of low-abundance polynucleotides
JP5221248B2 (ja) * 2008-08-26 2013-06-26 株式会社日立ハイテクノロジーズ 高発現遺伝子由来のｃＤＮＡクローンの含有率を低減させたｃＤＮＡライブラリーの作製方法
WO2011029899A1 (fr) * 2009-09-11 2011-03-17 The Chinese University Of Hong Kong Procédés d'évaluation des pathologies hépatiques
KR101875199B1 (ko) * 2010-11-11 2018-07-06 주식회사 파나진 Ｐｎａ 기반의 실시간 ｐｃｒ 클램핑을 이용한 ｂｃｒ-ａｂｌ 융합 유전자의 돌연변이 검출 방법 및 키트
CN102676638B (zh) * 2011-03-08 2014-06-04 苏州大学附属第一医院 检测bcr/abl融合基因abl激酶区耐药突变位点的方法及试剂盒
JP6531312B2 (ja) * 2014-10-17 2019-06-19 東洋鋼鈑株式会社 Ｂｃｒ−ａｂｌ阻害剤耐性関連変異の検出方法及びこれを用いたｂｃｒ−ａｂｌ阻害剤耐性を予測するためのデータ取得方法
RU2609641C1 (ru) * 2015-12-07 2017-02-02 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Способ анализа соматических мутаций в химерном гене BCR/ABL с использованием ОТ-ПЦР и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом)
CN105349681A (zh) * 2015-12-07 2016-02-24 湖南圣维基因科技有限公司 一种bcr-abl融合基因t315i突变荧光pcr检测试剂盒
CN105441568B (zh) * 2016-01-06 2019-01-08 武汉海吉力生物科技有限公司 用于检测人类bcr-abl融合基因t315i突变的引物、探针及试剂盒

Also Published As

Publication number Publication date
SG10201912849TA (en) 2020-02-27
SG11201909983QA (en) 2019-11-28
WO2018199136A1 (fr) 2018-11-01
KR20200002933A (ko) 2020-01-08
CN110997938A (zh) 2020-04-10
JPWO2018199136A1 (ja) 2020-05-14

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