JPS642092B2 - - Google Patents
Info
- Publication number
- JPS642092B2 JPS642092B2 JP55048256A JP4825680A JPS642092B2 JP S642092 B2 JPS642092 B2 JP S642092B2 JP 55048256 A JP55048256 A JP 55048256A JP 4825680 A JP4825680 A JP 4825680A JP S642092 B2 JPS642092 B2 JP S642092B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- palladium
- autoclave
- formula
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000006243 chemical reaction Methods 0.000 claims description 96
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 74
- 239000002904 solvent Substances 0.000 claims description 45
- 229910052763 palladium Inorganic materials 0.000 claims description 35
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 30
- 150000003003 phosphines Chemical class 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000011541 reaction mixture Substances 0.000 claims description 26
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 125000002015 acyclic group Chemical group 0.000 claims description 13
- 150000001993 dienes Chemical class 0.000 claims description 13
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical group O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 13
- 125000004429 atom Chemical group 0.000 claims description 11
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 10
- 150000003512 tertiary amines Chemical class 0.000 claims description 10
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 9
- 150000002941 palladium compounds Chemical class 0.000 claims description 8
- -1 alkali metal cation Chemical class 0.000 claims description 7
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- HZYABSBSRWFZEG-UHFFFAOYSA-N octa-1,3-dien-1-ol Chemical compound CCCCC=CC=CO HZYABSBSRWFZEG-UHFFFAOYSA-N 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 1
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 50
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 48
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 44
- 239000003054 catalyst Substances 0.000 description 32
- 238000003756 stirring Methods 0.000 description 29
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 27
- 229910001873 dinitrogen Inorganic materials 0.000 description 27
- 239000007788 liquid Substances 0.000 description 26
- 239000001569 carbon dioxide Substances 0.000 description 22
- 229910002092 carbon dioxide Inorganic materials 0.000 description 22
- 239000000047 product Substances 0.000 description 21
- 238000004821 distillation Methods 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 238000004817 gas chromatography Methods 0.000 description 12
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 12
- 239000012298 atmosphere Substances 0.000 description 11
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 10
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- 239000011521 glass Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 7
- 239000000498 cooling water Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 5
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 5
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 5
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 5
- LVEYOSJUKRVCCF-UHFFFAOYSA-N 1,3-bis(diphenylphosphino)propane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCP(C=1C=CC=CC=1)C1=CC=CC=C1 LVEYOSJUKRVCCF-UHFFFAOYSA-N 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- RBHJBMIOOPYDBQ-UHFFFAOYSA-N carbon dioxide;propan-2-one Chemical compound O=C=O.CC(C)=O RBHJBMIOOPYDBQ-UHFFFAOYSA-N 0.000 description 4
- 238000001465 metallisation Methods 0.000 description 4
- PCELKVAQHUEQKH-UHFFFAOYSA-N octa-1,7-dien-3-ol Chemical compound C=CC(O)CCCC=C PCELKVAQHUEQKH-UHFFFAOYSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000005292 vacuum distillation Methods 0.000 description 4
- YHYGSIBXYYKYFB-VOTSOKGWSA-N (2e)-octa-2,7-dien-1-ol Chemical compound OC\C=C\CCCC=C YHYGSIBXYYKYFB-VOTSOKGWSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- HZYABSBSRWFZEG-BSWSSELBSA-N (1E,3E)-octa-1,3-dien-1-ol Chemical compound CCCC\C=C\C=C\O HZYABSBSRWFZEG-BSWSSELBSA-N 0.000 description 2
- MLBZLJCMHFCTQM-UHFFFAOYSA-N (2-methylphenyl)-diphenylphosphane Chemical compound CC1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 MLBZLJCMHFCTQM-UHFFFAOYSA-N 0.000 description 2
- RXYPXQSKLGGKOL-UHFFFAOYSA-N 1,4-dimethylpiperazine Chemical compound CN1CCN(C)CC1 RXYPXQSKLGGKOL-UHFFFAOYSA-N 0.000 description 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 2
- VJOVLWOJWKWJDW-UHFFFAOYSA-N 1-octa-1,3-dienoxyocta-1,3-diene Chemical compound CCCCC=CC=COC=CC=CCCCC VJOVLWOJWKWJDW-UHFFFAOYSA-N 0.000 description 2
- SDJHPPZKZZWAKF-UHFFFAOYSA-N 2,3-dimethylbuta-1,3-diene Chemical compound CC(=C)C(C)=C SDJHPPZKZZWAKF-UHFFFAOYSA-N 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- JQCXWCOOWVGKMT-UHFFFAOYSA-N phthalic acid diheptyl ester Natural products CCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC JQCXWCOOWVGKMT-UHFFFAOYSA-N 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- UECIEVHMKVBVLE-UHFFFAOYSA-M sodium;3-diphenylphosphanylbenzenesulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)C1=CC=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 UECIEVHMKVBVLE-UHFFFAOYSA-M 0.000 description 2
- ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 2
- IFXORIIYQORRMJ-UHFFFAOYSA-N tribenzylphosphane Chemical compound C=1C=CC=CC=1CP(CC=1C=CC=CC=1)CC1=CC=CC=C1 IFXORIIYQORRMJ-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- UYUUAUOYLFIRJG-UHFFFAOYSA-N tris(4-methoxyphenyl)phosphane Chemical compound C1=CC(OC)=CC=C1P(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 UYUUAUOYLFIRJG-UHFFFAOYSA-N 0.000 description 2
- BWHDROKFUHTORW-UHFFFAOYSA-N tritert-butylphosphane Chemical compound CC(C)(C)P(C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-N 0.000 description 2
- KDPNQUKYJYHMHN-AATRIKPKSA-N (3E)-octa-3,7-dien-1-ol Chemical compound OCC\C=C\CCC=C KDPNQUKYJYHMHN-AATRIKPKSA-N 0.000 description 1
- ZTJHDEXGCKAXRZ-FNORWQNLSA-N (3e)-octa-1,3,7-triene Chemical compound C=CCC\C=C\C=C ZTJHDEXGCKAXRZ-FNORWQNLSA-N 0.000 description 1
- BSHLUPBYQADWQM-UHFFFAOYSA-N (4-chlorophenyl)-diphenylphosphane Chemical compound C1=CC(Cl)=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 BSHLUPBYQADWQM-UHFFFAOYSA-N 0.000 description 1
- PMJHHCWVYXUKFD-SNAWJCMRSA-N (E)-1,3-pentadiene Chemical group C\C=C\C=C PMJHHCWVYXUKFD-SNAWJCMRSA-N 0.000 description 1
- XGCDBGRZEKYHNV-UHFFFAOYSA-N 1,1-bis(diphenylphosphino)methane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CP(C=1C=CC=CC=1)C1=CC=CC=C1 XGCDBGRZEKYHNV-UHFFFAOYSA-N 0.000 description 1
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 description 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- VYXHVRARDIDEHS-UHFFFAOYSA-N 1,5-cyclooctadiene Chemical compound C1CC=CCCC=C1 VYXHVRARDIDEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004912 1,5-cyclooctadiene Substances 0.000 description 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- KOCUMXQOUWPSLK-UHFFFAOYSA-N 1-methoxybuta-1,3-diene Chemical compound COC=CC=C KOCUMXQOUWPSLK-UHFFFAOYSA-N 0.000 description 1
- AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 1
- AXFVIWBTKYFOCY-UHFFFAOYSA-N 1-n,1-n,3-n,3-n-tetramethylbutane-1,3-diamine Chemical compound CN(C)C(C)CCN(C)C AXFVIWBTKYFOCY-UHFFFAOYSA-N 0.000 description 1
- YJJKYKYXZZCJEE-UHFFFAOYSA-N 2,2-diphenylethylphosphane Chemical compound C=1C=CC=CC=1C(CP)C1=CC=CC=C1 YJJKYKYXZZCJEE-UHFFFAOYSA-N 0.000 description 1
- HMVFITKXZCNKSS-UHFFFAOYSA-N 2-methoxy-n,n-dimethylethanamine Chemical compound COCCN(C)C HMVFITKXZCNKSS-UHFFFAOYSA-N 0.000 description 1
- IIFFFBSAXDNJHX-UHFFFAOYSA-N 2-methyl-n,n-bis(2-methylpropyl)propan-1-amine Chemical compound CC(C)CN(CC(C)C)CC(C)C IIFFFBSAXDNJHX-UHFFFAOYSA-N 0.000 description 1
- PPDFQRAASCRJAH-UHFFFAOYSA-N 2-methylthiolane 1,1-dioxide Chemical compound CC1CCCS1(=O)=O PPDFQRAASCRJAH-UHFFFAOYSA-N 0.000 description 1
- XLAXYNXVOVMHMJ-UHFFFAOYSA-N 3-ethoxy-n,n-dimethylpropan-1-amine Chemical compound CCOCCCN(C)C XLAXYNXVOVMHMJ-UHFFFAOYSA-N 0.000 description 1
