ZA845829B - 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases - Google Patents

1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases

Info

Publication number
ZA845829B
ZA845829B ZA845829A ZA845829A ZA845829B ZA 845829 B ZA845829 B ZA 845829B ZA 845829 A ZA845829 A ZA 845829A ZA 845829 A ZA845829 A ZA 845829A ZA 845829 B ZA845829 B ZA 845829B
Authority
ZA
South Africa
Prior art keywords
general formula
group
alkyl
see diagramm
groups
Prior art date
Application number
ZA845829A
Inventor
Gerhard Satzinger
Johannes Hartenstein
Karl Mannhardt
Juergen Kleinschroth
Manfred Herrmann
Edgar Fritschi
Horst-Dietmar Tauschel
Bernd Wagner
Guenter Wolf
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of ZA845829B publication Critical patent/ZA845829B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) Naphthyridinone derivatives of the general formula I see diagramm : EP0133530,P12,F4 wherein R**1 is a phenyl radical, which in 2- and/or 3-position may be substituted by halogen atoms, such as fluorine, chlorine or bromine, by nitro, trifluoromethyl, methoxy, difluoromethoxy, or cyano groups or lower alkylamino groups, preferably dimethylamino groups or diethylamino groups, or represents an unsubstituted pyridyl or thienyl radical, R**2 is hydrogen, an alkyl or alkylaminoalkyl group of the general formula II see diagramm : EP0133530,P13,F1 wherein R**5 and R**6 may be the same or different and represent a straight-chained or branched alkyl group with 1-4 C-atoms or represent together an alkylene group with 4-6 C-atoms, n represents the figure 2 or 3, R**3 is an amino group or a methyl or ethyl group and R**4 represents hydrogen or a straight-chained, branched or cyclic alkyl or alkoxyalkyl radical containing up to 6 carbon atoms, as well as optionally the pharmacologically safe salts thereof. 1. Claim (for the Contracting State AT) Process for the preparation of 1,6-naphthyridinone-derivatives of the general formula I see diagramm : EP0133530,P14,F4 wherein R**1 is a phenyl radical, which in 2- and/or 3-position may be substituted by halogen atoms, such as fluorine, chlorine or bromine, by nitro, trifluoromethyl, methoxy, difluoromethoxy, or cyano groups or lower alkylamino groups, preferably dimethylamino groups or diethylamino groups, or represents an unsubstituted pyridyl or thienyl radical, R**2 is hydrogen, an alkyl or alkylaminoalkyl group of the general formula II see diagramm : EP0133530,P15,F1 wherein R**5 and R**6 may be the same or different and represent a straight-chained or branched alkyl group with 1-4 C-atoms or represent together an alkylene group with 4-6 C-atoms, n represents the figure 2 or 3, R**3 is an amino group or a methyl or ethyl group and R**4 represents hydrogen or a straight-chained, branched or cyclic alkyl or alkoxyalkyl radical containing up to 6 carbon atoms, as well as optionally the pharmacologically safe salts thereof, characterized in that either a) 2,4-dihydroxypyridine is reacted in the presence of ammonia with a compound of the general formula III see diagramm : EP0133530,P15,F2 wherein R**1 , R**3 and R**4 have the aforementioned meaning, and the compounds so obtained of the general formula IV see diagramm : EP0133530,P15,F3 wherein R**1 , R**3 and R**4 have the aforementioned meaning, are reacted, if desired, in a manner known per se with a compound of the general formula V X-R**2 , wherein R**2 represents an alkyl or alkoxyalkyl group or an alkylamino alkyl group of the general formula II and X represents a halogen atom or b) a 1,4-dihydropyridine of the general formula see diagramm : EP0133530,P15,F4 wherein R**1 , R**3 and R**4 have the aforementioned meaning and R**7 represents an alkyl radical containing 1-4 carbon atoms, is reacted with s-triazine in the presence of a base and the compound obtained of the general formula IV is, if desired, subsequently alkylated or amino-alkylated with a compound of the general formula V or c) a 1,4-dihydropyridine of the general formula VI is reacted with a dialkylformamide-dialkyl acetal of the general formula VII see diagramm : EP0133530,P15,F5 wherein R**8 may be the same or different and represent a methyl or ethyl group and the radicals R**9 represent alkyl groups containing up to 4 carbon atoms or represent together an alkylene group containing up to 3 carbon atoms and the compound obtained of the general formula VIII see diagramm : EP0133530,P15,F6 wherein R**1 , R**3 , R**4 and R**8 have to aforementioned meaning, is converted into a compound of the general formula IV by means of ammonia, alkylating or amino-alkylating it, if desired, with a compound of the general formula V and converting the compounds obtained of the general formula I into their pharmacologically acceptable salts, optionally by reaction with organic or inorganic acids.
ZA845829A 1983-07-30 1984-07-27 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases ZA845829B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833327650 DE3327650A1 (en) 1983-07-30 1983-07-30 1,6-NAPHTHYRIDINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST VASCULAR DISEASES

Publications (1)

Publication Number Publication Date
ZA845829B true ZA845829B (en) 1985-03-27

Family

ID=6205414

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA845829A ZA845829B (en) 1983-07-30 1984-07-27 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases

Country Status (12)

