JPS646175B2 - - Google Patents
Info
- Publication number
- JPS646175B2 JPS646175B2 JP55081793A JP8179380A JPS646175B2 JP S646175 B2 JPS646175 B2 JP S646175B2 JP 55081793 A JP55081793 A JP 55081793A JP 8179380 A JP8179380 A JP 8179380A JP S646175 B2 JPS646175 B2 JP S646175B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- palladium
- autoclave
- mmol
- butadiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 78
- 239000003054 catalyst Substances 0.000 claims description 40
- 229910052763 palladium Inorganic materials 0.000 claims description 31
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 26
- 150000003003 phosphines Chemical class 0.000 claims description 24
- 150000001993 dienes Chemical class 0.000 claims description 21
- 125000002015 acyclic group Chemical group 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 14
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000004429 atom Chemical group 0.000 claims description 11
- 150000002894 organic compounds Chemical class 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- PPDFQRAASCRJAH-UHFFFAOYSA-N 2-methylthiolane 1,1-dioxide Chemical compound CC1CCCS1(=O)=O PPDFQRAASCRJAH-UHFFFAOYSA-N 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 description 81
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 80
- 239000011541 reaction mixture Substances 0.000 description 38
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 36
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 30
- 238000004821 distillation Methods 0.000 description 30
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 24
- 238000004817 gas chromatography Methods 0.000 description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- 229910001873 dinitrogen Inorganic materials 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 238000003756 stirring Methods 0.000 description 15
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- -1 phosphine compound Chemical class 0.000 description 11
- 235000011054 acetic acid Nutrition 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 8
- 238000000605 extraction Methods 0.000 description 7
- 238000003760 magnetic stirring Methods 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 6
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 6
- XWJBRBSPAODJER-UHFFFAOYSA-N 1,7-octadiene Chemical compound C=CCCCCC=C XWJBRBSPAODJER-UHFFFAOYSA-N 0.000 description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 5
- 235000019253 formic acid Nutrition 0.000 description 5
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- LVEYOSJUKRVCCF-UHFFFAOYSA-N 1,3-bis(diphenylphosphino)propane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCP(C=1C=CC=CC=1)C1=CC=CC=C1 LVEYOSJUKRVCCF-UHFFFAOYSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 150000002483 hydrogen compounds Chemical class 0.000 description 4
- 238000001465 metallisation Methods 0.000 description 4
- 230000003797 telogen phase Effects 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- 150000002941 palladium compounds Chemical class 0.000 description 3
- JKDRQYIYVJVOPF-FDGPNNRMSA-L palladium(ii) acetylacetonate Chemical compound [Pd+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O JKDRQYIYVJVOPF-FDGPNNRMSA-L 0.000 description 3
- 239000001294 propane Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- UECIEVHMKVBVLE-UHFFFAOYSA-M sodium;3-diphenylphosphanylbenzenesulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)C1=CC=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 UECIEVHMKVBVLE-UHFFFAOYSA-M 0.000 description 3
- 150000003512 tertiary amines Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MLBZLJCMHFCTQM-UHFFFAOYSA-N (2-methylphenyl)-diphenylphosphane Chemical compound CC1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 MLBZLJCMHFCTQM-UHFFFAOYSA-N 0.000 description 2
- QFMZQPDHXULLKC-UHFFFAOYSA-N 1,2-bis(diphenylphosphino)ethane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 QFMZQPDHXULLKC-UHFFFAOYSA-N 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N caprylic alcohol Natural products CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 238000005292 vacuum distillation Methods 0.000 description 2
- GDDAJHJRAKOILH-QFXXITGJSA-N (2e,5e)-octa-2,5-diene Chemical compound CC\C=C\C\C=C\C GDDAJHJRAKOILH-QFXXITGJSA-N 0.000 description 1
- ZTJHDEXGCKAXRZ-FNORWQNLSA-N (3e)-octa-1,3,7-triene Chemical compound C=CCC\C=C\C=C ZTJHDEXGCKAXRZ-FNORWQNLSA-N 0.000 description 1
- MGAXYKDBRBNWKT-UHFFFAOYSA-N (5-oxooxolan-2-yl)methyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCC1OC(=O)CC1 MGAXYKDBRBNWKT-UHFFFAOYSA-N 0.000 description 1
- HITROERJXNWVOI-SOFGYWHQSA-N (5e)-octa-1,5-diene Chemical compound CC\C=C\CCC=C HITROERJXNWVOI-SOFGYWHQSA-N 0.000 description 1
- RJUCIROUEDJQIB-GQCTYLIASA-N (6e)-octa-1,6-diene Chemical compound C\C=C\CCCC=C RJUCIROUEDJQIB-GQCTYLIASA-N 0.000 description 1
- PMJHHCWVYXUKFD-SNAWJCMRSA-N (E)-1,3-pentadiene Chemical group C\C=C\C=C PMJHHCWVYXUKFD-SNAWJCMRSA-N 0.000 description 1
- XGCDBGRZEKYHNV-UHFFFAOYSA-N 1,1-bis(diphenylphosphino)methane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CP(C=1C=CC=CC=1)C1=CC=CC=C1 XGCDBGRZEKYHNV-UHFFFAOYSA-N 0.000 description 1
- QTYUSOHYEPOHLV-FNORWQNLSA-N 1,3-Octadiene Chemical compound CCCC\C=C\C=C QTYUSOHYEPOHLV-FNORWQNLSA-N 0.000 description 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- VYXHVRARDIDEHS-UHFFFAOYSA-N 1,5-cyclooctadiene Chemical compound C1CC=CCCC=C1 VYXHVRARDIDEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004912 1,5-cyclooctadiene Substances 0.000 description 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- CVBUKMMMRLOKQR-UHFFFAOYSA-N 1-phenylbutane-1,3-dione Chemical compound CC(=O)CC(=O)C1=CC=CC=C1 CVBUKMMMRLOKQR-UHFFFAOYSA-N 0.000 description 1
- SDJHPPZKZZWAKF-UHFFFAOYSA-N 2,3-dimethylbuta-1,3-diene Chemical compound CC(=C)C(C)=C SDJHPPZKZZWAKF-UHFFFAOYSA-N 0.000 description 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- XURMIWYINDMTRH-UHFFFAOYSA-N 3-methoxyocta-1,7-diene Chemical compound COC(C=C)CCCC=C XURMIWYINDMTRH-UHFFFAOYSA-N 0.000 description 1
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 1
- MIJJHRIQVWIQGL-UHFFFAOYSA-N 8-methoxyocta-1,6-diene Chemical compound COCC=CCCCC=C MIJJHRIQVWIQGL-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- AFBPFSWMIHJQDM-UHFFFAOYSA-N N-methylaniline Chemical compound CNC1=CC=CC=C1 AFBPFSWMIHJQDM-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WXNOJTUTEXAZLD-UHFFFAOYSA-L benzonitrile;dichloropalladium Chemical compound Cl[Pd]Cl.N#CC1=CC=CC=C1.N#CC1=CC=CC=C1 WXNOJTUTEXAZLD-UHFFFAOYSA-L 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- CJSBUWDGPXGFGA-UHFFFAOYSA-N dimethyl-butadiene Natural products CC(C)=CC=C CJSBUWDGPXGFGA-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- UKFXDFUAPNAMPJ-UHFFFAOYSA-N ethylmalonic acid Chemical compound CCC(C(O)=O)C(O)=O UKFXDFUAPNAMPJ-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- UJNZOIKQAUQOCN-UHFFFAOYSA-N methyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C)C1=CC=CC=C1 UJNZOIKQAUQOCN-UHFFFAOYSA-N 0.000 description 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- RJUCIROUEDJQIB-UHFFFAOYSA-N octa-1,6-diene Chemical compound CC=CCCCC=C RJUCIROUEDJQIB-UHFFFAOYSA-N 0.000 description 1
- CSSYVPGEVYWPNO-UHFFFAOYSA-N octa-1,7-dien-3-yl acetate Chemical compound CC(=O)OC(C=C)CCCC=C CSSYVPGEVYWPNO-UHFFFAOYSA-N 0.000 description 1
- JSYXCWKUYDNSDW-UHFFFAOYSA-N octa-1,7-dien-3-yloxybenzene Chemical compound C=CCCCC(C=C)OC1=CC=CC=C1 JSYXCWKUYDNSDW-UHFFFAOYSA-N 0.000 description 1
- DIBTYNFILMOQJH-UHFFFAOYSA-N octa-2,7-dienoxybenzene Chemical compound C=CCCCC=CCOC1=CC=CC=C1 DIBTYNFILMOQJH-UHFFFAOYSA-N 0.000 description 1
- RDOHPVPONNHSPH-UHFFFAOYSA-N octa-2,7-dienyl acetate Chemical compound CC(=O)OCC=CCCCC=C RDOHPVPONNHSPH-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 1
- PENAXHPKEVTBLF-UHFFFAOYSA-L palladium(2+);prop-1-ene;dichloride Chemical compound [Pd+]Cl.[Pd+]Cl.[CH2-]C=C.[CH2-]C=C PENAXHPKEVTBLF-UHFFFAOYSA-L 0.000 description 1
- GPNDARIEYHPYAY-UHFFFAOYSA-N palladium(ii) nitrate Chemical compound [Pd+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O GPNDARIEYHPYAY-UHFFFAOYSA-N 0.000 description 1
- JGBZTJWQMWZVNX-UHFFFAOYSA-N palladium;tricyclohexylphosphane Chemical compound [Pd].C1CCCCC1P(C1CCCCC1)C1CCCCC1.C1CCCCC1P(C1CCCCC1)C1CCCCC1 JGBZTJWQMWZVNX-UHFFFAOYSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- PMJHHCWVYXUKFD-UHFFFAOYSA-N piperylene Natural products CC=CC=C PMJHHCWVYXUKFD-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- ASUAYTHWZCLXAN-UHFFFAOYSA-N prenol Chemical compound CC(C)=CCO ASUAYTHWZCLXAN-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 229940080818 propionamide Drugs 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- MDDUHVRJJAFRAU-YZNNVMRBSA-N tert-butyl-[(1r,3s,5z)-3-[tert-butyl(dimethyl)silyl]oxy-5-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane Chemical compound C1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C(=C)\C1=C/CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 MDDUHVRJJAFRAU-YZNNVMRBSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- DMEUUKUNSVFYAA-UHFFFAOYSA-N trinaphthalen-1-ylphosphane Chemical compound C1=CC=C2C(P(C=3C4=CC=CC=C4C=CC=3)C=3C4=CC=CC=C4C=CC=3)=CC=CC2=C1 DMEUUKUNSVFYAA-UHFFFAOYSA-N 0.000 description 1
- UYUUAUOYLFIRJG-UHFFFAOYSA-N tris(4-methoxyphenyl)phosphane Chemical compound C1=CC(OC)=CC=C1P(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 UYUUAUOYLFIRJG-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polymerisation Methods In General (AREA)
Description
æ¬çºæã¯æŽ»æ§æ°ŽçŽ ãæããææ©ååç©ããããŒ
ã²ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªå
æ¹æ³ã«é¢ããã 掻æ§æ°ŽçŽ ãæããåçš®ã®ææ©ååç©ãããâã²
ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåå
å¿ã«ããã¢ã«ã«ãžãšãã«ååç©ãçæããããšã¯
å ¬ç¥ã§ããïŒããšãã°Advances in
Organometal.Chem.ïŒVol.17ïŒAcademic
PressïŒNew YorkïŒ1979ïŒãéç°ç¶å ±åœ¹ãžãªã¬
ãã€ã³ã®ããã¡ãªååå¿ã¯éåžžãã©ãžãŠã 觊åªã®
ååšäžã§è¡ãªããããããã©ãžãŠã ã¯æ¥µããŠé«äŸ¡
ã§ããããããã®åå¿ãå·¥æ¥çèŠæš¡ã§å®æœããã«
ã¯è§ŠåªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶æããããšã
ãã³è§Šåªãå¹çãã埪ç°äœ¿çšããããšãäžå¯æ¬ ã§
ããã觊åªæŽ»æ§ã®å®å®åã«ããªããšãã«ãã¹ãã€
ã³ãªã©ã®ãã¹ãã€ã³é¡ã®æ·»å ãæå¹ã§ããããšã¯
åèšæç®ã«ããå ¬ç¥ã§ããããã©ãžãŠã ã«å¯ŸããŠ
éå°éã®ãã¹ãã€ã³é¡ãæ·»å ããããšã«ãã€ãŠè§Š
åªæŽ»æ§ãããçšåºŠç¶æããããšãã§ãããããã
ãªãããæ¬çºæè ãã®è©³çŽ°ãªæ€èšã«ãããšãã¹ã
ã€ã³é¡ã®æ·»å ã«ãã€ãŠããªã觊åªæŽ»æ§ãé·æã«äº
ã€ãŠå®å®ã«ç¶æããããšãã§ããªãããšãå€æã
ããããšãã°ãåå¿ã§çæããã¢ã«ã«ãžãšãã«å
åç©ã¯ãéåžžãèžçã«ãã€ãŠåå¿æ··å液ããåé¢
ãããããèžç枩床ãçŽ110âãè¶ãããšããšã
ãã©ãžãŠã ã«å¯ŸããŠå€§ééã®ãã¹ãã€ã³é¡ãæ·»å
ãããŠããŠã觊åªã®å€è³ªããã³ã¡ã¿ã«åãé¡èã«
èµ·ããããã©ãžãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«å
ã¯åã«è§ŠåªæŽ»æ§ãäœäžãããã®ã¿ãªãã觊åªã®é£
ç¶çãªåŸªç°äœ¿çšãå®è³ªçã«äžå¯èœã«ããããã©ãž
ãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åãæå¶ãããã
ã«110â以äžã®æž©åºŠã§èžçãè¡ãªããšãããªãã®
éã§çæããé«æ²žç¹å¯çæç©ã觊åªãå«ãæ®çç©
äžã«èç©ããããšãšãªããããã觊åªã®åŸªç°ãç¹°
ãè¿ãéçšã§è§ŠåªæŽ»æ§ãäœäžãããåå ãšãªãã®
ã§è§Šåªã埪ç°äœ¿çšããããšãã§ããªããªãã ãã®ããã«ãã©ãžãŠã 觊åªã®ååšäžæŽ»æ§æ°ŽçŽ ã
æããææ©ååç©ãããâã²ã³ãšããéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿ãå·¥æ¥çèŠæš¡ã§å®
æœããã«éããŠè§£æ±ºãã¹ã課é¡ã¯ã觊åªæŽ»æ§å¯¿åœ
ãé·æã«äºã€ãŠä¿æããããšãããã³è§Šåªã®æŽ»æ§
ãäœäžãããããšãªãåå¿æ··å液ããã®çæç©ã®
åé¢ãšè§Šåªã®åŸªç°äœ¿çšãè¡ãªãããšã§ããã 掻æ§æ°ŽçŽ ãæããææ©ååç©ãçšããŠãã©ãžãŠ
ã 觊åªããã³ãã¹ãã€ã³é¡ã®ååšäžã«éç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿ãè¡ãªãã«éããŠ
ã®åè¿°ããåŠãçš®ã ã®åé¡ç¹ã¯ãæ¬çºæã«ããã°
äžè¬åŒ ïŒåŒäžãã¯æ°ŽçŽ ååãâSO3NaãŸãã¯â
COONaãè¡šããïŒ ã§ç€ºãããå座é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã
ïŒã°ã©ã ååãããå°ããšãïŒã¢ã«ã®éã§çšãã
ãã€äºåº§é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©
ã ååããã0.3ãïŒã¢ã«ã®éã§æ·»å ããããšã«
ãã€ãŠæ¥µããŠå¹æçã«è§£æ±ºãããããšãèŠåºãã
ããäžè¿°ããããã«æ¬çºæã®æ¹æ³ã¯ç¹å®éã®å座
é äœæ§ãã¹ãã€ã³é¡ã«å¯ŸããŠäºåº§é äœæ§ãã¹ãã€
ã³é¡ã®ç¹å®éãçµåããŠçšããç¹ã«ç¹åŸŽãæããŠ
ãããããã«ããé«ãåå¿é床ã§ããã¡ãªååå¿
ãé²è¡ããã ãã§ãªãã觊åªã埪ç°äœ¿çšããå Žå
ã§ã觊åªå€±æŽ»ç©è³ªã®èç©ã«ãã觊åªã®æŽ»æ§äœäžã
æå¶ãããã®ã§è§ŠåªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶
æããããšãã§ããã®ã§ãããããã«æ¬çºæã«ã
ãã°ãåå¿æ··å液ããã®çæç©ã®èžçåé¢ã«éã
ãŠããã©ãžãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åãæ
å¶ãããããã觊åªã®æŽ»æ§ãäœäžãããããšãªã
觊åªã埪ç°äœ¿çšããããšãã§ããããã®ããã«æ¬
çºæã«åŸãã°æŽ»æ§æ°ŽçŽ ãæããææ©ååç©ããã
âã²ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãª
ååå¿ãå·¥æ¥çã«æå©ã«å®æœããããšãã§ããã ãã®ã»ãã«ãæ¬çºæã«ããã°åå¿ç³»ã«åŸ®éæ··å ¥
ããé žçŽ ã«ãã€ãŠãã¹ãã€ã³é¡ãé žåãããŠè§Šåª
æ¯ãšããŠäœçšãããã¹ãã€ã³ãªããµã€ããçæã
ãã®ãæå¶ããããšããå©ç¹ããããããããäž
è¿°ããåŠãæ¬çºæã®å¹æã¯å座é äœæ§ãã¹ãã€ã³
é¡ãšäºåº§é äœæ§ãã¹ãã€ã³é¡ãšãçµåããŠçšãã
ããšã«ãã€ãŠå§ããŠçºçŸããã®ã§ãã€ãŠãããšã
äºåº§é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã å
åããã0.3ãïŒã¢ã«ã®éã§åå¿ç³»ã«æ·»å ããŠã
å座é äœæ§ãã¹ãã€ã³é¡ãå šã䜿çšããªãå Žåã«
ã¯ãç¹å ¬æ47â25321å·å ¬å ±ããã³Bull.Chem.