- GNETVOUSGGAEDK-UHFFFAOYSA-N 4-bis[4-(dimethylamino)phenyl]phosphanyl-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1P(C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 GNETVOUSGGAEDK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WXNOJTUTEXAZLD-UHFFFAOYSA-L benzonitrile;dichloropalladium Chemical compound Cl[Pd]Cl.N#CC1=CC=CC=C1.N#CC1=CC=CC=C1 WXNOJTUTEXAZLD-UHFFFAOYSA-L 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- MFAXKNYFMHWMIG-UHFFFAOYSA-N ditert-butyl(octyl)phosphane Chemical compound CCCCCCCCP(C(C)(C)C)C(C)(C)C MFAXKNYFMHWMIG-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- UJNZOIKQAUQOCN-UHFFFAOYSA-N methyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C)C1=CC=CC=C1 UJNZOIKQAUQOCN-UHFFFAOYSA-N 0.000 description 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- DMQSHEKGGUOYJS-UHFFFAOYSA-N n,n,n',n'-tetramethylpropane-1,3-diamine Chemical compound CN(C)CCCN(C)C DMQSHEKGGUOYJS-UHFFFAOYSA-N 0.000 description 1
- XTAZYLNFDRKIHJ-UHFFFAOYSA-N n,n-dioctyloctan-1-amine Chemical compound CCCCCCCCN(CCCCCCCC)CCCCCCCC XTAZYLNFDRKIHJ-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- WZYUJMCDCAFUKD-UHFFFAOYSA-N octa-1,3-dien-3-ol Chemical compound CCCCC=C(O)C=C WZYUJMCDCAFUKD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- PENAXHPKEVTBLF-UHFFFAOYSA-L palladium(2+);prop-1-ene;dichloride Chemical compound [Pd+]Cl.[Pd+]Cl.[CH2-]C=C.[CH2-]C=C PENAXHPKEVTBLF-UHFFFAOYSA-L 0.000 description 1
- JKDRQYIYVJVOPF-FDGPNNRMSA-L palladium(ii) acetylacetonate Chemical compound [Pd+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O JKDRQYIYVJVOPF-FDGPNNRMSA-L 0.000 description 1
- GPNDARIEYHPYAY-UHFFFAOYSA-N palladium(ii) nitrate Chemical compound [Pd+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O GPNDARIEYHPYAY-UHFFFAOYSA-N 0.000 description 1
- JGBZTJWQMWZVNX-UHFFFAOYSA-N palladium;tricyclohexylphosphane Chemical compound [Pd].C1CCCCC1P(C1CCCCC1)C1CCCCC1.C1CCCCC1P(C1CCCCC1)C1CCCCC1 JGBZTJWQMWZVNX-UHFFFAOYSA-N 0.000 description 1
- 150000003012 phosphoric acid amides Chemical class 0.000 description 1
- PMJHHCWVYXUKFD-UHFFFAOYSA-N piperylene Natural products CC=CC=C PMJHHCWVYXUKFD-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 229940080818 propionamide Drugs 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- MDDUHVRJJAFRAU-YZNNVMRBSA-N tert-butyl-[(1r,3s,5z)-3-[tert-butyl(dimethyl)silyl]oxy-5-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane Chemical compound C1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C(=C)\C1=C/CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 MDDUHVRJJAFRAU-YZNNVMRBSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- IGNTWNVBGLNYDV-UHFFFAOYSA-N triisopropylphosphine Chemical compound CC(C)P(C(C)C)C(C)C IGNTWNVBGLNYDV-UHFFFAOYSA-N 0.000 description 1
- DMEUUKUNSVFYAA-UHFFFAOYSA-N trinaphthalen-1-ylphosphane Chemical compound C1=CC=C2C(P(C=3C4=CC=CC=C4C=CC=3)C=3C4=CC=CC=C4C=CC=3)=CC=CC2=C1 DMEUUKUNSVFYAA-UHFFFAOYSA-N 0.000 description 1
- RMZAYIKUYWXQPB-UHFFFAOYSA-N trioctylphosphane Chemical compound CCCCCCCCP(CCCCCCCC)CCCCCCCC RMZAYIKUYWXQPB-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
- WXAZIUYTQHYBFW-UHFFFAOYSA-N tris(4-methylphenyl)phosphane Chemical compound C1=CC(C)=CC=C1P(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 WXAZIUYTQHYBFW-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
æ¬çºæã¯éç°ç¶å
±åœ¹ãžãªã¬ãã€ã³ãšæ°Žãšãåå¿
ãããããšã«ããïœâã¢ã«ã«ãžãšããŒã«ã補é ã
ãããã®æ¹è¯ãããæ¹æ³ã«é¢ãããïœâã¢ã«ã«ãž
ãšããŒã«ã¯åææš¹èæ¹è³ªå€ã蟲è¬ãå»è¬ãéŠæãª
ã©ã®äžéäœãšããŠæçšãªååç©ã§ãããç¹ã«ãã¿
ãžãšã³ãšæ°Žãšã®åå¿ã«ããçæããïœâãªã¯ã¿ãž
ãšããŒã«ãæ°ŽçŽ éå ããŠåŸãããïœâãªã¯ã¿ãžãš
ããŒã«ã¯ããªå¡©åããã«ãªã©ã®å¯å¡å€ãšããŠåºã
å©çšãããŠãããžâïœâãªã¯ãã«ãã¿ã¬ãŒãã®å
æãšããŠéèŠã§ããããžâïœâãªã¯ãã«ãã¿ã¬ãŒ
ãã¯ïŒâãšãšãã«ãããµããŒã«ããåŸãããæ±çš
ã®ãžãªã¯ãã«ãã¿ã¬ãŒããšæ¯èŒããŠåçš®åºç€æ§èœ
ãåªããŠããã«ããããããããã®åæã§ããïœ
âãªã¯ã¿ãŒã«ãå·¥æ¥çã«å®äŸ¡ã«è£œé ããæ¹æ³ã確
ç«ãããŠããªãããå¯å¡å€ãšããŠå€§éã«äœ¿çšãã
ãã«ã¯è³ã€ãŠããªãã ãã®ãããªç¶æ³äžã«ãã€ãŠãïœâã¢ã«ã«ãžãšã
ãŒã«ãå®äŸ¡ã«è£œé ãããæ¹æ³ãšããŠãéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ãšæ°Žãšããããäž¡è ãå°ããšãéšå
çã«æº¶è§£ãã溶åªäžãçé žããã³ïŒãŸãã¯éçé ž
ã€ãªã³ããã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ãã
ãã³ãã¹ãã€ã³é¡ã®ååšäžã«åå¿ãããŠïœâã¢ã«
ã«ãžãšããŒã«ãåæããæ¹æ³ãææ¡ãããŠãã
ïŒããšãã°ç¹å ¬æ48â43327å·ãç¹å ¬æ50â10565
å·ãªã©ïŒããã©ãžãŠã ã¯æ¥µããŠé«äŸ¡ã§ããã®ã§ã
äžèšææ¡ã®æ¹æ³ã«ãããã€ãŠå·¥æ¥çèŠæš¡ã§ïœâã¢
ã«ã«ãžãšããŒã«ã補é ããã«ã¯ã觊åªæŽ»æ§ãé·æ
ã«äºã€ãŠå®å®ã«ç¶æããããšããã³è§Šåªãå¹çã
ã埪ç°äœ¿çšããããšãäžå¯æ¬ ã§ããã觊åªæŽ»æ§ã®
å®å®åã«ããªããšãã«ãã¹ãã€ã³ãªã©ã®ãã¹ãã€
ã³é¡ã®æ·»å ãæå¹ã§ããããšã¯åèšæç®ã«ããå ¬
ç¥ã§ããããã©ãžãŠã ã«å¯ŸããŠéå°éã®ãã¹ãã€
ã³é¡ãæ·»å ããããšã«ãã€ãŠè§ŠåªæŽ»æ§ãããçšåºŠ
ç¶æããããšãã§ãããããããªãããæ¬çºæè
ãã®è©³çŽ°ãªæ€èšã«ãããšããã¹ãã€ã³é¡ã®æ·»å ã«
ãã€ãŠããªã觊åªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶æ
ããããšãã§ããªãããšãå€æãããããšãã°ã
åå¿ã§çæããã¢ã«ã«ãžãšããŒã«é¡ã¯ãéåžžãèž
çã«ãã€ãŠåå¿æ··å液ããåé¢ãããããèžçæž©
床ãçŽ110âãè¶ãããšããšããã©ãžãŠã ã«å¯Ÿã
ãŠå€§ééã®ãã¹ãã€ã³é¡ãæ·»å ãããŠããŠã觊åª
ã®å€è³ªããã³ã¡ã¿ã«åãé¡èã«èµ·ããããã©ãžãŠ
ã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åã¯åã«è§ŠåªæŽ»æ§ã
äœäžãããã®ã¿ãªããã觊åªã®é£ç¶çãªåŸªç°äœ¿çš
ãå®è³ªçã«äžå¯èœã«ãããéç°ç¶å ±åœ¹ãžãªã¬ãã€
ã³ãšæ°Žãšã®åå¿ã«ãããŠã¯ãç®çãšããã¢ã«ã«ãž
ãšããŒã«é¡ã®ã»ãã«ãžã¢ã«ã«ãžãšãã«ãšãŒãã«ã
ã¯ãããšããé«æ²žç¹å¯çæç©ãçæããã®ã§ãã
ã©ãžãŠã 觊åªã®å€è³ªããã³ã¡ã¿ã«åãæå¶ããã
ãã«110â以äžã®æž©åºŠã§èžçãè¡ãªã€ãå Žåã«ã¯
ãããã®é«æ²žç¹å¯çæç©ã觊åªãå«ãæ®çç©äžã«
èç©ããçµæãšãªããããã觊åªã®åŸªç°ãç¹°ãè¿
ãéçšã§è§ŠåªæŽ»æ§ãäœäžãããã®ã§ããã®å Žåã
觊åªã®åŸªç°ã¯äžå¯èœãšãªãã ãã®ããã«ãã©ãžãŠã 觊åªãçšããŠéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ãšæ°Žãšã®åå¿ã«ããïœâã¢ã«ã«ãžãš
ããŒã«ãå·¥æ¥çèŠæš¡ã§è£œé ããã«éããŠã解決ã
ã¹ã課é¡ã¯ã觊åªæŽ»æ§å¯¿åœãé·æã«äºã€ãŠä¿æã
ãããšãããã³è§Šåªã®æŽ»æ§ãäœäžãããããšãªã
åå¿æ··å液ããçæç©ã®åé¢ãšè§Šåªã®åŸªç°ãè¡ãª
ãããšã§ããã éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšæ°Žãšããããäž¡è ã
å°ããšãéšåçã«æº¶è§£ãã溶åªäžãçé žããã³ïŒ
ãŸãã¯éçé žã€ãªã³ããã©ãžãŠã ãŸãã¯ãã©ãžãŠ
ã ååç©ãããã³ãã¹ãã€ã³é¡ã®ååšäžã«åå¿ã
ããŠïœâã¢ã«ã«ãžãšããŒã«ã補é ããã«éããŠã®
åè¿°ããçš®ã ã®åé¡ç¹ã¯æ¬çºæã«ããã°ãå座é
äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååãã
ãå°ããšãïŒã¢ã«ã®éã§çšãããã€äžèšäžè¬åŒ
ïŒïŒ ãåŒäžãã¯æ°ŽçŽ ååãŸãã¯âSO3Mãè¡šãã
ïŒïŒã¯ã¢ã«ã«ãªéå±ã®ã«ããªã³ãè¡šããïŒãã¯â
ïŒCH2ïŒoâïŒïœã¯ïŒãïŒã®æ°ãè¡šããïŒã
ãããããšã«ããïœâã¢ã«ã«ãžãšããŒã«ã補é ã
ãããã®æ¹è¯ãããæ¹æ³ã«é¢ãããïœâã¢ã«ã«ãž
ãšããŒã«ã¯åææš¹èæ¹è³ªå€ã蟲è¬ãå»è¬ãéŠæãª
ã©ã®äžéäœãšããŠæçšãªååç©ã§ãããç¹ã«ãã¿
ãžãšã³ãšæ°Žãšã®åå¿ã«ããçæããïœâãªã¯ã¿ãž
ãšããŒã«ãæ°ŽçŽ éå ããŠåŸãããïœâãªã¯ã¿ãžãš
ããŒã«ã¯ããªå¡©åããã«ãªã©ã®å¯å¡å€ãšããŠåºã
å©çšãããŠãããžâïœâãªã¯ãã«ãã¿ã¬ãŒãã®å
æãšããŠéèŠã§ããããžâïœâãªã¯ãã«ãã¿ã¬ãŒ
ãã¯ïŒâãšãšãã«ãããµããŒã«ããåŸãããæ±çš
ã®ãžãªã¯ãã«ãã¿ã¬ãŒããšæ¯èŒããŠåçš®åºç€æ§èœ
ãåªããŠããã«ããããããããã®åæã§ããïœ
âãªã¯ã¿ãŒã«ãå·¥æ¥çã«å®äŸ¡ã«è£œé ããæ¹æ³ã確
ç«ãããŠããªãããå¯å¡å€ãšããŠå€§éã«äœ¿çšãã
ãã«ã¯è³ã€ãŠããªãã ãã®ãããªç¶æ³äžã«ãã€ãŠãïœâã¢ã«ã«ãžãšã
ãŒã«ãå®äŸ¡ã«è£œé ãããæ¹æ³ãšããŠãéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ãšæ°Žãšããããäž¡è ãå°ããšãéšå
çã«æº¶è§£ãã溶åªäžãçé žããã³ïŒãŸãã¯éçé ž
ã€ãªã³ããã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ãã
ãã³ãã¹ãã€ã³é¡ã®ååšäžã«åå¿ãããŠïœâã¢ã«
ã«ãžãšããŒã«ãåæããæ¹æ³ãææ¡ãããŠãã
ïŒããšãã°ç¹å ¬æ48â43327å·ãç¹å ¬æ50â10565
å·ãªã©ïŒããã©ãžãŠã ã¯æ¥µããŠé«äŸ¡ã§ããã®ã§ã
äžèšææ¡ã®æ¹æ³ã«ãããã€ãŠå·¥æ¥çèŠæš¡ã§ïœâã¢
ã«ã«ãžãšããŒã«ã補é ããã«ã¯ã觊åªæŽ»æ§ãé·æ
ã«äºã€ãŠå®å®ã«ç¶æããããšããã³è§Šåªãå¹çã
ã埪ç°äœ¿çšããããšãäžå¯æ¬ ã§ããã觊åªæŽ»æ§ã®
å®å®åã«ããªããšãã«ãã¹ãã€ã³ãªã©ã®ãã¹ãã€
ã³é¡ã®æ·»å ãæå¹ã§ããããšã¯åèšæç®ã«ããå ¬
ç¥ã§ããããã©ãžãŠã ã«å¯ŸããŠéå°éã®ãã¹ãã€
ã³é¡ãæ·»å ããããšã«ãã€ãŠè§ŠåªæŽ»æ§ãããçšåºŠ
ç¶æããããšãã§ãããããããªãããæ¬çºæè
ãã®è©³çŽ°ãªæ€èšã«ãããšããã¹ãã€ã³é¡ã®æ·»å ã«
ãã€ãŠããªã觊åªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶æ
ããããšãã§ããªãããšãå€æãããããšãã°ã
åå¿ã§çæããã¢ã«ã«ãžãšããŒã«é¡ã¯ãéåžžãèž
çã«ãã€ãŠåå¿æ··å液ããåé¢ãããããèžçæž©
床ãçŽ110âãè¶ãããšããšããã©ãžãŠã ã«å¯Ÿã
ãŠå€§ééã®ãã¹ãã€ã³é¡ãæ·»å ãããŠããŠã觊åª
ã®å€è³ªããã³ã¡ã¿ã«åãé¡èã«èµ·ããããã©ãžãŠ
ã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åã¯åã«è§ŠåªæŽ»æ§ã
äœäžãããã®ã¿ãªããã觊åªã®é£ç¶çãªåŸªç°äœ¿çš
ãå®è³ªçã«äžå¯èœã«ãããéç°ç¶å ±åœ¹ãžãªã¬ãã€
ã³ãšæ°Žãšã®åå¿ã«ãããŠã¯ãç®çãšããã¢ã«ã«ãž
ãšããŒã«é¡ã®ã»ãã«ãžã¢ã«ã«ãžãšãã«ãšãŒãã«ã
ã¯ãããšããé«æ²žç¹å¯çæç©ãçæããã®ã§ãã
ã©ãžãŠã 觊åªã®å€è³ªããã³ã¡ã¿ã«åãæå¶ããã
ãã«110â以äžã®æž©åºŠã§èžçãè¡ãªã€ãå Žåã«ã¯
ãããã®é«æ²žç¹å¯çæç©ã觊åªãå«ãæ®çç©äžã«
èç©ããçµæãšãªããããã觊åªã®åŸªç°ãç¹°ãè¿
