JPS649979A - Hypoglycemiant oxazolidine-2-one derivative - Google Patents

Hypoglycemiant oxazolidine-2-one derivative

Info

Publication number
JPS649979A
JPS649979A JP63139787A JP13978788A JPS649979A JP S649979 A JPS649979 A JP S649979A JP 63139787 A JP63139787 A JP 63139787A JP 13978788 A JP13978788 A JP 13978788A JP S649979 A JPS649979 A JP S649979A
Authority
JP
Japan
Prior art keywords
pharmaceutically
salt
hypoglycemiant
oxazolidine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63139787A
Other languages
English (en)
Other versions
JPH0448791B2 (ja
Inventor
Aran Kuraaku Deibitsudo
Rosu Jiyonson Maikeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS649979A publication Critical patent/JPS649979A/ja
Publication of JPH0448791B2 publication Critical patent/JPH0448791B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP63139787A 1987-06-10 1988-06-07 Hypoglycemiant oxazolidine-2-one derivative Granted JPS649979A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001356 WO1988009661A1 (en) 1987-06-10 1987-06-10 Oxazolidin-2-one derivatives as hypoglycemic agents

Publications (2)

Publication Number Publication Date
JPS649979A true JPS649979A (en) 1989-01-13
JPH0448791B2 JPH0448791B2 (ja) 1992-08-07

Family

ID=22202413

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63139787A Granted JPS649979A (en) 1987-06-10 1988-06-07 Hypoglycemiant oxazolidine-2-one derivative

Country Status (21)

Country Link
US (1) US4968707A (ja)
EP (1) EP0294995B1 (ja)
JP (1) JPS649979A (ja)
KR (1) KR900007313B1 (ja)
AT (1) ATE82284T1 (ja)
AU (1) AU585196B2 (ja)
CA (1) CA1305152C (ja)
DE (1) DE3875806T2 (ja)
DK (1) DK313588A (ja)
ES (1) ES2045116T3 (ja)
FI (1) FI89479C (ja)
GR (1) GR3007059T3 (ja)
HU (1) HU203330B (ja)
IE (1) IE62029B1 (ja)
IL (1) IL86603A (ja)
MY (1) MY103297A (ja)
NO (1) NO171978C (ja)
NZ (1) NZ224957A (ja)
PT (1) PT87702B (ja)
WO (1) WO1988009661A1 (ja)
ZA (1) ZA884114B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019496A1 (en) * 1988-09-13 1991-12-26 Tanabe Seiyaku Co., Ltd. Hypolipidemic agent
WO1994022857A1 (en) * 1993-04-07 1994-10-13 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
JP2009519929A (ja) * 2005-12-15 2009-05-21 アストラゼネカ アクチボラグ オキサゾリジノン化合物及び代謝型グルタミン酸レセプター増強剤としてのそれらの使用
JP2009522290A (ja) * 2005-12-30 2009-06-11 メルク エンド カムパニー インコーポレーテッド Ｃｅｔｐ阻害剤として有用な１，３−オキサゾリジン−２−オン誘導体