Soc.JapanïŒ45ïŒ1183ïŒ1972ïŒã«å ±åãããŠãã
ããã«éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåã«åº
ã¥ãåå¿çæç©ã¯å šãåŸãããªãã§éç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ã«æŽ»æ§æ°ŽçŽ ãæããååç©ãä»å ãã
ååç©ãéžæçã«çæããã ãªãæ¬çºæã«ãããŠçšããããå座é äœæ§ãã¹
ãã€ã³é¡ã§ã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãž
ãŠã ïŒååã«å¯ŸããŠïŒå¯ŸïŒã§é äœããããããã«
察ããŠæ¬çºæã«ãããŠçšããããäºåº§é äœæ§ãã¹
ãã€ã³é¡ãšã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãž
ãŠã ïŒååã«å¯ŸããŠãã¬ãŒãé äœããããšãã§ã
ãããã«ååå ã«ïŒã€ã®é äœå¯èœãªååãæãã
ååç©ã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšãããããã©ãžãŠã 觊
åªãšããŠã¯åŸæ¥å ¬ç¥ã®ãã©ãžãŠã ãŸãã¯ãã©ãžãŠ
ã ååç©ããã¹ãŠäœ¿çšå¯èœã§ããããã©ãžãŠã ã¯
掻æ§çãªã©ã®äžæŽ»æ§ãªæ äœäžã«æ²çãããŠçšãã
ããšãã§ããããã©ãžãŠã ååç©ãšããŠã¯å ·äœç
ã«ã¯ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒããé ¢é žãã©
ãžãŠã ãïŒïŒïŒâã·ã¯ããªã¯ã¿ãžãšã³ãã©ãžãŠã
ã¯ãã©ã€ããÏâã¢ãªã«ãã©ãžãŠã ã¯ãã©ã€ãã
Ïâã¢ãªã«ãã©ãžãŠã ã¢ã»ããŒãããã¹ããªããš
ãã«ãã¹ãã€ã³ãã©ãžãŠã ã¯ãã©ã€ãããã¹ããª
ããšãã«ãã¹ãã€ã³ãã©ãžãŠã ã¢ã»ããŒãããã¹
ãããªã¹ïŒïœâã¡ããã·ããšãã«ïŒãã¹ãã€ã³ã
ãã©ãžãŠã ã¢ã»ããŒãããã¹ïŒïœâããªã«ãžããš
ãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€ããããã©
ãã¹ïŒããªããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãã
ãã©ãã¹ïŒããªãããã«ãã¹ãã€ã³ïŒãã©ãžãŠ
ã ãããã©ãã¹ïŒïœâããªã«ãžããšãã«ãã¹ãã€
ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒããªãã³ãžã«ãã¹
ãã€ã³ïŒãã©ãžãŠã ããã¹ïŒããªã·ã¯ãããã·ã«
ãã¹ãã€ã³ïŒãã©ãžãŠã ã¢ã»ããŒãããã¹ïŒã¡ã
ã«ãžããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€
ããããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒãš
ã¿ã³ããã©ãžãŠã ã¢ã»ããŒãããã¹ïŒãã³ãŸãã
ãªã«ïŒãã©ãžãŠã ã¯ãã©ã€ããå¡©åãã©ãžãŠã ã
ç¡é žãã©ãžãŠã ãç¡«é žãã©ãžãŠã ããããªãŠã ã¯
ãããã©ããŒããªã©ãæããããšãã§ãããéç°
ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåã«ãããçã®è§Š
åªæŽ»æ§çš®ã¯äœåå䟡ãã©ãžãŠã é¯äœã§ããã®ã§ã
äºäŸ¡ã®ãã©ãžãŠã ååç©ã觊åªãšããŠçšããå Žå
ã«ã¯åå¿ç³»äžã«ååšãããã¹ãã€ã³é¡ãŸãã¯éç°
ç¶å ±åœ¹ãžãªã¬ãã€ã³ã§éå ããããšã«ãã€ãŠæŽ»æ§
é¯äœãçæãããããšãã§ããããåäžåå¿ç³»å
ãŸãã¯å¥ã®åå¿å®¹åšå ã§éå äœçšãããååç©ã
å ±åãããããšã«ãã€ãŠè§ŠåªæŽ»æ§çš®ãçæãããŠ
䜿çšããããšãã§ããããã®ãããªç®çã«çšãã
ããéå å€ãšããŠã¯ã¢ã«ã«ãªéå±æ°Žé žåç©ãæ°ŽçŽ
åããŠçŽ ãããªãŠã ãäºéæ«ããã°ãã·ãŠã ãã
ãã©ãžã³ãã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããã¢ã«ã«ãª
éå±ã«ã«ãã³é žå¡©ãªã©ãæããããšãã§ãããé
å å€ã¯ãã©ãžãŠã ã®åå䟡ãå€ããããã«å¿ èŠãª
ååŠéè«éãªããååŠéè«éã®20åã®éä»è¿ã§äœ¿
çšãããããã©ãžãŠã 觊åªã®äœ¿çšéã«ã€ããŠç¹å¥
ãªå¶éã¯ãªãããå·¥æ¥çã«ã¯å šåå¿æ··å液ïŒã
ãããã©ãžãŠã ååãšããŠ0.1ã100ããªã°ã©ã å
åã奜ãŸããã¯0.5ã30ããªã°ã©ã ååã®æ¿åºŠã§
çšããã®ãæãŸããã æ¬çºæã§çšããåèšäžè¬åŒã§ç€ºãããå座é äœ
æ§ãã¹ãã€ã³é¡ã¯å ·äœçã«ã¯ããªããšãã«ãã¹ã
ã€ã³ã
ã²ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªå
æ¹æ³ã«é¢ããã 掻æ§æ°ŽçŽ ãæããåçš®ã®ææ©ååç©ãããâã²
ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåå
å¿ã«ããã¢ã«ã«ãžãšãã«ååç©ãçæããããšã¯
å ¬ç¥ã§ããïŒããšãã°Advances in
Organometal.Chem.ïŒVol.17ïŒAcademic
PressïŒNew YorkïŒ1979ïŒãéç°ç¶å ±åœ¹ãžãªã¬
ãã€ã³ã®ããã¡ãªååå¿ã¯éåžžãã©ãžãŠã 觊åªã®
ååšäžã§è¡ãªããããããã©ãžãŠã ã¯æ¥µããŠé«äŸ¡
ã§ããããããã®åå¿ãå·¥æ¥çèŠæš¡ã§å®æœããã«
ã¯è§ŠåªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶æããããšã
ãã³è§Šåªãå¹çãã埪ç°äœ¿çšããããšãäžå¯æ¬ ã§
ããã觊åªæŽ»æ§ã®å®å®åã«ããªããšãã«ãã¹ãã€
ã³ãªã©ã®ãã¹ãã€ã³é¡ã®æ·»å ãæå¹ã§ããããšã¯
åèšæç®ã«ããå ¬ç¥ã§ããããã©ãžãŠã ã«å¯ŸããŠ
éå°éã®ãã¹ãã€ã³é¡ãæ·»å ããããšã«ãã€ãŠè§Š
åªæŽ»æ§ãããçšåºŠç¶æããããšãã§ãããããã
ãªãããæ¬çºæè ãã®è©³çŽ°ãªæ€èšã«ãããšãã¹ã
ã€ã³é¡ã®æ·»å ã«ãã€ãŠããªã觊åªæŽ»æ§ãé·æã«äº
ã€ãŠå®å®ã«ç¶æããããšãã§ããªãããšãå€æã
ããããšãã°ãåå¿ã§çæããã¢ã«ã«ãžãšãã«å
åç©ã¯ãéåžžãèžçã«ãã€ãŠåå¿æ··å液ããåé¢
ãããããèžç枩床ãçŽ110âãè¶ãããšããšã
ãã©ãžãŠã ã«å¯ŸããŠå€§ééã®ãã¹ãã€ã³é¡ãæ·»å
ãããŠããŠã觊åªã®å€è³ªããã³ã¡ã¿ã«åãé¡èã«
èµ·ããããã©ãžãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«å
ã¯åã«è§ŠåªæŽ»æ§ãäœäžãããã®ã¿ãªãã觊åªã®é£
ç¶çãªåŸªç°äœ¿çšãå®è³ªçã«äžå¯èœã«ããããã©ãž
ãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åãæå¶ãããã
ã«110â以äžã®æž©åºŠã§èžçãè¡ãªããšãããªãã®
éã§çæããé«æ²žç¹å¯çæç©ã觊åªãå«ãæ®çç©
äžã«èç©ããããšãšãªããããã觊åªã®åŸªç°ãç¹°
ãè¿ãéçšã§è§ŠåªæŽ»æ§ãäœäžãããåå ãšãªãã®
ã§è§Šåªã埪ç°äœ¿çšããããšãã§ããªããªãã ãã®ããã«ãã©ãžãŠã 觊åªã®ååšäžæŽ»æ§æ°ŽçŽ ã
æããææ©ååç©ãããâã²ã³ãšããéç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿ãå·¥æ¥çèŠæš¡ã§å®
æœããã«éããŠè§£æ±ºãã¹ã課é¡ã¯ã觊åªæŽ»æ§å¯¿åœ
ãé·æã«äºã€ãŠä¿æããããšãããã³è§Šåªã®æŽ»æ§
ãäœäžãããããšãªãåå¿æ··å液ããã®çæç©ã®
åé¢ãšè§Šåªã®åŸªç°äœ¿çšãè¡ãªãããšã§ããã 掻æ§æ°ŽçŽ ãæããææ©ååç©ãçšããŠãã©ãžãŠ
ã 觊åªããã³ãã¹ãã€ã³é¡ã®ååšäžã«éç°ç¶å ±åœ¹
ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿ãè¡ãªãã«éããŠ
ã®åè¿°ããåŠãçš®ã ã®åé¡ç¹ã¯ãæ¬çºæã«ããã°
äžè¬åŒ ïŒåŒäžãã¯æ°ŽçŽ ååãâSO3NaãŸãã¯â
COONaãè¡šããïŒ ã§ç€ºãããå座é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã
ïŒã°ã©ã ååãããå°ããšãïŒã¢ã«ã®éã§çšãã
ãã€äºåº§é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©
ã ååããã0.3ãïŒã¢ã«ã®éã§æ·»å ããããšã«
ãã€ãŠæ¥µããŠå¹æçã«è§£æ±ºãããããšãèŠåºãã
ããäžè¿°ããããã«æ¬çºæã®æ¹æ³ã¯ç¹å®éã®å座
é äœæ§ãã¹ãã€ã³é¡ã«å¯ŸããŠäºåº§é äœæ§ãã¹ãã€
ã³é¡ã®ç¹å®éãçµåããŠçšããç¹ã«ç¹åŸŽãæããŠ
ãããããã«ããé«ãåå¿é床ã§ããã¡ãªååå¿
ãé²è¡ããã ãã§ãªãã觊åªã埪ç°äœ¿çšããå Žå
ã§ã觊åªå€±æŽ»ç©è³ªã®èç©ã«ãã觊åªã®æŽ»æ§äœäžã
æå¶ãããã®ã§è§ŠåªæŽ»æ§ãé·æã«äºã€ãŠå®å®ã«ç¶
æããããšãã§ããã®ã§ãããããã«æ¬çºæã«ã
ãã°ãåå¿æ··å液ããã®çæç©ã®èžçåé¢ã«éã
ãŠããã©ãžãŠã 觊åªã®å€è³ªãªãã³ã«ã¡ã¿ã«åãæ
å¶ãããããã觊åªã®æŽ»æ§ãäœäžãããããšãªã
觊åªã埪ç°äœ¿çšããããšãã§ããããã®ããã«æ¬
çºæã«åŸãã°æŽ»æ§æ°ŽçŽ ãæããææ©ååç©ããã
âã²ã³ãšããéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãª
ååå¿ãå·¥æ¥çã«æå©ã«å®æœããããšãã§ããã ãã®ã»ãã«ãæ¬çºæã«ããã°åå¿ç³»ã«åŸ®éæ··å ¥
ããé žçŽ ã«ãã€ãŠãã¹ãã€ã³é¡ãé žåãããŠè§Šåª
æ¯ãšããŠäœçšãããã¹ãã€ã³ãªããµã€ããçæã
ãã®ãæå¶ããããšããå©ç¹ããããããããäž
è¿°ããåŠãæ¬çºæã®å¹æã¯å座é äœæ§ãã¹ãã€ã³
é¡ãšäºåº§é äœæ§ãã¹ãã€ã³é¡ãšãçµåããŠçšãã
ããšã«ãã€ãŠå§ããŠçºçŸããã®ã§ãã€ãŠãããšã
äºåº§é äœæ§ãã¹ãã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã å
åããã0.3ãïŒã¢ã«ã®éã§åå¿ç³»ã«æ·»å ããŠã
å座é äœæ§ãã¹ãã€ã³é¡ãå šã䜿çšããªãå Žåã«
ã¯ãç¹å ¬æ47â25321å·å ¬å ±ããã³Bull.Chem.
Soc.JapanïŒ45ïŒ1183ïŒ1972ïŒã«å ±åãããŠãã
ããã«éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåã«åº
ã¥ãåå¿çæç©ã¯å šãåŸãããªãã§éç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ã«æŽ»æ§æ°ŽçŽ ãæããååç©ãä»å ãã
ååç©ãéžæçã«çæããã ãªãæ¬çºæã«ãããŠçšããããå座é äœæ§ãã¹
ãã€ã³é¡ã§ã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãž
ãŠã ïŒååã«å¯ŸããŠïŒå¯ŸïŒã§é äœããããããã«
察ããŠæ¬çºæã«ãããŠçšããããäºåº§é äœæ§ãã¹
ãã€ã³é¡ãšã¯ïŒååã®ãã¹ãã€ã³ååç©ããã©ãž
ãŠã ïŒååã«å¯ŸããŠãã¬ãŒãé äœããããšãã§ã
ãããã«ååå ã«ïŒã€ã®é äœå¯èœãªååãæãã
ååç©ã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšãããããã©ãžãŠã 觊
åªãšããŠã¯åŸæ¥å ¬ç¥ã®ãã©ãžãŠã ãŸãã¯ãã©ãžãŠ
ã ååç©ããã¹ãŠäœ¿çšå¯èœã§ããããã©ãžãŠã ã¯
掻æ§çãªã©ã®äžæŽ»æ§ãªæ äœäžã«æ²çãããŠçšãã
ããšãã§ããããã©ãžãŠã ååç©ãšããŠã¯å ·äœç
ã«ã¯ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒããé ¢é žãã©
ãžãŠã ãïŒïŒïŒâã·ã¯ããªã¯ã¿ãžãšã³ãã©ãžãŠã
ã¯ãã©ã€ããÏâã¢ãªã«ãã©ãžãŠã ã¯ãã©ã€ãã
Ïâã¢ãªã«ãã©ãžãŠã ã¢ã»ããŒãããã¹ããªããš
ãã«ãã¹ãã€ã³ãã©ãžãŠã ã¯ãã©ã€ãããã¹ããª
ããšãã«ãã¹ãã€ã³ãã©ãžãŠã ã¢ã»ããŒãããã¹
ãããªã¹ïŒïœâã¡ããã·ããšãã«ïŒãã¹ãã€ã³ã
ãã©ãžãŠã ã¢ã»ããŒãããã¹ïŒïœâããªã«ãžããš
ãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€ããããã©
ãã¹ïŒããªããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ãã
ãã©ãã¹ïŒããªãããã«ãã¹ãã€ã³ïŒãã©ãžãŠ
ã ãããã©ãã¹ïŒïœâããªã«ãžããšãã«ãã¹ãã€
ã³ïŒãã©ãžãŠã ãããã©ãã¹ïŒããªãã³ãžã«ãã¹
ãã€ã³ïŒãã©ãžãŠã ããã¹ïŒããªã·ã¯ãããã·ã«
ãã¹ãã€ã³ïŒãã©ãžãŠã ã¢ã»ããŒãããã¹ïŒã¡ã
ã«ãžããšãã«ãã¹ãã€ã³ïŒãã©ãžãŠã ã¯ãã©ã€
ããããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒãš
ã¿ã³ããã©ãžãŠã ã¢ã»ããŒãããã¹ïŒãã³ãŸãã
ãªã«ïŒãã©ãžãŠã ã¯ãã©ã€ããå¡©åãã©ãžãŠã ã
ç¡é žãã©ãžãŠã ãç¡«é žãã©ãžãŠã ããããªãŠã ã¯
ãããã©ããŒããªã©ãæããããšãã§ãããéç°
ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªåã«ãããçã®è§Š
åªæŽ»æ§çš®ã¯äœåå䟡ãã©ãžãŠã é¯äœã§ããã®ã§ã
äºäŸ¡ã®ãã©ãžãŠã ååç©ã觊åªãšããŠçšããå Žå
ã«ã¯åå¿ç³»äžã«ååšãããã¹ãã€ã³é¡ãŸãã¯éç°
ç¶å ±åœ¹ãžãªã¬ãã€ã³ã§éå ããããšã«ãã€ãŠæŽ»æ§
é¯äœãçæãããããšãã§ããããåäžåå¿ç³»å
ãŸãã¯å¥ã®åå¿å®¹åšå ã§éå äœçšãããååç©ã
å ±åãããããšã«ãã€ãŠè§ŠåªæŽ»æ§çš®ãçæãããŠ
䜿çšããããšãã§ããããã®ãããªç®çã«çšãã
ããéå å€ãšããŠã¯ã¢ã«ã«ãªéå±æ°Žé žåç©ãæ°ŽçŽ
åããŠçŽ ãããªãŠã ãäºéæ«ããã°ãã·ãŠã ãã
ãã©ãžã³ãã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããã¢ã«ã«ãª
éå±ã«ã«ãã³é žå¡©ãªã©ãæããããšãã§ãããé
å å€ã¯ãã©ãžãŠã ã®åå䟡ãå€ããããã«å¿ èŠãª
ååŠéè«éãªããååŠéè«éã®20åã®éä»è¿ã§äœ¿
çšãããããã©ãžãŠã 觊åªã®äœ¿çšéã«ã€ããŠç¹å¥
ãªå¶éã¯ãªãããå·¥æ¥çã«ã¯å šåå¿æ··å液ïŒã
ãããã©ãžãŠã ååãšããŠ0.1ã100ããªã°ã©ã å
åã奜ãŸããã¯0.5ã30ããªã°ã©ã ååã®æ¿åºŠã§
çšããã®ãæãŸããã æ¬çºæã§çšããåèšäžè¬åŒã§ç€ºãããå座é äœ
æ§ãã¹ãã€ã³é¡ã¯å ·äœçã«ã¯ããªããšãã«ãã¹ã
ã€ã³ã
ãåŒãããã³
ãåŒãã§ãããå座é
äœ
æ§ãã¹ãã€ã³é¡ã¯åç¬ã§çšããŠãããããã¯äºçš®
以äžãæ··åããŠçšããŠããããå座é äœæ§ãã¹ã
ã€ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååãããå°ããšã
ïŒã¢ã«ä»¥äžã奜ãŸããã¯10ã¢ã«ä»¥äžã®å²åã§äœ¿çš
ããããå座é äœæ§ãã¹ãã€ã³é¡ã®äœ¿çšéã«ã€ã
ãŠå³å¯ãªæå³ã§ã®äžéã¯ãªãããäžè¬ã«ã¯ãã©ãž
ãŠã ïŒã°ã©ã ååããã250ã¢ã«ä»¥äžã奜ãŸãã
ã¯50ã¢ã«ä»¥äžã§çšããã®ãæãŸããã æ¬çºæã®æ¹æ³ã«ãããŠãå座é äœæ§ãã¹ãã€ã³
é¡ãšçµåããŠçšããããäºåº§é äœæ§ãã¹ãã€ã³é¡
ãšããŠã¯äžèšã®ãã®ãå ·äœçã«äŸç€ºããããšãã§
ããã ïŒC6H5ïŒ2PCH2PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2P
ïŒC6H5ïŒ2ã ïŒC6H5ïŒ2PïŒCH2ïŒ3PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ4P
ïŒC6H5ïŒ2ã
以äžãæ··åããŠçšããŠããããå座é äœæ§ãã¹ã
ã€ã³é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååãããå°ããšã
ïŒã¢ã«ä»¥äžã奜ãŸããã¯10ã¢ã«ä»¥äžã®å²åã§äœ¿çš
ããããå座é äœæ§ãã¹ãã€ã³é¡ã®äœ¿çšéã«ã€ã
ãŠå³å¯ãªæå³ã§ã®äžéã¯ãªãããäžè¬ã«ã¯ãã©ãž
ãŠã ïŒã°ã©ã ååããã250ã¢ã«ä»¥äžã奜ãŸãã
ã¯50ã¢ã«ä»¥äžã§çšããã®ãæãŸããã æ¬çºæã®æ¹æ³ã«ãããŠãå座é äœæ§ãã¹ãã€ã³
é¡ãšçµåããŠçšããããäºåº§é äœæ§ãã¹ãã€ã³é¡
ãšããŠã¯äžèšã®ãã®ãå ·äœçã«äŸç€ºããããšãã§
ããã ïŒC6H5ïŒ2PCH2PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2P
ïŒC6H5ïŒ2ã ïŒC6H5ïŒ2PïŒCH2ïŒ3PïŒC6H5ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ4P
ïŒC6H5ïŒ2ã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ãåŒã
ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ2ãïŒC6H5ïŒ2PïŒCH2ïŒ2N
ïŒCH3ïŒ2ã ïŒC6H5ïŒ2PCH2CH2SO3Naã
ïŒC6H5ïŒ2PCH2COOC2H5ã ïŒC6H5ïŒ2PCH2CH2COONaã å座é äœæ§ãã¹ãã€ã³é¡ãšåæ§ã«äºåº§é äœæ§ã
ã¹ãã€ã³é¡ã¯åç¬ã§çšããŠãããããã¯äºçš®ä»¥äž
ãæ··åããŠçšããŠããããäºåº§é äœæ§ãã¹ãã€ã³
é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒã¢ã«
ã®å²åã§åå¿ç³»ã«æ·»å ããããæ·»å éã0.3ã¢ã«
æªæºã®å Žåã«ã¯äºåº§é äœæ§ãã¹ãã€ã³é¡ãæ·»å ã
ãããšã«ããå¹æãå®è³ªçã«çºçŸãããïŒã¢ã«ã
è¶ããå Žåã¯ããã€ãŠåå¿ãé»å®³ããåå¿é床ã
極床ã«äœäžããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããéç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ãšããŠã¯ããã¿ãžãšã³ãã€ãœãã¬ã³ã
ãããªã¬ã³ããžã¡ãã«ãã¿ãžãšã³ãªã©ãäŸç€ºãã
ããšãã§ããããŸã掻æ§æ°ŽçŽ ãæããææ©ååç©
ãšããŠã¯ãæ°Žé žåºãã«ã«ããã·ã«åºããã«ãã«
åºãã¢ããåºãŸãã¯æŽ»æ§ã¡ãã¬ã³åºãªã©ãæãã
ä»»æã®ååç©ãæããããšãã§ãããæ°Žé žåºãæ
ãã掻æ§æ°ŽçŽ ååç©ãšããŠã¯ã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãïœâãããããŒã«ãïœâãã¿ããŒã«ãã€ãœ
ãã¿ããŒã«ãïœâãªã¯ã¿ããŒã«ãïŒâãšãã«ãã
ãµããŒã«ãã¢ãªã«ã¢ã«ã³ãŒã«ããã¬ãã«ã¢ã«ã³ãŒ
ã«ããã³ãžã«ã¢ã«ã³ãŒã«ããšãã¬ã³ã°ãªã³ãŒã«ã
ãžãšãã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°ãªã³ãŒ
ã«ãã°ãªã»ãªã³ãªã©ã§ä»£è¡šãããã¢ã«ã³ãŒã«é¡ã
ããšããŒã«ãïœâã¯ããããšããŒã«ãïœâã¡ãã
ã·ããšããŒã«ãã¯ã¬ãŸãŒã«ãªã©ã§ä»£è¡šãããããš
ããŒã«é¡ãªã©ãã«ã«ããã·ã«åºãæãã掻æ§æ°ŽçŽ
ååç©ãšããŠã¯ã®é žãé ¢é žãããããªã³é žãã¢ãž
ãã³é žãã»ããã³é žãå®æ¯éŠé žããªã«ããã¿ã«
é žããã¬ãã¿ã«é žãªã©ã§ä»£è¡šãããã«ã«ãã³é ž
é¡ããã«ãã«åºãæããååç©ãšããŠã¯ãã«ã ã¢
ã«ããããã¢ã»ãã¢ã«ãããããã³ãºã¢ã«ããã
ãªã©ã§ä»£è¡šãããã¢ã«ãããé¡ãã¢ããåºãæã
ã掻æ§æ°ŽçŽ ååç©ãšããŠã¯ã¡ãã«ã¢ãã³ããšãã«
ã¢ãã³ãããã«ã¢ãã³ããžã¡ãã«ã¢ãã³ãã¡ãã«
ããã«ã¢ãã³ãã¢ããªã³ãã¡ãã«ã¢ããªã³ãã¢ã«
ããªã³ãããã©ãžã³ããããªãžã³ãªã©ã§ä»£è¡šãã
ãã¢ãã³é¡ã掻æ§ã¡ãã¬ã³åºãæããååç©ãšã
ãŠã¯ã¢ã»ãã«ã¢ã»ãã³ããã³ãŸã€ã«ã¢ã»ãã³ãã¢
ã»ãé ¢é žãšãã«ãããã³é žãšãã«ããããã¡ã¿ã³
ãªã©ãããããäŸç€ºããããšãã§ããã ãã©ãžãŠã 觊åªã®ååšäžã掻æ§æ°ŽçŽ ååç©ã«ã
ãéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãããã¡ãªåãããšã
äžè¬ã«ã¯ãéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšæŽ»æ§æ°ŽçŽ å
åç©ãšã®ïŒïŒïŒä»å äœã§ããã¢ã«ã«ãžãšãã«åå
ç©ãçæãããããšãã°ã¡ã¿ããŒã«ãçšããŠãã¿
ãžãšã³ãããã¡ãªåããå Žåã«ã¯ïŒâã¡ããã·â
2.7âãªã¯ã¿ãžãšã³ããã³ïŒâã¡ããã·â1.7âãª
ã¯ã¿ãžãšã³ãçæããã¢ã»ãã¢ã«ããããçšããŠ
åæ§ã«ãã¿ãžãšã³ãããã¡ãªåããå Žåã«ã¯
ïŒCH3ïŒ2ã ïŒC6H5ïŒ2PCH2CH2SO3Naã
ïŒC6H5ïŒ2PCH2COOC2H5ã ïŒC6H5ïŒ2PCH2CH2COONaã å座é äœæ§ãã¹ãã€ã³é¡ãšåæ§ã«äºåº§é äœæ§ã
ã¹ãã€ã³é¡ã¯åç¬ã§çšããŠãããããã¯äºçš®ä»¥äž
ãæ··åããŠçšããŠããããäºåº§é äœæ§ãã¹ãã€ã³
é¡ã¯ãã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒã¢ã«
ã®å²åã§åå¿ç³»ã«æ·»å ããããæ·»å éã0.3ã¢ã«
æªæºã®å Žåã«ã¯äºåº§é äœæ§ãã¹ãã€ã³é¡ãæ·»å ã
ãããšã«ããå¹æãå®è³ªçã«çºçŸãããïŒã¢ã«ã
è¶ããå Žåã¯ããã€ãŠåå¿ãé»å®³ããåå¿é床ã
極床ã«äœäžããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããéç°ç¶å ±åœ¹ãž
ãªã¬ãã€ã³ãšããŠã¯ããã¿ãžãšã³ãã€ãœãã¬ã³ã
ãããªã¬ã³ããžã¡ãã«ãã¿ãžãšã³ãªã©ãäŸç€ºãã
ããšãã§ããããŸã掻æ§æ°ŽçŽ ãæããææ©ååç©
ãšããŠã¯ãæ°Žé žåºãã«ã«ããã·ã«åºããã«ãã«
åºãã¢ããåºãŸãã¯æŽ»æ§ã¡ãã¬ã³åºãªã©ãæãã
ä»»æã®ååç©ãæããããšãã§ãããæ°Žé žåºãæ
ãã掻æ§æ°ŽçŽ ååç©ãšããŠã¯ã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãïœâãããããŒã«ãïœâãã¿ããŒã«ãã€ãœ
ãã¿ããŒã«ãïœâãªã¯ã¿ããŒã«ãïŒâãšãã«ãã
ãµããŒã«ãã¢ãªã«ã¢ã«ã³ãŒã«ããã¬ãã«ã¢ã«ã³ãŒ
ã«ããã³ãžã«ã¢ã«ã³ãŒã«ããšãã¬ã³ã°ãªã³ãŒã«ã
ãžãšãã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°ãªã³ãŒ
ã«ãã°ãªã»ãªã³ãªã©ã§ä»£è¡šãããã¢ã«ã³ãŒã«é¡ã
ããšããŒã«ãïœâã¯ããããšããŒã«ãïœâã¡ãã
ã·ããšããŒã«ãã¯ã¬ãŸãŒã«ãªã©ã§ä»£è¡šãããããš
ããŒã«é¡ãªã©ãã«ã«ããã·ã«åºãæãã掻æ§æ°ŽçŽ
ååç©ãšããŠã¯ã®é žãé ¢é žãããããªã³é žãã¢ãž
ãã³é žãã»ããã³é žãå®æ¯éŠé žããªã«ããã¿ã«
é žããã¬ãã¿ã«é žãªã©ã§ä»£è¡šãããã«ã«ãã³é ž
é¡ããã«ãã«åºãæããååç©ãšããŠã¯ãã«ã ã¢
ã«ããããã¢ã»ãã¢ã«ãããããã³ãºã¢ã«ããã
ãªã©ã§ä»£è¡šãããã¢ã«ãããé¡ãã¢ããåºãæã
ã掻æ§æ°ŽçŽ ååç©ãšããŠã¯ã¡ãã«ã¢ãã³ããšãã«
ã¢ãã³ãããã«ã¢ãã³ããžã¡ãã«ã¢ãã³ãã¡ãã«
ããã«ã¢ãã³ãã¢ããªã³ãã¡ãã«ã¢ããªã³ãã¢ã«
ããªã³ãããã©ãžã³ããããªãžã³ãªã©ã§ä»£è¡šãã
ãã¢ãã³é¡ã掻æ§ã¡ãã¬ã³åºãæããååç©ãšã
ãŠã¯ã¢ã»ãã«ã¢ã»ãã³ããã³ãŸã€ã«ã¢ã»ãã³ãã¢
ã»ãé ¢é žãšãã«ãããã³é žãšãã«ããããã¡ã¿ã³
ãªã©ãããããäŸç€ºããããšãã§ããã ãã©ãžãŠã 觊åªã®ååšäžã掻æ§æ°ŽçŽ ååç©ã«ã
ãéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãããã¡ãªåãããšã
äžè¬ã«ã¯ãéç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ãšæŽ»æ§æ°ŽçŽ å
åç©ãšã®ïŒïŒïŒä»å äœã§ããã¢ã«ã«ãžãšãã«åå
ç©ãçæãããããšãã°ã¡ã¿ããŒã«ãçšããŠãã¿
ãžãšã³ãããã¡ãªåããå Žåã«ã¯ïŒâã¡ããã·â
2.7âãªã¯ã¿ãžãšã³ããã³ïŒâã¡ããã·â1.7âãª
ã¯ã¿ãžãšã³ãçæããã¢ã»ãã¢ã«ããããçšããŠ
åæ§ã«ãã¿ãžãšã³ãããã¡ãªåããå Žåã«ã¯
ãåŒã
ãåŒãããã³
ãåŒããçæ
ããã掻æ§æ°ŽçŽ ãïŒå以äžæãã掻æ§æ°ŽçŽ ååç©
ãçšããŠåå¿ãè¡ãªã€ãå Žåã«ã¯éç°ç¶å ±åœ¹ãžãª
ã¬ãã€ã³ãšæŽ»æ§æ°ŽçŽ ååç©ãšã®ïŒïŒïŒä»å äœã
ïŒïŒïŒä»å äœãªã©ãå¯çããããšãã°ã¡ãã«ã¢ã
ã³ãçšãããã¿ãžãšã³ã®ããã¡ãªåã«ãã CH3NHCH2CHïŒCHïŒCH2ïŒ3CHïŒCH2 ããã³ ãçæããã ã®é žãçšããŠåå¿ãè¡ãªã€ãå Žåã«ã¯æ°ŽçŽ ãé
ç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®çŽéäºéäœã«ä»å ããç
æç©ãçæããããšãã°ãã¿ãžãšã³ã®ããã¡ãªå
ã«ãããªã¯ã¿â1.7âãžãšã³ããã³ãªã¯ã¿â1.6â
ãžãšã³ãçæãããããšåæã«çé žã¬ã¹ãçºçã
ããã¢ã«ã³ãŒã«é¡ãçšããŠäžé žåççŽ ã®ååšäžã«
åå¿ãè¡ã€ãå Žåã«ã¯ã¢ã«ã«ãžãšã³ã®ã«ã«ãã³é ž
ãšã¹ãã«ãçæããããšãã°ãã¿ãžãšã³ã®ããã¡
ãªåã«ãã3.8âãããžãšã³é žãšã¹ãã«ãçæã
ãã æ¬çºææ¹æ³ã«ãããŠåå¿ç³»ã«ç¡æ©é žããã³ïŒãŸ
ãã¯ç¬¬äžçŽã¢ãã³é¡ãæ·»å ããããšã«ããåå¿ã
èããä¿é²ããããçšãããç¡æ©é žãšããŠã¯ããš
ãã°ãªã³é žãããŠé žãªã©ãæãããããŸã第äžçŽ
ã¢ãã³é¡ãšããŠã¯ããªã¡ãã«ã¢ãã³ãããªãšãã«
ã¢ãã³ãâã¡ãã«ã¢ã«ããªã³ãªã©ãæããã
ãããããç¡æ©é žããã³ç¬¬äžçŽã¢ãã³é¡ã®äœ¿çšé
ã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããéåžžã掻æ§æ°ŽçŽ ã
æããææ©ååç©ãšçã¢ã«ãããã¯ãã以äžã®é
ã§äœ¿çšãããã æ¬çºæã«åŸãåå¿ãå®æœããã«ãããã掻æ§æ°Ž
çŽ ãæããææ©ååç©ã«æº¶åªãšããŠã®æ©èœãå Œã
ãããããšãã§ããã®ã§æº¶åªãå¿ ãããå¿ èŠãšã
ãªãããåå¿ã«äžæŽ»æ§ãªæº¶åªã§ããã°äœ¿çšããŠã
äœãããã€ãããªãã䜿çšå¯èœãªæº¶åªãšããŠã¯ã
ãžãšãã«ãšãŒãã«ããžããã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããžãªããœã©ã³ããšãã¬
ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãããã©ãšãã¬ã³
ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãå¹³åååéã200
ã2000ã®ããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒã
ã«ãªã©ã§ä»£è¡šããããšãŒãã«é¡ãïœâãã¿ããŒ
ã«ãã€ãœãããããŒã«ãªã©ã§ä»£è¡šããã第ïŒçŽãŸ
ãã¯ç¬¬ïŒçŽã®ã¢ã«ã³ãŒã«é¡ãã¢ã»ãã³ãã¡ãã«ãš
ãã«ã±ãã³ãã¡ãã«ã€ãœããã«ã±ããã³ãªã©ã§ä»£
è¡šãããã±ãã³é¡ãã¢ã»ããããªã«ããã³ãŸãã
ãªã«ãããããªãããªã«ãªã©ã§ä»£è¡šããããããª
ã«é¡ãã¢ã»ãã¢ãããããããªã³ã¢ãããïŒïŒ®
âãžã¡ãã«ãã«ã ã¢ãããïŒïŒ®âãžã¡ãã«ã¢ã»
ãã¢ãããªã©ã§ä»£è¡šãããã¢ããé¡ããžã¡ãã«ã¹
ã«ãããµã€ããªã©ã®ã¹ã«ãããµã€ãé¡ãã¹ã«ãã©
ã³ãã¡ãã«ã¹ã«ãã©ã³ãªã©ã§ä»£è¡šãããã¹ã«ãã³
é¡ããããµã¡ãã«ãã¹ããªã«ã¢ãããªã©ã§ä»£è¡šã
ãããªã³é žã¢ãããé ¢é žã¡ãã«ãé ¢é žãšãã«ãå®
æ¯éŠé žã¡ãã«ãªã©ã§ä»£è¡šããããšã¹ãã«é¡ããã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ããšãã«ãã³ãŒã³ãªã©
ã®è³éŠæç³»çåæ°ŽçŽ ãããã³ããã¿ã³ããããµ
ã³ãã·ã¯ã¯ãããµã³ãã¡ãã«ã·ã¯ããããµã³ãªã©
ã§ä»£è¡šãããèèªæç³»çåæ°ŽçŽ ãªã©ãæããã
ãã溶åªã®å€ãã¯éåžžåç¬ã§äœ¿çšããããã溶解
床ãçæç©åé¢ãªã©ã®ç¹ããäºçš®ä»¥äžãæ··å䜿çš
ããæ¹ãæå©ãšå€æãããå Žåã«ã¯é©åœã«æ··åã
ãŠäœ¿çšããŠãããã溶åªãšããŠç¹ã«ã¹ã«ãã©ã³ã
ãã³ã¡ãã«ã¹ã«ãã©ã³ã䜿çšããå Žåã«ã¯çåæ°Ž
çŽ é¡ã«ãã€ãŠåå¿æ··å液ããçæç©ãšè§Šåªãæœåº
åé¢ããããšãå¯èœãšãªããããã«ã¯éå°éã®ã
ã¹ãã€ã³é¡ã®æ·»å ã«ããåå¿é床ã®äœäžãä»ã®æº¶
åªã䜿çšããå Žåã«æ¯èŒããŠå°ãããšããå©ç¹ã
åŸããããæ¬åå¿ç³»ã«ã¯å Žåã«ããæ°Žãå ±åãã
ãŠããããå ååå¿æ§ã®é«ã掻æ§æ°ŽçŽ ååç©ãå
å¿ã«çšããå Žåã«ã¯æ°Žã¯æº¶åªãšããŠäœçšããã æ¬çºæã®æ¹æ³ãå®æœããã«ããããåå¿ã¯ãã
ãæ¹åŒããã³é£ç¶æ¹åŒã®ãããã§å®æœããããšã
ã§ããããå·¥æ¥çã«ã¯é£ç¶æ¹åŒãæå©ã§ãããå
å¿ã¯10ã150âã奜ãŸããã¯50ã120âã®æž©åºŠã§å®
æœãããã æ¬çºæã«åŸãåå¿ãå®æœããã«ããããåå¿ç
æç©ã¯åå¿æ··å液ãçŽæ¥èžçããããšã«ãã€ãŠå
é¢ããããšãã§ããããã¹ã«ãã©ã³ãã¡ãã«ã¹ã«
ãã©ã³ãªã©ã®æº¶åªã«
ãçšããŠåå¿ãè¡ãªã€ãå Žåã«ã¯éç°ç¶å ±åœ¹ãžãª
ã¬ãã€ã³ãšæŽ»æ§æ°ŽçŽ ååç©ãšã®ïŒïŒïŒä»å äœã
ïŒïŒïŒä»å äœãªã©ãå¯çããããšãã°ã¡ãã«ã¢ã
ã³ãçšãããã¿ãžãšã³ã®ããã¡ãªåã«ãã CH3NHCH2CHïŒCHïŒCH2ïŒ3CHïŒCH2 ããã³ ãçæããã ã®é žãçšããŠåå¿ãè¡ãªã€ãå Žåã«ã¯æ°ŽçŽ ãé
ç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®çŽéäºéäœã«ä»å ããç
æç©ãçæããããšãã°ãã¿ãžãšã³ã®ããã¡ãªå
ã«ãããªã¯ã¿â1.7âãžãšã³ããã³ãªã¯ã¿â1.6â
ãžãšã³ãçæãããããšåæã«çé žã¬ã¹ãçºçã
ããã¢ã«ã³ãŒã«é¡ãçšããŠäžé žåççŽ ã®ååšäžã«
åå¿ãè¡ã€ãå Žåã«ã¯ã¢ã«ã«ãžãšã³ã®ã«ã«ãã³é ž
ãšã¹ãã«ãçæããããšãã°ãã¿ãžãšã³ã®ããã¡
ãªåã«ãã3.8âãããžãšã³é žãšã¹ãã«ãçæã
ãã æ¬çºææ¹æ³ã«ãããŠåå¿ç³»ã«ç¡æ©é žããã³ïŒãŸ
ãã¯ç¬¬äžçŽã¢ãã³é¡ãæ·»å ããããšã«ããåå¿ã
èããä¿é²ããããçšãããç¡æ©é žãšããŠã¯ããš
ãã°ãªã³é žãããŠé žãªã©ãæãããããŸã第äžçŽ
ã¢ãã³é¡ãšããŠã¯ããªã¡ãã«ã¢ãã³ãããªãšãã«
ã¢ãã³ãâã¡ãã«ã¢ã«ããªã³ãªã©ãæããã
ãããããç¡æ©é žããã³ç¬¬äžçŽã¢ãã³é¡ã®äœ¿çšé
ã«ã€ããŠç¹å¥ãªå¶éã¯ãªãããéåžžã掻æ§æ°ŽçŽ ã
æããææ©ååç©ãšçã¢ã«ãããã¯ãã以äžã®é
ã§äœ¿çšãããã æ¬çºæã«åŸãåå¿ãå®æœããã«ãããã掻æ§æ°Ž
çŽ ãæããææ©ååç©ã«æº¶åªãšããŠã®æ©èœãå Œã
ãããããšãã§ããã®ã§æº¶åªãå¿ ãããå¿ èŠãšã
ãªãããåå¿ã«äžæŽ»æ§ãªæº¶åªã§ããã°äœ¿çšããŠã
äœãããã€ãããªãã䜿çšå¯èœãªæº¶åªãšããŠã¯ã
ãžãšãã«ãšãŒãã«ããžããã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããžãªããœã©ã³ããšãã¬
ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãããã©ãšãã¬ã³
ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ãå¹³åååéã200
ã2000ã®ããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒã
ã«ãªã©ã§ä»£è¡šããããšãŒãã«é¡ãïœâãã¿ããŒ
ã«ãã€ãœãããããŒã«ãªã©ã§ä»£è¡šããã第ïŒçŽãŸ
ãã¯ç¬¬ïŒçŽã®ã¢ã«ã³ãŒã«é¡ãã¢ã»ãã³ãã¡ãã«ãš
ãã«ã±ãã³ãã¡ãã«ã€ãœããã«ã±ããã³ãªã©ã§ä»£
è¡šãããã±ãã³é¡ãã¢ã»ããããªã«ããã³ãŸãã
ãªã«ãããããªãããªã«ãªã©ã§ä»£è¡šããããããª
ã«é¡ãã¢ã»ãã¢ãããããããªã³ã¢ãããïŒïŒ®
âãžã¡ãã«ãã«ã ã¢ãããïŒïŒ®âãžã¡ãã«ã¢ã»
ãã¢ãããªã©ã§ä»£è¡šãããã¢ããé¡ããžã¡ãã«ã¹
ã«ãããµã€ããªã©ã®ã¹ã«ãããµã€ãé¡ãã¹ã«ãã©
ã³ãã¡ãã«ã¹ã«ãã©ã³ãªã©ã§ä»£è¡šãããã¹ã«ãã³
é¡ããããµã¡ãã«ãã¹ããªã«ã¢ãããªã©ã§ä»£è¡šã
ãããªã³é žã¢ãããé ¢é žã¡ãã«ãé ¢é žãšãã«ãå®
æ¯éŠé žã¡ãã«ãªã©ã§ä»£è¡šããããšã¹ãã«é¡ããã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ããšãã«ãã³ãŒã³ãªã©
ã®è³éŠæç³»çåæ°ŽçŽ ãããã³ããã¿ã³ããããµ
ã³ãã·ã¯ã¯ãããµã³ãã¡ãã«ã·ã¯ããããµã³ãªã©
ã§ä»£è¡šãããèèªæç³»çåæ°ŽçŽ ãªã©ãæããã
ãã溶åªã®å€ãã¯éåžžåç¬ã§äœ¿çšããããã溶解
床ãçæç©åé¢ãªã©ã®ç¹ããäºçš®ä»¥äžãæ··å䜿çš
ããæ¹ãæå©ãšå€æãããå Žåã«ã¯é©åœã«æ··åã
ãŠäœ¿çšããŠãããã溶åªãšããŠç¹ã«ã¹ã«ãã©ã³ã
ãã³ã¡ãã«ã¹ã«ãã©ã³ã䜿çšããå Žåã«ã¯çåæ°Ž
çŽ é¡ã«ãã€ãŠåå¿æ··å液ããçæç©ãšè§Šåªãæœåº
åé¢ããããšãå¯èœãšãªããããã«ã¯éå°éã®ã
ã¹ãã€ã³é¡ã®æ·»å ã«ããåå¿é床ã®äœäžãä»ã®æº¶
åªã䜿çšããå Žåã«æ¯èŒããŠå°ãããšããå©ç¹ã
åŸããããæ¬åå¿ç³»ã«ã¯å Žåã«ããæ°Žãå ±åãã
ãŠããããå ååå¿æ§ã®é«ã掻æ§æ°ŽçŽ ååç©ãå
å¿ã«çšããå Žåã«ã¯æ°Žã¯æº¶åªãšããŠäœçšããã æ¬çºæã®æ¹æ³ãå®æœããã«ããããåå¿ã¯ãã
ãæ¹åŒããã³é£ç¶æ¹åŒã®ãããã§å®æœããããšã
ã§ããããå·¥æ¥çã«ã¯é£ç¶æ¹åŒãæå©ã§ãããå
å¿ã¯10ã150âã奜ãŸããã¯50ã120âã®æž©åºŠã§å®
æœãããã æ¬çºæã«åŸãåå¿ãå®æœããã«ããããåå¿ç
æç©ã¯åå¿æ··å液ãçŽæ¥èžçããããšã«ãã€ãŠå
é¢ããããšãã§ããããã¹ã«ãã©ã³ãã¡ãã«ã¹ã«
ãã©ã³ãªã©ã®æº¶åªã«
ãåŒãããã³
ãåŒãã®ããšã芪氎æ§ã®
å座é
äœæ§ãã¹ãã€ã³é¡ãçµåããŠçšããã€å«æ°Ž
ææ©æº¶åªæº¶æ¶²äžã§åå¿ãè¡ãªãå Žåã«ã¯çåæ°ŽçŽ
é¡ã«ãã€ãŠçæç©ãæœåºåé¢ããããšãã§ããã
åå¿çæç©ãæœåºæ³ã§åé¢ããå Žåã«ã¯è§Šåªæå
ãèžçæã®å ç±ã«ãããããªãã®ã§è§ŠåªæŽ»æ§ãã
ãé·æã«äºã€ãŠå®å®ã«ç¶æããããšãã§ããã觊
åªæåãå«ããèžçåŸã®æ®æ¶²ãŸãã¯æœåºã«ããæœ
æ®æ¶²ã¯ãã®ãŸãŸãããã¯äžéšè§Šåªè³ŠæŽ»ããã®ã¡é
ç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿å·¥çšã«å
ã³äœ¿çšã§ããã æ¬çºæã®æ¹æ³ã«ãã€ãŠåŸãããçæç©ã¯é«åå
æ·»å å€ãæš¹èãå¯å¡å€ãæŽæµå€ãªã©ã®åæãšã
ãŠããããã¯å»è¬ã蟲è¬ãéŠæãªã©ã®åæäžéäœ
ãšããŠæçšã§ããã 以äžãå®æœäŸã«ããæ¬çºæãå ·äœçã«èª¬æãã
ããæ¬çºæã¯ãããå ·äœäŸã«ãã€ãŠäœãå¶éãã
ããã®ã§ã¯ãªãã å®æœäŸïŒãïŒããã³æ¯èŒäŸïŒ å 容ç©100mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«é ¢
é žãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒãããªããšã
ã«ãã¹ãã€ã³131mgïŒ0.5ããªã¢ã«ïŒãé ¢é žïŒïœã
ããªãšãã«ã¢ãã³6.7ïœãã¹ã«ãã©ã³ïŒmlããã³
ãã¿ãžãšã³12ïœãä»èŸŒã¿ãããã«çš®ã ã®äºåº§é äœ
æ§ãã¹ãã€ã³ãè¡šïŒã«ç€ºãéã§æ·»å ããã®ã¡ãªãŒ
ãã¯ã¬ãŒããéãã800rpmã®é床ã§æ¹æããªã
ãå æž©75âã§ïŒæéåå¿ããããåå¿çµäºåŸããª
ãŒãã¯ã¬ãŒããå·åŽããã®ã¡åå¿æ··å液ãåãåº
ããåå¿çæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã«ãã€
ãŠåæãããçµæãè¡šïŒã«ç€ºãã
ææ©æº¶åªæº¶æ¶²äžã§åå¿ãè¡ãªãå Žåã«ã¯çåæ°ŽçŽ
é¡ã«ãã€ãŠçæç©ãæœåºåé¢ããããšãã§ããã
åå¿çæç©ãæœåºæ³ã§åé¢ããå Žåã«ã¯è§Šåªæå
ãèžçæã®å ç±ã«ãããããªãã®ã§è§ŠåªæŽ»æ§ãã
ãé·æã«äºã€ãŠå®å®ã«ç¶æããããšãã§ããã觊
åªæåãå«ããèžçåŸã®æ®æ¶²ãŸãã¯æœåºã«ããæœ
æ®æ¶²ã¯ãã®ãŸãŸãããã¯äžéšè§Šåªè³ŠæŽ»ããã®ã¡é
ç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡ãªååå¿å·¥çšã«å
ã³äœ¿çšã§ããã æ¬çºæã®æ¹æ³ã«ãã€ãŠåŸãããçæç©ã¯é«åå
æ·»å å€ãæš¹èãå¯å¡å€ãæŽæµå€ãªã©ã®åæãšã
ãŠããããã¯å»è¬ã蟲è¬ãéŠæãªã©ã®åæäžéäœ
ãšããŠæçšã§ããã 以äžãå®æœäŸã«ããæ¬çºæãå ·äœçã«èª¬æãã
ããæ¬çºæã¯ãããå ·äœäŸã«ãã€ãŠäœãå¶éãã
ããã®ã§ã¯ãªãã å®æœäŸïŒãïŒããã³æ¯èŒäŸïŒ å 容ç©100mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«é ¢
é žãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒãããªããšã
ã«ãã¹ãã€ã³131mgïŒ0.5ããªã¢ã«ïŒãé ¢é žïŒïœã
ããªãšãã«ã¢ãã³6.7ïœãã¹ã«ãã©ã³ïŒmlããã³
ãã¿ãžãšã³12ïœãä»èŸŒã¿ãããã«çš®ã ã®äºåº§é äœ
æ§ãã¹ãã€ã³ãè¡šïŒã«ç€ºãéã§æ·»å ããã®ã¡ãªãŒ
ãã¯ã¬ãŒããéãã800rpmã®é床ã§æ¹æããªã
ãå æž©75âã§ïŒæéåå¿ããããåå¿çµäºåŸããª
ãŒãã¯ã¬ãŒããå·åŽããã®ã¡åå¿æ··å液ãåãåº
ããåå¿çæç©ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã«ãã€
ãŠåæãããçµæãè¡šïŒã«ç€ºãã
ãè¡šã
å®æœäŸ ïŒ
å
容ç©300mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«ã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³1.31ïœïŒïŒããª
ã¢ã«ïŒããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒ
ãããã³206mgïŒ0.5ããªã¢ã«ã察Pdæ¯1.0ïŒã溶
解ãã溶液ãé ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³äžã®
ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒãã¯
ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§800rpm
ã®é床ã§æ¹æããªããïŒæéåå¿ããããåå¿çµ
äºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®ãã¿ãž
ãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®åå¿æ··å
液ã空æ°ã«ãµããªãããã«ããŠå§éããŠèžçãã©
ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®ãªã€ã«
ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµçã«ã¯20
mmHgã®æžå§åºŠã«ãŸã§å€åãããŠïŒæéãããŠæž
å§èžçãããèžçã«ãã€ãŠåŸãããå šåå¿æ··å液
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšãããç
æç©ãšããŠïŒïŒïŒïŒïŒâãªã¯ã¿ããªãšã³3.6ïœã
ïŒâã¢ã»ããã·â2.7âãªã¯ã¿ãžãšã³34.3ïœãã
ã³ïŒâã¢ã»ããã·â1.7âãªã¯ã¿ãžãšã³14.5ïœã
çæããŠããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ããããããšå
æ§ã®æäœãåèšã§ïŒåã«ãªããŸã§ç¹°ãè¿ãè¡ãªã€
ããç¹°ãè¿ãå®éšã«ããåå¿çµæã¯è¡šïŒã«ç€ºãé
ãã§ããããã©ãžãŠã 觊åªã®å€è³ªã«ãã掻æ§äœäž
ã¯èªããããªãã€ãã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³1.31ïœïŒïŒããª
ã¢ã«ïŒããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€ãïŒ
ãããã³206mgïŒ0.5ããªã¢ã«ã察Pdæ¯1.0ïŒã溶
解ãã溶液ãé ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³äžã®
ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒãã¯
ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§800rpm
ã®é床ã§æ¹æããªããïŒæéåå¿ããããåå¿çµ
äºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®ãã¿ãž
ãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®åå¿æ··å
液ã空æ°ã«ãµããªãããã«ããŠå§éããŠèžçãã©
ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®ãªã€ã«
ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµçã«ã¯20
mmHgã®æžå§åºŠã«ãŸã§å€åãããŠïŒæéãããŠæž
å§èžçãããèžçã«ãã€ãŠåŸãããå šåå¿æ··å液
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšãããç
æç©ãšããŠïŒïŒïŒïŒïŒâãªã¯ã¿ããªãšã³3.6ïœã
ïŒâã¢ã»ããã·â2.7âãªã¯ã¿ãžãšã³34.3ïœãã
ã³ïŒâã¢ã»ããã·â1.7âãªã¯ã¿ãžãšã³14.5ïœã
çæããŠããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ããããããšå
æ§ã®æäœãåèšã§ïŒåã«ãªããŸã§ç¹°ãè¿ãè¡ãªã€
ããç¹°ãè¿ãå®éšã«ããåå¿çµæã¯è¡šïŒã«ç€ºãé
ãã§ããããã©ãžãŠã 觊åªã®å€è³ªã«ãã掻æ§äœäž
ã¯èªããããªãã€ãã
ãè¡šã
æ¯èŒäŸ ïŒãïŒ
ãã¹ïŒ1.3âãžããšãã«ãã¹ãã€ãïŒãããã³
ã®æ·»å éãè¡šïŒã«ç€ºãããã«å€åãããã€ããè¿
ãåæ°ãïŒåã«æžããã以å€ã¯å®æœäŸïŒãšåäžã®
åå¿æ¡ä»¶äžã§åå¿ãè¡ãªã€ããçµæãè¡šïŒã«ç€º
ããåå¿åŸã®åå¿æ··å液ããçæç©ãæžå§äžã«èž
çåé¢ããéã«è§Šåªæ¶²ãé»å€ããåæã«æŽ»æ§ãè
ããäœäžããã
ã®æ·»å éãè¡šïŒã«ç€ºãããã«å€åãããã€ããè¿
ãåæ°ãïŒåã«æžããã以å€ã¯å®æœäŸïŒãšåäžã®
åå¿æ¡ä»¶äžã§åå¿ãè¡ãªã€ããçµæãè¡šïŒã«ç€º
ããåå¿åŸã®åå¿æ··å液ããçæç©ãæžå§äžã«èž
çåé¢ããéã«è§Šåªæ¶²ãé»å€ããåæã«æŽ»æ§ãè
ããäœäžããã
ãè¡šã
å®æœäŸ ïŒ
å
容ç©100mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«é
¢
é žãã©ãžãŠã 45mgïŒ0.2ããªã¢ã«ïŒãããªããšãã«
ãã¹ãã€ã³500mgïŒ1.9ããªã¢ã«ïŒããã¹ïŒ1.2âãž
ããšãã«ãã¹ãã€ãïŒãšã¿ã³79mgïŒ0.2ããªã¢ã«ã
察Pdæ¯1.0ïŒãã¢ã»ãé ¢é žãšãã«26ïœããããªãŠã
ããšããªããµã€ã0.3ïœããã³ãã¿ãžãšã³30ïœã
ä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå æž©130â
ã§ïŒæéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒ
ããå·åŽããæªåå¿ãã¿ãžãšã³ãé€å»ããã®ã¡å
å¿æ··å液ãåãåºãããšããããã©ãžãŠã ã¡ã¿ã«
ã®æåºã¯ãŸã€ããèªããããªãã€ããåå¿æ··å液
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšããã 17ïœã
é žãã©ãžãŠã 45mgïŒ0.2ããªã¢ã«ïŒãããªããšãã«
ãã¹ãã€ã³500mgïŒ1.9ããªã¢ã«ïŒããã¹ïŒ1.2âãž
ããšãã«ãã¹ãã€ãïŒãšã¿ã³79mgïŒ0.2ããªã¢ã«ã
察Pdæ¯1.0ïŒãã¢ã»ãé ¢é žãšãã«26ïœããããªãŠã
ããšããªããµã€ã0.3ïœããã³ãã¿ãžãšã³30ïœã
ä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå æž©130â
ã§ïŒæéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒ
ããå·åŽããæªåå¿ãã¿ãžãšã³ãé€å»ããã®ã¡å
å¿æ··å液ãåãåºãããšããããã©ãžãŠã ã¡ã¿ã«
ã®æåºã¯ãŸã€ããèªããããªãã€ããåå¿æ··å液
ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšããã 17ïœã
ãåŒãïŒïœã
ãã³
14ïœãçæããŠããã
æ¯èŒäŸ ïŒ
ãã¹ïŒ1.2âãžããšãã«ãã¹ãã€ãïŒãšã¿ã³ã
æ·»å ããªãã§å®æœäŸïŒãšåäžã®åå¿æ¡ä»¶äžã§åå¿
ãè¡ãªã€ããåå¿çµäºåŸã®åå¿æ··å液ã¯é»å€ãã
ãã©ãžãŠã ã¡ã¿ã«ã®æåºãèªããããã æ¯èŒäŸ ïŒ ããªããšãã«ãã¹ãã€ã³ãæ·»å ããªãã§å®æœäŸ
ïŒãšåäžã®åå¿æ¡ä»¶äžã§åå¿ãè¡ãªã€ããåå¿çµ
äºåŸãåå¿æ··å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããšããããªã¯ã¿ãžãšãã«èªå°äœã¯ãŸã€ãã
çæããŠããªãã€ããäž»çæç©ã¯
æ·»å ããªãã§å®æœäŸïŒãšåäžã®åå¿æ¡ä»¶äžã§åå¿
ãè¡ãªã€ããåå¿çµäºåŸã®åå¿æ··å液ã¯é»å€ãã
ãã©ãžãŠã ã¡ã¿ã«ã®æåºãèªããããã æ¯èŒäŸ ïŒ ããªããšãã«ãã¹ãã€ã³ãæ·»å ããªãã§å®æœäŸ
ïŒãšåäžã®åå¿æ¡ä»¶äžã§åå¿ãè¡ãªã€ããåå¿çµ
äºåŸãåå¿æ··å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§å
æãããšããããªã¯ã¿ãžãšãã«èªå°äœã¯ãŸã€ãã
çæããŠããªãã€ããäž»çæç©ã¯
ãåŒãã§ããããã®ã
ã®ã14ïœçæããŠããã
å®æœäŸ ïŒ
å
容ç©100mlã®é»ç£æ¹æè£
眮ãåãããªãŒãã¯
ã¬ãŒãã«ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒã66mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³500mg
ïŒ1.9ããªã¢ã«ïŒããã¹ïŒ1.3âãžããšãã«ãã¹ãã€
ãïŒãããã³82mgïŒ0.2ããªã¢ã«ã察Pdæ¯1.0ïŒã
ã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœãä»èŸŒ
ã¿ã800rpmã®é床ã§æ¹æããªããå æž©110âã§ïŒ
æéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒãã
å·åŽããã®ã¡ãåå¿æ··å液ãåãåºãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ããã·â
2.7âãžã¡ãã«ãªã¯ã¿ãžãšã³â2.7 ïŒïœãšïŒâã¡
ããã·â2.7âãžã¡ãã«ãªã¯ã¿ãžãšã³â1.7 ïŒïœ
ãçæããŠããã å®æœäŸ ïŒ å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«å¡©åã
ã©ãžãŠã 17.7mgïŒ0.1ããªã¢ã«ïŒãããªããšãã«ã
ã¹ãã€ã³262mgïŒ1.0ããªã¢ã«ïŒããã¹ïŒ1.3âãžã
ãšãã«ãã¹ãã€ãïŒãããã³41.2mgïŒ0.1ããªã¢
ã«ã察Pdæ¯1.0ïŒããããªãŠã ããšãããµã€ã116
mgãããšããŒã«13ïœãã¢ã»ããããªã«15mlããã³
ãã¿ãžãšã³30ïœãå§å ¥ããŠä»èŸŒã¿ã800rpmã®é