Country Link
EP (1) EP0133530B1 (en)
JP (1) JPS6054385A (en)
AT (1) ATE41423T1 (en)
AU (1) AU3129984A (en)
DD (1) DD223151A5 (en)
DE (2) DE3327650A1 (en)
DK (1) DK369384A (en)
ES (1) ES8504800A1 (en)
FI (1) FI843005A (en)
GR (1) GR82225B (en)
HU (1) HUT34485A (en)
ZA (1) ZA845829B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502831A1 (en) * 1985-01-29 1986-07-31 Gödecke AG, 1000 Berlin 1,6-NAPHTHYRIDINONE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
US4698341A (en) * 1983-07-30 1987-10-06 Godecke Aktiengesellschaft Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis
US4532247A (en) * 1983-08-08 1985-07-30 Sterling Drug Inc. 5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3602655A1 (en) * 1985-01-29 1987-07-30 Goedecke Ag 1,6-Naphthyridine derivatives, process for their preparation, and their use
DE3431303A1 (en) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-Naphthyridine derivatives, process for their preparation and their use
IT1201454B (en) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-dihydropyridine-2-SUBSTITUTED
DE3605742A1 (en) * 1986-02-22 1987-08-27 Goedecke Ag PYRROLO (3,4-B) PYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF
IT1229118B (en) * 1988-07-29 1991-07-22 Simes ACTIVE COMPOUNDS ON THE CARDIOVASCULAR SYSTEM THAT PRESENT BOTH THE STRUCTURE OF BETA-LOCKERS AND A FOOTBALL-ANTAGONIST PORTION
JPH0734202A (en) * 1993-07-23 1995-02-03 Toshiba Corp Steam turbine rotor
FR2800124B1 (en) 1999-10-21 2004-03-19 Toshiba Kk ROTOR COMBINED STEAM TURBINE
EP1307453A2 (en) * 2000-08-02 2003-05-07 Abbott Laboratories Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
JP4509664B2 (en) 2003-07-30 2010-07-21 株式会社東芝 Steam turbine power generation equipment
DE102006026583A1 (en) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituted hetero-bicyclic compounds and their use
DE102006026585A1 (en) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and their use
DE102007009494A1 (en) 2007-02-27 2008-08-28 Bayer Healthcare Ag New 1,6-naphthyridine or 8-azaquinazoline derivatives useful for treating aldosteronism, hypertension, cardiac insufficiency, myocardial infarct sequelae, liver cirrhosis, renal insufficiency and stroke

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553291A (en) * 1978-10-17 1980-04-18 Nippon Kayaku Co Ltd Naphthylidine derivative and its preparation
HU183174B (en) * 1980-06-26 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 1,6-naphtirine derivatives
US4304914A (en) * 1980-07-07 1981-12-08 Usv Pharmaceutical Corporation Naphthyridone derivatives
DE3169626D1 (en) * 1981-02-27 1985-05-02 American Home Prod Antihypertensive agents

Also Published As

Publication number Publication date
DE3327650A1 (en) 1985-02-14
ES534685A0 (en) 1985-05-01
ATE41423T1 (en) 1989-04-15
DK369384A (en) 1985-01-31
ES8504800A1 (en) 1985-05-01
JPS6346077B2 (en) 1988-09-13
JPS6054385A (en) 1985-03-28
DD223151A5 (en) 1985-06-05
FI843005A0 (en) 1984-07-27
DK369384D0 (en) 1984-07-27
AU3129984A (en) 1985-01-31
FI843005A (en) 1985-01-31
DE3477195D1 (en) 1989-04-20
EP0133530B1 (en) 1989-03-15
EP0133530A3 (en) 1987-12-23
GR82225B (en) 1984-12-13
HUT34485A (en) 1985-03-28
EP0133530A2 (en) 1985-02-27

Similar Documents

Publication Publication Date Title
ZA845829B (en) 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases
ATE123771T1 (en) NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE.
MY104376A (en) N-imidazolyl deravatives of bicyclic compounds and process for their preparation.
PL317726A1 (en) Novel compounds, methods of obtaining them and antineoplastic agents
ES2176311T3 (en) NEW IMIDAZOL DERIVATIVES AND PROCEDURE FOR PREPARATION.
PL250215A1 (en) Method of obtaining new dihydropyridine derivatives
EP0135975A3 (en) Quinazoline and isoquinoline derivatives
GR3003776T3 (en)
KR960009263B1 (en) Process of producing sulfonylurea derivatives
HUT37756A (en) Process for preparing 1,4-dihydro-pyridina derivatives
HU900402D0 (en) Process for producing imidazolyl - and pyridyl- derivatives of phenyl-substituted 1,4-dihydro-pyridines
IL117414A0 (en) 4-alkylthio-pyrimidin- 5-ylacetic acid derivatives their preparation and their use as fungicides
DE3468101D1 (en) Process for the preparation of cyclopropane derivatives
DE68926016D1 (en) Halogeno-4-methylpyrazoles and process for their preparation
JPS55143988A (en) Preparation of thienodiazepin-2-one derivative containing novel diamine derivative and novel diazepin derivative
DE3669157D1 (en) ALPHA-ALLYLATED ARYLALKYLTRIAZOLES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES.