JPS63284109A - Beautifying cosmetic - Google Patents

Abstract

PURPOSE:To obtain a beautifying agent eliminating or preventing blackening of skin by ultraviolet rays, stain or freckle, containing a liberated fatty acid having limited numbers of carbons and unsaturated bonds, a salt thereof or an ester with an alcohol as an active ingredient. CONSTITUTION:A beautifying cosmetic containing 0.1-10wt.% fatty acid (e.g. linoleic acid, gamma-linolenic acid, arachidonic acid or eicosapentaenoic acid) having 18-22C and two or more unsaturated bonds in the molecular structure, salt (e.g. Na salt, arginine salt or triethanolamine salt) or ester (e.g. methyl ester). The cosmetic can eliminate or prevent blackening of skin by ultraviolet rays, skin chromatosis such as stain or freckle and can show excellent beautifying effects without causing side effects. The purified liberated fatty acid of raw material is preferably used.

Description

[Detailed description of the invention] East! TECHNICAL FIELD The present invention relates to whitening cosmetics that contain specific fatty acids or derivatives thereof in a cosmetic base to eliminate or prevent darkening of the skin or skin pigmentation such as spots and freckles caused by ultraviolet rays.

Conventional Techniques and Problems Conventionally, whitening cosmetic compositions containing vitamin C and its derivatives, reducing agents, and tyrosinase activity inhibitors such as placenta extract are known. However, these conventional whitening cosmetics are in vitro using cultured cells.
Although TRO's experiment shows that it has an effect of inhibiting melanin production, when it is actually applied to the skin, it has not been able to sufficiently eliminate or prevent pigmentation.

An object of the present invention is to provide a cosmetic that exhibits excellent whitening effects without side effects when actually applied to the skin.

Means for Solving the Problems As a result of extensive research to achieve the above object, the present inventors have found that certain fatty acids and their derivatives have an excellent effect on eliminating or preventing skin pigmentation. This discovery led to the completion of the present invention.

In other words, the present invention is based on the number of carbon atoms! The present invention provides a whitening cosmetic containing as an active ingredient a free fatty acid having 8 to 22 unsaturations and 2 or more unsaturations in its molecular structure, a salt thereof, or an ester with a monohydric or dihydric alcohol.

The fatty acids having 18 to 22 carbon atoms and having 2 or more unsaturations in the molecular structure, such as linoleic acid and γ-lylunic acid, which are blended into the composition of the present invention, are contained in vegetable oils and animal fats. . However, these fatty acids rarely exist in a free state, and most of them exist in the form of triglycerides.

Such triglycerides, unlike free fatty acids or their alkyl esters, have not been found to have an excellent pigmentation suppressing effect in animal tests.

Similarly, saturated fatty acids such as valmitic acid and stearic acid do not have the same effect on suppressing pigmentation, and in some cases may even promote melanin production. Since such saturated fatty acids are contained in large amounts in vegetable oils and animal fats, they can be used in the cosmetics of the present invention.

When blending linoleic acid, etc., it is preferable to use purified linoleic acid.

Typical free fatty acids with 18 to 22 carbon atoms and 2 or more unsaturations in the molecular structure that are blended into the whitening cosmetics of the present invention include linoleic acid, linoleaidic acid, α-lilunic acid, and γ-linoleic acid. -lyllunic acid, dihomo-γ-lyllunic acid, arachidonic acid, eicosapencitric acid, etc., and one or more of these may be used.

In addition, as salts of these free fatty acids, sodium salts,
Examples include metal salts such as potassium salts, amino acid salts such as arginine salts and lysine salts, and amine salts such as triethanolamine salts and monoethanolamine salts.

Furthermore, as the alkyl ester of the free fatty acid,
Esters with m alcohols such as methanol, ethanol, isopropyl alcohol, ethylene glycol,
Examples include esters with dihydric alcohols such as propylene glycol and 1,3-butylene glycol.

The amount of these free fatty acids, salts, or esters in cosmetics is preferably 0.1 to 10% by weight. If the amount is less than 0.1% by weight, there will be no effect of suppressing pigmentation, while if it exceeds 10% by weight, it will be highly irritating.

Next, the results of evaluating the pigmentation suppressing effects of various active ingredients are shown.

Test method: The back of an English brown guinea pig was pricked with hair and irradiated with ultraviolet light (UV8 intensity: IJ/cm).

This operation was repeated for 3 days, during which time a sample prepared by dissolving fatty acids such as linoleic acid or other components in ethanol at 1 (w/v)% was applied to the ultraviolet irradiated area.

After standing for 10 days, the degree of pigmentation was visually judged according to the criteria shown below.

Judgment criteria d - No pigmentation ± Slight pigmentation Soil, moderate pigmentation +10 Intense pigmentation The results are shown in Table 1 below.

Table 1 Ethanol ++
Linoleic acid 1 -Linoleic acid sodium salt l -Methyl linoleate l -Ethyl linoleate 1 -Isopropyl linoleate l -γ-Lilunic acid
1 -α-lylunic acid 1
-Arachidonic acid l
-Palmitic acid 1
++Stearic acid 1
++Oleic acid 1
++Linoleic acid triglyceride l
+Ryrunic acid triglyceride 1
+Safflower oil 1
++ Linseed oil 1
++ Vitamin C! ++ Placenta extract l ++
Linoleic acid 0.01 +
+linoleic acid 0.1
±Linoleic acid 1 -Linoleic acid 10 -As is clear from Table 1, the number of carbons! When a free fatty acid, its salt, or alkyl ester with a molecular structure of 8 to 22 and 2 or more unsaturations is blended, an inhibitory effect on pigmentation is observed. Fatty acids have no such effect.

