JPS6346077B2 - - Google Patents

Info

Publication number
JPS6346077B2
JPS6346077B2 JP59157086A JP15708684A JPS6346077B2 JP S6346077 B2 JPS6346077 B2 JP S6346077B2 JP 59157086 A JP59157086 A JP 59157086A JP 15708684 A JP15708684 A JP 15708684A JP S6346077 B2 JPS6346077 B2 JP S6346077B2
Authority
JP
Japan
Prior art keywords
group
general formula
methyl
compound
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP59157086A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6054385A (ja
Inventor
Satsujingaa Geruharuto
Harutensutain Yohanesu
Manharuto Kaaru
Kurainsukurosu Yurugen
Heruman Manfuretsudo
Furitsutsusuki Edogaa
Tausukeru Horusutoodeietomaa
Wagunaa Berunto
Uorufu Gyuntaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of JPS6054385A publication Critical patent/JPS6054385A/ja
Publication of JPS6346077B2 publication Critical patent/JPS6346077B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
JP59157086A 1983-07-30 1984-07-27 ナフチリジノン誘導体およびその製法ならびに血管狭窄予防および治療剤としての使用 Granted JPS6054385A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3327650.1 1983-07-30
DE19833327650 DE3327650A1 (de) 1983-07-30 1983-07-30 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen

Publications (2)

Publication Number Publication Date
JPS6054385A JPS6054385A (ja) 1985-03-28
JPS6346077B2 true JPS6346077B2 (en, 2012) 1988-09-13

Family

ID=6205414

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59157086A Granted JPS6054385A (ja) 1983-07-30 1984-07-27 ナフチリジノン誘導体およびその製法ならびに血管狭窄予防および治療剤としての使用

Country Status (12)

Country Link
EP (1) EP0133530B1 (en, 2012)
JP (1) JPS6054385A (en, 2012)
AT (1) ATE41423T1 (en, 2012)
AU (1) AU3129984A (en, 2012)
DD (1) DD223151A5 (en, 2012)
DE (2) DE3327650A1 (en, 2012)
DK (1) DK369384A (en, 2012)
ES (1) ES8504800A1 (en, 2012)
FI (1) FI843005A7 (en, 2012)
GR (1) GR82225B (en, 2012)
HU (1) HUT34485A (en, 2012)
ZA (1) ZA845829B (en, 2012)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698341A (en) * 1983-07-30 1987-10-06 Godecke Aktiengesellschaft Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis
DE3502831A1 (de) * 1985-01-29 1986-07-31 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung
US4532247A (en) * 1983-08-08 1985-07-30 Sterling Drug Inc. 5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE3602655A1 (de) * 1985-01-29 1987-07-30 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
DE3605742A1 (de) * 1986-02-22 1987-08-27 Goedecke Ag Pyrrolo(3,4-b)pyridine, verfahren zu deren herstellung und deren verwendung
IT1229118B (it) * 1988-07-29 1991-07-22 Simes Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista
JPH0734202A (ja) * 1993-07-23 1995-02-03 Toshiba Corp 蒸気タービン用ロータ
US6499946B1 (en) 1999-10-21 2002-12-31 Kabushiki Kaisha Toshiba Steam turbine rotor and manufacturing method thereof
EP1307453A2 (en) * 2000-08-02 2003-05-07 Abbott Laboratories Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
JP4509664B2 (ja) 2003-07-30 2010-07-21 株式会社東芝 蒸気タービン発電設備
DE102006026585A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102006026583A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553291A (en) * 1978-10-17 1980-04-18 Nippon Kayaku Co Ltd Naphthylidine derivative and its preparation
HU183174B (en) * 1980-06-26 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 1,6-naphtirine derivatives
US4304914A (en) * 1980-07-07 1981-12-08 Usv Pharmaceutical Corporation Naphthyridone derivatives
EP0059291B1 (en) * 1981-02-27 1985-03-27 American Home Products Corporation Antihypertensive agents

Also Published As

Publication number Publication date
ATE41423T1 (de) 1989-04-15
DK369384D0 (da) 1984-07-27
EP0133530A3 (en) 1987-12-23
ES534685A0 (es) 1985-05-01
DD223151A5 (de) 1985-06-05
FI843005A0 (fi) 1984-07-27
GR82225B (en, 2012) 1984-12-13
ZA845829B (en) 1985-03-27
EP0133530A2 (de) 1985-02-27
DE3477195D1 (en) 1989-04-20
FI843005L (fi) 1985-01-31
DE3327650A1 (de) 1985-02-14
JPS6054385A (ja) 1985-03-28
EP0133530B1 (de) 1989-03-15
AU3129984A (en) 1985-01-31
HUT34485A (en) 1985-03-28
DK369384A (da) 1985-01-31
ES8504800A1 (es) 1985-05-01
FI843005A7 (fi) 1985-01-31

Similar Documents

Publication Publication Date Title
AU715879B2 (en) 2(1H)-quinolone derivatives as serotonin antagonists
JPS6346077B2 (en, 2012)
FR2511247A1 (fr) Dihydropyridines ayant une action positivement inotrope, leur utilisation comme medicaments et un procede pour leur preparation
DD161210A5 (de) Verfahren zur herstellung neuer 3-substituierter beta-carboline
SU1644718A3 (ru) Способ получени производных пиразоло[3,4- @ ]хинолина или пиридо [2,3- @ ]хиназолина или их солей
PL140573B1 (en) Method of obtaining new dihydropyridine derivatives
DK164594B (da) 1,4-dihydro-pyridin-3,5-yl-dicarboxylsyrederivater, farmaceutiske praeparater indeholdende disse derivater samt fremgangsmaade til fremstilling deraf
CS241549B2 (en) Method of 1,4-dihydropyridines production
JPH0311067A (ja) 興奮性アミノ酸拮抗剤
US4698341A (en) Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis
JPS5965089A (ja) ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法
KR930005175B1 (ko) 4,7-디히드로티에노 [2,3-b] 피리딘 유도체의 제조방법
US4446323A (en) Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives
DE3431303C2 (en, 2012)
IE852085L (en) 1,6-naphthyridine derivatives
KR950014868B1 (ko) 치환된 티아시클로알케노[3,2-b]피리딘, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US4677108A (en) 4-oxo-pyrido[2,3-d]pyrimidinone derivatives
RU2057754C1 (ru) Гетероциклические соединения или их кислотно-аддитивные соли
NZ220022A (en) 1,4-dihydropyridine derivatives and pharmaceutical compositions
US4681885A (en) 5-oxo-pyrido[4,3-]pyrimidine derivatives
NO164596B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinderivater.
EP0189898A1 (de) 1,6-Naphthyridinon-Derivate und Verfahren zu deren Herstellung
DE3017564A1 (de) Geminale dihalogenderivate kondensierter pyrimidin-4-on-verbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische kompositionen
KR930009011B1 (ko) 9-(치환된 티오)-4H-피리도[1,2-a]피리미딘-4-온 유도체의 제조방법
IE66677B1 (en) New Diaryl Compounds