JPS6361920B2 - - Google Patents
Info
- Publication number
- JPS6361920B2 JPS6361920B2 JP59253935A JP25393584A JPS6361920B2 JP S6361920 B2 JPS6361920 B2 JP S6361920B2 JP 59253935 A JP59253935 A JP 59253935A JP 25393584 A JP25393584 A JP 25393584A JP S6361920 B2 JPS6361920 B2 JP S6361920B2
- Authority
- JP
- Japan
- Prior art keywords
- leif
- mature human
- leukocyte interferon
- human leukocyte
- interferon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
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ã¿ããšãã³ãæšç€ºãããLeIF ããLeIF ã«
ã€ããŠããã®ãããªã察ç«éºäŒåå€ç°ã¯ãæšç€ºã®
ç¯å²å ãŸãã¯ããã®å®çŸ©å ã«å«ãŸããåŸã€ãŠãæ¬
çºæã®ç¯å²å ã«å«ãŸãããšããã ã€ãã«ãè¡šããã³å³ã«ã€ããŠèª¬æããã ãè¡šã ãè¡šã ã ã ã
ã ã ã ã
ã ã ã ã
LeIF A TGAGCCTAAACCTTAGGCTCACCCATT
TCAACCAGTCTAGCAGCATCTGCAACATCTACAATGGCCTTGACCTTTGC
TTTACTGGTGGCCCTCCTGGTGC
LeIF B
TACTAGCTCAGCAGCATCC
GCAACATCTACAATGGCCTTGACTTTTTATTTAATGGTGGCCCTAGTGGT
GC
LeIF C
CAAGGTTATCCATCTCAAGTAGCCTAGCAATATTTGCAACATCCCAATG
GCCCTGTCCTTTTCTTTACTTATGGCCGTGCTGGTGC
LeIF D CAAGGTTCAGAGTCA
CCCATCTCAGCAAGCCCAGAAGTATCTGCAATATCTACGATGGCCTCGCC
CTTTGCTTTACTGATGGTCCTGGTGGTGC
LeIF E
LeIF F
ACATCCCAATGGCCCTGTCCTTT
TCTTTACTGATGGCCGTGCTGGTGC
LeIF G
LeIF H CCAAGGTTCAGTGTTACCC
CTCATCAACCAGCCCAGCAGCATCTTCGGGATTCCCAATGGCATTGCCCT
TTGCTTTAATGATGGCCCTGGTGGTGC
60
80 100
120 140
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A TCAGCTGCAAGTCAAGCTGCTCTGTGG
GCTGTGATCTGCCTCAAACCCACAGCCTGGGTAGCAGGAGGACCTTGATG
CTCCTGGCACAGATGAGGAAAAT
LeIF B TCAGCTACAAGTCATTCAGCTCTCTGG
GCTGTGATCTGCCTCAGACTCACAGCCTGGGTAACAGGAGGGCCTTGATA
CTCCTGGCACAAATGCGAAGAAT
LeIF C TCAGCTACAAATCCATCTGTTCTCTGG
GCTGTGATCTGCCTCAGACCCACAGCCTCGGTAATAGGAGGGCCTTGATA
CTCCTGGGACAAATGGGAAGAAT
LeIF D TCAGCTGCAAGTCAAGCTGCTCTCTGG
GCTGTGATCTCCCTGAGACCCACAGCCTGGATAACAGGAGGACCTTGATG
CTCCTGGCACAAATGAGCAGAAT
LeIF E
CTGCCTCTGGGCTGTGATCTGCCTCAGGCCCACAGCGTGGGTA
ACAGGAGGGCCTTCATACTCCTGACACAAATGAGGAGAAT
LeIF F TCAGCTACAAATCCATCTGTTCTCTGG
GCTGTGATCTGCCTCAGACCCACAGCCTGGGTAATAGGAGGGCCTTGATA
CTCCTGGCACAAATGGGAAGAAT
LeIF G
LeIF H TCAGCTGCAAGTCAAGCTGCTCTCTGG
GCTGTAATCTGTCTCAAACCCACAGCCTGAATAACAGGAGGACTTTGATG
CTCATGGCACAAATGAGGAGAAT
160
180 200
220 240
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A CTCTCTTTTCTCCTGCTTGAAGGACAG
ACATGACTTTGGATTTCCC CAGGAGGAGTTT GGCAACCAGTT
CCAAAAGGCTGAAACCATCCCTGTCCT
LeIF B CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGAATTCCCC CAGGAGGAGTTTGATGATAAACAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF C CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGATTTCCGAATCCCC CAGGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF D CTCTCCTTCCTCCTGTCTGATGGACAG
ACATGACTTTGGATTTCCC CAGGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCCAGCTATCTCCCTCCT
LeIF E CTCTCCTTTTTCTTACCTGAAGGACAG
ACATGACTTTGATTTTCCATCATCAGGTGTTTCATGGCAACCACTTCCAG
AAGGTTCAAGCTATCTTCCTTTT
LeIF F CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGGATTCCCC CAAGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF G
CATGACTTTGGATTTCCT C
AGGAGGAGTTTGATGGCAACCAGTTCCAGAAGGCTCAAGCCATCTCTGTC
CT
LeIF H CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGAATTTCCC CAGGAGGAATTTGATGGCAACCAGTTCCA
GAAAGCTCAAGCCATCTCTGTCCT
260
280 300
320 340
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A CCATGAGATGATCCAGCAGATCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTGCTTGGGATGAGACCCTCCTAG
ACAAATTCTACACTGAACTCTAC
LeIF B CCATGAGATGATCCAGCAGACCTTCAA
