JPWO2005087219A1 - 記憶固定促進剤 - Google Patents
記憶固定促進剤 Download PDFInfo
- Publication number
- JPWO2005087219A1 JPWO2005087219A1 JP2006510949A JP2006510949A JPWO2005087219A1 JP WO2005087219 A1 JPWO2005087219 A1 JP WO2005087219A1 JP 2006510949 A JP2006510949 A JP 2006510949A JP 2006510949 A JP2006510949 A JP 2006510949A JP WO2005087219 A1 JPWO2005087219 A1 JP WO2005087219A1
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- JP
- Japan
- Prior art keywords
- retinoid
- group
- memory
- medicament
- benzoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1(*)C(*)=C(*)C(*)=C(*)C1*c(cc1)ccc1C(O)=O Chemical compound CC1(*)C(*)=C(*)C(*)=C(*)C1*c(cc1)ccc1C(O)=O 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
Description
本発明のさらに別の観点からは、4-[(5,6,7,8-テトラヒドロ-5,5,8,8-テトラメチル-2-ナフタレニル)カルバモイル]安息香酸又は4-[(3,5-ビストリメチルシリルフェニル)カルボキサミド]安息香酸を有効成分として含む神経変性疾患、好ましくはアルツハイマー病又はパーキンソン病の予防及び/又は治療のための医薬が提供される。
例1
6週齢のSlc:Wistar雄性ラットを用いて1週間の検疫期間を含む予備飼育の後に動物を実験に供した。予備飼育及び実験期間をとおして温度22±3℃、湿度50±20%、照明12時間(8:00〜20:00)の環境下で動物を個別に飼育し、固形飼料(ラボMRストック、日本農産工業株式会社)及び水道水を自由に与えた。動物を体重を指標として群分けし(10匹/群)、記憶の獲得及び再生試行を行った。各試行はシャトル型回避実験箱を用いて行い、片側を明室、もう一方を暗室とし、2室の間に開閉式の仕切りを設けて暗室のみ通電するようにセットした。動物を明室に入れ、暗室に移動するまでの時間(潜時)を5分間まで測定し、ラットが暗室に移動した場合には仕切りを閉めて通電によるショックを与えた。
例1と同様にして、スコポラミンの投与量を0.25mg/kg又は0.5mg/kgとしてAm80を2mg/kg、5mg/kg、又は12.5mg/kg、Tac101(4-[(3,5-ビストリメチルシリルフェニル)カルボキサミド]安息香酸)を30mg/kg、HX630(4-[2,3-(2,5-ジメチル-2,5-ヘキサノ)ジベンゾ[b,f][1,4]-チアゼピン-11-イル]安息香酸)を10mg/kg投与して試験を行った。また、Am80(5mg/kg)及びHX630(10mg/kg)の併用についても同様に試験を行った。薬剤投与は2日目から行った。例1の結果と同様にAm80投与群、Tac101、及びHX630投与群、並びにAm80とHX630の併用群では対照群に比べて徐々に潜時が延長した。
例2と同様にしてスコポラミンの投与量を0.25mg/kgとし、4-[5-(4,7-ジメチルベンゾフラン-2-イル)ピロール-2-イル]安息香酸(IT-K-1001)を10mg/kg経口投与した。表3に結果を示す。この化合物は顕著にスコポラミンの効果を抑制した。
Claims (6)
- 記憶固定を促進するための医薬であって、非天然型のレチノイド、好ましくは芳香環と芳香族カルボン酸又はトロポロンとが連結基を介して結合した基本骨格を有するレチノイドを有効成分として含む医薬。
- 神経変性疾患に伴う記憶固定障害の予防及び/又は治療のための医薬として用いる請求の範囲第1項に記載の医薬。
- 該レチノイドがレチノイン酸レセプター(RAR)・サブタイプα及びサブタイプβに結合し、実質的にレチノイン酸レセプター・サブタイプγに結合しないレチノイドである請求の範囲第1項又は第2項に記載の医薬。
- 該レチノイドが置換フェニル基と安息香酸とが連結基を介して結合した基本骨格を有するレチノイドである請求の範囲第3項に記載の医薬。
- 該レチノイドが4-[(5,6,7,8-テトラヒドロ-5,5,8,8-テトラメチル-2-ナフタレニル)カルバモイル]安息香酸又は4-[(3,5-ビストリメチルシリルフェニル)カルボキサミド]安息香酸である請求の範囲第4項に記載の医薬。
- 4-[(5,6,7,8-テトラヒドロ-5,5,8,8-テトラメチル-2-ナフタレニル)カルバモイル]安息香酸又は4-[(3,5-ビストリメチルシリルフェニル)カルボキサミド]安息香酸を有効成分として含む神経変性疾患の予防及び/又は治療のための医薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006510949A JP4884963B2 (ja) | 2004-03-10 | 2005-03-09 | 記憶固定促進剤 |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004066996 | 2004-03-10 | ||
JP2004066996 | 2004-03-10 | ||
US62261804P | 2004-10-28 | 2004-10-28 | |
US60/622,618 | 2004-10-28 | ||
JP2006510949A JP4884963B2 (ja) | 2004-03-10 | 2005-03-09 | 記憶固定促進剤 |
PCT/JP2005/004051 WO2005087219A1 (ja) | 2004-03-10 | 2005-03-09 | 記憶固定促進剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2005087219A1 true JPWO2005087219A1 (ja) | 2008-01-24 |
JP4884963B2 JP4884963B2 (ja) | 2012-02-29 |
Family
ID=38083438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006510949A Expired - Fee Related JP4884963B2 (ja) | 2004-03-10 | 2005-03-09 | 記憶固定促進剤 |
Country Status (6)
Country | Link |
---|---|
US (2) | US8198329B2 (ja) |
EP (1) | EP1733722A4 (ja) |
JP (1) | JP4884963B2 (ja) |
KR (1) | KR20070007818A (ja) |
CN (1) | CN100548288C (ja) |
WO (1) | WO2005087219A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070007818A (ko) | 2004-03-10 | 2007-01-16 | 재단법인 이쯔우 연구소 | 기억 고정 촉진제 |
EP2286807A3 (en) * | 2005-09-09 | 2012-08-29 | Kemphys Ltd. | Medicament for preventive and/or therapeutic treatment of adhesion of bowel |
US7902260B2 (en) * | 2007-02-28 | 2011-03-08 | Kemphys Ltd. | Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom |
WO2011118812A1 (ja) * | 2010-03-26 | 2011-09-29 | 国立大学法人北海道大学 | 神経変性疾患治療薬 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10338658A (ja) * | 1997-04-08 | 1998-12-22 | Hoechst Marion Roussel Kk | レチノイド作用調節剤 |
JP2000502707A (ja) * | 1995-12-29 | 2000-03-07 | ビジョン・ファーマシューティカルズ・リミテッド・パートナーシップ | RARα受容体特異的または選択的活性を有する化合物による処置方法 |
WO2002053523A1 (fr) * | 2000-12-26 | 2002-07-11 | Research Foundation Itsuu Laboratory | Derive de tropolone |
US20030008919A1 (en) * | 1999-06-03 | 2003-01-09 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2752630B2 (ja) * | 1988-03-29 | 1998-05-18 | 大鵬薬品工業株式会社 | 新規安息香酸誘導体及びその製造方法 |
JP3865829B2 (ja) * | 1995-09-21 | 2007-01-10 | 株式会社医薬分子設計研究所 | レチノイド作用増強性化合物 |
EP0906907B1 (en) | 1995-09-21 | 2002-03-06 | Institute of Medicinal Molecular Design, Inc. | Compounds potentiating retinoid |
US6127382A (en) * | 1999-08-16 | 2000-10-03 | Allergan Sales, Inc. | Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
US6093838A (en) * | 1999-08-16 | 2000-07-25 | Allergan Sales, Inc. | Amines substituted with a dihydro-benzofuranyl or with a dihydro-isobenzofuranyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
HUP0301146A3 (en) | 2000-04-28 | 2004-08-30 | Sankyo Co | 2-chlor-5-nitrophenyl carboxamide derivatives, pharmaceutical compositions containing them and their use |
US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
KR100682144B1 (ko) * | 2000-10-02 | 2007-02-28 | 에프. 호프만-라 로슈 아게 | 기종의 치료를 위한 신규한 레티노이드 |
CA2482147A1 (en) | 2002-04-22 | 2003-10-30 | Research Foundation Itsuu Laboratory | Medicament for therapeutic treatment of vascular disease |
KR20070007818A (ko) | 2004-03-10 | 2007-01-16 | 재단법인 이쯔우 연구소 | 기억 고정 촉진제 |
EP2286807A3 (en) * | 2005-09-09 | 2012-08-29 | Kemphys Ltd. | Medicament for preventive and/or therapeutic treatment of adhesion of bowel |
JP2008081427A (ja) * | 2006-09-27 | 2008-04-10 | R&R Inc | 分泌障害性疾患の予防及び/又は治療のための医薬 |
JP2008184396A (ja) * | 2007-01-29 | 2008-08-14 | St Marianna Univ School Of Medicine | 神経損傷に起因する身体機能障害の予防及び治療のための医薬 |
US7902260B2 (en) * | 2007-02-28 | 2011-03-08 | Kemphys Ltd. | Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom |
-
2005
- 2005-03-09 KR KR1020067020907A patent/KR20070007818A/ko active IP Right Grant
- 2005-03-09 JP JP2006510949A patent/JP4884963B2/ja not_active Expired - Fee Related
- 2005-03-09 US US10/598,709 patent/US8198329B2/en not_active Expired - Fee Related
- 2005-03-09 WO PCT/JP2005/004051 patent/WO2005087219A1/ja active Application Filing
- 2005-03-09 EP EP05720323A patent/EP1733722A4/en not_active Withdrawn
- 2005-03-09 CN CNB2005800075844A patent/CN100548288C/zh not_active Expired - Fee Related
-
2012
- 2012-04-30 US US13/459,959 patent/US8431613B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000502707A (ja) * | 1995-12-29 | 2000-03-07 | ビジョン・ファーマシューティカルズ・リミテッド・パートナーシップ | RARα受容体特異的または選択的活性を有する化合物による処置方法 |
JPH10338658A (ja) * | 1997-04-08 | 1998-12-22 | Hoechst Marion Roussel Kk | レチノイド作用調節剤 |
US20030008919A1 (en) * | 1999-06-03 | 2003-01-09 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
WO2002053523A1 (fr) * | 2000-12-26 | 2002-07-11 | Research Foundation Itsuu Laboratory | Derive de tropolone |
Also Published As
Publication number | Publication date |
---|---|
CN1964709A (zh) | 2007-05-16 |
KR20070007818A (ko) | 2007-01-16 |
EP1733722A4 (en) | 2010-07-14 |
EP1733722A1 (en) | 2006-12-20 |
CN100548288C (zh) | 2009-10-14 |
JP4884963B2 (ja) | 2012-02-29 |
US20080021108A1 (en) | 2008-01-24 |
US8198329B2 (en) | 2012-06-12 |
US8431613B2 (en) | 2013-04-30 |
WO2005087219A1 (ja) | 2005-09-22 |
US20120214763A1 (en) | 2012-08-23 |
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