JPWO2018064232A5 - - Google Patents
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- JPWO2018064232A5 JPWO2018064232A5 JP2019516389A JP2019516389A JPWO2018064232A5 JP WO2018064232 A5 JPWO2018064232 A5 JP WO2018064232A5 JP 2019516389 A JP2019516389 A JP 2019516389A JP 2019516389 A JP2019516389 A JP 2019516389A JP WO2018064232 A5 JPWO2018064232 A5 JP WO2018064232A5
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- vaccine
- herpes
- hsv
- polypeptide
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| EP3519427A4 (en) | 2016-09-28 | 2020-03-11 | Genocea Biosciences Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HERPES |
| AU2019238345A1 (en) | 2018-03-23 | 2020-10-15 | Epivax, Inc. | Coxiella burnetii epitopes for T cell-targeted Q fever vaccines |
| CN110090228A (zh) * | 2018-04-18 | 2019-08-06 | 浙江大学 | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 |
| CN111620955B (zh) * | 2020-07-01 | 2022-11-08 | 北京康爱瑞浩细胞技术有限公司 | 一种多靶位复合抗原及其应用 |
| CN111986743A (zh) * | 2020-08-07 | 2020-11-24 | 上海神桥医药科技有限公司 | 一种医学审核方法及其应用 |
| CN116672614B (zh) * | 2023-06-15 | 2024-02-13 | 广州穗海新峰医疗设备制造股份有限公司 | 紫外线治疗系统、方法及装置 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818694A (en) | 1982-07-20 | 1989-04-04 | American Cyanamid Company | Production of herpes simplex viral protein |
| NZ209308A (en) | 1983-08-30 | 1991-08-27 | Genentech Inc | Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein |
| US7264817B1 (en) | 1983-08-30 | 2007-09-04 | Genentech, Inc. | Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US5244792A (en) | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
| US5612041A (en) | 1984-07-17 | 1997-03-18 | Chiron Corporation | Recombinant herpes simplex gD vaccine |
| US5149529A (en) | 1988-04-08 | 1992-09-22 | Board Of Trustees Of Leland Chiron Corporation | Compositions and treatment for herpes simplex |
| WO1990013652A1 (en) | 1989-05-12 | 1990-11-15 | Triton Diagnostics, Inc. | Herpes simplex virus type 2-glycoprotein g proteins and polypeptides |
| DK0541692T3 (da) | 1990-08-02 | 1999-11-01 | Chiron Corp | Herpes simplex virus VP-16-vacciner |
| DK31991D0 (da) | 1991-02-25 | 1991-02-25 | Carlbiotech Ltd As | Peptid og farmaceutisk praeparat indeholdende et saadant peptid |
| GB9105992D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| US5679348A (en) | 1992-02-03 | 1997-10-21 | Cedars-Sinai Medical Center | Immunotherapy for recurrent HSV infections |
| US5955088A (en) | 1992-02-03 | 1999-09-21 | Cedars-Sinai Medical Center | Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| CA2164601A1 (en) | 1993-06-08 | 1994-12-22 | Kevin R. Steffy | Herpes simplex virus type-2 protease |
| EP0714399A4 (en) | 1993-08-20 | 1999-01-27 | Smithkline Beecham Corp | HSV-2 UL26 GEN, ENVELOPE PROTEINS, IMMUNOASSAYS AND PROTEAS INHIBITORS |
| GB9325496D0 (en) | 1993-12-14 | 1994-02-16 | Smithkline Beecham Biolog | Vaccines |
| US7094767B2 (en) | 1994-07-22 | 2006-08-22 | Merck & Co., Inc. | Polynucleotide herpes virus vaccine |
| US6156319A (en) | 1994-07-25 | 2000-12-05 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex vaccine |
| US5807557A (en) | 1994-07-25 | 1998-09-15 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US6197497B1 (en) | 1995-04-21 | 2001-03-06 | University Of New Mexico | Immunoassay for herpes simplex virus |
| US5654174A (en) | 1995-07-07 | 1997-08-05 | Competitive Technologies, Inc. | Herpes simplex virus glycoprotein D variants |
| US5876923A (en) | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
| US5958895A (en) | 1996-10-23 | 1999-09-28 | American Home Products Corporation | DNA vaccines for herpes simplex virus |