CCTCTTCAGCACAAAGGACTCATCTGCTGCTTTGGATGAGACCCTTCTAG
ATGAATTCTACATCGAACTTGAC
LeIF C CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAGAGGACTCATCTGCTGCTTGGGAACAGAGCCTCCTAG
AAAAATTTTCCACTGAACTTTAC
LeIF D CCATGAGCTGATCCAGCAGATCTTCAA
CCTCTTTACCACAAAAGATTCATCTGCTGCTTGGGATGAGGACCTCCTAG
ACAAATTCTGCACCGAACTCTAC
LeIF E CCATGAGATGATGCAGCAGACCTTCAA
CCTCTTCAGCACAAAGGACTCATCTGATACTTGGGATGAGACCCTTTTAG
ACAAATCCTACACTGAACTTTAC
LeIF F CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTACTTGGGAACAGAGCCTCCTAG
AAAAATTTTCCACTGAACTTAAC
LeIF G CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTACTTGGGATGAGACACTTCTAG
ACAAATTCTACACTGAACTTTAC
LeIF H CCATGAGATGATGCAGCAGACCTTCAA
TCTCTTCAGCACAAAGAACTCATCTGCTGCTTGGGATGAGACCCTCCTAG
AAAAATTCTACATTGAACTTTTC
ãè¡šã ã ã
ã ã ã ã
ã ã ã ã
LeIF A CAGCAGCTGAATGACCTGGAAGCCTGT
GTGATACAGGGGGTGGGGGTGACAGAGACTCCCCTGATGAAGGAGGACTC
CATTCTGGCTGTGAGGAAATACT
LeIF B CAGCAGCTGAATGACCTGGAAGTCCTG
TGTGATCAGGAAGTGGGGGTGATAGAGTCTCCCCTGATGTACGAGGACTC
CATCCTGGCTGTGAGGAAATACT
LeIF C CAGCAACTGAATGACCTGGAAGCATGT
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGAGGACTC
CATCCTGGCTGTGAGGAAATACT
LeIF D CAGCAGCTGAATGACTTGGAAGCCTGT
GTGATGCAGGAGGAGAGGGTGGGAGAAACTCCCCTGATGAATGTGGACTC
CATCTTGGCTGTGAAGAAATACT
LeIF E CAGCAGCTGAATGACCTGGAAGCCTGT
GTGATGTAGAAGGTTGGAGTGGAAGAGACTCCCCTGAGGAATGTGGACTC
CATCCTGGCTGTGAGAAAATACT
LeIF F CAGCAGCTGAATGACATGGAAGCCTGC
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGTGGACTC
CATCTTGGCTGTGAAGAAATACT
LeIF G CAGCAGCTGAATGACCTGGAAGCCTGTAT
GATGCAGGAGGTTGGAGTGGAAGACACTCCTCTGATGAATGTGGACTCTA
TCCTGACTGTGAGAAAATACT
LeIF H CAGCAAATGAATGACCTGGAAGCCTGT
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGAGGACTC
CATCCTGGCTGTGAAGAAATACT
460
480 500
520 540
ã ã
ã ã ã ã
ã ã ã ã
LeIF A TCCAAAGAATCACTCTCTATCTGAAAG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCTTTTTCTTTGTCAACAAA
LeIF B TCCAAAGAATCACTCTATATCTGACAG
AGAAGAAATACAGCTCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATCAATCAA
LeIF C TCCAAAGAATCACTCTTTATCTAATAG
AGAGGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
ASATCCCTCTCGTTTTCAACAAA
LeIF D TCCGAAGAATCACTCTCTATCTGACAG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCCTCTCTTTATCAACAAA
LeIF E TTCAAAGAATCACTCTTTATCTGACAA
AGAAGAAGTATAGCCCTTGTTCCTGGGAGGCTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATGAACGAA
LeIF F TCCAAAGAATCACTCTTTATCTGACAG
AGAAGAAATACAGCCCTTGTGCTTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATCAAAAAT
LeIF G TTCAAAGAATCACCCTCTATCTGACAGAG
AAGAAATACAGCCCTTGTGCATGGGAGGTTGTCAGAGCAGAAATCATGAG
ATCCTTCTCTTTATCAGCAAA
LeIF H TCCAAAGAATCACTCTTTATCTGATGG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTTTCAACAAA
560
580 600
620 640
ã ã
ã ã ã ã
ã ã ã ã
LeIF A CTTGCAAGAAAGTTTAAGAAGTAAGGA
ATGAAAACTGGTTCAACATGGAAATGATTTTCATTGATTCGTATGCCAGC
TCACCTTTTTATGATCTGCCATT
LeIF B CTTGCAAAAAAGATTGAAGAGTAAGGA
ATGAGACCTGGTACAACACGGAAATGATTCTCATAGACTAATACAGCAGT
CTACACTTTGACAAGTTGTGCTC
LeIF C CTTGCAAAAAAGATTAAGGAGGAAGGA
TTGAAAACTGGTTCAACATGGCAATGATCCTGATTGACTAATACATTATC
TCACACTTTCATGAGTTCTTCCA
LeIF D CTTGCAAGAAAGATTAAGGAGGAAGGA
ATAATATCTGGTCCAACATGAAAACAATTCTTATTGACTCATACACCAGG
TCACGCTTTCATGAATTCTGTCA
LeIF E CTTGCAGGAAAGATTAAGGAGGAAGGA
ATGAAAACTGGTTCAACATGGAAATGAGAAACATTTCCATGATTAATACA
TCATCTCACACATTCATGAATTC
LeIF F TTTTCAAGAAAGATTAAGGAGGAAGGA
ATGAAACCGTTTCAACATGGAAATGATCTGTATTGACTAATACACCAGTC
CACACTTCTATGACTTCTGCCAT
LeIF G CTTGCAAGAAAGATTAAGGAGGAAGGAAT