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356908A (en) * 1989-04-21 1994-10-18 E. I. Du Pont De Nemours And Company Fungicidal oxazolidinones
WO1991003474A1 (en) * 1989-08-29 1991-03-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5068342A (en) * 1989-10-27 1991-11-26 American Home Products Corporation 5-[(1- and 2-naphthalenyl)thio and sulfonyl]-2,4-thiazolidinediones and derivatives thereof
CA2083891A1 (en) * 1991-12-03 1993-06-04 Angus Murray Macleod Heterocyclic compounds, compositions containing them and their use in therapy
CA2133413C (en) * 1992-04-07 2001-04-10 John Eugene Macor Indole derivatives as 5-ht1 antagonists
DE69326736T2 (de) * 1992-08-31 2000-06-08 Sankyo Co Oxazolidin-Derivate mit Antidiabetika und Anti-Fettleibigkeit-Eigenschaften, ihre Herstellung und therapeutische Verwendung
US5629200A (en) * 1993-11-18 1997-05-13 Daicel Chemical Industries, Ltd. Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
TW363959B (en) * 1994-03-23 1999-07-11 Sankyo Co Thiazolidine and oxazolidine derivatives, their preparation and their medical use
WO2003059884A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
JP2008524335A (ja) * 2004-12-21 2008-07-10 ギリアド サイエンシズ， インコーポレイテッド イミダゾ［４，５−ｃ］ピリジン化合物および抗ウイルス処置法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909467A (en) * 1958-07-09 1959-10-20 Us Vitamin Pharm Corp 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
DD153682A1 (de) * 1978-10-19 1982-01-27 Horst Bercher Verfahren zur herstellung neuer alkanolamine
DE3162756D1 (en) * 1980-05-22 1984-04-26 Beecham Group Plc Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
SG56656G (en) * 1980-07-28 1987-03-27 Pfizer Hypoglycemic 5-substituted oxazolidine-2, 4-diones
US4407811A (en) * 1981-01-02 1983-10-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
ES515751A0 (es) * 1981-10-13 1983-10-16 Pfizer "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
GR78120B (ja) * 1982-03-01 1984-09-26 Pfizer
JPS58183676A (ja) * 1982-04-19 1983-10-26 Takeda Chem Ind Ltd オキサゾ−ル誘導体
US4430337A (en) * 1982-06-23 1984-02-07 Pfizer Inc. Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
DE3476386D1 (de) * 1983-11-02 1989-03-02 Beecham Group Plc Morpholine derivatives
DE3466387D1 (en) * 1983-11-04 1987-10-29 Beecham Group Plc Tertiary amines
CA1249992A (en) * 1983-11-10 1989-02-14 Marcel Muller Oxazolidines
GB8412862D0 (en) * 1984-05-19 1984-06-27 Beecham Group Plc Compounds
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
WO1986002073A1 (en) * 1984-10-03 1986-04-10 Takeda Chemical Industries, Ltd. Thiazolidinedione derivatives, process for their preparation, and pharmaceutical composition containing same
DE3438839A1 (de) * 1984-10-19 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische praeparate
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4812570A (en) * 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
EP0295828A1 (en) * 1987-06-13 1988-12-21 Beecham Group Plc Novel compounds
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019496A1 (en) * 1988-09-13 1991-12-26 Tanabe Seiyaku Co., Ltd. Hypolipidemic agent
WO1994022857A1 (en) * 1993-04-07 1994-10-13 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
JP2009519929A (ja) * 2005-12-15 2009-05-21 アストラゼネカ アクチボラグ オキサゾリジノン化合物及び代謝型グルタミン酸レセプター増強剤としてのそれらの使用
JP2009522290A (ja) * 2005-12-30 2009-06-11 メルク エンド カムパニー インコーポレーテッド Ｃｅｔｐ阻害剤として有用な１，３−オキサゾリジン−２−オン誘導体

Also Published As

Publication number Publication date
EP0294995B1 (en) 1992-11-11
ATE82284T1 (de) 1992-11-15
PT87702A (pt) 1988-07-01
DK313588D0 (da) 1988-06-09
GR3007059T3 (ja) 1993-07-30
ES2045116T3 (es) 1994-01-16
EP0294995A1 (en) 1988-12-14
DE3875806D1 (de) 1992-12-17
IE881734L (en) 1988-12-10
FI895815A0 (fi) 1989-12-05
IL86603A0 (en) 1988-11-30
JPH0448791B2 (ja) 1992-08-07
AU585196B2 (en) 1989-06-08
AU1753488A (en) 1988-12-15
WO1988009661A1 (en) 1988-12-15
MY103297A (en) 1993-05-29
KR890000447A (ko) 1989-03-14
CA1305152C (en) 1992-07-14
NO890529D0 (no) 1989-02-08
PT87702B (pt) 1992-10-30
FI89479C (fi) 1993-10-11
IL86603A (en) 1992-09-06
FI89479B (fi) 1993-06-30
NO171978B (no) 1993-02-15
HUT53623A (en) 1990-11-28
KR900007313B1 (ko) 1990-10-08
DE3875806T2 (de) 1993-04-08
HU203330B (en) 1991-07-29
NZ224957A (en) 1990-03-27
DK313588A (da) 1989-02-10
NO171978C (no) 1993-05-26
NO890529L (no) 1989-02-08
IE62029B1 (en) 1994-12-14
US4968707A (en) 1990-11-06
ZA884114B (en) 1990-02-28

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