床ã§æ¹æããªããå æž©70âã§ïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªåå¿ã
ã¿ãžãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæãããšãããïŒâããš
ããã·â2.7âãªã¯ã¿ãžãšã³74ããªã¢ã«ããã³ïŒ
âããšããã·â1.7âãªã¯ã¿ãžãšã³ïŒããªã¢ã«ã
çæããŠããã å®æœäŸ 10 å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«ãé ¢é ž
ãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒããããªãŠã ãž
ããšãã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒ
ãã»ïŒæ°Žåç©400mgïŒ1.0ããªã¢ã«ïŒããã³
ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ213mgïŒ0.053ããªã¢ã«ã察
Pdæ¯1.07ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15mlã«æº¶è§£
ãã溶液ãã®é ž6.4ïœãããªãšãã«ã¢ãã³14ïœã
ãã³ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床ã§
æ¹æããªããå æž©70âã§ïŒæéåå¿ããããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªåå¿ãã¿ãž
ãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºãããšã
ããåå¿æ··å液ã¯ç¡è²ã®äžå±€ãšè§Šåªãå«ãã é»è²
ã®äžå±€ãšã«åé¢ããŠãããäžå±€ãåæãããšãã
1.7âãªã¯ã¿ãžãšã³11ïœããã³1.6âãªã¯ã¿ãžãšã³
ïŒïœãçæããŠããã å®æœäŸ 11 å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«ãé ¢é ž
ãã©ãžãŠã 56.1mgïŒ0.25ããªã¢ã«ïŒããããªãŠã
ãžããšãã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒ
ãã»ïŒæ°Žåç©ïŒïœïŒ2.5ããªã¢ã«ïŒããã³
ïŒC6H5ïŒ2PCH2CH2SO3Na79mgïŒ0.25ããªã¢ã«ã
察Pdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15mlã«æº¶
解ãã溶液ãã¢ã«ããªã³8.7ïœããã³ãã¿ãžãšã³
15ïœãä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå
æž©80âã§ïŒæéåå¿ããããåå¿çµäºåŸãªãŒãã¯
ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãžãšã³ãé€å»ããã®
ã¡åå¿æ··å液ãåãåºããïœâãããµã³80mlãå
ããŠæœåºåé¢ãããšãããç¡è²ã®äžå±€ãšè§Šåªãå«
ãã é»è²ã®äžå±€ãšã«åé¢ãããäžå±€ãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããšããã
ã¬ãŒãã«ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒã66mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³500mg
ïŒ1.9ããªã¢ã«ïŒããã¹ïŒ1.3âãžããšãã«ãã¹ãã€
ãïŒãããã³82mgïŒ0.2ããªã¢ã«ã察Pdæ¯1.0ïŒã
ã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœãä»èŸŒ
ã¿ã800rpmã®é床ã§æ¹æããªããå æž©110âã§ïŒ
æéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒãã
å·åŽããã®ã¡ãåå¿æ··å液ãåãåºãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ããã·â
2.7âãžã¡ãã«ãªã¯ã¿ãžãšã³â2.7 ïŒïœãšïŒâã¡
ããã·â2.7âãžã¡ãã«ãªã¯ã¿ãžãšã³â1.7 ïŒïœ
ãçæããŠããã å®æœäŸ ïŒ å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«å¡©åã
ã©ãžãŠã 17.7mgïŒ0.1ããªã¢ã«ïŒãããªããšãã«ã
ã¹ãã€ã³262mgïŒ1.0ããªã¢ã«ïŒããã¹ïŒ1.3âãžã
ãšãã«ãã¹ãã€ãïŒãããã³41.2mgïŒ0.1ããªã¢
ã«ã察Pdæ¯1.0ïŒããããªãŠã ããšãããµã€ã116
mgãããšããŒã«13ïœãã¢ã»ããããªã«15mlããã³
ãã¿ãžãšã³30ïœãå§å ¥ããŠä»èŸŒã¿ã800rpmã®é
床ã§æ¹æããªããå æž©70âã§ïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªåå¿ã
ã¿ãžãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæãããšãããïŒâããš
ããã·â2.7âãªã¯ã¿ãžãšã³74ããªã¢ã«ããã³ïŒ
âããšããã·â1.7âãªã¯ã¿ãžãšã³ïŒããªã¢ã«ã
çæããŠããã å®æœäŸ 10 å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«ãé ¢é ž
ãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒããããªãŠã ãž
ããšãã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒ
ãã»ïŒæ°Žåç©400mgïŒ1.0ããªã¢ã«ïŒããã³
ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ213mgïŒ0.053ããªã¢ã«ã察
Pdæ¯1.07ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15mlã«æº¶è§£
ãã溶液ãã®é ž6.4ïœãããªãšãã«ã¢ãã³14ïœã
ãã³ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床ã§
æ¹æããªããå æž©70âã§ïŒæéåå¿ããããåå¿
çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªåå¿ãã¿ãž
ãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºãããšã
ããåå¿æ··å液ã¯ç¡è²ã®äžå±€ãšè§Šåªãå«ãã é»è²
ã®äžå±€ãšã«åé¢ããŠãããäžå±€ãåæãããšãã
1.7âãªã¯ã¿ãžãšã³11ïœããã³1.6âãªã¯ã¿ãžãšã³
ïŒïœãçæããŠããã å®æœäŸ 11 å®æœäŸïŒã§çšããã®ãšåäžã®åå¿è£ 眮ã«ãé ¢é ž
ãã©ãžãŠã 56.1mgïŒ0.25ããªã¢ã«ïŒããããªãŠã
ãžããšãã«ãã¹ãã€ããã³ãŒã³âïœâã¹ã«ãããŒ
ãã»ïŒæ°Žåç©ïŒïœïŒ2.5ããªã¢ã«ïŒããã³
ïŒC6H5ïŒ2PCH2CH2SO3Na79mgïŒ0.25ããªã¢ã«ã
察Pdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15mlã«æº¶
解ãã溶液ãã¢ã«ããªã³8.7ïœããã³ãã¿ãžãšã³
15ïœãä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå
æž©80âã§ïŒæéåå¿ããããåå¿çµäºåŸãªãŒãã¯
ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãžãšã³ãé€å»ããã®
ã¡åå¿æ··å液ãåãåºããïœâãããµã³80mlãå
ããŠæœåºåé¢ãããšãããç¡è²ã®äžå±€ãšè§Šåªãå«
ãã é»è²ã®äžå±€ãšã«åé¢ãããäžå±€ãã¬ã¹ã¯ãã
ãã°ã©ãã€ãŒã§åæãããšããã
ãåŒã13.6ïœ
ããã³
ãåŒã0.5ïœãç
æããŠãããäžæ¹ãäžå±€ã¯ããã«ã¢ã«ããªã³6.5
ïœãå ããã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãã
ãã«ãã¿ãžãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ã
ãŠåå¿ãè¡ãªããæœåºåŠçãããäžåç®ãšåæ§ã«
äžå±€ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšã
ãã
ïœãå ããã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãã
ãã«ãã¿ãžãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ã
ãŠåå¿ãè¡ãªããæœåºåŠçãããäžåç®ãšåæ§ã«
äžå±€ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæãããšã
ãã
ãåŒã15
ïœããã³
ãåŒã0.4ïœãç
æããŠããã
å®æœäŸ 12
å
容ç©300mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«ã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³0.786ïœïŒïŒããª
ã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€
ãïŒãããã³515mgïŒ1.25ããªã¢ã«ã察Pdæ¯2.5ïŒ
ã溶解ãã溶液ãé ¢é ž20ïœãªãã³ã«ããªãšãã«ã¢
ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³
äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒ
ãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§
800rpmã®é床ã§æ¹æããªããïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®
ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®å
å¿æ··å液ã空æ°ã«ãµããªãããã«ããŠå§éããŠèž
çãã©ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®
ã€ãªã«ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµç
ã«ã¯20mgHgã®æžå§åºŠã«ãŸã§å€åãããŠçŽïŒæé
ãããŠæžå§èžçãããèžçã«ãã€ãŠåŸãããå šå
å¿æ··å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³0.786ïœïŒïŒããª
ã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€
ãïŒãããã³515mgïŒ1.25ããªã¢ã«ã察Pdæ¯2.5ïŒ
ã溶解ãã溶液ãé ¢é ž20ïœãªãã³ã«ããªãšãã«ã¢
ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³
äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒ
ãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§
800rpmã®é床ã§æ¹æããªããïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®
ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®å
å¿æ··å液ã空æ°ã«ãµããªãããã«ããŠå§éããŠèž
çãã©ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®
ã€ãªã«ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµç
ã«ã¯20mgHgã®æžå§åºŠã«ãŸã§å€åãããŠçŽïŒæé
ãããŠæžå§èžçãããèžçã«ãã€ãŠåŸãããå šå
å¿æ··å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ãè¡šã
ãè¡šã
å®æœäŸ 13
å
容ç©100mlã®é»ç£æ¹æè£
眮ãåãããªãŒãã¯
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 56.1mgïŒ0.25ããªã¢
ã«ïŒã
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 56.1mgïŒ0.25ããªã¢
ã«ïŒã
ãåŒã0.82ïœïŒ2.5ã
ãªã¢ã«ïŒããã³ïŒC6H5ïŒ2PCH2CH2SO3Na79mg
ïŒ0.25ããªã¢ã«ã察Pdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«
ãã©ã³15mlã«æº¶è§£ãã溶液ãã¢ã«ããªã³8.7ïœãª
ãã³ã«ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床
ã§æ¹æããªããå æž©80âã§ïŒæéåå¿ããããå
å¿çµäºåŸãªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãž
ãšã³ãé€å»ããã®ã¡åå¿æ··å液ãåãåºããïœâ
ãããµã³80mlãå ããŠæœåºåé¢ãããšãããç¡è²
ã®äžå±€ãšè§Šåªãå«ãã é»è²ã®äžå±€ãšã«åé¢ããã
äžå±€ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã äžæ¹ãäžå±€ã¯ããã«ã¢ã«ããªã³6.5ïœãå ãã
ã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãããã«ãã¿ãž
ãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ããŠåå¿ãè¡