ãéçšã§è§ŠåªæŽ»æ§ãäœäžãããã®ã§ããã®å Žåã
觊åªã®åŸªç°ã¯äžå¯èœãšãªãã ãã®ããã«ãã©ãžãŠã 觊åªãçšããŠéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ãšæ°Žãšã®åå¿ã«ããïœâã¢ã«ã«ãžãš
ããŒã«ãå·¥æ¥çèŠæš¡ã§è£œé ããã«éããŠã解決ã
ã¹ã課é¡ã¯ã觊åªæŽ»æ§å¯¿åœãé·æã«äºã€ãŠä¿æã
ãããšãããã³è§Šåªã®æŽ»æ§ãäœäžãããããšãªã
åå¿æ··å液ããçæç©ã®åé¢ãšè§Šåªã®åŸªç°ãè¡ãª
ãããšã§ããã éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšæ°Žãšããããäž¡è ã
å°ããšãéšåçã«æº¶è§£ãã溶åªäžãçé žããã³ïŒ
ãŸãã¯éçé žã€ãªã³ããã©ãžãŠã ãŸãã¯ãã©ãžãŠ
ã ååç©ãããã³ãã¹ãã€ã³é¡ã®ååšäžã«åå¿ã
ããŠïœâã¢ã«ã«ãžãšããŒã«ã補é ããã«éããŠã®
åè¿°ããçš®ã ã®åé¡ç¹ã¯æ¬çºæã«ããã°ãå座é
äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååãã
ãå°ããšãïŒã¢ã«ã®éã§çšãããã€äžèšäžè¬åŒ
ïŒïŒ ãåŒäžãã¯æ°ŽçŽ ååãŸãã¯âSO3Mãè¡šãã
ïŒïŒã¯ã¢ã«ã«ãªéå±ã®ã«ããªã³ãè¡šããïŒãã¯â
ïŒCH2ïŒoâïŒïœã¯ïŒãïŒã®æ°ãè¡šããïŒã
ãåŒããŸãã¯
ãåŒããè¡šãããã¯
ãåŒãâïŒCH3ïŒ2ãâCOOMãŸãã¯â
SO3Mãè¡šããïŒãã ããããã³ïŒã¯åèšãšå
ããã®ãè¡šããïŒãã§ç€ºãããäºåº§é äœæ§ãã¹ã
ã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒ
ã¢ã«ã®éã§æ·»å ããããšã«ãã€ãŠæ¥µããŠå¹æçã«
解決ãããããšãèŠåºããããäžè¿°ããããã«æ¬
çºæã®æ¹æ³ã¯ç¹å®éã®å座é äœæ§ãã¹ãã€ã³é¡ã«
察ããŠç¹å®ã®æ§é ãæããäºåº§é äœæ§ãã¹ãã€ã³
é¡ã®ç¹å®éãçµåããŠçšããç¹ã«ç¹åŸŽãæãã
ããããã«ããé«ãåå¿é床ã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããã ãã§ãªãã觊åªã埪ç°
䜿çšããå Žåã§ã觊åªå€±æŽ»ç©è³ªã®èç©ã«ãã觊åª
ã®æŽ»æ§äœäžãæå¶ãããã®ã§è§ŠåªæŽ»æ§ãé·æã«äº
ã€ãŠå®å®ã«ç¶æããããšãã§ããã®ã§ããããã
ã«æ¬çºæã«ããã°ãåå¿æ··å液ããã®ïœâã¢ã«ã«
ãžãšããŒã«ã®èžçåé¢ã«éããŠããã©ãžãŠã 觊åª
ã®å€è³ªããã³ã¡ã¿ã«åãæå¶ãããããã觊åªã®
掻æ§ãäœäžãããããšãªã觊åªã埪ç°ããããšã
ã§ããããããã€ãŠæ¬çºæã«ããã°éç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ãšæ°Žãšã®åå¿ã«ããïœâã¢ã«ã«ãžãšã
ãŒã«ã®è£œé ãå·¥æ¥çã«æå©ã«å®æœããããšãã§ã
ãã ãã®ã»ãã«ãæ¬çºæã«ããã°åå¿ç³»ã«åŸ®éæ··å ¥
ããé žçŽ ã«ãã€ãŠãã¹ãã€ã³é¡ãé žåãããŠè§Šåª
æ¯ãšããŠäœçšãããã¹ãã€ã³ãªããµã€ããçæã
ãã®ãæå¶ããããšããå©ç¹ãããããããã ãªãæ¬çºæã«ãããŠçšããããå座é äœæ§ãã¹
ãã€ã³ãšã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãžãŠ
ã ïŒååã«å¯ŸããŠïŒå¯ŸïŒã§é äœãããååç©ã§ã
ããäºåº§é äœæ§ãã¹ãã€ã³ãšã¯ïŒååã®ãã¹ãã€
ã³ååç©ããã©ãžãŠã ïŒååã«å¯ŸããŠãã¬ãŒãé
äœããããšãã§ããããã«ååå ã«ïŒã€ã®é äœå¯
èœãªååãæããååç©ã§ããã æ¬çºæã®æ¹æ³ã«ãããŠè§ŠåªãšããŠçšããããã
ã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ãšããŠã¯åŸæ¥å ¬
ç¥ã®ãã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ããã¹ãŠ
䜿çšå¯èœã§ããããã©ãžãŠã ã¯æŽ»æ§çãªã©ã®äžæŽ»
æ§ãªæ äœäžã«æ²çãããŠçšããããšãã§ãããã
ã©ãžãŠã ååç©ãšããŠã¯å ·äœçã«ã¯ãã©ãžãŠã ã¢
ã»ãã«ã¢ã»ãããŒããé ¢é žãã©ãžãŠã ãïŒïŒïŒâ
ã·ã¯ããªã¯ã¿ãžãšã³ãã©ãžãŠã ã¯ãã©ã€ããÏâ
ã¢ãªã«ãã©ãžãŠã ã¯ãã©ã€ããÏâã¢ãªã«ãã©ãž
ãŠã ã¢ã»ããŒãããã¹ããªããšãã«ãã¹ãã€ã³ã
ã©ãžãŠã ã¯ãã©ã€ãããã¹ããªããšãã«ãã¹ãã€
ã³ãã©ãžãŠã ã¢ã»ããŒãããã¹ãããªã¹ïŒïœâã¡
ããã·ããšãã«ïŒãã¹ãã€ã³ããã©ãžãŠã ã¢ã»ã
ãŒãããã¹ïŒïœâããªã«ãžããšãã«ãã¹ãã€ã³ïŒ
ãã©ãžãŠã ã¯ãã©ã€ããããã©ãã¹ïŒããªããšã
ã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒããªã
ããã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒïœ
âããªã«ãžããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãã
ãã©ãã¹ïŒããªãã³ãžã«ãã¹ãã€ã³ïŒãã©ãžãŠ
ã ããã¹ïŒããªã·ã¯ãããã·ã«ãã¹ãã€ã³ïŒãã©
ãžãŠã ã¢ã»ããŒãããã¹ïŒã¡ãã«ãžããšãã«ãã¹
ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€ããããã¹ïŒïŒïŒïŒ
âãžããšãã«ãã¹ãã€ãïŒãšã¿ã³ããã©ãžãŠã ã¢
ã»ããŒãããã¹ïŒãã³ãŸãããªã«ïŒãã©ãžãŠã ã¯
ãã©ã€ããå¡©åãã©ãžãŠã ãç¡é žãã©ãžãŠã ãç¡«
é žãã©ãžãŠã ããããªãŠã ã¯ãããã©ããŒããªã©
ãæããããšãã§ãããïœâã¢ã«ã«ãžãšããŒã«å
æã«ãããçã®è§ŠåªæŽ»æ§çš®ã¯äœåå䟡ãã©ãžãŠã
é¯äœã§ããã®ã§ãäºäŸ¡ã®ãã©ãžãŠã ååç©ã觊åª
ãšããŠçšããå Žåã«ã¯åå¿ç³»äžã«ååšãããã¹ã
ã€ã³é¡ãŸãã¯ãã¿ãžãšã³ã§éå ããããšã«ãã€ãŠ
掻æ§é¯äœãçæãããããšãã§ããããåäžåå¿
ç³»å ãŸãã¯å¥ã®åå¿å®¹åšå ã§éå äœçšãããåå
ç©ãå ±åãããããšã«ãã€ãŠè§ŠåªæŽ»æ§çš®ãçæã
ããŠäœ¿çšããããšãã§ããããã®ãããªç®çã«çš
ããããéå å€ãšããŠã¯ã¢ã«ã«ãªéå±æ°Žé žåç©ã
æ°ŽçŽ åããŠçŽ ãããªãŠã ãäºéæ«ããã°ãã·ãŠ
ã ãããã©ãžã³ãã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããã¢
ã«ã«ãªéå±ã«ã«ãã³é žå¡©ãªã©ãæããããšãã§ã
ããéå å€ã¯ãã©ãžãŠã ã®åå䟡ãå€ããããã«
å¿ èŠãªååŠéè«éä»è¿ã§äœ¿çšããã®ãå®çšçã§ã
ãããã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ã®äœ¿çšé
ã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããå·¥æ¥çã«ã¯åå¿ç³»
ã«ååšãã溶åªããã³æ°Žã®åèšéïŒããããã©
ãžãŠã ååãšããŠ0.1ã100ããªã°ã©ã ååã奜ãŸ
ããã¯0.5ã30ããªã°ã©ã ååã®æ¿åºŠã§çšããã®
ãæãŸããã å座é äœæ§ãã¹ãã€ã³é¡ãšããŠã¯ããããŸã§ïœ
âã¢ã«ã«ãžãšããŒã«ã®åæã«ãããŠææ¡ãããŠã
ãå座é äœæ§ã®ãã¹ãã€ã³é¡ããã¹ãŠæããããš
ãã§ãããå ·äœçã«ã¯ããªãªã¯ãã«ãã¹ãã€ã³ã
ããªâïœâããã«ãã¹ãã€ã³ãããªã€ãœãããã«
ãã¹ãã€ã³ãããªããã«ãã¹ãã€ã³ãããªã·ã¯ã
ããã·ã«ãã¹ãã€ã³ããžâïœâããã«ãªã¯ãã«ã
ã¹ãã€ã³ãããªããšãã«ãã¹ãã€ã³ãããªâïœâ
ããªã«ãã¹ãã€ã³ãããªâïœâããªã«ãã¹ãã€
ã³ããžããšãã«âïœâã¯ããããšãã«ãã¹ãã€
ã³ãããªã¹ïŒïœâãžã¡ãã«ã¢ããããšãã«ïŒãã¹
ãã€ã³ãããªã¹ïŒïœâã¡ããã·ããšãã«ïŒãã¹ã
ã€ã³ã
ããã®ãè¡šããïŒãã§ç€ºãããäºåº§é äœæ§ãã¹ã
ã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒ
ã¢ã«ã®éã§æ·»å ããããšã«ãã€ãŠæ¥µããŠå¹æçã«
解決ãããããšãèŠåºããããäžè¿°ããããã«æ¬
çºæã®æ¹æ³ã¯ç¹å®éã®å座é äœæ§ãã¹ãã€ã³é¡ã«
察ããŠç¹å®ã®æ§é ãæããäºåº§é äœæ§ãã¹ãã€ã³
é¡ã®ç¹å®éãçµåããŠçšããç¹ã«ç¹åŸŽãæãã
ããããã«ããé«ãåå¿é床ã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããã ãã§ãªãã觊åªã埪ç°
䜿çšããå Žåã§ã觊åªå€±æŽ»ç©è³ªã®èç©ã«ãã觊åª
ã®æŽ»æ§äœäžãæå¶ãããã®ã§è§ŠåªæŽ»æ§ãé·æã«äº
ã€ãŠå®å®ã«ç¶æããããšãã§ããã®ã§ããããã
ã«æ¬çºæã«ããã°ãåå¿æ··å液ããã®ïœâã¢ã«ã«
ãžãšããŒã«ã®èžçåé¢ã«éããŠããã©ãžãŠã 觊åª
ã®å€è³ªããã³ã¡ã¿ã«åãæå¶ãããããã觊åªã®
掻æ§ãäœäžãããããšãªã觊åªã埪ç°ããããšã
ã§ããããããã€ãŠæ¬çºæã«ããã°éç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ãšæ°Žãšã®åå¿ã«ããïœâã¢ã«ã«ãžãšã
ãŒã«ã®è£œé ãå·¥æ¥çã«æå©ã«å®æœããããšãã§ã
ãã ãã®ã»ãã«ãæ¬çºæã«ããã°åå¿ç³»ã«åŸ®éæ··å ¥
ããé žçŽ ã«ãã€ãŠãã¹ãã€ã³é¡ãé žåãããŠè§Šåª
æ¯ãšããŠäœçšãããã¹ãã€ã³ãªããµã€ããçæã
ãã®ãæå¶ããããšããå©ç¹ãããããããã ãªãæ¬çºæã«ãããŠçšããããå座é äœæ§ãã¹
ãã€ã³ãšã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãžãŠ
ã ïŒååã«å¯ŸããŠïŒå¯ŸïŒã§é äœãããååç©ã§ã
ããäºåº§é äœæ§ãã¹ãã€ã³ãšã¯ïŒååã®ãã¹ãã€
ã³ååç©ããã©ãžãŠã ïŒååã«å¯ŸããŠãã¬ãŒãé
äœããããšãã§ããããã«ååå ã«ïŒã€ã®é äœå¯
èœãªååãæããååç©ã§ããã æ¬çºæã®æ¹æ³ã«ãããŠè§ŠåªãšããŠçšããããã
ã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ãšããŠã¯åŸæ¥å ¬
ç¥ã®ãã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ããã¹ãŠ
䜿çšå¯èœã§ããããã©ãžãŠã ã¯æŽ»æ§çãªã©ã®äžæŽ»
æ§ãªæ äœäžã«æ²çãããŠçšããããšãã§ãããã
ã©ãžãŠã ååç©ãšããŠã¯å ·äœçã«ã¯ãã©ãžãŠã ã¢
ã»ãã«ã¢ã»ãããŒããé ¢é žãã©ãžãŠã ãïŒïŒïŒâ
ã·ã¯ããªã¯ã¿ãžãšã³ãã©ãžãŠã ã¯ãã©ã€ããÏâ
ã¢ãªã«ãã©ãžãŠã ã¯ãã©ã€ããÏâã¢ãªã«ãã©ãž
ãŠã ã¢ã»ããŒãããã¹ããªããšãã«ãã¹ãã€ã³ã
ã©ãžãŠã ã¯ãã©ã€ãããã¹ããªããšãã«ãã¹ãã€
ã³ãã©ãžãŠã ã¢ã»ããŒãããã¹ãããªã¹ïŒïœâã¡
ããã·ããšãã«ïŒãã¹ãã€ã³ããã©ãžãŠã ã¢ã»ã
ãŒãããã¹ïŒïœâããªã«ãžããšãã«ãã¹ãã€ã³ïŒ
ãã©ãžãŠã ã¯ãã©ã€ããããã©ãã¹ïŒããªããšã
ã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒããªã
ããã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒïœ
âããªã«ãžããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãã
ãã©ãã¹ïŒããªãã³ãžã«ãã¹ãã€ã³ïŒãã©ãžãŠ
ã ããã¹ïŒããªã·ã¯ãããã·ã«ãã¹ãã€ã³ïŒãã©
ãžãŠã ã¢ã»ããŒãããã¹ïŒã¡ãã«ãžããšãã«ãã¹
ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€ããããã¹ïŒïŒïŒïŒ
âãžããšãã«ãã¹ãã€ãïŒãšã¿ã³ããã©ãžãŠã ã¢
ã»ããŒãããã¹ïŒãã³ãŸãããªã«ïŒãã©ãžãŠã ã¯
ãã©ã€ããå¡©åãã©ãžãŠã ãç¡é žãã©ãžãŠã ãç¡«
é žãã©ãžãŠã ããããªãŠã ã¯ãããã©ããŒããªã©
ãæããããšãã§ãããïœâã¢ã«ã«ãžãšããŒã«å
æã«ãããçã®è§ŠåªæŽ»æ§çš®ã¯äœåå䟡ãã©ãžãŠã
é¯äœã§ããã®ã§ãäºäŸ¡ã®ãã©ãžãŠã ååç©ã觊åª
ãšããŠçšããå Žåã«ã¯åå¿ç³»äžã«ååšãããã¹ã
ã€ã³é¡ãŸãã¯ãã¿ãžãšã³ã§éå ããããšã«ãã€ãŠ
掻æ§é¯äœãçæãããããšãã§ããããåäžåå¿
ç³»å ãŸãã¯å¥ã®åå¿å®¹åšå ã§éå äœçšãããåå
ç©ãå ±åãããããšã«ãã€ãŠè§ŠåªæŽ»æ§çš®ãçæã
ããŠäœ¿çšããããšãã§ããããã®ãããªç®çã«çš
ããããéå å€ãšããŠã¯ã¢ã«ã«ãªéå±æ°Žé žåç©ã
æ°ŽçŽ åããŠçŽ ãããªãŠã ãäºéæ«ããã°ãã·ãŠ
ã ãããã©ãžã³ãã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããã¢
ã«ã«ãªéå±ã«ã«ãã³é žå¡©ãªã©ãæããããšãã§ã
ããéå å€ã¯ãã©ãžãŠã ã®åå䟡ãå€ããããã«
å¿ èŠãªååŠéè«éä»è¿ã§äœ¿çšããã®ãå®çšçã§ã
ãããã©ãžãŠã ãŸãã¯ãã©ãžãŠã ååç©ã®äœ¿çšé
ã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããå·¥æ¥çã«ã¯åå¿ç³»
ã«ååšãã溶åªããã³æ°Žã®åèšéïŒããããã©
ãžãŠã ååãšããŠ0.1ã100ããªã°ã©ã ååã奜ãŸ
ããã¯0.5ã30ããªã°ã©ã ååã®æ¿åºŠã§çšããã®
ãæãŸããã å座é äœæ§ãã¹ãã€ã³é¡ãšããŠã¯ããããŸã§ïœ
âã¢ã«ã«ãžãšããŒã«ã®åæã«ãããŠææ¡ãããŠã
ãå座é äœæ§ã®ãã¹ãã€ã³é¡ããã¹ãŠæããããš
ãã§ãããå ·äœçã«ã¯ããªãªã¯ãã«ãã¹ãã€ã³ã
ããªâïœâããã«ãã¹ãã€ã³ãããªã€ãœãããã«
ãã¹ãã€ã³ãããªããã«ãã¹ãã€ã³ãããªã·ã¯ã
ããã·ã«ãã¹ãã€ã³ããžâïœâããã«ãªã¯ãã«ã
ã¹ãã€ã³ãããªããšãã«ãã¹ãã€ã³ãããªâïœâ
ããªã«ãã¹ãã€ã³ãããªâïœâããªã«ãã¹ãã€
ã³ããžããšãã«âïœâã¯ããããšãã«ãã¹ãã€
ã³ãããªã¹ïŒïœâãžã¡ãã«ã¢ããããšãã«ïŒãã¹
ãã€ã³ãããªã¹ïŒïœâã¡ããã·ããšãã«ïŒãã¹ã
ã€ã³ã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒããžããšãã«ãšãã«
ãã¹ãã€ã³ãããªãã³ãžã«ãã¹ãã€ã³ã
ïŒC6H5ïŒ2PCïŒCH3ïŒ2COONaã
ïŒC6H5ïŒ2PCïŒCH3ïŒ2COONaã
ãåŒãïŒC6H5ïŒ2PC