The whitening cosmetic of the present invention is manufactured in the form of lotion, cosmetic oil, cream, milky lotion, pack, powder, etc. by a known method.

Further, the cosmetic composition of the present invention may contain any known ingredients as appropriate, depending on the type thereof, within a range that does not impair performance.

Note that conventionally used melanin production inhibitors (vitamin C1 placenta extract), ultraviolet absorbers, ultraviolet scattering agents, anti-inflammatory agents, antioxidants, and the like may be added.

Kantaneho Next, the present invention will be explained in more detail with reference to Examples.

Example 1 (Lotion) Ingredients Formula! (Weight%) Linoleic acid 0゜5 Glycerin 6.0 Ethanol
8.0 Polyoxyethylene hydrogenated castor oil 0.8 Methyl paraoxybenzoate
0.05 citric acid
0.05 Sodium citrate 0.
07 Fragrance 0.1 Water-soluble placenta extract 2.0 Purified water
Dissolve glycerin, citric acid, sodium citrate, and water-soluble placenta extract in the remaining purified water. Separately, linoleic acid, polyoxyethylene hydrogenated castor oil (60E, O,), methylparaben, and fragrance were dissolved in ethanol, added to the purified aqueous solution, solubilized, and filtered to obtain a lotion.

Example 2 (cosmetic oil) Ingredients Amount (wt%)
) Ethyl linoleate 1.0 Ascorbyl palmitate 0.2 Retinol acetate 0.3 Cholesteryl stearate 1.0 Olive oil
2.0 squalane
A cosmetic oil was obtained by uniformly dissolving other ingredients in the remaining squalane.

Example 3 (cream) Ingredients Amount (wt%)
Component (A) γ-Lilunic acid 2.0 Ascorbyl stearate 1.0 Acetic acid dJ2-
α-tocopherol 0.2 white beeswax
4.0 cetanol
2.0 stearic acid
1.0 Isopropyl myristate
5.0 lanolin
2.0 Liquid paraffin 9.0
Self-emulsifying glyceryl monostearate 3.0 Polyoxyethylene sorbitan monostearate (20E, O,) 1.
5 Propyl paraoxybenzoate 0.1 Ingredient (B) Methyl paraoxybenzoate 0.2 Propylene glycol 5.0 Fragrance
0.2 component (A) is heated and dissolved and maintained at 80°C.

Separately, component (B) excluding perfume is dissolved by heating and maintained at 80° C., and component (A) is added to this with stirring and mixed thoroughly. The mixture was further cooled while stirring, a flavoring agent was added, and the mixture was further cooled to obtain a cream.

Example 4 (Emulsion) Component (A) Isopropyl linoleate 2.0 Stearyl glycyrrhetinate 0.1 Liquid paraffin
5.0 Vaseline
2,0 beeswax 1
．． 0 Sorbitan sesquioleate 2,0 Ingredients Σ Ethyl paraoxybenzoate 0.2 Propylene glycol 5.0 Carboxyvinyl polymer 0.5 Potassium hydroxide
0.5 fragrance 0.2
Purified ice remaining component (A)
The mixture is heated and dissolved at 80°C, and added to component (B) other than the fragrance, which was separately heated (80°C) and dissolved, with stirring, and thoroughly mixed. Next, the mixture was cooled while stirring, perfume was added, and the mixture was further cooled to obtain a milky lotion.

Example 5 (Pack) Ingredients Amount (wt%) Linoleic acid 380 Water-soluble placenta extract 2.0 Vinyl acetate-styrene copolymer 10.0 Polyvinyl alcohol 1
0.0 Sorbit 5.0 Titanium oxide 8.0 Kaolin
7.0 ethanol
5.0 fragrance
2.0 Ethyl paraoxybenzoate 0.2 Uniformly dissolve linoleic acid, fragrance and ethanol. This is added to a uniform mixture of vinyl acetate/styrene copolymer, polyvinylalconyl, sorbitol, titanium oxide, and kaolin.

To this, a solution in which water-soluble placenta extract and ethyl paraoxybenzoate were uniformly dissolved in purified water was added and mixed uniformly to obtain a pack.

Example 6 (powder) Ingredients Amount (wt%) Linoleic acid 2.0 Dextrin
95.0 talc 2.0
Decaglyceryl Stearate 1.0 Linoleic acid and decaglyceryl stearate were heated and dissolved, maintained at 70°C, and gradually added to a mixture of dextrin and talc with stirring to obtain a powder.

"Reward" Δ class result

Claims (2)

[Claims] (1) 18 to 22 carbon atoms and 2 unsaturations in the molecular structure
A whitening cosmetic containing the above free fatty acids, their salts, or esters with monohydric or dihydric alcohols as active ingredients. (2) The amount of the active ingredient added to the entire composition is 0.
The whitening cosmetic according to item (1) above, which contains 1 to 10% by weight.