GAAAACTGGTTCAACATCGAAATGATTCTCATTGACTAGTACACCATTTC
ACACTTCTTGAGTTCTGCCGT
LeIF H CTTGCAAAAAAGATTAAGGAGGAAGGA
TTGAAAACTGGTTCATCATGGAAATGATTCTCATTGACTAATACATCATC
TCACACTTTCATGTTCTTCCATT
660
680 700
720 740
ã ã
ã ã ã ã
ã ã ã ã
LeIF A TCAAAGACTCATGTTTCTGCTATGACC
ATGACACGATTTAAATCTTTTCAAATGTTTTTAGGASTATTAATCAACAT
TGTATTCAGCTCTTAAGGCACTA
LeIF B TTTCAAAGACCCTTGTTTCTGCCAAAA
CCATGCTATGAATTGAATCAAATGTGTCAAGTGTTTTCAGGAGTGTTAAG
CAACATCCTGTTCAGCTGTATGG
LeIF C TTTCAAAGACTCACTTCTATAACCACG
ACGCGTTGAATCAAAATTTTCAAATGTTTTCAGCAGTGTAAAGAAGTGTC
GTGTATACCTGTGCAGGCACTAG
LeIF D TTTCAAAGACTCTCACCCCTGCTATAA
CTATGACCATGCTGATAAACTGATTTATCTATTTAAATATTTATTTAACT
ATTCATAAGATTTAAATTATTTT
LeIF E TGCCATTTCTCATTTTTGCTATATCCA
TGACATGAGTTGAATCAAAATTTTAAAATGTTTTCAGGAATGTTAAGCAG
CATCATGTTCAGCTGTACAGGCA
LeIF F TTCAAAGACTCATTTCTCCTATAACCA
CCGCATGAGTTGAATCAAAATTTTCAGATCTTTTCAGGAGTGTAAGGAAA
CATCATGTTTACCTGTGCAGGCA
LeIF G TTCAAATATTAATTTCTGCTATATCCATG
ACTTGAGTTGAATCAAAATTTTCAAACGTTTCACACGTGTTAAGCAACAC
TTCTTTAGCTCCACAGGGACA
LeIF H TCAAAGACTCACTTCTATAACCACCAC
AAGTTGAATCAAAATTTCCAAATGTTTTCAGGAGTGTTAAGAAGCATCGT
GTTTACCTGTGCAGGCACTAGTC
ãè¡šã ã ã
ã ã ã ã
ã ã ã ã
LeIF A GTCCCTTACAGAGGACCATGCTGACTG
ATCCATTATCTATTTAAATATTTTTAAAATATTATTTATTTAACTATTTA
TAAAACAACTTATTTTTGTTCAT
LeIF B GCACTAGTCCCTTACAGATGACCATGC
TGATGGATCTATTCATCTATTTATTTAAATCTTTATTTAGTTAACTACTA
TAGGGACTTAAATTAGTTTTGTT
LeIF C TCCTTTACAGATGACCATTCTGATGTC
TCTGTTCATCTTTTGTTTAAATATTTATTTAATTATTTTTAAAATTTATG
TAATATCATGAGTCGCTTTACAT
LeIF D TGTTCATATAACGTCATGTGCACCTTT
ACACTGTGGTTAGTGTAATAAAACATGTTCCTTATATTTACTCãpoly(
A)
LeIF E CTAGTTCCTTACGGATGATCATGCTGA
TGGATCTGTTTATCTATTTGTCTAAATAATTATTTAACTATTTATAATAT
TTAAAATCTTCTTTTCATGTATC
LeIF F CTAGTCCTTTACAGATGACCATGCTGA
TAGATCTAATTATCTATCTATTGAAATATTTATTTATTTATTAGATTTAA
ATTATTTTTGTCCATGTAATATT
LeIF G AAATCTTTACAGATGATCATGCCAATCTA
TCTATTCTATCTATTTATCTATCTGTCTGTCTTCTATCTAATCTATTTAA
ATATTTATTTATTTATAAGAT
LeIF H CTTTACAGATGACCATTCTGATGTCTC
CTTTCATCTATTTATTTAAATATTTATTTATTTAACTATTTTTATTATTT
AAATTATTTTTTATGTAATATCA
860
880 900
920 940
ã ã
ã ã ã ã
ã ã ã ã
LeIF A ATTACGTCATGTGCACCTTTGCACAGT
GGTTAATGTAATAAAATATGTTCTTTGTATTTGGTãpoly(A)
LeIF B CATATTATATTATGTGAACTTTTACAT
TGTGAATTGTGTAACAAAAACATGTTCTTATATTTATTATTTTGCCATGT
TTATTAAATTTTTACTATGAAAA
LeIF C TGTGGTTAATGTAACAATATATGTTCT
TCATATTTAGCCAATATATTAATTTCCTTTTTCATTAAATTTTTACTATA
Cãpoly(A)
LeIF E ATGTATTTTTACTTTGTGGTTAATATA
ACAACACATGTTCTTTATATTTAGTCAATATATTACTTTGCTTTTTTCAT
TAAATTTTTACTATGGãpoly(A)
LeIF F ATGTGTACTTTTACATTGTGTTATATC
AAAATATGTTAATCTAATATTTAGTCAATATATTATTTTCTTTTTATTAA
TTTTTACTATTAAAACTTCTTAT
LeIF G TTAAATTATTTTAAACTTATGTTTGTT
CAGGTAATATTACATCCACCTTACTTTGTGGCTAATATAATAAAATATGT
TCTTTATGTTTTGTCãpoly(A)
LeIF H TGAGTACCTTTACATTGTGGTTAATGTAA
CAAATATGTTCTTCATATTTAGCCAATATATTAATTTCCTTTTTCATTAA
ATTTTTACTATãpoly(A)
960
980 1000
ã ã
ã ã ã ã
ã
LeIF B AATTCTTTATTTATTCTTTAAAATTGA
ACTCCAACCCATGAATTGTGCAAACTGATTAAAGAATGGATGGTãpoly
(A)
LeIF F ATTATTTGGTTATTCTTTAATAAAGAA
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S L F S C L K D R H D F G F P Q
LeIF B M A L T F Y L M V A L V V L
S Y K S F S S L G C D L P Q T H S
L G N R R A L I L L A Q M R R I
S P F S C L K D R H D F E F P Q
LeIF C M A L S F S L L M A V L V L
S Y K S I C S L G C D L P Q T H S
L G N R R A L I L L G Q M G R I
S P F S C L K D R H D F R I P Q
LeIF D M A S P F A L L M V L V V L
S C K S S C S L G C D L P E T H S
L D N R R T L M L L A Q M S R I