ïŒCH3ïŒ2NïŒC2H5ïŒ2ãïŒC6H5ïŒ2PCH2CHïŒCH3ïŒïŒ®
ïŒCH3ïŒ2ãªã©ãæããããšãã§ãããå座é äœæ§
ãã¹ãã€ã³é¡ã¯åç¬ã§çšããŠãããããã¯äºçš®ä»¥
äžãæ··åããŠçšããŠããããå座é äœæ§ãã¹ãã€
ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååãããå°ããšãïŒ
ã¢ã«ä»¥äžã奜ãŸããã¯10ã¢ã«ä»¥äžã®å²åã§äœ¿çšã
ãããå座é äœæ§ãã¹ãã€ã³é¡ã®äœ¿çšéã«ã€ããŠ
å³å¯ãªæå³ã§ã®äžéã¯ãªãããäžè¬ã«ã¯ãã©ãžãŠ
ã ïŒã°ã©ã ååããã250ã¢ã«ä»¥äžã奜ãŸããã¯
50ã¢ã«ä»¥äžã§çšããã®ãæãŸããã å座é äœæ§ãã¹ãã€ã³é¡ãšçµåããŠçšãããã
äžè¬åŒïŒïŒã§ç€ºãããäºåº§é äœæ§ãã¹ãã€ã³é¡
ã«ãããŠããŸãã¯ïŒ¢ã§è¡šããããâSO3Mãã
ã³âCOOMã®ïŒã¯ãããªãŠã ãã«ãªãŠã ãªã©ã®
ã¢ã«ã«ãªéå±ã®ã«ããªã³ã§ãããïŒãšããŠã¯ãšã
ã«ãããªãŠã ããã³ã«ãªãŠã ã®ã«ããªã³ã奜ãŸã
ããäºåº§é äœæ§ãã¹ãã€ã³é¡ãšããŠã¯äžèšã®ãã®
ãäŸç€ºããããšãã§ããã ïŒC6H5ïŒ2PCH2PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2P
ïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ3PïŒC6H5ïŒ2ã
ïŒC6H5ïŒ2PïŒCH2ïŒ4PïŒC6H5ïŒ2ã
ïŒCH3ïŒ2ãªã©ãæããããšãã§ãããå座é äœæ§
ãã¹ãã€ã³é¡ã¯åç¬ã§çšããŠãããããã¯äºçš®ä»¥
äžãæ··åããŠçšããŠããããå座é äœæ§ãã¹ãã€
ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååãããå°ããšãïŒ
ã¢ã«ä»¥äžã奜ãŸããã¯10ã¢ã«ä»¥äžã®å²åã§äœ¿çšã
ãããå座é äœæ§ãã¹ãã€ã³é¡ã®äœ¿çšéã«ã€ããŠ
å³å¯ãªæå³ã§ã®äžéã¯ãªãããäžè¬ã«ã¯ãã©ãžãŠ
ã ïŒã°ã©ã ååããã250ã¢ã«ä»¥äžã奜ãŸããã¯
50ã¢ã«ä»¥äžã§çšããã®ãæãŸããã å座é äœæ§ãã¹ãã€ã³é¡ãšçµåããŠçšãããã
äžè¬åŒïŒïŒã§ç€ºãããäºåº§é äœæ§ãã¹ãã€ã³é¡
ã«ãããŠããŸãã¯ïŒ¢ã§è¡šããããâSO3Mãã
ã³âCOOMã®ïŒã¯ãããªãŠã ãã«ãªãŠã ãªã©ã®
ã¢ã«ã«ãªéå±ã®ã«ããªã³ã§ãããïŒãšããŠã¯ãšã
ã«ãããªãŠã ããã³ã«ãªãŠã ã®ã«ããªã³ã奜ãŸã
ããäºåº§é äœæ§ãã¹ãã€ã³é¡ãšããŠã¯äžèšã®ãã®
ãäŸç€ºããããšãã§ããã ïŒC6H5ïŒ2PCH2PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2P
ïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ3PïŒC6H5ïŒ2ã
ïŒC6H5ïŒ2PïŒCH2ïŒ4PïŒC6H5ïŒ2ã
ãåŒã
ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2N
ïŒCH3ïŒ2ãïŒC6H5ïŒ2PCH2CH2SO3Naã
ïŒC6H5ïŒ2PCH2CH2COONaãå座é äœæ§ãã¹ãã€
ã³é¡ãšåæ§ã«äºåº§é äœæ§ãã¹ãã€ã³é¡ã¯åç¬ã§çš
ããŠãããããã¯äºçš®ä»¥äžãæ··åããŠçšããŠãã
ããäºåº§é äœæ§ãã¹ãã€ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©
ã ååããã0.3ãïŒã¢ã«ã®å²åã§åå¿ç³»ã«æ·»å
ããããæ·»å éã0.3ã¢ã«æªæºã®å Žåã«ã¯äºåº§é
äœæ§ãã¹ãã€ã³é¡ãæ·»å ããããšã«ããå¹æãå®
質çã«çºçŸãããïŒã¢ã«ãè¶ããå Žåã¯ããã€ãŠ
åå¿ãé»å®³ããåå¿é床ã極端ã«äœäžããã æ¬çºæã«ãããŠåå¿ç³»ã«å¡©åºæ§å®æ°pKaãïŒä»¥
äžã®å座é äœæ§ç¬¬äžçŽã¢ãã³é¡ãæ·»å ããããšã«
ããåå¿ãèããä¿é²ããããã¢ãã³é¡ã®æ·»å ã«
ããåå¿ã®ä¿é²å¹æã¯ãããšãã°ããªãžã³ãªã©ã®
pKaãïŒæªæºã®å座é äœæ§ç¬¬äžçŽã¢ãã³ãããã
ã¯ããšãpKaãïŒä»¥äžãã€ãŠãïŒïŒ®ïŒNâ²ïŒ
Nâ²âããã©ã¡ãã«âïŒïŒïŒâãšã¿ã³ãžã¢ãã³ã
ïŒïŒ®ïŒNâ²ïŒNâ²âããã©ã¡ãã«âïŒïŒïŒâãã
ãã³ãžã¢ãã³ãªã©ã®äºåº§é äœæ§ã®ç¬¬äžçŽã¢ãã³ã
çšããã®ã§ã¯ããããããªããæ¬çºæã§çšããã
ãå座é äœæ§ç¬¬äžçŽã¢ãã³é¡ã®å ·äœäŸãšããŠã¯ã
ããªã¡ãã«ã¢ãã³ãããªãšãã«ã¢ãã³ãããªãã
ãã«ã¢ãã³ãããªã€ãœããã«ã¢ãã³ãããªãªã¯ã
ã«ã¢ãã³ãªã©ã§ä»£è¡šãããããªã¢ã«ãã«ã¢ãã³
é¡ãïŒâïŒïŒ®âãžã¡ãã«ã¢ããâïŒâãããã
ãŒã«ãïŒâïŒïŒ®âãžã¡ãã«ã¢ããâïŒâãã¿ã
ãŒã«ãªã©ã®ã¢ããã¢ã«ã³ãŒã«é¡ãããã³ïŒ®ïŒïŒ®â
ãžã¡ãã«âïŒâã¡ããã·ãšãã«ã¢ãã³ãïŒïŒ®â
ãžã¡ãã«âïŒâãšããã·ãããã«ã¢ãã³ãâã¡
ãã«ãããªãžã³ãâã¡ãã«ãããªãžã³ãâã¡
ãã«ã¢ã«ããªã³ãïŒNâ²âãžã¡ãã«ããã©ãžã³ã
âã¡ãã«ããã³ãªã³ãïŒïŒ®ïŒNâ²ïŒNâ²âãã
ã©ã¡ãã«âïŒïŒïŒâãã¿ã³ãžã¢ãã³ãïŒïŒ®ïŒ
Nâ²ïŒNâ²âããã©ã¡ãã«ãããµã¡ãã¬ã³ãžã¢ãã³
ãªã©ãæããããããããã®ãã¡åå¿æ瞟ã沞
ç¹ã溶解æ§ãäŸ¡æ Œãªã©ã®è«žç¹ãèæ ®ãããšããªãš
ãã«ã¢ãã³ãç¹ã«å¥œãŸãããããã第äžçŽã¢ãã³
é¡ã®äœ¿çšéã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããäžè¬ç
ã«ã¯æº¶åªãšæ°Žãšã®åèšéã«å¯ŸããŠå®¹éæ¯ã§ïŒã70
容éããŒã»ã³ãã®å²åã§äœ¿çšãããã æ¬çºæã®æ¹æ³ã«ãããŠãåŸæ¥ææ¡ãããŠããæ¹
æ³ãšåæ§ã«çé žãŸãã¯éçé žã€ãªã³ãçšããããš
ã«ããïœâã¢ã«ã«ãžãšããŒã«ã®çæé床ãä¿é²ã
ãããçé žãŸãã¯éçé žã€ãªã³ãšããŠã¯åå¿ç³»å
ã§ãããäžããäºé žåççŽ ããã³ïŒãŸãã¯éçé ž
ãããªãŠã ãçšããã®ãå®çšçã§ãããåå¿ç³»å
ã«ãããçé žãŸãã¯éçé žã€ãªã³ã®æ¿åºŠã¯å¥œãŸã
ãã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã«å¯Ÿããã¢ã«æ¯ã§
0.01ã5.0ã®ç¯å²ã§ãããåå¿ç³»å ã«ãããçé ž
ãŸãã¯éçé žã€ãªã³ã®ç¬¬äžçŽã¢ãã³é¡ã«å¯Ÿããã¢
ã«æ¯ãïŒä»¥äžã®å Žåçé žã¯äž»ãšããŠåå¿ç³»å ã«ã
ããŠç¬¬äžçŽã¢ãã³é¡ãšçé žå¡©ã圢æããŠæº¶è§£ããŠ
ãããã®ãšèããããã æ°Žã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã«å¯ŸããŠååŠéè«
é以äžçšããããšãå¿ èŠã§ãããéåžžåå¿æ··å液
ã«å¯Ÿããæ¿åºŠã§ïŒééããŒã»ã³ã以äžã奜ãŸãã
ã¯10ã80ééããŒã»ã³ãã®ç¯å²ã§çšããããã 溶åªã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ããã³æ°Žã®äž¡è
ãå°ãªããšãéšåçã«æº¶è§£ããããšãå¿ èŠã§ã
ãããããæ¡ä»¶ãæºè¶³ãã溶åªãšããŠã¯åŸæ¥ææ¡
ãããŠããåçš®ã®ææ©æº¶åªãæããããšãã§ã
ããå ·äœçã«ã¯ãžãšãã«ãšãŒãã«ããžããã«ãšãŒ
ãã«ãããã©ããããã©ã³ããžãªããµã³ããžãªã
ãœã©ã³ããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ã
ããã©ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãå¹³
åååéã200ã2000ã®ããªãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãïœâãã¿ã
ãŒã«ãã€ãœãããããŒã«ãªã©ã®ç¬¬ïŒçŽãŸãã¯ç¬¬ïŒ
çŽã®ã¢ã«ã³ãŒã«é¡ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ã
ã³ãã¡ãã«ã€ãœããã«ã±ãã³ãªã©ã®ã±ãã³é¡ãã¢
ã»ããããªã«ããã³ãŸãããªã«ãããããªãããª
ã«ãªã©ã®ãããªã«é¡ãã¢ã»ãã¢ãããããããªã³
ã¢ãããïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãããïŒïŒ®
âãžã¡ãã«ã¢ã»ãã¢ãããªã©ã®ã¢ããé¡ããžã¡ã
ã«ã¹ã«ãããµã€ããªã©ã®ã¹ã«ãããµã€ãé¡ãã¹ã«
ãã©ã³ãã¡ãã«ã¹ã«ãã©ã³ãªã©ã®ã¹ã«ãã³é¡ãã
ããµã¡ãã«ãã¹ããªã«ã¢ãããªã©ã®ãªã³é žã¢ãã
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãå®æ¯éŠé žã¡ãã«ãª
ã©ã®ãšã¹ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬
ã³ããšãã«ãã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ ããã
ã³ããã¿ã³ããããµã³ãã·ã¯ããããµã³ãã¡ãã«
ã·ã¯ããããµã³ãªã©ã®èèªæçåæ°ŽçŽ çãæãã
ããã溶åªã®å€ãã¯éåžžåç¬ã§äœ¿çšãããããæ··
åããŠäœ¿çšããŠãäœãããã€ãããªãã溶çœãšã
ãŠå¥œãŸããçšããããã®ã¯ã¢ã»ããããªã«ããã³
ã¹ã«ãã©ã³ã§ããããããã®æº¶åªãçšããããšã«
ããåè¿°ã®ç¬¬äžçŽã¢ãã³é¡ã®æ·»å å¹æãèããçº
çŸããŠé«ãåå¿é床ãšéžæçã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããããã©ãžãŠã ã«å¯ŸããŠã
ã¹ãã€ã³é¡ãéå°éçšãããšäžè¬ã«åå¿é床ãè
ããäœäžãããããšãšãã«ïœâã¢ã«ã«ãžãšããŒã«
ã®éžæçãäœäžãããã溶åªãšããŠç¹ã«ã¹ã«ãã©
ã³ãçšããå Žåã«ã¯ããšããã©ãžãŠã ïŒã°ã©ã å
åã«å¯ŸããŠãã¹ãã€ã³é¡ã10ã¢ã«ä»¥äžäœ¿çšããŠã
çŽ90ïŒ ä»¥äžãšããé«ãéžæçã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããã éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšããŠã¯ãã¿ãžãšã³ã
ã€ãœãã¬ã³ããããªã¬ã³ãïŒïŒïŒâãžã¡ãã«ãã¿
ãžãšã³ãã¯ãããã¬ã³ãã¡ããã·ãã¿ãžãšã³ãªã©
ãäŸç€ºããããšãã§ããããã¿ãžãšã³ãšããŠã¯ç³
æ²¹ååŠå·¥æ¥ã«ãããŠC4çåãšåŒã°ããŠããçå
æ°ŽçŽ æ··åç©ã䜿çšããããšãã§ãããåå¿æ··å液
äžã®éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®æ¿åºŠã«ã€ããŠç¹å¥
ãªå¶éã¯ãªãã æ¬çºæã«ãããŠåå¿ã¯ãéåžžããã©ãžãŠã 觊
åªãå座é äœæ§ãã¹ãã€ã³é¡ãäºåº§é äœæ§ãã¹ã
ã€ã³é¡ãçé žããã³ïŒãŸãã¯éçé žã€ãªã³ãæ°Žã
溶åªãããã³å¿ èŠã«ããçšããããå¡©åºæ§å®æ°
pKaãïŒä»¥äžã®å座é äœæ§ç¬¬äžçŽã¢ãã³é¡ãããª
ãæ··å溶液ã«å¯ŸããŠéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãäŸ
絊ããããšã«ããå®æœããããåå¿ã¯10ã150âã
奜ãŸããã¯50ã120âã®æž©åºŠã§å®æœããããåå¿
è£ çœ®ãšããŠã¯æ¹æååå¿æ§œãæ°æ³¡å¡åå¿æ§œãªã©ã
ãèªäœå ¬ç¥ã®æ°æ¶²æ¥è§Šåã®è£ 眮ãçšããããšãã§
ãããåå¿ã¯ãããæ¹åŒã§ãå®æœããããšãã§ã
ãããå·¥æ¥çã«ã¯é£ç¶æ¹åŒã§å®æœããã®ãæãŸã
ãã çæããïœâã¢ã«ã«ãžãšããŒã«ã¯åå¿æ··å液ã
çŽæ¥èžçããããšã«ãã€ãŠåé¢ããããšãã§ãã
ããã¹ã«ãã©ã³ãã¢ã»ããããªã«ãªã©ã®æº¶åªã«èŠª
æ°Žæ§ã®å座é äœæ§ãã¹ãã€ã³é¡ãçµåããŠçšãã
ã€åå¿æ··å液ã«å¯Ÿããæ°Žã®æ¿åºŠã30ééïŒ ä»¥äžã«
ä¿ã¡ãªããåå¿ãè¡ãªãå Žåã«ã¯æœåºæ³ã«ãã€ãŠ
åé¢ããã®ãæå©ã§ãããçæç©ã®åé¢ã«æœåºæ³
ãæ¡çšããå Žåã«ã¯åå¿æ··å液ãçåæ°ŽçŽ é¡ã§æœ
åºããããšã«ãã€ãŠïœâã¢ã«ã«ãžãšããŒã«ãåé¢
ããæœåºå±€ããèžçã«ãã€ãŠïœâã¢ã«ã«ãžãšããŒ
ã«ãåé¢ååŸããããšãã§ããããã®å Žåã¯è§Šåª
æåãèžçæã®å ç±ã«ãããããªãã®ã§è§ŠåªæŽ»æ§
ãããé·æã«äºã€ãŠå®å®ã«ç¶æããããšãã§ã
ããæœåºæ³ã«ããçæç©ã®åé¢ãå¯èœã«ãã芪氎
æ§ã®å座é äœæ§ãã¹ãã€ã³é¡ãšã¯ãããšãã°åå
å ã«âSO3Mâ²âCOOMâ²ã
ïŒCH3ïŒ2ãïŒC6H5ïŒ2PCH2CH2SO3Naã
ïŒC6H5ïŒ2PCH2CH2COONaãå座é äœæ§ãã¹ãã€
ã³é¡ãšåæ§ã«äºåº§é äœæ§ãã¹ãã€ã³é¡ã¯åç¬ã§çš
ããŠãããããã¯äºçš®ä»¥äžãæ··åããŠçšããŠãã
ããäºåº§é äœæ§ãã¹ãã€ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©
ã ååããã0.3ãïŒã¢ã«ã®å²åã§åå¿ç³»ã«æ·»å
ããããæ·»å éã0.3ã¢ã«æªæºã®å Žåã«ã¯äºåº§é
äœæ§ãã¹ãã€ã³é¡ãæ·»å ããããšã«ããå¹æãå®
質çã«çºçŸãããïŒã¢ã«ãè¶ããå Žåã¯ããã€ãŠ
åå¿ãé»å®³ããåå¿é床ã極端ã«äœäžããã æ¬çºæã«ãããŠåå¿ç³»ã«å¡©åºæ§å®æ°pKaãïŒä»¥
äžã®å座é äœæ§ç¬¬äžçŽã¢ãã³é¡ãæ·»å ããããšã«
ããåå¿ãèããä¿é²ããããã¢ãã³é¡ã®æ·»å ã«
ããåå¿ã®ä¿é²å¹æã¯ãããšãã°ããªãžã³ãªã©ã®
pKaãïŒæªæºã®å座é äœæ§ç¬¬äžçŽã¢ãã³ãããã
ã¯ããšãpKaãïŒä»¥äžãã€ãŠãïŒïŒ®ïŒNâ²ïŒ
Nâ²âããã©ã¡ãã«âïŒïŒïŒâãšã¿ã³ãžã¢ãã³ã
ïŒïŒ®ïŒNâ²ïŒNâ²âããã©ã¡ãã«âïŒïŒïŒâãã
ãã³ãžã¢ãã³ãªã©ã®äºåº§é äœæ§ã®ç¬¬äžçŽã¢ãã³ã
çšããã®ã§ã¯ããããããªããæ¬çºæã§çšããã
ãå座é äœæ§ç¬¬äžçŽã¢ãã³é¡ã®å ·äœäŸãšããŠã¯ã
ããªã¡ãã«ã¢ãã³ãããªãšãã«ã¢ãã³ãããªãã
ãã«ã¢ãã³ãããªã€ãœããã«ã¢ãã³ãããªãªã¯ã
ã«ã¢ãã³ãªã©ã§ä»£è¡šãããããªã¢ã«ãã«ã¢ãã³
é¡ãïŒâïŒïŒ®âãžã¡ãã«ã¢ããâïŒâãããã
ãŒã«ãïŒâïŒïŒ®âãžã¡ãã«ã¢ããâïŒâãã¿ã
ãŒã«ãªã©ã®ã¢ããã¢ã«ã³ãŒã«é¡ãããã³ïŒ®ïŒïŒ®â
ãžã¡ãã«âïŒâã¡ããã·ãšãã«ã¢ãã³ãïŒïŒ®â
ãžã¡ãã«âïŒâãšããã·ãããã«ã¢ãã³ãâã¡
ãã«ãããªãžã³ãâã¡ãã«ãããªãžã³ãâã¡
ãã«ã¢ã«ããªã³ãïŒNâ²âãžã¡ãã«ããã©ãžã³ã