| EP0948508A4 (en) | 1996-11-04 | 2001-11-07 | Smithkline Beecham Corp | NEW CODING SEQUENCES FOR HERPES SIMPLEX TYPE 2 VIRUS |
| JP2002503251A (ja) | 1997-06-02 | 2002-01-29 | カイロン コーポレイション | 単純ヘルペスウイルスｖｐ２２ワクチンおよび使用の方法 |
| US6015832A (en) | 1997-12-31 | 2000-01-18 | The Regents Of The University Of Michigan | Methods of inactivating bacteria including bacterial spores |
| US6054131A (en) | 1998-01-16 | 2000-04-25 | University Of Maryland Baltimore | Vaccine composition for herpes simplex virus and method of using |
| ATE339223T1 (de) | 1998-03-09 | 2006-10-15 | Glaxosmithkline Biolog Sa | Kombinierte impfstoffzusammensetzungen |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| JP2002522451A (ja) | 1998-08-07 | 2002-07-23 | ユニバーシティ オブ ワシントン | 免疫学的単純ヘルペスウイルス抗原とその使用法 |
| US6692752B1 (en) | 1999-09-08 | 2004-02-17 | Smithkline Beecham Biologicals S.A. | Methods of treating human females susceptible to HSV infection |
| US6635676B2 (en) | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| US6559189B2 (en) | 1999-04-28 | 2003-05-06 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| US6506803B1 (en) | 1999-04-28 | 2003-01-14 | Regents Of The University Of Michigan | Methods of preventing and treating microbial infections |
| BR0011732B1 (pt) | 1999-06-10 | 2014-02-04 | Vacinas de dna para animais de companhia e de esporte | |
| GB9921146D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| US6413518B1 (en) | 1999-09-30 | 2002-07-02 | University Of Washington | Immunologically significant herpes simplex virus antigens and methods for identifying and using same |
| US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
| DK1238086T3 (da) | 1999-12-17 | 2006-06-26 | Wyeth Corp | Vaccine til forögelse af immunreaktioner på herpes simplex virus |
| US7078388B2 (en) | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
| US7157437B2 (en) | 2000-03-10 | 2007-01-02 | Dynavax Technologies Corporation | Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences |
| US20030165819A1 (en) | 2000-06-29 | 2003-09-04 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US6821519B2 (en) | 2000-06-29 | 2004-11-23 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| DE60125537D1 (de) | 2000-06-29 | 2007-02-08 | Corixa Corp | Zusammensetzung zur diagnose und behandlung von herpes simplex virusinfektionen |
| US6682892B2 (en) | 2000-07-13 | 2004-01-27 | Pharmacia & Upjohn Company | Method for treating herpes viruses |
| JP2004505113A (ja) | 2000-07-27 | 2004-02-19 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 単純疱疹ウイルス糖蛋白質ｄを用いた組成物及びそれを用いて免疫応答を抑制する方法 |
| EP1178111A1 (en) | 2000-08-03 | 2002-02-06 | Lohmann Animal Health GmbH & Co. KG | Vaccination against host cell-associated herpesviruses |
| US20040220076A1 (en) | 2000-11-16 | 2004-11-04 | Laure Aurelian | Prevention of recurrent viral disease |
| US6867000B2 (en) | 2000-12-07 | 2005-03-15 | Wyeth Holdings Corporation | Method of enhancing immune responses to herpes |
| US7314624B2 (en) | 2001-06-05 | 2008-01-01 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| DE60238330D1 (de) | 2001-07-31 | 2010-12-30 | Univ Washington | Immunologisch bedeutende herpes-simplex-virus-antigene und verfahren für ihre verwendung |
| WO2003020108A2 (en) | 2001-09-04 | 2003-03-13 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US20080299140A1 (en) | 2002-05-24 | 2008-12-04 | The Regents Of The University Of California, | Immunogenic Composition and Peptide Sequences for Prevention and Treatment of an Hsv Condition |
| US20030219448A1 (en) | 2002-05-24 | 2003-11-27 | Cedars-Sinai Medical Center | Peptide epitope-based vaccine for treating herpes simplex virus infections and related diseases |
| CA2492598C (en) | 2002-07-18 | 2013-12-17 | University Of Washington | Rapid, efficient purification of hsv-specific t-lymphocytes and hsv antigens identified via same |
| US7267940B2 (en) | 2003-03-04 | 2007-09-11 | Bio-Rad Laboratories, Inc. | HSV-2 type-specific immunoassays using glycoprotein G2 peptides |
| CA2538794C (en) | 2003-09-12 | 2016-04-19 | Antigenics, Inc. | Vaccine for treatment and prevention of herpes simplex virus infection |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| AU2006338570B2 (en) | 2005-11-18 | 2013-07-11 | The Ohio State University Research Foundation | Viral gene products and methods for vaccination to prevent viral associated diseases |
| US8501194B2 (en) | 2006-03-10 | 2013-08-06 | The Regents Of The University Of California | Vaccine for viruses that cause persistent or latent infections |
| JP5872755B2 (ja) | 2006-07-20 | 2016-03-01 | バイカル インコーポレイテッド | 抗ｈｓｖ−２ワクチン接種のための組成物および方法 |
| WO2008027394A2 (en) | 2006-08-28 | 2008-03-06 | The Wistar Institute Of Anatomy And Biology | Constructs for enhancing immune responses |
| US8871223B2 (en) | 2006-09-08 | 2014-10-28 | The Trustees Of The University Of Pennsylvania | HSV-1 and HSV-2 vaccines and methods of use thereof |
| WO2008140478A2 (en) | 2006-11-01 | 2008-11-20 | Immport Therapeutics, Inc. | Compositions and methods for immunodominant antigens |
| WO2008085486A1 (en) | 2006-12-28 | 2008-07-17 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
| US8057804B2 (en) | 2006-12-28 | 2011-11-15 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
| WO2009006618A2 (en) | 2007-07-05 | 2009-01-08 | University Of Kansas | Herpes simplex virus mutant icp0 protein |
| US20130273088A1 (en) | 2007-07-06 | 2013-10-17 | Anthony Lawrence Cunningham | Epitopes of herpes simplex virus |
| SE532551C2 (sv) | 2008-06-30 | 2010-02-16 | Senseair Ab | Ett för spektralanalys anpassat arrangemang |
| WO2010002993A1 (en) | 2008-07-01 | 2010-01-07 | Genocea Biosciences, Inc. | Antigen screening system |
| CA2781805A1 (en) | 2008-12-17 | 2010-07-08 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| US8460674B2 (en) | 2009-02-07 | 2013-06-11 | University Of Washington | HSV-1 epitopes and methods for using same |
| RU2011140858A (ru) | 2009-03-09 | 2013-04-20 | Уилльям ХЕНРИ | Конъюгаты гаптен-носитель, содержащие в качестве носителя бактериальные токсины, обладающие сигнальным пептидом, и их применение в иммуногенных композициях |
| SG176207A1 (en) | 2009-05-22 | 2011-12-29 | Genocea Biosciences Inc | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| WO2011106607A2 (en) | 2010-02-26 | 2011-09-01 | Juvaris Biotherapeutics, Inc. | Subunit vaccines for herpes viruses and methods of use |
| ES2651005T3 (es) | 2010-03-09 | 2018-01-23 | Biomedical Research Models, Inc. | Una nueva estrategia de vacunación mucosa para el virus del herpes simple tipo-2 |
| US20120135025A1 (en) | 2010-10-20 | 2012-05-31 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| CA2856697A1 (en) | 2010-11-24 | 2012-06-07 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| EP2782597B1 (en) * | 2011-11-23 | 2022-04-13 | Genocea Biosciences, Inc. | Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| EP3519427A4 (en) | 2016-09-28 | 2020-03-11 | Genocea Biosciences Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HERPES |
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- 2017-09-27 JP JP2019516389A patent/JP2019537555A/ja active Pending
- 2017-09-27 WO PCT/US2017/053835 patent/WO2018064232A1/en unknown
- 2017-09-27 US US15/717,849 patent/US10350288B2/en active Active - Reinstated
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