JPS64931B2 - - Google Patents
Info
- Publication number
- JPS64931B2 JPS64931B2 JP58058548A JP5854883A JPS64931B2 JP S64931 B2 JPS64931 B2 JP S64931B2 JP 58058548 A JP58058548 A JP 58058548A JP 5854883 A JP5854883 A JP 5854883A JP S64931 B2 JPS64931 B2 JP S64931B2
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- culture
- fraction
- pertussis
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 241000588832 Bordetella pertussis Species 0.000 claims description 16
- 229940066827 pertussis vaccine Drugs 0.000 claims description 15
- 229920000858 Cyclodextrin Polymers 0.000 claims description 11
- 235000001014 amino acid Nutrition 0.000 claims description 11
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 8
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- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 4
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- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 3
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- 108010024636 Glutathione Proteins 0.000 claims description 2
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- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
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- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
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- 239000004472 Lysine Substances 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
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- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
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- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
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- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 2
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- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
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- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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- 101710154643 Filamentous hemagglutinin Proteins 0.000 description 1
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- 241000699666 Mus <mouse, genus> Species 0.000 description 1
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- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
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Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58058548A JPS59184132A (ja) | 1983-04-02 | 1983-04-02 | 百日ぜきワクチンの製造方法 |
| CA000450495A CA1213234A (en) | 1983-03-30 | 1984-03-26 | Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine |
| EP84103504A EP0121249B1 (en) | 1983-03-30 | 1984-03-29 | Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine |
| KR1019840001645A KR900007658B1 (ko) | 1983-03-30 | 1984-03-29 | 백일해균 예방항원을 함유하는 ha 유분(留分)과 백일해 왁진의 제조방법 |
| DE8484103504T DE3484778D1 (de) | 1983-03-30 | 1984-03-29 | Verfahren zur herstellung der bordetella-pertussis-schutzantigene enthaltenden ha fraktion und keuchhustenvakzin. |
| ES531112A ES8505818A1 (es) | 1983-03-30 | 1984-03-29 | Un metodo para la produccion de una fraccion ha que contiene antigenos protectores de bordetella pertussis |
| AU26230/84A AU564634B2 (en) | 1983-03-30 | 1984-03-29 | Method for production of ha fraction containing protective antigens |
| AT84103504T ATE65028T1 (de) | 1983-03-30 | 1984-03-29 | Verfahren zur herstellung der bordetellapertussis-schutzantigene enthaltenden ha fraktion und keuchhustenvakzin. |
| US06/874,670 US4687738A (en) | 1983-03-30 | 1986-06-16 | Method for the production of HA fraction containing protective antigens of Bordetella pertussis and pertussis vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58058548A JPS59184132A (ja) | 1983-04-02 | 1983-04-02 | 百日ぜきワクチンの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59184132A JPS59184132A (ja) | 1984-10-19 |
| JPS64931B2 true JPS64931B2 (en, 2012) | 1989-01-10 |
Family
ID=13087507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58058548A Granted JPS59184132A (ja) | 1983-03-30 | 1983-04-02 | 百日ぜきワクチンの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59184132A (en, 2012) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61271986A (ja) * | 1985-05-27 | 1986-12-02 | Agency Of Ind Science & Technol | リンパ系細胞用培地 |
| WO2007111326A1 (ja) * | 2006-03-27 | 2007-10-04 | The Kitasato Institute | 長期保存においても毒性復帰がおこらない特徴を持つ全菌体細菌ワクチンならびにその用途 |
| SI2809343T1 (en) * | 2012-02-01 | 2018-01-31 | Glaxosmithkline Biologicals S.A. | Fermentation process |
-
1983
- 1983-04-02 JP JP58058548A patent/JPS59184132A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59184132A (ja) | 1984-10-19 |
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