âã¡ãã«ããã³ãªã³ãïŒïŒ®ïŒNâ²ïŒNâ²âãã
ã©ã¡ãã«âïŒïŒïŒâãã¿ã³ãžã¢ãã³ãïŒïŒ®ïŒ
Nâ²ïŒNâ²âããã©ã¡ãã«ãããµã¡ãã¬ã³ãžã¢ãã³
ãªã©ãæããããããããã®ãã¡åå¿æ瞟ã沞
ç¹ã溶解æ§ãäŸ¡æ Œãªã©ã®è«žç¹ãèæ ®ãããšããªãš
ãã«ã¢ãã³ãç¹ã«å¥œãŸãããããã第äžçŽã¢ãã³
é¡ã®äœ¿çšéã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããäžè¬ç
ã«ã¯æº¶åªãšæ°Žãšã®åèšéã«å¯ŸããŠå®¹éæ¯ã§ïŒã70
容éããŒã»ã³ãã®å²åã§äœ¿çšãããã æ¬çºæã®æ¹æ³ã«ãããŠãåŸæ¥ææ¡ãããŠããæ¹
æ³ãšåæ§ã«çé žãŸãã¯éçé žã€ãªã³ãçšããããš
ã«ããïœâã¢ã«ã«ãžãšããŒã«ã®çæé床ãä¿é²ã
ãããçé žãŸãã¯éçé žã€ãªã³ãšããŠã¯åå¿ç³»å
ã§ãããäžããäºé žåççŽ ããã³ïŒãŸãã¯éçé ž
ãããªãŠã ãçšããã®ãå®çšçã§ãããåå¿ç³»å
ã«ãããçé žãŸãã¯éçé žã€ãªã³ã®æ¿åºŠã¯å¥œãŸã
ãã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã«å¯Ÿããã¢ã«æ¯ã§
0.01ã5.0ã®ç¯å²ã§ãããåå¿ç³»å ã«ãããçé ž
ãŸãã¯éçé žã€ãªã³ã®ç¬¬äžçŽã¢ãã³é¡ã«å¯Ÿããã¢
ã«æ¯ãïŒä»¥äžã®å Žåçé žã¯äž»ãšããŠåå¿ç³»å ã«ã
ããŠç¬¬äžçŽã¢ãã³é¡ãšçé žå¡©ã圢æããŠæº¶è§£ããŠ
ãããã®ãšèããããã æ°Žã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã«å¯ŸããŠååŠéè«
é以äžçšããããšãå¿ èŠã§ãããéåžžåå¿æ··å液
ã«å¯Ÿããæ¿åºŠã§ïŒééããŒã»ã³ã以äžã奜ãŸãã
ã¯10ã80ééããŒã»ã³ãã®ç¯å²ã§çšããããã 溶åªã¯éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ããã³æ°Žã®äž¡è
ãå°ãªããšãéšåçã«æº¶è§£ããããšãå¿ èŠã§ã
ãããããæ¡ä»¶ãæºè¶³ãã溶åªãšããŠã¯åŸæ¥ææ¡
ãããŠããåçš®ã®ææ©æº¶åªãæããããšãã§ã
ããå ·äœçã«ã¯ãžãšãã«ãšãŒãã«ããžããã«ãšãŒ
ãã«ãããã©ããããã©ã³ããžãªããµã³ããžãªã
ãœã©ã³ããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ã
ããã©ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãå¹³
åååéã200ã2000ã®ããªãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãïœâãã¿ã
ãŒã«ãã€ãœãããããŒã«ãªã©ã®ç¬¬ïŒçŽãŸãã¯ç¬¬ïŒ
çŽã®ã¢ã«ã³ãŒã«é¡ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ã
ã³ãã¡ãã«ã€ãœããã«ã±ãã³ãªã©ã®ã±ãã³é¡ãã¢
ã»ããããªã«ããã³ãŸãããªã«ãããããªãããª
ã«ãªã©ã®ãããªã«é¡ãã¢ã»ãã¢ãããããããªã³
ã¢ãããïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãããïŒïŒ®
âãžã¡ãã«ã¢ã»ãã¢ãããªã©ã®ã¢ããé¡ããžã¡ã
ã«ã¹ã«ãããµã€ããªã©ã®ã¹ã«ãããµã€ãé¡ãã¹ã«
ãã©ã³ãã¡ãã«ã¹ã«ãã©ã³ãªã©ã®ã¹ã«ãã³é¡ãã
ããµã¡ãã«ãã¹ããªã«ã¢ãããªã©ã®ãªã³é žã¢ãã
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãå®æ¯éŠé žã¡ãã«ãª
ã©ã®ãšã¹ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬
ã³ããšãã«ãã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ ããã
ã³ããã¿ã³ããããµã³ãã·ã¯ããããµã³ãã¡ãã«
ã·ã¯ããããµã³ãªã©ã®èèªæçåæ°ŽçŽ çãæãã
ããã溶åªã®å€ãã¯éåžžåç¬ã§äœ¿çšãããããæ··
åããŠäœ¿çšããŠãäœãããã€ãããªãã溶çœãšã
ãŠå¥œãŸããçšããããã®ã¯ã¢ã»ããããªã«ããã³
ã¹ã«ãã©ã³ã§ããããããã®æº¶åªãçšããããšã«
ããåè¿°ã®ç¬¬äžçŽã¢ãã³é¡ã®æ·»å å¹æãèããçº
çŸããŠé«ãåå¿é床ãšéžæçã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããããã©ãžãŠã ã«å¯ŸããŠã
ã¹ãã€ã³é¡ãéå°éçšãããšäžè¬ã«åå¿é床ãè
ããäœäžãããããšãšãã«ïœâã¢ã«ã«ãžãšããŒã«
ã®éžæçãäœäžãããã溶åªãšããŠç¹ã«ã¹ã«ãã©
ã³ãçšããå Žåã«ã¯ããšããã©ãžãŠã ïŒã°ã©ã å
åã«å¯ŸããŠãã¹ãã€ã³é¡ã10ã¢ã«ä»¥äžäœ¿çšããŠã
çŽ90ïŒ ä»¥äžãšããé«ãéžæçã§ïœâã¢ã«ã«ãžãšã
ãŒã«ãåŸãããšãã§ããã éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšããŠã¯ãã¿ãžãšã³ã
ã€ãœãã¬ã³ããããªã¬ã³ãïŒïŒïŒâãžã¡ãã«ãã¿
ãžãšã³ãã¯ãããã¬ã³ãã¡ããã·ãã¿ãžãšã³ãªã©
ãäŸç€ºããããšãã§ããããã¿ãžãšã³ãšããŠã¯ç³
æ²¹ååŠå·¥æ¥ã«ãããŠC4çåãšåŒã°ããŠããçå
æ°ŽçŽ æ··åç©ã䜿çšããããšãã§ãããåå¿æ··å液
äžã®éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®æ¿åºŠã«ã€ããŠç¹å¥
ãªå¶éã¯ãªãã æ¬çºæã«ãããŠåå¿ã¯ãéåžžããã©ãžãŠã 觊
åªãå座é äœæ§ãã¹ãã€ã³é¡ãäºåº§é äœæ§ãã¹ã
ã€ã³é¡ãçé žããã³ïŒãŸãã¯éçé žã€ãªã³ãæ°Žã
溶åªãããã³å¿ èŠã«ããçšããããå¡©åºæ§å®æ°
pKaãïŒä»¥äžã®å座é äœæ§ç¬¬äžçŽã¢ãã³é¡ãããª
ãæ··å溶液ã«å¯ŸããŠéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãäŸ
絊ããããšã«ããå®æœããããåå¿ã¯10ã150âã
奜ãŸããã¯50ã120âã®æž©åºŠã§å®æœããããåå¿
è£ çœ®ãšããŠã¯æ¹æååå¿æ§œãæ°æ³¡å¡åå¿æ§œãªã©ã
ãèªäœå ¬ç¥ã®æ°æ¶²æ¥è§Šåã®è£ 眮ãçšããããšãã§
ãããåå¿ã¯ãããæ¹åŒã§ãå®æœããããšãã§ã
ãããå·¥æ¥çã«ã¯é£ç¶æ¹åŒã§å®æœããã®ãæãŸã
ãã çæããïœâã¢ã«ã«ãžãšããŒã«ã¯åå¿æ··å液ã
çŽæ¥èžçããããšã«ãã€ãŠåé¢ããããšãã§ãã
ããã¹ã«ãã©ã³ãã¢ã»ããããªã«ãªã©ã®æº¶åªã«èŠª
æ°Žæ§ã®å座é äœæ§ãã¹ãã€ã³é¡ãçµåããŠçšãã
ã€åå¿æ··å液ã«å¯Ÿããæ°Žã®æ¿åºŠã30ééïŒ ä»¥äžã«
ä¿ã¡ãªããåå¿ãè¡ãªãå Žåã«ã¯æœåºæ³ã«ãã€ãŠ
åé¢ããã®ãæå©ã§ãããçæç©ã®åé¢ã«æœåºæ³
ãæ¡çšããå Žåã«ã¯åå¿æ··å液ãçåæ°ŽçŽ é¡ã§æœ
åºããããšã«ãã€ãŠïœâã¢ã«ã«ãžãšããŒã«ãåé¢
ããæœåºå±€ããèžçã«ãã€ãŠïœâã¢ã«ã«ãžãšããŒ
ã«ãåé¢ååŸããããšãã§ããããã®å Žåã¯è§Šåª
æåãèžçæã®å ç±ã«ãããããªãã®ã§è§ŠåªæŽ»æ§
ãããé·æã«äºã€ãŠå®å®ã«ç¶æããããšãã§ã
ããæœåºæ³ã«ããçæç©ã®åé¢ãå¯èœã«ãã芪氎
æ§ã®å座é äœæ§ãã¹ãã€ã³é¡ãšã¯ãããšãã°åå
å ã«âSO3Mâ²âCOOMâ²ã
ãåŒãïŒMâ²ã¯æ°ŽçŽ
ååãã¢ã«ã³ãŒã«æ®åºãŸãã¯ã¢ã«ã«ãªéå±ããã³
ã¢ã«ã«ãªåé¡éå±ããéžã°ããã«ããªã³ãè¡šã
ãïŒãªã©ã®åºãæããååç©ã§ãããå ·äœçã«ã¯
ã¢ã«ã«ãªåé¡éå±ããéžã°ããã«ããªã³ãè¡šã
ãïŒãªã©ã®åºãæããååç©ã§ãããå ·äœçã«ã¯
ãåŒã
ãåŒã
ãåŒãããã³
ãåŒããäŸç€ºããããšã
ã§ããã觊åªæåãå«ããèžçåŸã®æ®æ¶²ãŸãã¯æœ
åºã«ããæœæ®æ¶²ã¯ãã®ãŸãŸãããã¯äžéšè§Šåªè³ŠæŽ»
ããã®ã¡ãïœâã¢ã«ã«ãžãšããŒã«ã®åæåå¿ã«åŸª
ç°ãããã æ¬çºæã®æ¹æ³ã«ãã€ãŠåŸãããïœâã¢ã«ã«ãžãš
ããŒã«ã¯ãã®ãŸãŸååŠåæãšããŠäœ¿çšããããšã
ã§ããããããã«å ¬ç¥ã®æ¹æ³ã§æ°ŽçŽ éå ããŠïœâ
ã¢ã«ã«ããŒã«ã«å€æããããšãã§ããã 以äžå®æœäŸã«ãã€ãŠæ¬çºæã®æ¹æ³ãå ·äœçã«èª¬
æããããæ¬çºæã¯ãããå®æœäŸã«ãã€ãŠå¶éã
åãããã®ã§ã¯ãªãã å®æœäŸ ïŒ æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«
ãã¹ãã€ãïŒãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã
溶解ãããã€16.5ééïŒ ã®æ°Žãå«ã60mlã®ã¹ã«ã
ã©ã³æ°Žæº¶æ¶²ãããªãšãã«ã¢ãã³12ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11ïœããªãŒ
ãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€
ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æã
ãªãã30åéã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠ
ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå 液æãåº
ãå£ããå 液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæãããšãããïŒïŒïŒïŒïŒ
âãªã¯ã¿ããªãšã³0.3ïœãïŒïŒïŒâãªã¯ã¿ãžãšã³
âïŒâãªãŒã«21ïœãïŒïŒïŒâãªã¯ã¿ãžãšã³âïŒâ
ãªãŒã«1.6ïœããã³ãžãªã¯ã¿ãžãšãã«ãšãŒãã«0.5
ïœãçæããŠããããªãŒãã¯ã¬ãŒãå ã®å§åãåžž
å§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ããã©ã€ã¢ã€ã¹
âã¢ã»ãã³ãã¹ã«æµžãããã©ãããåããæžå§èž
çè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130âã«ä¿ã€ãŠ100
ã20mmïœã®æžå§äžã«åå¿æ··å液ãïŒæéåãã
ãŠèžçãããèžçæ··åç©ãšããŠ43ïœåŸãããããª
ãŒãã¯ã¬ãŒããå·åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ
ã¬ã¹ã§åžžå§ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã§åŸã
ããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãã
ãšãããïŒïŒïŒïŒïŒâãªã¯ã¿ããªãšã³0.3ïœãïŒïŒ
ïŒâãªã¯ã¿ãžãšã³âïŒâãªãŒã«22ïœãïŒïŒïŒâãª
ã¯ã¿ãžãšã³âïŒâãªãŒã«1.6ïœããã³ãžãªã¯ã¿ãž
ãšãã«ãšãŒãã«0.6ïœãçæããŠãããäžåç®ãš
äºåç®ã®åå¿çµæããæãããªããã«èžçã«ãã
觊åªæŽ»æ§ã®äœäžã¯ãŸã€ããèªããããªãã€ãã æ¯èŒäŸïŒããã³ïŒ ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒããã
ã³ã®æ·»å éãè¡šïŒã«ç€ºããããã«å€åããã以å€
ã¯ãå®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡ãªã€ãã
äºåç®ã®åå¿çµäºåŸãåå¿æ··å液äžã«ã¯å€éã®ã
ã©ãžãŠã ã¡ã¿ã«ãæåºããŠãããäžåç®ããã³äº
åç®ã®åå¿çµæãè¡šïŒã«ç€ºããã
åºã«ããæœæ®æ¶²ã¯ãã®ãŸãŸãããã¯äžéšè§Šåªè³ŠæŽ»
ããã®ã¡ãïœâã¢ã«ã«ãžãšããŒã«ã®åæåå¿ã«åŸª
ç°ãããã æ¬çºæã®æ¹æ³ã«ãã€ãŠåŸãããïœâã¢ã«ã«ãžãš
ããŒã«ã¯ãã®ãŸãŸååŠåæãšããŠäœ¿çšããããšã
ã§ããããããã«å ¬ç¥ã®æ¹æ³ã§æ°ŽçŽ éå ããŠïœâ
ã¢ã«ã«ããŒã«ã«å€æããããšãã§ããã 以äžå®æœäŸã«ãã€ãŠæ¬çºæã®æ¹æ³ãå ·äœçã«èª¬
æããããæ¬çºæã¯ãããå®æœäŸã«ãã€ãŠå¶éã
åãããã®ã§ã¯ãªãã å®æœäŸ ïŒ æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«
ãã¹ãã€ãïŒãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã
溶解ãããã€16.5ééïŒ ã®æ°Žãå«ã60mlã®ã¹ã«ã
ã©ã³æ°Žæº¶æ¶²ãããªãšãã«ã¢ãã³12ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11ïœããªãŒ
ãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€
ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æã
ãªãã30åéã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠ
ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå 液æãåº
ãå£ããå 液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæãããšãããïŒïŒïŒïŒïŒ
âãªã¯ã¿ããªãšã³0.3ïœãïŒïŒïŒâãªã¯ã¿ãžãšã³
âïŒâãªãŒã«21ïœãïŒïŒïŒâãªã¯ã¿ãžãšã³âïŒâ
ãªãŒã«1.6ïœããã³ãžãªã¯ã¿ãžãšãã«ãšãŒãã«0.5
ïœãçæããŠããããªãŒãã¯ã¬ãŒãå ã®å§åãåžž
å§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ããã©ã€ã¢ã€ã¹
âã¢ã»ãã³ãã¹ã«æµžãããã©ãããåããæžå§èž
çè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130âã«ä¿ã€ãŠ100
ã20mmïœã®æžå§äžã«åå¿æ··å液ãïŒæéåãã
ãŠèžçãããèžçæ··åç©ãšããŠ43ïœåŸãããããª
ãŒãã¯ã¬ãŒããå·åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ
ã¬ã¹ã§åžžå§ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã§åŸã
ããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãã
ãšãããïŒïŒïŒïŒïŒâãªã¯ã¿ããªãšã³0.3ïœãïŒïŒ
ïŒâãªã¯ã¿ãžãšã³âïŒâãªãŒã«22ïœãïŒïŒïŒâãª
ã¯ã¿ãžãšã³âïŒâãªãŒã«1.6ïœããã³ãžãªã¯ã¿ãž
ãšãã«ãšãŒãã«0.6ïœãçæããŠãããäžåç®ãš
äºåç®ã®åå¿çµæããæãããªããã«èžçã«ãã
觊åªæŽ»æ§ã®äœäžã¯ãŸã€ããèªããããªãã€ãã æ¯èŒäŸïŒããã³ïŒ ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒããã
ã³ã®æ·»å éãè¡šïŒã«ç€ºããããã«å€åããã以å€
ã¯ãå®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡ãªã€ãã
äºåç®ã®åå¿çµäºåŸãåå¿æ··å液äžã«ã¯å€éã®ã
ã©ãžãŠã ã¡ã¿ã«ãæåºããŠãããäžåç®ããã³äº
åç®ã®åå¿çµæãè¡šïŒã«ç€ºããã
ãè¡šã
å®æœäŸïŒããã³ïŒ
ã¹ã«ãã©ã³ã«å€ããŠè¡šïŒã«ç€ºãã溶åªã䜿çšã
ã以å€ã¯ãå®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡ãª
ã€ããäžåç®ããã³äºåç®ã®åå¿çµæãè¡šïŒã«ç€º
ããã
ã以å€ã¯ãå®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡ãª
ã€ããäžåç®ããã³äºåç®ã®åå¿çµæãè¡šïŒã«ç€º
ããã
ãè¡šã
å®æœäŸ ïŒãïŒ
ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒããã
ã³ã«å€ããŠè¡šïŒã«ç€ºãäºåº§é äœæ§ãã¹ãã€ã³ã䜿
çšãã以å€ã¯å®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡
ãªã€ããçµæãè¡šïŒã«ç€ºããã
ã³ã«å€ããŠè¡šïŒã«ç€ºãäºåº§é äœæ§ãã¹ãã€ã³ã䜿
çšãã以å€ã¯å®æœäŸïŒãšãŸã€ããåäžã®åå¿ãè¡
ãªã€ããçµæãè¡šïŒã«ç€ºããã
ãè¡šã
å®æœäŸïŒãïŒããã³æ¯èŒäŸïŒãïŒ
å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£
眮ã«ã16.5
ééïŒ ã®æ°Žãå«ãã 30mlã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ã«é ¢
é žãã©ãžãŠã 22mgïŒ0.1ããªã¢ã«ïŒãããªããšãã«
ãã¹ãã€ã³393mgïŒ1.5ããªã¢ã«ïŒããã³è¡šïŒã«ç€º
ãäºåº§é äœæ§ãã¹ãã€ã³ãè¡šïŒã«ç€ºããéã§æº¶è§£
ãã溶液ãããªãšãã«ã¢ãã³6.5ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³30ïœããã³äºé žåççŽ 8.8ïœããª
ãŒãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããª
ã€ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æ
ããªãã30åéã§å æž©ã75âãšããã®ã¡ããã®æž©
床ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸããªãŒãã¯
ã¬ãŒãäžãåžžå§ã«ãã©ããã®ã¡ããªãŒãã¯ã¬ãŒã
ã®ãµããéããåå¿æ··åç©ãåãåºããçæç©ã
ã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããçµæãè¡šïŒ
ã«ç€ºããã
ééïŒ ã®æ°Žãå«ãã 30mlã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ã«é ¢
é žãã©ãžãŠã 22mgïŒ0.1ããªã¢ã«ïŒãããªããšãã«
ãã¹ãã€ã³393mgïŒ1.5ããªã¢ã«ïŒããã³è¡šïŒã«ç€º
ãäºåº§é äœæ§ãã¹ãã€ã³ãè¡šïŒã«ç€ºããéã§æº¶è§£
ãã溶液ãããªãšãã«ã¢ãã³6.5ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³30ïœããã³äºé žåççŽ 8.8ïœããª
ãŒãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããª
ã€ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æ
ããªãã30åéã§å æž©ã75âãšããã®ã¡ããã®æž©
床ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸããªãŒãã¯
ã¬ãŒãäžãåžžå§ã«ãã©ããã®ã¡ããªãŒãã¯ã¬ãŒã
ã®ãµããéããåå¿æ··åç©ãåãåºããçæç©ã
ã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããçµæãè¡šïŒ
ã«ç€ºããã
ãè¡šã
å®æœäŸ 10
å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£
眮ã«ãããŠ
å 液æãåºãå£ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã
液æãåºãå£ããã³æº¶åªä»èŸŒã¿å£ãåããå 容é
ïŒã®é»ç£æ¹æåŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒã
ã«çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žã
ã©ãžãŠã 44mgããããªãŠã ãžããšãã«ãã¹ãã€ã
ãã³ãŒã³âïœâã¹ã«ãããŒãã»ïŒæ°Žåç©1200mgã
ãã³ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ248.6mgã55ééïŒ ã®
ã¹ã«ãã©ã³æ°Žæº¶æ¶²60mlã«æº¶è§£ãã溶液ãªãã³ã«ã
ãªãšãã«ã¢ãã³ïŒïœãçªçŽ ã¬ã¹é°å²æ°äžã«ä»èŸŒ
ã¿ããªãŒãã¯ã¬ãŒãã®ä»èŸŒã¿å£ããšããã次ã
ã§ããã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒ
ãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«ã€ã
800rpmã®é床ã§æ¹æããªããå æž©ã30åéã§80
âã«äžãããã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽæ°ŽãçšããŠæ¥å·ã
ãã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãåŽ
ã«å§éãããã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒããåžžå§ã«ã
ã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äžã«ã·ã¯ããããµã³
200mlããã³æ°ŽïŒïœãå ããŠçŽïŒåéæ¿ããæ¹æ
ãããæ¹æãæ¢ãéæ¢ãããšããç¡è²ã®äžå±€ãšé»
è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·ã¯ããããµã³å±€ã
æãåºããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããäžæ¹ãæœæ®æ¶²ã¯ããªãšãã«ã¢ãã³0.5ïœ
ãå ããã®ã¡åã³åå¿æ§œåŽã«çªçŽ ã¬ã¹ãçšããŠå§
éãããåå¿æ§œåŽã«ã¯äžåç®ãšåæ§ã«ããŠãã¿ãž
ãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒãã ã®ã¡ã
äžåç®ãšåäžã®å®éšãããè¿ããã以äžã®ããã«
ããŠïŒåã®ããè¿ãå®éšãå®æœããçµæãè¡šïŒã«
瀺ããã
å 液æãåºãå£ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã
液æãåºãå£ããã³æº¶åªä»èŸŒã¿å£ãåããå 容é
ïŒã®é»ç£æ¹æåŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒã
ã«çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žã
ã©ãžãŠã 44mgããããªãŠã ãžããšãã«ãã¹ãã€ã
ãã³ãŒã³âïœâã¹ã«ãããŒãã»ïŒæ°Žåç©1200mgã
ãã³ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ248.6mgã55ééïŒ ã®
ã¹ã«ãã©ã³æ°Žæº¶æ¶²60mlã«æº¶è§£ãã溶液ãªãã³ã«ã
ãªãšãã«ã¢ãã³ïŒïœãçªçŽ ã¬ã¹é°å²æ°äžã«ä»èŸŒ
ã¿ããªãŒãã¯ã¬ãŒãã®ä»èŸŒã¿å£ããšããã次ã
ã§ããã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒ
ãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«ã€ã
800rpmã®é床ã§æ¹æããªããå æž©ã30åéã§80
âã«äžãããã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽæ°ŽãçšããŠæ¥å·ã
ãã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãåŽ
ã«å§éãããã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒããåžžå§ã«ã
ã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äžã«ã·ã¯ããããµã³
200mlããã³æ°ŽïŒïœãå ããŠçŽïŒåéæ¿ããæ¹æ
ãããæ¹æãæ¢ãéæ¢ãããšããç¡è²ã®äžå±€ãšé»
è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·ã¯ããããµã³å±€ã
æãåºããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããäžæ¹ãæœæ®æ¶²ã¯ããªãšãã«ã¢ãã³0.5ïœ
ãå ããã®ã¡åã³åå¿æ§œåŽã«çªçŽ ã¬ã¹ãçšããŠå§
éãããåå¿æ§œåŽã«ã¯äžåç®ãšåæ§ã«ããŠãã¿ãž
ãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒãã ã®ã¡ã
äžåç®ãšåäžã®å®éšãããè¿ããã以äžã®ããã«
ããŠïŒåã®ããè¿ãå®éšãå®æœããçµæãè¡šïŒã«
瀺ããã
ãè¡šã
å®æœäŸ 11ã14
æ¹æè£
眮ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³æå®éã®äºåº§é äœæ§ãã¹ã
ã€ã³é¡ã溶解ãããã€16.5ééïŒ ã®æ°Žãå«ã60ml
ã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ãããªãšãã«ã¢ãã³12ïœãç
æç©åæçšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ã
ãã³ãžãªã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°
äžã«æº¶åªä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ã
éããã®ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11
ïœããªãŒãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒ
ãããªã€ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床
ã§æ¹æããªãã30åéã§å æž©ã85âãšããã®ã¡ã
ãã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå
液æãåºãå£ããå 液çŽïŒmlãæãåºããçæç©
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããããªãŒãã¯
ã¬ãŒãå ã®å§åãåžžå§ã«ãã©ããã®ã¡ã溶åªä»èŸŒ
ã¿å£ããã©ã€ã¢ã€ã¹âã¢ã»ãã³ãã¹ã«æµžãããã©
ãããåããæžå§èžçè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹
ã130âã«ä¿ã€ãŠ100ã20mmïœã®æžå§äžã«åå¿æ··
å液ãçŽïŒæéåãããŠèžçããããªãŒãã¯ã¬ãŒ
ããå·åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§
ã«ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã«ãã€
ãŠåŸãããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³ãã®äœ¿
çšéïŒãã©ãžãŠã ïŒã°ã©ã ååãããã®ã¢ã«æ°ïŒ
ãªãã³ã«äžåãã®åå¿ããã³äºåãã®åå¿ã§ã®å
å¿æ瞟ãè¡šïŒã«ç€ºãã
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³æå®éã®äºåº§é äœæ§ãã¹ã
ã€ã³é¡ã溶解ãããã€16.5ééïŒ ã®æ°Žãå«ã60ml
ã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ãããªãšãã«ã¢ãã³12ïœãç
æç©åæçšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ã
ãã³ãžãªã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°
äžã«æº¶åªä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ã
éããã®ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11
ïœããªãŒãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒ
ãããªã€ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床
ã§æ¹æããªãã30åéã§å æž©ã85âãšããã®ã¡ã
ãã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå
液æãåºãå£ããå 液çŽïŒmlãæãåºããçæç©
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããããªãŒãã¯
ã¬ãŒãå ã®å§åãåžžå§ã«ãã©ããã®ã¡ã溶åªä»èŸŒ
ã¿å£ããã©ã€ã¢ã€ã¹âã¢ã»ãã³ãã¹ã«æµžãããã©
ãããåããæžå§èžçè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹
ã130âã«ä¿ã€ãŠ100ã20mmïœã®æžå§äžã«åå¿æ··
å液ãçŽïŒæéåãããŠèžçããããªãŒãã¯ã¬ãŒ
ããå·åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§
ã«ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã«ãã€
ãŠåŸãããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³ãã®äœ¿
çšéïŒãã©ãžãŠã ïŒã°ã©ã ååãããã®ã¢ã«æ°ïŒ
ãªãã³ã«äžåãã®åå¿ããã³äºåãã®åå¿ã§ã®å
å¿æ瞟ãè¡šïŒã«ç€ºãã
ãè¡šã
å®æœäŸ 15
æ¹æè£
眮ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ å°å ¥å£ã溶åªä»èŸŒã¿å£ãã
ã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹æ
åŒãªãŒãã¯ã¬ãŒãïŒåå¿è£ 眮ïŒã®å 液æãåºãå£
ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã液æãåºãå£ã
ãã³æº¶åªä»èŸŒã¿å£ãåããå 容éïŒã®é»ç£æ¹å¹»
åŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãïŒæœåºè£ 眮ïŒã«
çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žãã©
ãžãŠã 44mgïŒ0.2ããªã¢ã«ïŒããããªãŠã ãžããšã
ã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒãã»ïŒæ°Ž