S P S S C L M D R H D F G F P Q
LeIF E
L P L G C
D L P Q A H S V G N R R A F I L L
T Q M R R I S P F S Y L K D R H D
F D F P H
LeIF F M A L S F S L L M A V L V L
S Y K S I C S L G C D L P Q T H S
L G N R R A L I L L A Q M G R I
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LeIF G
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S C K S S C S L G C N L S Q T H S
L N N R R T L M L M A Q M R R I
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All M A F L
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Q M I S S C L D
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70 80
90 100
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LeIF A E E F ã G N Q F Q K A E T I
P V L H E M I Q Q I F N L F S T
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LeIF B E E F D D K Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A A L D E T L L D E F Y I
E L D Q Q L N D L E V L C D Q E
LeIF C E E F D G N Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A A W E Q S L L D K F S T
E L Y Q Q L N D L E A C V I Q E
LeIF D E E F D G N Q F Q K A P A I
S V L H E L I Q Q I F N L F T T K
D S S A A W D E D L L D K F C T
E L Y Q Q L N D L E A C V M Q E
LeIF E Q V F H G N H F Q K V Q A I
F L F H E M M Q Q T F N L F S T K
D S S D T W D E T L L D K S Y T
E L Y Q Q L N D L E A C V M K
LeIF F E E F D G N Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A T W E Q S L L E K F S T
E L N Q Q L N D M E A C V I Q E
LeIF G E E F D G N Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A T W D E T L L D K F Y T
E L Y Q Q L N D L E A C M M Q E
LeIF H E E F D G N Q F Q K A Q A I
S V L H E M M Q Q T F N L F S T K
N S S A A W D E T L L E K F Y T
E L F Q Q M N D L E A C V I Q E
All E E F D Q F Q K A
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L F E L Q Q N D
E Q
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130 140
150 160 166
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LeIF A V G V T E T P L M K E D S I
L A V R K Y F Q R I T L Y L K E K
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LeIF B V G V I E S P L M Y E D S I
L A V R K Y F Q R I T L Y L T E K
K Y S S C A W E V V R A E I M R
S F S L S I N L Q K R L K S K E
LeIF C V G V E E T P L M N E D S I
L A V R K Y F Q R I T L Y L I E R
K Y S P C A W E V V R A E I M R
S L S F S T N L Q K R L R R K D
LeIF D E R V G E T P L M N V D S I
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K Y S P C A W E V V R A E I M R
S L S L S T N L Q E R L R R K E
LeIF E V G V E E T P L R N V D S I
L A V R K Y F Q R I T L Y L T K K
K Y S P C S W E A V R A E I M R
S F S L T N L Q E R L R R K E
LeIF F V G V E E T P L M N V D S I
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LeIF G V G V E E T P L M N V D S I
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K Y S P C A W E V V R A E I M R
S F S F S T N L Q K R L R R K D
All V P L M
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L E K Y S C A W E V V R
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ã¿ããšãã³ãæšç€ºãããLeIF ããLeIF ã«
ã€ããŠããã®ãããªã察ç«éºäŒåå€ç°ã¯ãæšç€ºã®
ç¯å²å ãŸãã¯ããã®å®çŸ©å ã«å«ãŸããåŸã€ãŠãæ¬
çºæã®ç¯å²å ã«å«ãŸãããšããã ã€ãã«ãè¡šããã³å³ã«ã€ããŠèª¬æããã ãè¡šã ãè¡šã ã ã ã
ã ã ã ã
ã ã ã ã
LeIF A TGAGCCTAAACCTTAGGCTCACCCATT
TCAACCAGTCTAGCAGCATCTGCAACATCTACAATGGCCTTGACCTTTGC
TTTACTGGTGGCCCTCCTGGTGC
LeIF B
TACTAGCTCAGCAGCATCC
GCAACATCTACAATGGCCTTGACTTTTTATTTAATGGTGGCCCTAGTGGT
GC
LeIF C
CAAGGTTATCCATCTCAAGTAGCCTAGCAATATTTGCAACATCCCAATG
GCCCTGTCCTTTTCTTTACTTATGGCCGTGCTGGTGC
LeIF D CAAGGTTCAGAGTCA
CCCATCTCAGCAAGCCCAGAAGTATCTGCAATATCTACGATGGCCTCGCC
CTTTGCTTTACTGATGGTCCTGGTGGTGC
LeIF E
LeIF F
ACATCCCAATGGCCCTGTCCTTT
TCTTTACTGATGGCCGTGCTGGTGC
LeIF G
LeIF H CCAAGGTTCAGTGTTACCC
CTCATCAACCAGCCCAGCAGCATCTTCGGGATTCCCAATGGCATTGCCCT
TTGCTTTAATGATGGCCCTGGTGGTGC
60
80 100
120 140
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A TCAGCTGCAAGTCAAGCTGCTCTGTGG
GCTGTGATCTGCCTCAAACCCACAGCCTGGGTAGCAGGAGGACCTTGATG
CTCCTGGCACAGATGAGGAAAAT
LeIF B TCAGCTACAAGTCATTCAGCTCTCTGG
GCTGTGATCTGCCTCAGACTCACAGCCTGGGTAACAGGAGGGCCTTGATA
CTCCTGGCACAAATGCGAAGAAT
LeIF C TCAGCTACAAATCCATCTGTTCTCTGG
GCTGTGATCTGCCTCAGACCCACAGCCTCGGTAATAGGAGGGCCTTGATA
CTCCTGGGACAAATGGGAAGAAT
LeIF D TCAGCTGCAAGTCAAGCTGCTCTCTGG
GCTGTGATCTCCCTGAGACCCACAGCCTGGATAACAGGAGGACCTTGATG
CTCCTGGCACAAATGAGCAGAAT
LeIF E
CTGCCTCTGGGCTGTGATCTGCCTCAGGCCCACAGCGTGGGTA
ACAGGAGGGCCTTCATACTCCTGACACAAATGAGGAGAAT
LeIF F TCAGCTACAAATCCATCTGTTCTCTGG
GCTGTGATCTGCCTCAGACCCACAGCCTGGGTAATAGGAGGGCCTTGATA
CTCCTGGCACAAATGGGAAGAAT
LeIF G
LeIF H TCAGCTGCAAGTCAAGCTGCTCTCTGG
GCTGTAATCTGTCTCAAACCCACAGCCTGAATAACAGGAGGACTTTGATG
CTCATGGCACAAATGAGGAGAAT
160
180 200
220 240
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A CTCTCTTTTCTCCTGCTTGAAGGACAG
ACATGACTTTGGATTTCCC CAGGAGGAGTTT GGCAACCAGTT
CCAAAAGGCTGAAACCATCCCTGTCCT
LeIF B CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGAATTCCCC CAGGAGGAGTTTGATGATAAACAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF C CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGATTTCCGAATCCCC CAGGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF D CTCTCCTTCCTCCTGTCTGATGGACAG
ACATGACTTTGGATTTCCC CAGGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCCAGCTATCTCCCTCCT
LeIF E CTCTCCTTTTTCTTACCTGAAGGACAG
ACATGACTTTGATTTTCCATCATCAGGTGTTTCATGGCAACCACTTCCAG
AAGGTTCAAGCTATCTTCCTTTT
LeIF F CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGGATTCCCC CAAGAGGAGTTTGATGGCAACCAGTTCCA
GAAGGCTCAAGCCATCTCTGTCCT
LeIF G
CATGACTTTGGATTTCCT C
AGGAGGAGTTTGATGGCAACCAGTTCCAGAAGGCTCAAGCCATCTCTGTC
CT
LeIF H CTCTCCTTTCTCCTGCCTGAAGGACAG
ACATGACTTTGAATTTCCC CAGGAGGAATTTGATGGCAACCAGTTCCA
GAAAGCTCAAGCCATCTCTGTCCT
260
280 300
320 340
ã ã
ã ã ã ã
ã ã ã
ã
LeIF A CCATGAGATGATCCAGCAGATCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTGCTTGGGATGAGACCCTCCTAG
ACAAATTCTACACTGAACTCTAC
LeIF B CCATGAGATGATCCAGCAGACCTTCAA
CCTCTTCAGCACAAAGGACTCATCTGCTGCTTTGGATGAGACCCTTCTAG
ATGAATTCTACATCGAACTTGAC
LeIF C CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAGAGGACTCATCTGCTGCTTGGGAACAGAGCCTCCTAG
AAAAATTTTCCACTGAACTTTAC
LeIF D CCATGAGCTGATCCAGCAGATCTTCAA
CCTCTTTACCACAAAAGATTCATCTGCTGCTTGGGATGAGGACCTCCTAG
ACAAATTCTGCACCGAACTCTAC
LeIF E CCATGAGATGATGCAGCAGACCTTCAA
CCTCTTCAGCACAAAGGACTCATCTGATACTTGGGATGAGACCCTTTTAG
ACAAATCCTACACTGAACTTTAC
LeIF F CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTACTTGGGAACAGAGCCTCCTAG
AAAAATTTTCCACTGAACTTAAC
LeIF G CCATGAGATGATCCAGCAGACCTTCAA
TCTCTTCAGCACAAAGGACTCATCTGCTACTTGGGATGAGACACTTCTAG
ACAAATTCTACACTGAACTTTAC
LeIF H CCATGAGATGATGCAGCAGACCTTCAA
TCTCTTCAGCACAAAGAACTCATCTGCTGCTTGGGATGAGACCCTCCTAG
AAAAATTCTACATTGAACTTTTC
ãè¡šã ã ã
ã ã ã ã
ã ã ã ã
LeIF A CAGCAGCTGAATGACCTGGAAGCCTGT
GTGATACAGGGGGTGGGGGTGACAGAGACTCCCCTGATGAAGGAGGACTC
CATTCTGGCTGTGAGGAAATACT
LeIF B CAGCAGCTGAATGACCTGGAAGTCCTG
TGTGATCAGGAAGTGGGGGTGATAGAGTCTCCCCTGATGTACGAGGACTC
CATCCTGGCTGTGAGGAAATACT
LeIF C CAGCAACTGAATGACCTGGAAGCATGT
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGAGGACTC
CATCCTGGCTGTGAGGAAATACT
LeIF D CAGCAGCTGAATGACTTGGAAGCCTGT
GTGATGCAGGAGGAGAGGGTGGGAGAAACTCCCCTGATGAATGTGGACTC
CATCTTGGCTGTGAAGAAATACT
LeIF E CAGCAGCTGAATGACCTGGAAGCCTGT
GTGATGTAGAAGGTTGGAGTGGAAGAGACTCCCCTGAGGAATGTGGACTC
CATCCTGGCTGTGAGAAAATACT
LeIF F CAGCAGCTGAATGACATGGAAGCCTGC
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGTGGACTC
CATCTTGGCTGTGAAGAAATACT
LeIF G CAGCAGCTGAATGACCTGGAAGCCTGTAT
GATGCAGGAGGTTGGAGTGGAAGACACTCCTCTGATGAATGTGGACTCTA
TCCTGACTGTGAGAAAATACT
LeIF H CAGCAAATGAATGACCTGGAAGCCTGT
GTGATACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGAGGACTC
CATCCTGGCTGTGAAGAAATACT
460
480 500
520 540
ã ã
ã ã ã ã
ã ã ã ã
LeIF A TCCAAAGAATCACTCTCTATCTGAAAG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCTTTTTCTTTGTCAACAAA
LeIF B TCCAAAGAATCACTCTATATCTGACAG
AGAAGAAATACAGCTCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATCAATCAA
LeIF C TCCAAAGAATCACTCTTTATCTAATAG
AGAGGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
ASATCCCTCTCGTTTTCAACAAA
LeIF D TCCGAAGAATCACTCTCTATCTGACAG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCCTCTCTTTATCAACAAA
LeIF E TTCAAAGAATCACTCTTTATCTGACAA
AGAAGAAGTATAGCCCTTGTTCCTGGGAGGCTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATGAACGAA
LeIF F TCCAAAGAATCACTCTTTATCTGACAG
AGAAGAAATACAGCCCTTGTGCTTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTATCAAAAAT
LeIF G TTCAAAGAATCACCCTCTATCTGACAGAG
AAGAAATACAGCCCTTGTGCATGGGAGGTTGTCAGAGCAGAAATCATGAG
ATCCTTCTCTTTATCAGCAAA
LeIF H TCCAAAGAATCACTCTTTATCTGATGG
AGAAGAAATACAGCCCTTGTGCCTGGGAGGTTGTCAGAGCAGAAATCATG
AGATCCTTCTCTTTTTCAACAAA
560
580 600
620 640
ã ã
ã ã ã ã
ã ã ã ã
LeIF A CTTGCAAGAAAGTTTAAGAAGTAAGGA
ATGAAAACTGGTTCAACATGGAAATGATTTTCATTGATTCGTATGCCAGC
TCACCTTTTTATGATCTGCCATT
LeIF B CTTGCAAAAAAGATTGAAGAGTAAGGA
ATGAGACCTGGTACAACACGGAAATGATTCTCATAGACTAATACAGCAGT
CTACACTTTGACAAGTTGTGCTC
LeIF C CTTGCAAAAAAGATTAAGGAGGAAGGA
TTGAAAACTGGTTCAACATGGCAATGATCCTGATTGACTAATACATTATC
TCACACTTTCATGAGTTCTTCCA
LeIF D CTTGCAAGAAAGATTAAGGAGGAAGGA
ATAATATCTGGTCCAACATGAAAACAATTCTTATTGACTCATACACCAGG
TCACGCTTTCATGAATTCTGTCA
LeIF E CTTGCAGGAAAGATTAAGGAGGAAGGA
ATGAAAACTGGTTCAACATGGAAATGAGAAACATTTCCATGATTAATACA
TCATCTCACACATTCATGAATTC
LeIF F TTTTCAAGAAAGATTAAGGAGGAAGGA
ATGAAACCGTTTCAACATGGAAATGATCTGTATTGACTAATACACCAGTC
CACACTTCTATGACTTCTGCCAT
LeIF G CTTGCAAGAAAGATTAAGGAGGAAGGAAT
GAAAACTGGTTCAACATCGAAATGATTCTCATTGACTAGTACACCATTTC
ACACTTCTTGAGTTCTGCCGT
LeIF H CTTGCAAAAAAGATTAAGGAGGAAGGA
TTGAAAACTGGTTCATCATGGAAATGATTCTCATTGACTAATACATCATC
TCACACTTTCATGTTCTTCCATT
660
680 700
720 740
ã ã
ã ã ã ã
ã ã ã ã
LeIF A TCAAAGACTCATGTTTCTGCTATGACC
ATGACACGATTTAAATCTTTTCAAATGTTTTTAGGASTATTAATCAACAT
TGTATTCAGCTCTTAAGGCACTA
LeIF B TTTCAAAGACCCTTGTTTCTGCCAAAA
CCATGCTATGAATTGAATCAAATGTGTCAAGTGTTTTCAGGAGTGTTAAG
CAACATCCTGTTCAGCTGTATGG
LeIF C TTTCAAAGACTCACTTCTATAACCACG
ACGCGTTGAATCAAAATTTTCAAATGTTTTCAGCAGTGTAAAGAAGTGTC
GTGTATACCTGTGCAGGCACTAG
LeIF D TTTCAAAGACTCTCACCCCTGCTATAA
CTATGACCATGCTGATAAACTGATTTATCTATTTAAATATTTATTTAACT
ATTCATAAGATTTAAATTATTTT
LeIF E TGCCATTTCTCATTTTTGCTATATCCA
TGACATGAGTTGAATCAAAATTTTAAAATGTTTTCAGGAATGTTAAGCAG
CATCATGTTCAGCTGTACAGGCA
LeIF F TTCAAAGACTCATTTCTCCTATAACCA
CCGCATGAGTTGAATCAAAATTTTCAGATCTTTTCAGGAGTGTAAGGAAA
CATCATGTTTACCTGTGCAGGCA
LeIF G TTCAAATATTAATTTCTGCTATATCCATG
ACTTGAGTTGAATCAAAATTTTCAAACGTTTCACACGTGTTAAGCAACAC
TTCTTTAGCTCCACAGGGACA
LeIF H TCAAAGACTCACTTCTATAACCACCAC
AAGTTGAATCAAAATTTCCAAATGTTTTCAGGAGTGTTAAGAAGCATCGT
GTTTACCTGTGCAGGCACTAGTC
ãè¡šã ã ã
ã ã ã ã
ã ã ã ã
LeIF A GTCCCTTACAGAGGACCATGCTGACTG
ATCCATTATCTATTTAAATATTTTTAAAATATTATTTATTTAACTATTTA
TAAAACAACTTATTTTTGTTCAT
LeIF B GCACTAGTCCCTTACAGATGACCATGC
TGATGGATCTATTCATCTATTTATTTAAATCTTTATTTAGTTAACTACTA
TAGGGACTTAAATTAGTTTTGTT
LeIF C TCCTTTACAGATGACCATTCTGATGTC
TCTGTTCATCTTTTGTTTAAATATTTATTTAATTATTTTTAAAATTTATG
TAATATCATGAGTCGCTTTACAT
LeIF D TGTTCATATAACGTCATGTGCACCTTT
ACACTGTGGTTAGTGTAATAAAACATGTTCCTTATATTTACTCãpoly(
A)
LeIF E CTAGTTCCTTACGGATGATCATGCTGA
TGGATCTGTTTATCTATTTGTCTAAATAATTATTTAACTATTTATAATAT
TTAAAATCTTCTTTTCATGTATC
LeIF F CTAGTCCTTTACAGATGACCATGCTGA
TAGATCTAATTATCTATCTATTGAAATATTTATTTATTTATTAGATTTAA
ATTATTTTTGTCCATGTAATATT
LeIF G AAATCTTTACAGATGATCATGCCAATCTA
TCTATTCTATCTATTTATCTATCTGTCTGTCTTCTATCTAATCTATTTAA
ATATTTATTTATTTATAAGAT
LeIF H CTTTACAGATGACCATTCTGATGTCTC
CTTTCATCTATTTATTTAAATATTTATTTATTTAACTATTTTTATTATTT
AAATTATTTTTTATGTAATATCA
860
880 900
920 940
ã ã
ã ã ã ã
ã ã ã ã
LeIF A ATTACGTCATGTGCACCTTTGCACAGT
GGTTAATGTAATAAAATATGTTCTTTGTATTTGGTãpoly(A)
LeIF B CATATTATATTATGTGAACTTTTACAT
TGTGAATTGTGTAACAAAAACATGTTCTTATATTTATTATTTTGCCATGT
TTATTAAATTTTTACTATGAAAA
LeIF C TGTGGTTAATGTAACAATATATGTTCT
TCATATTTAGCCAATATATTAATTTCCTTTTTCATTAAATTTTTACTATA
Cãpoly(A)
LeIF E ATGTATTTTTACTTTGTGGTTAATATA
ACAACACATGTTCTTTATATTTAGTCAATATATTACTTTGCTTTTTTCAT
TAAATTTTTACTATGGãpoly(A)
LeIF F ATGTGTACTTTTACATTGTGTTATATC
AAAATATGTTAATCTAATATTTAGTCAATATATTATTTTCTTTTTATTAA
TTTTTACTATTAAAACTTCTTAT
LeIF G TTAAATTATTTTAAACTTATGTTTGTT
CAGGTAATATTACATCCACCTTACTTTGTGGCTAATATAATAAAATATGT
TCTTTATGTTTTGTCãpoly(A)
LeIF H TGAGTACCTTTACATTGTGGTTAATGTAA
CAAATATGTTCTTCATATTTAGCCAATATATTAATTTCCTTTTTCATTAA
ATTTTTACTATãpoly(A)
960
980 1000
ã ã
ã ã ã ã
ã
LeIF B AATTCTTTATTTATTCTTTAAAATTGA
ACTCCAACCCATGAATTGTGCAAACTGATTAAAGAATGGATGGTãpoly
(A)
LeIF F ATTATTTGGTTATTCTTTAATAAAGAA
ATTCCAAGCCCãpoly(A)
ãè¡šã ã ã
ã ã ã
ã ã
ã
LeIF A M A L T F A L L V A L L V L
S C K S S C S V G C D L P Q T H S
L G S R R T L M L L A Q M R K I
S L F S C L K D R H D F G F P Q
LeIF B M A L T F Y L M V A L V V L
S Y K S F S S L G C D L P Q T H S
L G N R R A L I L L A Q M R R I
S P F S C L K D R H D F E F P Q
LeIF C M A L S F S L L M A V L V L
S Y K S I C S L G C D L P Q T H S
L G N R R A L I L L G Q M G R I
S P F S C L K D R H D F R I P Q
LeIF D M A S P F A L L M V L V V L
S C K S S C S L G C D L P E T H S
L D N R R T L M L L A Q M S R I
S P S S C L M D R H D F G F P Q
LeIF E
L P L G C
D L P Q A H S V G N R R A F I L L
T Q M R R I S P F S Y L K D R H D
F D F P H
LeIF F M A L S F S L L M A V L V L
S Y K S I C S L G C D L P Q T H S
L G N R R A L I L L A Q M G R I
S P F S C L K D R H G F G F P Q
LeIF G
H D F G F P
Q
LeIF H M A L P F S L M M A L V V L
S C K S S C S L G C N L S Q T H S
L N N R R T L M L M A Q M R R I
S P F S C L K D R H D F E F P Q
All M A F L
V L S K S S G C L
T H S L R R L L
Q M I S S C L D
R H D F P Q
50 60
70 80
90 100
ã
ã ã
ã ã
ã
LeIF A E E F ã G N Q F Q K A E T I
P V L H E M I Q Q I F N L F S T
K D S S A A W D E T L L D K F Y T
E L Y Q Q L N D L E A C V I Q G
LeIF B E E F D D K Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A A L D E T L L D E F Y I
E L D Q Q L N D L E V L C D Q E
LeIF C E E F D G N Q F Q K A Q A I
S V L H E M I Q Q T F N L F S T K
D S S A A W E Q S L L D K F S T