ãªããæœåºåŠçãããäžåç®ãšåæ§ã«äžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ïŒ0.25ããªã¢ã«ã察Pdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«
ãã©ã³15mlã«æº¶è§£ãã溶液ãã¢ã«ããªã³8.7ïœãª
ãã³ã«ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床
ã§æ¹æããªããå æž©80âã§ïŒæéåå¿ããããå
å¿çµäºåŸãªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãž
ãšã³ãé€å»ããã®ã¡åå¿æ··å液ãåãåºããïœâ
ãããµã³80mlãå ããŠæœåºåé¢ãããšãããç¡è²
ã®äžå±€ãšè§Šåªãå«ãã é»è²ã®äžå±€ãšã«åé¢ããã
äžå±€ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã äžæ¹ãäžå±€ã¯ããã«ã¢ã«ããªã³6.5ïœãå ãã
ã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãããã«ãã¿ãž
ãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ããŠåå¿ãè¡
ãªããæœåºåŠçãããäžåç®ãšåæ§ã«äžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ãè¡šã
å®æœäŸ 14
å
容ç©300mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«ã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³10.5ïœïŒ40ããª
ã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€
ãïŒãããã³103mgïŒ0.25ããªã¢ã«ã察Pdæ¯0.5ïŒ
ã溶解ãã溶液ãé ¢é ž20ïœãªãã³ã«ããªãšãã«ã¢
ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³
äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒ
ãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§
800rpmã®é床ã§æ¹æããªããïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®
ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®å
å¿æ··å液ã空æ°ã«ãµããªãããã«å§éããŠèžçã
ã©ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®ãªã€
ã«ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµçã«ã¯
20mmHgã®æžå§åºŠã«ãŸã§å€åãããŠçŽïŒæéãã
ãŠæžå§èžçãããèžçã«ãã€ãŠåŸãããå šåå¿æ··
å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³10.5ïœïŒ40ããª
ã¢ã«ïŒããã³ãã¹ïŒïŒïŒïŒâãžããšãã«ãã¹ãã€
ãïŒãããã³103mgïŒ0.25ããªã¢ã«ã察Pdæ¯0.5ïŒ
ã溶解ãã溶液ãé ¢é ž20ïœãªãã³ã«ããªãšãã«ã¢
ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥ãã次ãã§èå§ãã³
äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹ã§å§å ¥ããããªãŒ
ãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµžããå æž©80âã§
800rpmã®é床ã§æ¹æããªããïŒæéåå¿ãããã
åå¿çµäºåŸããªãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ã®
ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒãã¯ã¬ãŒãå ã®å
å¿æ··å液ã空æ°ã«ãµããªãããã«å§éããŠèžçã
ã©ã¹ã³å ã«ç§»ãããèžçãã©ã¹ã³ã130âã®ãªã€
ã«ãã¹ã«æµžããç³»å ã®å§åãåžžå§ããæçµçã«ã¯
20mmHgã®æžå§åºŠã«ãŸã§å€åãããŠçŽïŒæéãã
ãŠæžå§èžçãããèžçã«ãã€ãŠåŸãããå šåå¿æ··
å液ãã¬ã¹ã¯ãããã°ã©ãã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžåç®ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ
瞟ãè¡šïŒã«ç€ºãã
ãè¡šã
ãšã³ãšãåãããçæé
å®æœäŸ 15ã18 å 容ç©300mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«ã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³1.31ïœïŒïŒããª
ã¢ã«ïŒããã³äºåº§é äœæ§ãã¹ãã€ã³é¡ã®0.5ããª
ã¢ã«ïŒå¯ŸPdæ¯1.0ïŒã溶解ãã溶液ãé ¢é ž20ïœãª
ãã³ã«ããªãšãã«ã¢ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥
ãã次ãã§èå§ãã³äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬
ã¹ã§å§å ¥ããããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµž
ããå æž©80âã§800rpmã®é床ã§æ¹æããªããïŒ
æéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒãã
æ¥å·ããæªåå¿ã®ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒ
ãã¯ã¬ãŒãå ã®åå¿æ··å液ã空æ°ã«ãµããªããã
ã«ããŠå§éããŠèžçãã©ã¹ã³å ã«ç§»ãããèžçã
ã©ã¹ã³ã130âã®ãªã€ã«ãã¹ã«æµžããç³»å ã®å§å
ãåžžå§ããæçµçã«ã¯20mmHgã®æžå§åºŠã«ãŸã§å€
åãããŠçŽïŒæéãããŠæžå§èžçãããèžçã«ã
ã€ãŠåŸãããå šåå¿æ··å液ãã¬ã¹ã¯ãããã°ã©ã
ã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³äžåç®
ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ瞟ãè¡šïŒ
ã«ç€ºãã
å®æœäŸ 15ã18 å 容ç©300mlã®é»ç£æ¹æåŒãªãŒãã¯ã¬ãŒãã«ã
ã¹ã«ãã©ã³25mlã«é ¢é žãã©ãžãŠã 110mgïŒ0.5ããª
ã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³1.31ïœïŒïŒããª
ã¢ã«ïŒããã³äºåº§é äœæ§ãã¹ãã€ã³é¡ã®0.5ããª
ã¢ã«ïŒå¯ŸPdæ¯1.0ïŒã溶解ãã溶液ãé ¢é ž20ïœãª
ãã³ã«ããªãšãã«ã¢ãã³33.5ïœãçªçŽ ã¬ã¹ã§å§å ¥
ãã次ãã§èå§ãã³äžã®ãã¿ãžãšã³60ïœãçªçŽ ã¬
ã¹ã§å§å ¥ããããªãŒãã¯ã¬ãŒãããªã€ã«ãã¹ã«æµž
ããå æž©80âã§800rpmã®é床ã§æ¹æããªããïŒ
æéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒãã
æ¥å·ããæªåå¿ã®ãã¿ãžãšã³ãé€å»ããã®ã¡ãªãŒ
ãã¯ã¬ãŒãå ã®åå¿æ··å液ã空æ°ã«ãµããªããã
ã«ããŠå§éããŠèžçãã©ã¹ã³å ã«ç§»ãããèžçã
ã©ã¹ã³ã130âã®ãªã€ã«ãã¹ã«æµžããç³»å ã®å§å
ãåžžå§ããæçµçã«ã¯20mmHgã®æžå§åºŠã«ãŸã§å€
åãããŠçŽïŒæéãããŠæžå§èžçãããèžçã«ã
ã€ãŠåŸãããå šåå¿æ··å液ãã¬ã¹ã¯ãããã°ã©ã
ã€ãŒã§åæããã èžçæ®æ¶²ã«é ¢é ž20ïœããã³ããªãšãã«ã¢ãã³
33.5ïœãå ããã®ã¡ãããçªçŽ ã¬ã¹ã§ãªãŒãã¯ã¬
ãŒãã«å§å ¥ãã次ãã§ãã¿ãžãšã³60ïœãçªçŽ ã¬ã¹
ã§ãªãŒãã¯ã¬ãŒãã«å§å ¥ãããäžèšãšåæ§ã®æäœ
ã§ãã¿ãžãšã³ã®ããã¡ãªååå¿ãïŒæéè¡ãªãã
åå¿æ··å液ããçæç©ãèžçåé¢ãããããã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³äžåç®
ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ瞟ãè¡šïŒ
ã«ç€ºãã
ãè¡šã
ãè¡šã
å®æœäŸ 19ã21
é»ç£æ¹æè£
眮ãåããå
容ç©100mlã®ãªãŒãã¯
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 56.1mgïŒ0.25ããªã¢
ã«ïŒããããªãŠã ãžããšãã«ãã¹ãã€ããã³ãŒã³
âïœâã¹ã«ãããŒãã»ïŒæ°Žåç©ïŒïœïŒ2.5ããªã¢
ã«ïŒããã³äºåº§é äœæ§ãã¹ãã€ã³é¡ã®0.25ããªã¢
ã«ïŒå¯ŸPdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15ml
ã«æº¶è§£ãã溶液ãã¢ã«ããªã³8.7ïœãªãã³ã«ãã¿
ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床ã§æ¹æããª
ããå æž©80âã§ïŒæéåå¿ããããåå¿çµäºåŸãª
ãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãžãšã³ãé€å»
ããã®ã¡åå¿æ··å液ãåãåºããïœâãããµã³80
mlãå ããŠæœåºåé¢ãããšãããç¡è²ã®äžå±€ãšè§Š
åªãå«ãã é»è²ã®äžå±€ãšã«åé¢ãããäžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžæ¹ãäžå±€ã¯ããã«ã¢ã«ããªã³6.5ïœãå ãã
ã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãããã«ãã¿ãž
ãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ããŠåå¿ãè¡
ãªããæœåºåŠçãããäžåç®ãšåæ§ã«äžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³äžåç®
ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ瞟ãè¡šïŒ
ã«ç€ºãã
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 56.1mgïŒ0.25ããªã¢
ã«ïŒããããªãŠã ãžããšãã«ãã¹ãã€ããã³ãŒã³
âïœâã¹ã«ãããŒãã»ïŒæ°Žåç©ïŒïœïŒ2.5ããªã¢
ã«ïŒããã³äºåº§é äœæ§ãã¹ãã€ã³é¡ã®0.25ããªã¢
ã«ïŒå¯ŸPdæ¯1.0ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15ml
ã«æº¶è§£ãã溶液ãã¢ã«ããªã³8.7ïœãªãã³ã«ãã¿
ãžãšã³15ïœãä»èŸŒã¿ã800rpmã®é床ã§æ¹æããª
ããå æž©80âã§ïŒæéåå¿ããããåå¿çµäºåŸãª
ãŒãã¯ã¬ãŒããæ¥å·ããæªåå¿ãã¿ãžãšã³ãé€å»
ããã®ã¡åå¿æ··å液ãåãåºããïœâãããµã³80
mlãå ããŠæœåºåé¢ãããšãããç¡è²ã®äžå±€ãšè§Š
åªãå«ãã é»è²ã®äžå±€ãšã«åé¢ãããäžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã äžæ¹ãäžå±€ã¯ããã«ã¢ã«ããªã³6.5ïœãå ãã
ã®ã¡åã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãããã«ãã¿ãž
ãšã³15ïœãå§å ¥ããŠäžåç®ãšåæ§ã«ããŠåå¿ãè¡
ãªããæœåºåŠçãããäžåç®ãšåæ§ã«äžå±€ãã¬ã¹
ã¯ãããã°ã©ãã€ãŒã§åæããã 䜿çšããäºåº§é äœæ§ãã¹ãã€ã³é¡ããã³äžåç®
ã®åå¿ãšäºåç®ã®åå¿ã§åŸãããåå¿æ瞟ãè¡šïŒ
ã«ç€ºãã
ãè¡šã
å®æœäŸ 22
é»ç£æ¹æè£
眮ãåããå
容ç©100mlã®ãªãŒãã¯
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒã
ãããªãŠã ãžããšãã«ãã¹ãã€ããã³ãŒã³âïœâ
ã¹ã«ãããŒãã»ïŒæ°Žåç©400mgïŒ1.0ããªã¢ã«ïŒã
ãã³ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ213mgïŒ0.053ããªã¢
ã«ã察Pdæ¯1.07ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15ml
ã«æº¶è§£ãã溶液ãã®é ž6.4ïœãããªãšãã«ã¢ãã³
14ïœãªãã³ã«ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpm
ã®é床ã§æ¹æããªããå æž©70âã§ïŒæéåå¿ãã
ããåå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªå
å¿ãã¿ãžãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºã
ããšãããåå¿æ··å液ã¯ç¡è²ã®äžå±€ãšè§Šåªãå«ã
ã é»è²ã®äžå±€ãšã«åé¢ããŠãããäžå±€ãåæãã
ãšããïŒïŒïŒâãªã¯ã¿ãžãšã³11ïœããã³ïŒïŒïŒâ
ãªã¯ã¿ãžãšã³ïŒïœãçæããŠããã äžæ¹ãäžå±€ãåã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãã®
é ž6.4ïœããã³ãã¿ãžãšã³15ïœãå ããã®ã¡ãäž
åç®ã®åå¿ã«ããããšåæ§ã«ããŠåå¿ãè¡ãªã€
ããåå¿çµäºåŸãäžåç®ã®æäœãšåæ§ã«ããŠåå¿
æ··å液ã®äžå±€ãåæãããšãããïŒïŒïŒâãªã¯ã¿
ãžãšã³11ïœããã³ïŒïŒïŒâãªã¯ã¿ãžãšã³ïŒïœãç
æããŠããã å®æœäŸ 23 å 容ç©100mlã®é»ç£æ¹æè£ çœ®ãåãããªãŒãã¯
ã¬ãŒãã«ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒã66mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³500mg
ïŒ1.9ããªã¢ã«ïŒããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹
ãã€ãïŒãããã³82mgïŒ0.2ããªã¢ã«ã察Pdæ¯
1.0ïŒãã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœã
ä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå æž©110â
ã§ïŒæéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒ
ããå·åŽããã®ã¡ãåå¿æ··å液ãåãåºãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ãã
ã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³âïŒïŒïŒ ïŒ
ïœãšïŒâã¡ããã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãš
ã³âïŒïŒïŒ ïŒïœãçæããŠããã åŸãããåå¿æ··å液ããçæç©ãåžžå§ãã10mm
Hgã®å§åäžã100âã®ãã¹æž©äžã§èžçºåé¢ããã
æ®æž£ã«ã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœã
ä»èŸŒã¿ãäžåç®ã®åå¿ã«ããããšåæ§ã«ããŠåå¿
ãè¡ãªã€ããåŸãããåå¿æ··å液ãã¬ã¹ã¯ããã
ã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ããã·â
ïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³âïŒïŒïŒ 6.8ïœ
ãšïŒâã¡ããã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³
âïŒïŒïŒ 2.1ïœãçæããŠããã
ã¬ãŒãã«ãé ¢é žãã©ãžãŠã 11mgïŒ0.05ããªã¢ã«ïŒã
ãããªãŠã ãžããšãã«ãã¹ãã€ããã³ãŒã³âïœâ
ã¹ã«ãããŒãã»ïŒæ°Žåç©400mgïŒ1.0ããªã¢ã«ïŒã
ãã³ïŒC6H5ïŒ2PCH2NïŒCH3ïŒ213mgïŒ0.053ããªã¢
ã«ã察Pdæ¯1.07ïŒã50ééïŒ å«æ°Žã¹ã«ãã©ã³15ml
ã«æº¶è§£ãã溶液ãã®é ž6.4ïœãããªãšãã«ã¢ãã³
14ïœãªãã³ã«ãã¿ãžãšã³15ïœãä»èŸŒã¿ã800rpm
ã®é床ã§æ¹æããªããå æž©70âã§ïŒæéåå¿ãã
ããåå¿çµäºåŸããªãŒãã¯ã¬ãŒããå·åŽããæªå
å¿ãã¿ãžãšã³ãé€ããã®ã¡åå¿æ··å液ãåãåºã
ããšãããåå¿æ··å液ã¯ç¡è²ã®äžå±€ãšè§Šåªãå«ã
ã é»è²ã®äžå±€ãšã«åé¢ããŠãããäžå±€ãåæãã
ãšããïŒïŒïŒâãªã¯ã¿ãžãšã³11ïœããã³ïŒïŒïŒâ
ãªã¯ã¿ãžãšã³ïŒïœãçæããŠããã äžæ¹ãäžå±€ãåã³ãªãŒãã¯ã¬ãŒãã«ä»èŸŒã¿ãã®
é ž6.4ïœããã³ãã¿ãžãšã³15ïœãå ããã®ã¡ãäž
åç®ã®åå¿ã«ããããšåæ§ã«ããŠåå¿ãè¡ãªã€
ããåå¿çµäºåŸãäžåç®ã®æäœãšåæ§ã«ããŠåå¿
æ··å液ã®äžå±€ãåæãããšãããïŒïŒïŒâãªã¯ã¿
ãžãšã³11ïœããã³ïŒïŒïŒâãªã¯ã¿ãžãšã³ïŒïœãç
æããŠããã å®æœäŸ 23 å 容ç©100mlã®é»ç£æ¹æè£ çœ®ãåãããªãŒãã¯
ã¬ãŒãã«ãã©ãžãŠã ã¢ã»ãã«ã¢ã»ãããŒã66mg
ïŒ0.2ããªã¢ã«ïŒãããªããšãã«ãã¹ãã€ã³500mg
ïŒ1.9ããªã¢ã«ïŒããã¹ïŒïŒïŒïŒâãžããšãã«ãã¹
ãã€ãïŒãããã³82mgïŒ0.2ããªã¢ã«ã察Pdæ¯
1.0ïŒãã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœã
ä»èŸŒã¿ã800rpmã®é床ã§æ¹æããªããå æž©110â
ã§ïŒæéåå¿ããããåå¿çµäºåŸããªãŒãã¯ã¬ãŒ
ããå·åŽããã®ã¡ãåå¿æ··å液ãåãåºãã¬ã¹ã¯
ãããã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ãã
ã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³âïŒïŒïŒ ïŒ
ïœãšïŒâã¡ããã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãš
ã³âïŒïŒïŒ ïŒïœãçæããŠããã åŸãããåå¿æ··å液ããçæç©ãåžžå§ãã10mm
Hgã®å§åäžã100âã®ãã¹æž©äžã§èžçºåé¢ããã
æ®æž£ã«ã¡ã¿ããŒã«30mlããã³ã€ãœãã¬ã³13.6ïœã
ä»èŸŒã¿ãäžåç®ã®åå¿ã«ããããšåæ§ã«ããŠåå¿
ãè¡ãªã€ããåŸãããåå¿æ··å液ãã¬ã¹ã¯ããã
ã°ã©ãã€ãŒã§åæãããšãããïŒâã¡ããã·â
ïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³âïŒïŒïŒ 6.8ïœ
ãšïŒâã¡ããã·âïŒïŒïŒâãžã¡ãã«ãªã¯ã¿ãžãšã³
âïŒïŒïŒ 2.1ïœãçæããŠããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ æŽ»æ§æ°ŽçŽ ãæããææ©ååç©ãçšããŠãã©ãž
ãŠã 觊åªããã³ãã¹ãã€ã³é¡ã®ååšäžã«éç°ç¶å ±
圹ãžãªã¬ãã€ã³ãããã¡ãªåããã«éããäžè¬åŒ ïŒåŒäžãã¯æ°ŽçŽ ååãâSO3NaãŸãã¯â
COONaãè¡šããïŒã§ç€ºãããå座é äœæ§ãã¹ã
ã€ã³é¡ããã©ãžãŠã ïŒã°ã©ã ååãããå°ããšã
ïŒã¢ã«ã®éã§çšãããã€äºåº§é äœæ§ãã¹ãã€ã³é¡
ããã©ãžãŠã ïŒã°ã©ã ååããã0.3ãïŒã¢ã«ã®
éã§åå¿ç³»ã«æ·»å ããããšãç¹åŸŽãšããéç°ç¶å ±
圹ãžãªã¬ãã€ã³ã®ããã¡ãªåæ¹æ³ã ïŒ æº¶åªãšããŠã®ã¹ã«ãã©ã³ãŸãã¯ã¡ãã«ã¹ã«ã
ã©ã³ã®ååšäžã«éç°ç¶å ±åœ¹ãžãªã¬ãã€ã³ã®ããã¡
ãªåãè¡ãªãç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8179380A JPS577426A (en) | 1980-06-16 | 1980-06-16 | Telomerization of acyclic conjugated diolefin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8179380A JPS577426A (en) | 1980-06-16 | 1980-06-16 | Telomerization of acyclic conjugated diolefin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS577426A JPS577426A (en) | 1982-01-14 |
| JPS646175B2 true JPS646175B2 (ja) | 1989-02-02 |
Family
ID=13756360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8179380A Granted JPS577426A (en) | 1980-06-16 | 1980-06-16 | Telomerization of acyclic conjugated diolefin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS577426A (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536604A (en) * | 1984-03-15 | 1985-08-20 | Texaco Inc. | Butadiene reductive dimerization using a platinum catalyst and polymeric amine promoter |
| US5236909A (en) * | 1990-07-25 | 1993-08-17 | Henkel Research Corporation | Octyl ethers and octadienyl ethers |
| US5206396A (en) * | 1990-07-25 | 1993-04-27 | Henkel Research Corporation | Telomerization of 1,3-butadiene |
| US5198598A (en) * | 1991-07-19 | 1993-03-30 | Henkel Kommanditgesellschaft Auf Aktien | Telomerization process of a conjugated alkadiene with a polyol |
| US6794553B2 (en) * | 2001-11-09 | 2004-09-21 | Shell Oil Company | Process for the telomerization of a conjugated diene, catalyst and bidentate ligand useful therein |
-
1980
- 1980-06-16 JP JP8179380A patent/JPS577426A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS577426A (en) | 1982-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6903042B2 (en) | Catalytic composition and process for oligomerizing ethylene, in particular to 1-hexene | |
| JPS6345649B2 (ja) | ||
| US5057631A (en) | Process for continuous production of octa-2,7-dien-1-ol | |
| JP3556686B2 (ja) | ããããã«ãã«åæ³ããã³ãã®ããã®ãã€ã¡ã¿ã«è§Šåª | |
| EP0461222B2 (en) | Continuous process for the telomerization of conjugated dienes | |
| EP0715616A1 (en) | Process for the preparation of a mixture of alkyl pentenoates | |
| CA2204133C (en) | Hydroformylation process | |
| JPS646175B2 (ja) | ||
| Onopchenko et al. | Electron transfer with aliphatic substrates. Oxidations of cycloaliphatic substrates with cobalt (III) and manganese (III) ions alone and in the presence of oxygen | |
| EP0440995B1 (en) | Process for preparing 1-octene | |
| US3377398A (en) | Dimerization process | |
| CA1140160A (en) | Process for producing alkadienes | |
| EP1249455B1 (en) | Phosphorus-containing molecules and processes for production of and uses for the same, and phosphines deriving the same and processes for production of the phosphines | |
| JPS6228944B2 (ja) | ||
| US4642392A (en) | Conjugated alkadiene telomerization to organo-oxyalkadienes | |
| JPS6337774B2 (ja) | ||
| US4536604A (en) | Butadiene reductive dimerization using a platinum catalyst and polymeric amine promoter | |
| JP4053325B2 (ja) | ãã¹ãããŠã å¡©ããã®è£œé æ¹æ³ããã³ãã®çšé | |
| EP4121407B1 (en) | Catalytic process for preparing an alpha, beta-ethylenically unsaturated carboxylic acid salt | |
| US5583271A (en) | Method for continuously producing alkadienols | |
| JP3444059B2 (ja) | ã¢ãªã«ã¢ã«ã³ãŒã«é¡ã®è£œé æ¹æ³ | |
| Lapidus et al. | Carboxylation of styrene in the N (C 4 H 9) 4 Brâheptane system | |
| JPS642092B2 (ja) | ||
| JP3062752B1 (ja) | ãããããªé žé觊åªã«ãã第äžçŽã«ã«ãã³é žåã³ãã®ãšã¹ãã«ã®è£œé æ³ | |
| JP3498457B2 (ja) | ã¢ã«ã«ãžãšããŒã«é¡ã®é£ç¶ç補é æ¹æ³ |