åç©1200mgããã³
ã¬ã¹ããã³äºé žåççŽ å°å ¥å£ã溶åªä»èŸŒã¿å£ãã
ã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹æ
åŒãªãŒãã¯ã¬ãŒãïŒåå¿è£ 眮ïŒã®å 液æãåºãå£
ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã液æãåºãå£ã
ãã³æº¶åªä»èŸŒã¿å£ãåããå 容éïŒã®é»ç£æ¹å¹»
åŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãïŒæœåºè£ 眮ïŒã«
çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žãã©
ãžãŠã 44mgïŒ0.2ããªã¢ã«ïŒããããªãŠã ãžããšã
ã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒãã»ïŒæ°Ž
åç©1200mgããã³
ãåŒãã®126mg
ïŒ0.2ããªã¢ã«ïŒã55ééïŒ
ã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²60
mlã«æº¶è§£ãã溶液ãªãã³ã«ããªãšãã«ã¢ãã³ïŒïœ
ãçªçŽ ã¬ã¹é°å²æ°äžã«ä»èŸŒã¿ããªãŒãã¯ã¬ãŒãã®
ä»èŸŒã¿å£ããšããã次ãã§ããã¿ãžãšã³25ïœãã
ã³äºé žåççŽ ïŒïœãä»èŸŒãã ããªãŒãã¯ã¬ãŒãã
ãªã€ã«ãã¹ã«ã€ã800rpmã®é床ã§æ¹æããªãã
å æž©ã30åéã§80âã«äžãããã®æž©åºŠã§ïŒæéå
å¿ãç¶ãããåå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽ
æ°ŽãçšããŠæ¥å·ããã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œ
ãªãŒãã¯ã¬ãŒãåŽã«å§éãããã¬ã©ã¹è£œãªãŒãã¯
ã¬ãŒããåžžå§ã«ãã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äž
ã«ã·ã¯ããããµã³200mlããã³æ°ŽïŒïœãå ããŠçŽ
ïŒåéæ¿ããæ¹æãããæ¹æãæ¢ãé眮ãããšã
ãç¡è²ã®äžå±€ãšé»è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·
ã¯ããããµã³å±€ãæãåºããçæç©ãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããäžæ¹ãæœæ®æ¶²ã¯ããªãš
ãã«ã¢ãã³0.5ïœãå ããã®ã¡åã³åå¿æ§œåŽã«çª
çŽ ã¬ã¹ãçšããŠå§éãããåå¿æ§œåŽã«ã¯äžåç®ãš
åæ§ã«ããŠãã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœ
ãä»èŸŒãã ã®ã¡ãäžåç®ãšåäžã®å®éšãããè¿ã
ãã以äžã®ããã«ããŠïŒåã®ããè¿ãå®éšãè¡ãª
ã€ããïŒãïŒåãã®åå¿ã«ããããªã¯ã¿ãžãšããŒ
ã«ã®çæéã¯126ã129ããªã¢ã«ã®ç¯å²å ã§ããã
ãã®ïŒïŒïŒâãªã¯ã¿ãžãšã³âïŒâãªãŒã«å¯ŸïŒïŒïŒ
âãªã¯ã¿ãžãšã³âïŒâãªãŒã«ã®ã¢ã«æ¯ã¯ãããã
92ïŒïŒã§ãã€ãã å®æœäŸ 16ã22 æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãæå®éã®å座é äœæ§ãã¹ãã€ã³
é¡ããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒ
ãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã溶解ãããã€
16.5ééïŒ ã®æ°Žãå«ã60mlã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ã
ããªãšãã«ã¢ãã12ïœãçæç©åæçšã®å éšæšæº
ç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãªã¯ãã«ãšãŒã
ã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åªä»èŸŒã¿å£ãã
ä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®ã¡ããã¿ãžãš
ã³38ïœããã³äºé žåççŽ 11ïœããªãŒãã¯ã¬ãŒãäž
ã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµž
ããå 容ç©ã800rpmã®é床ã§æ¹æããªãã30å
éã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠã§ïŒæéå
å¿ãç¶ãããåå¿çµäºåŸãå 液æãåºãå£ããå
液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯ãããã°ã©
ãã€ãŒã§åæããããªãŒãã¯ã¬ãŒãå ã®å§åãåžž
å§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ããã©ã€ã¢ã€ã¹
âã¢ã»ãã³ãã¹ã«æµžãããã©ãããåããæžå§èž
çè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130âã«ä¿ã€ãŠ100
ã20mmïœã®æžå§äžã«åå¿æ··å液ãçŽïŒæéåã
ããŠèžçããããªãŒãã¯ã¬ãŒããå·åŽããŠå®€æž©ã«
ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§ã«ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã«ãã€
ãŠåŸãããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æããã 䜿çšããå座é äœæ§ãã¹ãã€ã³é¡ãšãã®äœ¿çšé
ïŒãã©ãžãŠã ïŒã°ã©ã ååãããã®ã¢ã«é¡ïŒãã
ã³äžåãã®åå¿ãšäºåãã®åå¿ã§ã®åå¿æ瞟ãè¡š
ïŒã«ç€ºãã
mlã«æº¶è§£ãã溶液ãªãã³ã«ããªãšãã«ã¢ãã³ïŒïœ
ãçªçŽ ã¬ã¹é°å²æ°äžã«ä»èŸŒã¿ããªãŒãã¯ã¬ãŒãã®
ä»èŸŒã¿å£ããšããã次ãã§ããã¿ãžãšã³25ïœãã
ã³äºé žåççŽ ïŒïœãä»èŸŒãã ããªãŒãã¯ã¬ãŒãã
ãªã€ã«ãã¹ã«ã€ã800rpmã®é床ã§æ¹æããªãã
å æž©ã30åéã§80âã«äžãããã®æž©åºŠã§ïŒæéå
å¿ãç¶ãããåå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽ
æ°ŽãçšããŠæ¥å·ããã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œ
ãªãŒãã¯ã¬ãŒãåŽã«å§éãããã¬ã©ã¹è£œãªãŒãã¯
ã¬ãŒããåžžå§ã«ãã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äž
ã«ã·ã¯ããããµã³200mlããã³æ°ŽïŒïœãå ããŠçŽ
ïŒåéæ¿ããæ¹æãããæ¹æãæ¢ãé眮ãããšã
ãç¡è²ã®äžå±€ãšé»è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·
ã¯ããããµã³å±€ãæãåºããçæç©ãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããäžæ¹ãæœæ®æ¶²ã¯ããªãš
ãã«ã¢ãã³0.5ïœãå ããã®ã¡åã³åå¿æ§œåŽã«çª
çŽ ã¬ã¹ãçšããŠå§éãããåå¿æ§œåŽã«ã¯äžåç®ãš
åæ§ã«ããŠãã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœ
ãä»èŸŒãã ã®ã¡ãäžåç®ãšåäžã®å®éšãããè¿ã
ãã以äžã®ããã«ããŠïŒåã®ããè¿ãå®éšãè¡ãª
ã€ããïŒãïŒåãã®åå¿ã«ããããªã¯ã¿ãžãšããŒ
ã«ã®çæéã¯126ã129ããªã¢ã«ã®ç¯å²å ã§ããã
ãã®ïŒïŒïŒâãªã¯ã¿ãžãšã³âïŒâãªãŒã«å¯ŸïŒïŒïŒ
âãªã¯ã¿ãžãšã³âïŒâãªãŒã«ã®ã¢ã«æ¯ã¯ãããã
92ïŒïŒã§ãã€ãã å®æœäŸ 16ã22 æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãæå®éã®å座é äœæ§ãã¹ãã€ã³
é¡ããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒ
ãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã溶解ãããã€
16.5ééïŒ ã®æ°Žãå«ã60mlã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²ã
ããªãšãã«ã¢ãã12ïœãçæç©åæçšã®å éšæšæº
ç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãªã¯ãã«ãšãŒã
ã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åªä»èŸŒã¿å£ãã
ä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®ã¡ããã¿ãžãš
ã³38ïœããã³äºé žåççŽ 11ïœããªãŒãã¯ã¬ãŒãäž
ã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµž
ããå 容ç©ã800rpmã®é床ã§æ¹æããªãã30å
éã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠã§ïŒæéå
å¿ãç¶ãããåå¿çµäºåŸãå 液æãåºãå£ããå
液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯ãããã°ã©
ãã€ãŒã§åæããããªãŒãã¯ã¬ãŒãå ã®å§åãåžž
å§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ããã©ã€ã¢ã€ã¹
âã¢ã»ãã³ãã¹ã«æµžãããã©ãããåããæžå§èž
çè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130âã«ä¿ã€ãŠ100
ã20mmïœã®æžå§äžã«åå¿æ··å液ãçŽïŒæéåã
ããŠèžçããããªãŒãã¯ã¬ãŒããå·åŽããŠå®€æž©ã«
ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§ã«ããã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœããã³ããªãšã
ã«ã¢ãã³12ïœãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœã
ãã³äºé žåççŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ãã
åäžã®åå¿æ¡ä»¶äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸ
ãªãŒãã¯ã¬ãŒããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒã
ã¯ã¬ãŒãå ãåžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµã
ãéããŠåå¿æ··å液ã®ãã¹ãŠãåãåºãããåå¿
æ··å液ã¯é»è²ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯
ãŸã€ããèªããããªãã€ããäºåç®ã®åå¿ã«ãã€
ãŠåŸãããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æããã 䜿çšããå座é äœæ§ãã¹ãã€ã³é¡ãšãã®äœ¿çšé
ïŒãã©ãžãŠã ïŒã°ã©ã ååãããã®ã¢ã«é¡ïŒãã
ã³äžåãã®åå¿ãšäºåãã®åå¿ã§ã®åå¿æ瞟ãè¡š
ïŒã«ç€ºãã
ãè¡šã
å®æœäŸ 23
æ¹å¹»è£
眮ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ å°å ¥å£ã溶åªä»èŸŒã¿å£ãã
ã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹æ
åŒãªãŒãã¯ã¬ãŒãïŒåå¿è£ 眮ïŒã®å 液æãåºãå£
ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã液æãåºãå£ã
ãã³æº¶åªä»èŸŒã¿å£ãåããå 容éïŒã®é»ç£æ¹æ
åŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãïŒæœåºè£ 眮ïŒã«
çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žãã©
ãžãŠã 44mgïŒ0.2ããªã¢ã«ïŒã
ã¬ã¹ããã³äºé žåççŽ å°å ¥å£ã溶åªä»èŸŒã¿å£ãã
ã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹æ
åŒãªãŒãã¯ã¬ãŒãïŒåå¿è£ 眮ïŒã®å 液æãåºãå£
ããæ¹æè£ çœ®ãçªçŽ ã¬ã¹å°å ¥å£ã液æãåºãå£ã
ãã³æº¶åªä»èŸŒã¿å£ãåããå 容éïŒã®é»ç£æ¹æ
åŒã®èå§ã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãïŒæœåºè£ 眮ïŒã«
çŽçµãããåå¿çšãªãŒãã¯ã¬ãŒãäžã«ãé ¢é žãã©
ãžãŠã 44mgïŒ0.2ããªã¢ã«ïŒã
ãåŒãã®1400mgïŒïŒããªã¢
ã«ïŒããã³ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ248.6mgã55é
éïŒ ã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²60mlã«æº¶è§£ãã溶液ãªã
ã³ã«ããªãšãã«ã¢ãã³ïŒïœãçªçŽ ã¬ã¹é°å²æ°äžã«
ä»èŸŒã¿ããªãŒãã¯ã¬ãŒãã®ä»èŸŒã¿å£ããšããã次
ãã§ããã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœãä»
蟌ãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«ã€ã
800rpmã®é床ã§æ¹æããªããå æž©ã30åéã§80
âã«äžãããã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽæ°ŽãçšããŠæ¥å·ã
ãã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãåŽ
ã«å§éãããã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒããåžžå§ã«ã
ã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äžã«ã·ã¯ããããµã³
200mlããã³æ°ŽïŒïœãå ããŠçŽïŒåéæ¿ããæ¹æ
ãããæ¹æãæ¢ãé眮ãããšããç¡è²ã®äžå±€ãšé»
è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·ã¯ããããµã³å±€ã
æãåºããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããäžæ¹ãæœæ®æ¶²ã¯ããªãšãã«ã¢ãã³0.5ïœ
ãå ããã®ã¡åã³åå¿æ§œåŽã«çªçŽ ã¬ã¹ãçšããŠå§
éãããåå¿æ§œåŽã«ã¯äžåç®ãšåæ§ã«ããŠãã¿ãž
ãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒãã ã®ã¡ã
äžåç®ãšåäžã®å®éšãããè¿ããã以äžã®ããã«
ããŠïŒåã®ããè¿ãå®éšãè¡ãªã€ããïŒãïŒåã
ã®åå¿ã«ããããªã¯ã¿ãžãšããŒã«ã®çæéã¯129
ã131ããªã¢ã«ã®ç¯å²å ã§ããããã®ïŒïŒïŒâãª
ã¯ã¿ãžãšã³âïŒâãªãŒã«å¯ŸïŒïŒïŒâãªã¯ã¿ãžãšã³
