JPWO2011062073A1 - ヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤 - Google Patents
ヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
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- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
このように、変形性膝関節症においては、被験物質の示す薬効が動物モデルと臨床とで乖離していることが多い。実際、動物モデルに対しては、変形性膝関節症の研究手段としての妥当性に疑問が提示されており[非特許文献21]、臨床効果を予測できるゴールド・スタンダードな動物モデル構築の必要性が指摘されている[非特許文献22]。従って、既存の動物モデルにおける試験成績からヒトにおける有効性を予測することは不可能であり、拠って、現状においては、ヒトにおける変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤の発見・同定は、ヒトでの試験が唯一の評価手段とならざるを得ない。
統計局による国勢調査における全国の同年齢の女性人口である3,597,754人で除した値を用いた。
Claims (6)
- 副甲状腺ホルモン(PTH)またはPTH誘導体を有効成分とするヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
- PTHが、ヒトPTH(1−84)である請求項1記載のヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
- PTH誘導体がヒトPTH(1−34)である請求項1記載のヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
- 副甲状腺ホルモン(PTH)またはPTH誘導体を有効成分とする骨粗鬆症に合併するヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
- PTHが、ヒトPTH(1−84)である請求項4記載の骨粗鬆症に合併するヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
- PTH誘導体がヒトPTH(1−34)である請求項4記載の骨粗鬆症に合併するヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26221409P | 2009-11-18 | 2009-11-18 | |
US61/262214 | 2009-11-18 | ||
PCT/JP2010/069742 WO2011062073A1 (ja) | 2009-11-18 | 2010-11-05 | ヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤 |
Publications (2)
Publication Number | Publication Date |
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JPWO2011062073A1 true JPWO2011062073A1 (ja) | 2013-04-04 |
JP5969763B2 JP5969763B2 (ja) | 2016-08-17 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011541883A Active JP5969763B2 (ja) | 2009-11-18 | 2010-11-05 | ヒト変形性膝関節症の予防剤および/または治療剤および/または増悪抑制剤 |
Country Status (14)
Country | Link |
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US (2) | US20110172154A1 (ja) |
EP (1) | EP2502632B1 (ja) |
JP (1) | JP5969763B2 (ja) |
KR (1) | KR101686271B1 (ja) |
CN (1) | CN102686236A (ja) |
AU (1) | AU2010320272B2 (ja) |
BR (1) | BR112012002391A2 (ja) |
CA (1) | CA2770340C (ja) |
ES (1) | ES2616004T3 (ja) |
IL (1) | IL217722B (ja) |
MX (1) | MX339484B (ja) |
NZ (1) | NZ598856A (ja) |
RU (1) | RU2569754C2 (ja) |
WO (1) | WO2011062073A1 (ja) |
Families Citing this family (3)
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WO2017006908A1 (ja) * | 2015-07-07 | 2017-01-12 | 旭化成ファーマ株式会社 | 特発性大腿骨頭壊死症の発症予防及び/又は進行抑制剤 |
AU2017277747A1 (en) * | 2016-06-10 | 2019-01-17 | Regulaxis | Peptides for the treatment of osteoarthritis |
EP3576774A4 (en) * | 2017-02-01 | 2020-10-07 | The Johns Hopkins University | PARATHYROID HORMONE AND REGENERATION OF DEGENERATIVE DISCS |
Family Cites Families (24)
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JPS56140924A (en) | 1980-04-04 | 1981-11-04 | Teijin Ltd | Calcitonin pharmaceutical preparation |
GB2092002B (en) | 1981-01-14 | 1985-09-11 | Toyo Jozo Kk | Suppositories injectable solutions |
CA1188987A (en) | 1981-03-06 | 1985-06-18 | Masataka Morishita | Preparation having excellent absorption property |
JPS60161924A (ja) | 1984-02-01 | 1985-08-23 | Fujisawa Pharmaceut Co Ltd | 肺吸収用組成物 |
JPS63243033A (ja) | 1987-03-31 | 1988-10-07 | Toyo Jozo Co Ltd | 経鼻投与組成物 |
JPS63316737A (ja) | 1987-06-19 | 1988-12-26 | Toyo Jozo Co Ltd | 経鼻投与用医薬組成物 |
JP2505812B2 (ja) | 1987-07-10 | 1996-06-12 | 旭化成工業株式会社 | h―PTH(1―34)凍結乾燥組成物 |
JPH02111A (ja) | 1987-08-03 | 1990-01-05 | Toyo Jozo Co Ltd | 経鼻投与用生理活性ペプチド製剤 |
JPH01230530A (ja) | 1987-11-21 | 1989-09-14 | Toyo Jozo Co Ltd | カルシトニン類経鼻投与用液剤組成物 |
JPH02104531A (ja) | 1988-10-14 | 1990-04-17 | Toyo Jozo Co Ltd | 経鼻投与用生理活性ペプチド組成物 |
JPH078806B2 (ja) | 1990-08-16 | 1995-02-01 | 旭化成工業株式会社 | カルシトニン類含有経鼻投与用乳剤 |
JP2006137768A (ja) | 1993-10-27 | 2006-06-01 | Chugai Pharmaceut Co Ltd | 軟骨整復術治療促進剤 |
JPH07238033A (ja) | 1993-10-27 | 1995-09-12 | Chugai Pharmaceut Co Ltd | 軟骨整復術治療促進剤 |
EP0811383B1 (en) * | 1995-02-20 | 2007-05-30 | Yukio Kato | Remedies for arthrosis deformans and inflammatory joint diseases |
JP3901761B2 (ja) | 1995-02-20 | 2007-04-04 | 幸夫 加藤 | 変形性関節症および炎症性関節疾患治療剤 |
US7087248B2 (en) | 2000-06-30 | 2006-08-08 | Daiichi Asubio Pharma Co., Ltd. | Pharmaceutical component based on human parathyroid hormone and a pharmaceutical composition for intranasal administration comprising the component |
WO2004067021A1 (en) * | 2003-01-24 | 2004-08-12 | Gardella Thomas J | Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges |
WO2005102381A1 (ja) | 2004-04-26 | 2005-11-03 | Ono Pharmaceutical Co., Ltd. | カテプシンk阻害薬およびpth類を併用することを特徴とする骨密度増加剤 |
JP2006143603A (ja) * | 2004-11-16 | 2006-06-08 | Asahi Kasei Pharma Kk | 骨疾患治療用医薬複合剤 |
US20090010940A1 (en) * | 2005-09-06 | 2009-01-08 | Paul Morley | Parathyroid Hormone Analogues and Methods of Use |
WO2010045229A2 (en) * | 2008-10-13 | 2010-04-22 | University Of Rochester | Protecting and repairing cartilage and musculoskeletal soft tissues |
US8530420B2 (en) * | 2008-12-16 | 2013-09-10 | Kaohsiung Medical University | Treatment of arthritis with parathyroid hormone |
US8586533B2 (en) * | 2008-12-16 | 2013-11-19 | Kaohsiung Medical University | Treatment of early-stage osteoarthritis |
KR20150021590A (ko) * | 2009-09-09 | 2015-03-02 | 아사히 가세이 파마 가부시키가이샤 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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2010
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- 2010-11-05 JP JP2011541883A patent/JP5969763B2/ja active Active
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- 2010-11-05 CN CN2010800456724A patent/CN102686236A/zh active Pending
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2012
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- 2012-09-13 US US13/613,180 patent/US20130012440A1/en not_active Abandoned
Also Published As
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EP2502632A1 (en) | 2012-09-26 |
MX339484B (es) | 2016-05-27 |
WO2011062073A1 (ja) | 2011-05-26 |
RU2012125066A (ru) | 2013-12-27 |
EP2502632A4 (en) | 2013-04-03 |
AU2010320272A1 (en) | 2012-04-12 |
JP5969763B2 (ja) | 2016-08-17 |
NZ598856A (en) | 2013-10-25 |
CA2770340C (en) | 2019-08-27 |
CA2770340A1 (en) | 2011-05-26 |
CN102686236A (zh) | 2012-09-19 |
RU2569754C2 (ru) | 2015-11-27 |
ES2616004T3 (es) | 2017-06-09 |
US20130012440A1 (en) | 2013-01-10 |
EP2502632B1 (en) | 2016-12-28 |
KR101686271B1 (ko) | 2016-12-13 |
US20110172154A1 (en) | 2011-07-14 |
AU2010320272B2 (en) | 2015-01-22 |
BR112012002391A2 (pt) | 2016-06-07 |
IL217722B (en) | 2018-06-28 |
MX2012003892A (es) | 2012-05-08 |
KR20120116901A (ko) | 2012-10-23 |
IL217722A0 (en) | 2012-03-29 |
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