JPS6411615B2 - - Google Patents
Info
- Publication number
- JPS6411615B2 JPS6411615B2 JP53086825A JP8682578A JPS6411615B2 JP S6411615 B2 JPS6411615 B2 JP S6411615B2 JP 53086825 A JP53086825 A JP 53086825A JP 8682578 A JP8682578 A JP 8682578A JP S6411615 B2 JPS6411615 B2 JP S6411615B2
- Authority
- JP
- Japan
- Prior art keywords
- dispersion
- propellant
- inhalable
- sorbitan
- suspension according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000006185 dispersion Substances 0.000 claims description 37
- 239000000725 suspension Substances 0.000 claims description 29
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims description 20
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 20
- 235000019404 dichlorodifluoromethane Nutrition 0.000 claims description 20
- -1 sorbitol ester Chemical class 0.000 claims description 16
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 13
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical group O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 13
- 235000010445 lecithin Nutrition 0.000 claims description 13
- 239000000787 lecithin Substances 0.000 claims description 13
- 229940067606 lecithin Drugs 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- 229960000265 cromoglicic acid Drugs 0.000 claims description 11
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 4
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 4
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 4
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 4
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 3
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 229950004959 sorbitan oleate Drugs 0.000 claims description 2
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 25
- 238000009472 formulation Methods 0.000 description 9
- 239000004094 surface-active agent Substances 0.000 description 9
- 239000003380 propellant Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3016977 | 1977-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5435209A JPS5435209A (en) | 1979-03-15 |
| JPS6411615B2 true JPS6411615B2 (ko) | 1989-02-27 |
Family
ID=10303374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8682578A Granted JPS5435209A (en) | 1977-07-19 | 1978-07-18 | Dispersion or suspension of lecithin * sorbitane or sorbitol ester |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5435209A (ko) |
| AU (1) | AU522792B2 (ko) |
| BE (1) | BE869055A (ko) |
| CA (1) | CA1112567A (ko) |
| CH (1) | CH627075A5 (ko) |
| DE (1) | DE2831419A1 (ko) |
| FR (1) | FR2397833A1 (ko) |
| HK (1) | HK51585A (ko) |
| IE (1) | IE47128B1 (ko) |
| IL (1) | IL55161A (ko) |
| IT (1) | IT1158890B (ko) |
| MY (1) | MY8400252A (ko) |
| NL (1) | NL7807625A (ko) |
| NZ (1) | NZ187894A (ko) |
| SE (1) | SE443087B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8501015D0 (en) * | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
| HU205249B (en) * | 1990-11-09 | 1992-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing suspensive aerosole composition |
| DE4425255A1 (de) | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB367276A (en) * | 1931-06-20 | 1932-02-18 | Schmidt Sche Heissdampf | Improvements in or relating to independently fired steam superheaters |
| BE555319A (ko) * | 1956-03-21 | 1900-01-01 | ||
| BE556587A (ko) * | 1957-01-31 | 1957-04-11 | ||
| GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| US3513104A (en) * | 1965-03-26 | 1970-05-19 | Colgate Palmolive Co | Self-propelling powder compositions |
| US3560507A (en) * | 1968-02-27 | 1971-02-02 | Millmaster Onyx Corp | Quaternary ammonium alkenyl succinates |
| GB1384895A (en) * | 1971-01-25 | 1975-02-26 | Colgate Palmolive Co | Fabric conditioning |
| DE2151706B1 (en) * | 1971-10-18 | 1973-05-03 | Cegla, Ulrich, Dr med , 600 0 Frank fürt Niederrad | Tantalum-contg x-ray contrast agents - in aerosol form for bronchography |
| IL44022A0 (en) * | 1973-01-23 | 1974-05-16 | Fisons Ltd | Novel salts of anti-inflammatory quinoline derivatives,their preparation and pharmaceutical compositions containing them |
| IT1039699B (it) * | 1975-07-03 | 1979-12-10 | Prephar | Composizione spermicida a base di derivati benzisotiazolici |
| GB1562901A (en) * | 1976-01-30 | 1980-03-19 | Fisons Ltd | Disodium cromoglycate |
| FI770215A (ko) * | 1976-01-30 | 1977-07-31 | Fisons Ltd | |
| GB2001334B (en) | 1977-07-19 | 1982-03-03 | Fisons Ltd | Pressurised aerosol formulation |
| GB1590126A (en) | 1977-11-23 | 1981-05-28 | Booth B H | Method of bulking yarns |
-
1978
- 1978-07-14 AU AU38057/78A patent/AU522792B2/en not_active Expired
- 1978-07-17 IE IE1432/78A patent/IE47128B1/en not_active IP Right Cessation
- 1978-07-17 NL NL7807625A patent/NL7807625A/xx active Search and Examination
- 1978-07-17 CA CA307,480A patent/CA1112567A/en not_active Expired
- 1978-07-17 FR FR7821172A patent/FR2397833A1/fr active Granted
- 1978-07-17 BE BE189326A patent/BE869055A/xx not_active IP Right Cessation
- 1978-07-18 DE DE19782831419 patent/DE2831419A1/de active Granted
- 1978-07-18 IL IL55161A patent/IL55161A/xx unknown
- 1978-07-18 CH CH774178A patent/CH627075A5/fr not_active IP Right Cessation
- 1978-07-18 IT IT25845/78A patent/IT1158890B/it active Protection Beyond IP Right Term
- 1978-07-18 NZ NZ187894A patent/NZ187894A/en unknown
- 1978-07-18 JP JP8682578A patent/JPS5435209A/ja active Granted
- 1978-07-18 SE SE7807934A patent/SE443087B/sv not_active IP Right Cessation
-
1984
- 1984-12-30 MY MY252/84A patent/MY8400252A/xx unknown
-
1985
- 1985-07-04 HK HK515/85A patent/HK51585A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY8400252A (en) | 1984-12-31 |
| NL7807625A (nl) | 1979-01-23 |
| HK51585A (en) | 1985-07-12 |
| AU522792B2 (en) | 1982-06-24 |
| IL55161A (en) | 1981-12-31 |
| CH627075A5 (en) | 1981-12-31 |
| CA1112567A (en) | 1981-11-17 |
| IT7825845A0 (it) | 1978-07-18 |
| JPS5435209A (en) | 1979-03-15 |
| FR2397833B1 (ko) | 1982-06-25 |
| IL55161A0 (en) | 1978-09-29 |
| DE2831419A1 (de) | 1979-02-01 |
| IT1158890B (it) | 1987-02-25 |
| FR2397833A1 (fr) | 1979-02-16 |
| DE2831419C2 (ko) | 1989-01-05 |
| AU3805778A (en) | 1980-01-17 |
| SE443087B (sv) | 1986-02-17 |
| IE47128B1 (en) | 1983-12-28 |
| BE869055A (fr) | 1979-01-17 |
| IE781432L (en) | 1979-01-19 |
| NZ187894A (en) | 1984-05-31 |
| SE7807934L (sv) | 1979-01-20 |
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