âïŒâãªãŒã«ã®ã¢ã«æ¯ã¯ãããã91ïŒïŒã§ãã€
ãã å®æœäŸ 24ã31 æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«
ãã¹ãã€ãïŒãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã
溶解ãããã€16.5ééïŒ ã®æ°Žããã³æº¶åªãå«ã60
mlã®æ··å液ãããªãšãã«ã¢ãã³12ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11ïœããªãŒ
ãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€
ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æã
ãªãã30åéã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠ
ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå 液æãåº
ãå£ããå 液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæããããªãŒãã¯ã¬ãŒãå
ã®å§åãåžžå§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ãã
ã©ã€ã¢ã€ã¹âã¢ã»ãã³ãã¹ã«æµžãããã©ãããå
ããæžå§èžçè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130â
ã«ä¿ã€ãŠ100ã20mmïœã®æžå§äžã«åå¿æ··å液ã
çŽïŒæéåãããŠèžçããããªãŒãã¯ã¬ãŒããå·
åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§ã«ã
ãã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœãããªãšãã«ã¢
ãã³12ïœããã³èžçæã«çåºããéãšåéã®æº¶åª
ãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœããã³äºé žåç
çŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ããåäžã®åå¿æ¡
件äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸãªãŒãã¯ã¬ãŒ
ããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒãã¯ã¬ãŒãå ã
åžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµããéããŠåå¿
æ··å液ã®ãã¹ãŠãåãåºãããåå¿æ··å液ã¯é»è²
ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯ãŸã€ããèªã
ãããªãã€ããäºåç®ã®åå¿ã«ãã€ãŠåŸãããç
æç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšãã溶åªããã³äžåãã®åå¿ãšäºåãã®å
å¿ã§ã®åå¿æ瞟ãè¡šïŒã«ç€ºãã
éïŒ ã®ã¹ã«ãã©ã³æ°Žæº¶æ¶²60mlã«æº¶è§£ãã溶液ãªã
ã³ã«ããªãšãã«ã¢ãã³ïŒïœãçªçŽ ã¬ã¹é°å²æ°äžã«
ä»èŸŒã¿ããªãŒãã¯ã¬ãŒãã®ä»èŸŒã¿å£ããšããã次
ãã§ããã¿ãžãšã³25ïœããã³äºé žåççŽ ïŒïœãä»
蟌ãã ããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«ã€ã
800rpmã®é床ã§æ¹æããªããå æž©ã30åéã§80
âã«äžãããã®æž©åºŠã§ïŒæéåå¿ãç¶ãããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽæ°ŽãçšããŠæ¥å·ã
ãã®ã¡ãåå¿æ··å液ãã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒãåŽ
ã«å§éãããã¬ã©ã¹è£œãªãŒãã¯ã¬ãŒããåžžå§ã«ã
ã©ããã®ã¡ãçªçŽ ã¬ã¹é°å²æ°äžã«ã·ã¯ããããµã³
200mlããã³æ°ŽïŒïœãå ããŠçŽïŒåéæ¿ããæ¹æ
ãããæ¹æãæ¢ãé眮ãããšããç¡è²ã®äžå±€ãšé»
è²ã®äžå±€ã«åé¢ãããäžå±€ã®ã·ã¯ããããµã³å±€ã
æãåºããçæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããäžæ¹ãæœæ®æ¶²ã¯ããªãšãã«ã¢ãã³0.5ïœ
ãå ããã®ã¡åã³åå¿æ§œåŽã«çªçŽ ã¬ã¹ãçšããŠå§
éãããåå¿æ§œåŽã«ã¯äžåç®ãšåæ§ã«ããŠãã¿ãž
ãšã³25ïœããã³äºé žåççŽ ïŒïœãä»èŸŒãã ã®ã¡ã
äžåç®ãšåäžã®å®éšãããè¿ããã以äžã®ããã«
ããŠïŒåã®ããè¿ãå®éšãè¡ãªã€ããïŒãïŒåã
ã®åå¿ã«ããããªã¯ã¿ãžãšããŒã«ã®çæéã¯129
ã131ããªã¢ã«ã®ç¯å²å ã§ããããã®ïŒïŒïŒâãª
ã¯ã¿ãžãšã³âïŒâãªãŒã«å¯ŸïŒïŒïŒâãªã¯ã¿ãžãšã³
âïŒâãªãŒã«ã®ã¢ã«æ¯ã¯ãããã91ïŒïŒã§ãã€
ãã å®æœäŸ 24ã31 æ¹æè£ çœ®ã枩床èšããã¿ãžãšã³ä»èŸŒã¿å£ãçªçŽ
ã¬ã¹ããã³äºé žåççŽ ã®å°å ¥å£ã溶åªä»èŸŒã¿å£ã
ãã³å 液æãåºãå£ãåããå 容200mlã®é»ç£æ¹
æåŒãªãŒãã¯ã¬ãŒãäžã«é ¢é žãã©ãžãŠã 44mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³629mg
ïŒ2.4ããªã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«
ãã¹ãã€ãïŒãããã³82.4mgïŒ0.2ããªã¢ã«ïŒã
溶解ãããã€16.5ééïŒ ã®æ°Žããã³æº¶åªãå«ã60
mlã®æ··å液ãããªãšãã«ã¢ãã³12ïœãçæç©åæ
çšã®å éšæšæºç©è³ªãšããŠïŒâãªã¯ãã³ããã³ãžãª
ã¯ãã«ãšãŒãã«åïŒmlãçªçŽ ã¬ã¹é°å²æ°äžã«æº¶åª
ä»èŸŒã¿å£ããä»èŸŒãã ã溶åªä»èŸŒã¿å£ãéããã®
ã¡ããã¿ãžãšã³38ïœããã³äºé žåççŽ 11ïœããªãŒ
ãã¯ã¬ãŒãäžã«ä»èŸŒãã ããªãŒãã¯ã¬ãŒãããªã€
ã«ãã¹ã«æµžããå 容ç©ã800rpmã®é床ã§æ¹æã
ãªãã30åéã§å æž©ã85âãšããã®ã¡ããã®æž©åºŠ
ã§ïŒæéåå¿ãç¶ãããåå¿çµäºåŸãå 液æãåº
ãå£ããå 液çŽïŒmlãæãåºããçæç©ãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæããããªãŒãã¯ã¬ãŒãå
ã®å§åãåžžå§ã«ãã©ããã®ã¡ã溶åªä»èŸŒã¿å£ãã
ã©ã€ã¢ã€ã¹âã¢ã»ãã³ãã¹ã«æµžãããã©ãããå
ããæžå§èžçè£ çœ®ã«æ¥ç¶ãããªã€ã«ãã¹ã130â
ã«ä¿ã€ãŠ100ã20mmïœã®æžå§äžã«åå¿æ··å液ã
çŽïŒæéåãããŠèžçããããªãŒãã¯ã¬ãŒããå·
åŽããŠå®€æž©ã«ãã©ããã®ã¡çªçŽ ã¬ã¹ã§åžžå§ã«ã
ãã 次ãã§èžçåŸã®æ®æ¶²ãçšããŠäºåç®ã®åå¿ãè¡
ãªã€ãã溶åªä»èŸŒã¿å£ããæ°Ž12ïœãããªãšãã«ã¢
ãã³12ïœããã³èžçæã«çåºããéãšåéã®æº¶åª
ãä»èŸŒã¿ã次ãã§ãã¿ãžãšã³38ïœããã³äºé žåç
çŽ 11ïœãä»èŸŒã¿ãäžåç®ãšãŸã€ããåäžã®åå¿æ¡
件äžã«åå¿ãè¡ãªã€ããåå¿çµäºåŸãªãŒãã¯ã¬ãŒ
ããå·åŽæ°Žã§æ¥å·ããã®ã¡ããªãŒãã¯ã¬ãŒãå ã
åžžå§ã«ãã©ããªãŒãã¯ã¬ãŒãã®ãµããéããŠåå¿
æ··å液ã®ãã¹ãŠãåãåºãããåå¿æ··å液ã¯é»è²
ã§ããããã©ãžãŠã ã¡ã¿ã«ã®æåºã¯ãŸã€ããèªã
ãããªãã€ããäºåç®ã®åå¿ã«ãã€ãŠåŸãããç
æç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšãã溶åªããã³äžåãã®åå¿ãšäºåãã®å
å¿ã§ã®åå¿æ瞟ãè¡šïŒã«ç€ºãã
ãè¡šã
æ¯ãæå³ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšæ°Žãšããããäž¡è
ãå°ããšãéšåçã«æº¶è§£ãã溶åªäžãçé žãã
ã³ïŒãŸãã¯éçé žã€ãªã³ããã©ãžãŠã ãŸãã¯ãã©
ãžãŠã ååç©ãããã³ãã¹ãã€ã³é¡ã®ååšäžã«å
å¿ãããŠïœâã¢ã«ã«ãžãšããŒã«ã補é ããã«é
ããå座é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©
ã ååãããå°ããšãïŒã¢ã«ã®éã§çšãããã€äž
èšã®äžè¬åŒïŒïŒ ãåŒäžãã¯æ°ŽçŽ ååãŸãã¯âSO3Mãè¡šãã
ïŒïŒã¯ã¢ã«ã«ãªéå±ã®ã«ããªã³ãè¡šããïŒãã¯â
ïŒCH2ïŒoâïŒïœã¯ïŒãïŒã®æ°ãè¡šããïŒã
ãåŒããåŒããŸã㯠ãåŒããè¡šããã㯠ãåŒãâïŒCH3ïŒ2ãâCOOMãŸãã¯â SO3Mãè¡šããïŒãã ããããã³ïŒã¯åèšãšå
ããã®ãè¡šããïŒãã§ç€ºãããäºåº§é äœæ§ãã¹ã
ã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒ
ã¢ã«ã®éã§åå¿ç³»ã«æ·»å ããããšãç¹åŸŽãšããïœ
âã¢ã«ã«ãžãšããŒã«ã®è£œé æ¹æ³ã ïŒ çé žããã³ïŒãŸãã¯éçé žã€ãªã³ãšçµåããŠ
å¡©åºæ§å®æ°ïŒpKaïŒãïŒä»¥äžã®å座é äœæ§ç¬¬äžçŽ
ã¢ãã³é¡ãåå¿ç³»ã«æ·»å ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒ
é èšèŒã®æ¹æ³ã ïŒ æº¶åªãã¹ã«ãã©ã³ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒ
é èšèŒã®æ¹æ³ã ïŒ æº¶åªãšããŠã®ã¹ã«ãã©ã³ãšèŠªæ°Žæ§ã®å座é äœ
æ§ãã¹ãã€ã³é¡ãšãçšããŠåå¿ãè¡ãªããåå¿åŸ
ã®åå¿æ··å液ããæœåºæ³ã«ãã€ãŠïœâãªã¯ã¿ãžãš
ããŒã«ãåé¢ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹
æ³ã
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4825680A JPS56145235A (en) | 1980-04-11 | 1980-04-11 | Preparation of n-alkadienol |
GB8109243A GB2074156B (en) | 1980-03-28 | 1981-03-24 | Preparation of n-octadienol |
US06/247,290 US4356333A (en) | 1980-03-28 | 1981-03-25 | Process for preparing n-octadienol |
CA000374074A CA1171100A (en) | 1980-03-28 | 1981-03-27 | Process for preparing n-octadienol |
DE3112213A DE3112213C2 (de) | 1980-03-28 | 1981-03-27 | Verfahren zur Herstellung von 2,7-Octadien-(1)-ol |
FR8106319A FR2479187B1 (fr) | 1980-03-28 | 1981-03-30 | Procede de preparation de n-octadienol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4825680A JPS56145235A (en) | 1980-04-11 | 1980-04-11 | Preparation of n-alkadienol |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56145235A JPS56145235A (en) | 1981-11-11 |
JPS642092B2 true JPS642092B2 (ja) | 1989-01-13 |
Family
ID=12798357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4825680A Granted JPS56145235A (en) | 1980-03-28 | 1980-04-11 | Preparation of n-alkadienol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56145235A (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0605735B1 (en) * | 1992-06-30 | 1997-11-05 | Mitsubishi Chemical Corporation | Process for producing alkadienol |
-
1980
- 1980-04-11 JP JP4825680A patent/JPS56145235A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS56145235A (en) | 1981-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4356333A (en) | Process for preparing n-octadienol | |
US3670029A (en) | Preparation of unsaturated ethers | |
CA1174246A (en) | Process for producing normal-octanol | |
EP0287066B1 (en) | Process for continuous production of octa -2,7-dien-1-ol | |
US5254782A (en) | Continuous process for the telomerization of conjugated dienes | |
US4298499A (en) | Recovery of catalysts | |
US2446132A (en) | Silver catalysts | |
US5118885A (en) | Process for producing octa-2,7-dien-1-ol | |
US3767709A (en) | Alcohol amine interchange | |
EP0008139B1 (en) | A process for preparing 1,7-octadiene | |
JPS642092B2 (ja) | ||
JP2888509B2 (ja) | ãªã¯ã¿âïŒïŒïŒâãžãšã³âïŒâãªãŒã«ã®è£œé æ¹æ³ | |
JPH0639409B2 (ja) | ãªã¯ã¿ã³èªå°äœã®è£œé æ³ | |
US5302750A (en) | Method for producing n-octadienol from butadiene | |
JPS6337774B2 (ja) | ||
CA1140160A (en) | Process for producing alkadienes | |
JPH0251552B2 (ja) | ||
JPS646175B2 (ja) | ||
JP2613251B2 (ja) | ãªã¯ã¿âïŒïŒïŒâãžãšã³âïŒâãªãŒã«ã®é£ç¶ç補é æ³ | |
JP2510785B2 (ja) | ãªã¯ã¿âïŒïŒïŒâãžãšã³âïŒâãªâã«ã®è£œé æ³ | |
US2816932A (en) | Process for preparing the monoethers of propylene glycol | |
JPS5849534B2 (ja) | ã¢ã«ãããã®è£œé æ¹æ³ | |
US10843998B2 (en) | Method for producing bis-acyloxylated exomethylene compound | |
JPH0567129B2 (ja) | ||
JP3609878B2 (ja) | ãªã¯ã¿ãžãšã³ã®è£œé æ¹æ³ |