JPS641169B2 - - Google Patents
Info
- Publication number
- JPS641169B2 JPS641169B2 JP11946178A JP11946178A JPS641169B2 JP S641169 B2 JPS641169 B2 JP S641169B2 JP 11946178 A JP11946178 A JP 11946178A JP 11946178 A JP11946178 A JP 11946178A JP S641169 B2 JPS641169 B2 JP S641169B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- liquid
- aqueous solution
- spherical
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000008186 Collagen Human genes 0.000 claims description 115
- 108010035532 Collagen Proteins 0.000 claims description 115
- 229920001436 collagen Polymers 0.000 claims description 115
- 239000007788 liquid Substances 0.000 claims description 37
- 239000007864 aqueous solution Substances 0.000 claims description 31
- 239000011324 bead Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000006185 dispersion Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000835 fiber Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 150000001299 aldehydes Chemical class 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000012024 dehydrating agents Substances 0.000 claims 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 239000000243 solution Substances 0.000 description 13
- 239000002245 particle Substances 0.000 description 7
- 239000002736 nonionic surfactant Substances 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 230000001804 emulsifying effect Effects 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- YXGWBKCOOBHTPT-UHFFFAOYSA-N benzene;chlorobenzene Chemical compound C1=CC=CC=C1.ClC1=CC=CC=C1 YXGWBKCOOBHTPT-UHFFFAOYSA-N 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- ZVKXPPXCNUMUOR-IKYXTRRCSA-N Trollichrome Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C1OC2(C)CC(O)CC(C)(C)C2=C1)C=CC=C(/C)C=C=C3C(C)(C)CC(O)CC3(C)O ZVKXPPXCNUMUOR-IKYXTRRCSA-N 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- ZVKXPPXCNUMUOR-CBRRPZDLSA-N neochrome Natural products CC(=CC=CC=C(C)C=CC=C(C)[C@@H]1O[C@]2(C)C[C@@H](O)CC(C)(C)C2=C1)C=CC=C(C)C=C=C3C(C)(C)C[C@@H](O)C[C@]3(C)O ZVKXPPXCNUMUOR-CBRRPZDLSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Glanulating (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11946178A JPS5547130A (en) | 1978-09-28 | 1978-09-28 | Manufacture of collagen bead |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11946178A JPS5547130A (en) | 1978-09-28 | 1978-09-28 | Manufacture of collagen bead |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5547130A JPS5547130A (en) | 1980-04-03 |
| JPS641169B2 true JPS641169B2 (en, 2012) | 1989-01-10 |
Family
ID=14761923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11946178A Granted JPS5547130A (en) | 1978-09-28 | 1978-09-28 | Manufacture of collagen bead |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5547130A (en, 2012) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59164723A (ja) * | 1983-03-10 | 1984-09-17 | Koken:Kk | 再生コラーゲンフイブリルを含有する基質及びその製造方法 |
| JPS60174725A (ja) * | 1984-02-22 | 1985-09-09 | Koken:Kk | 再生コラ−ゲンフイプリルを含有する基質及びその製造方法 |
| ES2118219T3 (es) * | 1991-12-20 | 1998-09-16 | Allied Signal Inc | Materiales de baja densidad que tienen alta superficie especifica, y articulos formados a partir de ellos para uso en la recuperacion de metales. |
| JPH05246422A (ja) * | 1992-02-28 | 1993-09-24 | Enshu Shikogyo Kk | 防水段ボール箱の製造方法 |
| JPH05294753A (ja) * | 1992-04-23 | 1993-11-09 | Fuji Elelctrochem Co Ltd | フェライト多孔体の製造方法 |
| KR100735675B1 (ko) | 2004-10-16 | 2007-07-04 | 유향자 | 저분자화 및 친수성을 높여 콜라겐의 유효이용율을향상시키기 위한 제조방법 |
| US20060222680A1 (en) * | 2005-03-31 | 2006-10-05 | Chunlin Yang | Method of preparing crosslinked collagen microspheres |
| JP4764665B2 (ja) * | 2005-06-10 | 2011-09-07 | 国立大学法人群馬大学 | 細胞培養用微粒子及びその製造方法並びにこの微粒子を用いた細胞培養方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5332762B2 (en, 2012) * | 1973-06-23 | 1978-09-09 | ||
| JPS51141289A (en) * | 1975-05-21 | 1976-12-04 | Nisshin Oil Mills Ltd | Artificial silkwormmfeeding stuffs |
-
1978
- 1978-09-28 JP JP11946178A patent/JPS5547130A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5547130A (en) | 1980-04-03 |
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