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16498680A | 1980-07-01 | 1980-07-01 | |
| US164986 | 1980-07-01 | ||
| US184909 | 1980-09-08 | ||
| US205578 | 1980-11-10 | ||
| US256204 | 1981-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60227694A JPS60227694A (ja) | 1985-11-12 |
| JPS6361920B2 true JPS6361920B2 (ja) | 1988-11-30 |
Family
ID=22596929
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56103123A Granted JPS5779897A (en) | 1980-07-01 | 1981-07-01 | Polypeptide containing amino acid arrangement of aged human corpuscle interferone |
| JP25393784A Granted JPS60221094A (ja) | 1980-07-01 | 1984-11-30 | çºçŸããã¯ã« |
| JP59253935A Granted JPS60227694A (ja) | 1980-07-01 | 1984-11-30 | ããæççœè¡çã€ã³ã¿ããšãã³ã®ã¢ããé žé åãå«ãããªããããã®è£œé æ¹æ³ |
| JP59253936A Granted JPS60221093A (ja) | 1980-07-01 | 1984-11-30 | ïœïœé å |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56103123A Granted JPS5779897A (en) | 1980-07-01 | 1981-07-01 | Polypeptide containing amino acid arrangement of aged human corpuscle interferone |
| JP25393784A Granted JPS60221094A (ja) | 1980-07-01 | 1984-11-30 | çºçŸããã¯ã« |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59253936A Granted JPS60221093A (ja) | 1980-07-01 | 1984-11-30 | ïœïœé å |
Country Status (3)
| Country | Link |
|---|---|
| JP (4) | JPS5779897A (ja) |
| MW (1) | MW2581A1 (ja) |
| ZA (1) | ZA814375B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582800A (en) * | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| WO1984001149A1 (en) * | 1982-09-22 | 1984-03-29 | Takeda Chemical Industries Ltd | Novel polypeptide and its use |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| GB8303383D0 (en) * | 1983-02-08 | 1983-03-16 | Biogen Nv | Sequences recombinant dna molecules |
| ATE89005T1 (de) * | 1985-02-05 | 1993-05-15 | Synergen Biolog Inc | Rekombinantes vektorsystem fuer metalloproteinase- inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren. |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| JPS62100292A (ja) * | 1985-10-28 | 1987-05-09 | Sumitomo Chem Co Ltd | ããã©ã¹ã»ããŠãªã³ã²ã³ã·ã¹ã»ã¢ã€ã¶ã¯ã€ïœïœïœæ ªã®æ®ºè«æ§èçœéºäŒå |
| JPS63242397A (ja) * | 1987-03-31 | 1988-10-07 | Kubota Ltd | å»æ°ŽåŠçæ¹æ³ |
| JPH0753113B2 (ja) * | 1987-05-21 | 1995-06-07 | 蟲æ¥çç©éºäŒåæ§é 解ææè¡ç 究çµå | ãã¥ãŠãªã¢ã¶ã€ã¯ãŠã€ã«ã¹ã®å€è¢«èçœè³ªãã³âãããéºäŒå |
| JPH0753114B2 (ja) * | 1987-07-06 | 1995-06-07 | 蟲æ¥çç©éºäŒåæ§é 解ææè¡ç 究çµå | ããŠãŠãªã¢ã¶ã€ã¯ãŠã€ã«ã¹ã®ïŒïœèçœè³ªãã³âãããéºäŒå |
| FR2825716B1 (fr) | 2001-06-11 | 2004-09-24 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'ifn alpha 7 |
-
1981
- 1981-06-26 ZA ZA814375A patent/ZA814375B/xx unknown
- 1981-06-30 MW MW2581A patent/MW2581A1/xx unknown
- 1981-07-01 JP JP56103123A patent/JPS5779897A/ja active Granted
-
1984
- 1984-11-30 JP JP25393784A patent/JPS60221094A/ja active Granted
- 1984-11-30 JP JP59253935A patent/JPS60227694A/ja active Granted
- 1984-11-30 JP JP59253936A patent/JPS60221093A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6361960B2 (ja) | 1988-11-30 |
| ZA814375B (en) | 1982-07-28 |
| JPS6363198B2 (ja) | 1988-12-06 |
| JPS60221093A (ja) | 1985-11-05 |
| JPS5779897A (en) | 1982-05-19 |
| JPS6363199B2 (ja) | 1988-12-06 |
| JPS60227694A (ja) | 1985-11-12 |
| MW2581A1 (en) | 1982-10-13 |
| JPS60221094A (ja) | 1985-11-05 |
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