JPH0193520A - Beautifying and whitening cosmetic - Google Patents
Beautifying and whitening cosmeticInfo
- Publication number
- JPH0193520A JPH0193520A JP25037487A JP25037487A JPH0193520A JP H0193520 A JPH0193520 A JP H0193520A JP 25037487 A JP25037487 A JP 25037487A JP 25037487 A JP25037487 A JP 25037487A JP H0193520 A JPH0193520 A JP H0193520A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- acetate
- vitamin
- cosmetic
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 20
- 230000002087 whitening effect Effects 0.000 title claims abstract description 12
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 20
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 19
- 235000021588 free fatty acids Nutrition 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 150000002148 esters Chemical class 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 17
- 239000000203 mixture Substances 0.000 abstract description 13
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract description 10
- 239000004615 ingredient Substances 0.000 abstract description 9
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 4
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract description 2
- OYHQOLUKZRVURQ-AVQMFFATSA-N linoelaidic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-AVQMFFATSA-N 0.000 abstract description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229960004488 linolenic acid Drugs 0.000 abstract 1
- 230000000485 pigmenting effect Effects 0.000 abstract 1
- 208000012641 Pigmentation disease Diseases 0.000 description 19
- 230000019612 pigmentation Effects 0.000 description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- -1 amino acid salts Chemical class 0.000 description 8
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 7
- 235000020778 linoleic acid Nutrition 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 210000002826 placenta Anatomy 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 125000005907 alkyl ester group Chemical group 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000008099 melanin synthesis Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 description 2
- 229940031016 ethyl linoleate Drugs 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 description 1
- 239000004261 Ascorbyl stearate Substances 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 235000019276 ascorbyl stearate Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- XHRPOTDGOASDJS-UHFFFAOYSA-N cholesterol n-octadecanoate Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCCCCCCCCCCC)C2 XHRPOTDGOASDJS-UHFFFAOYSA-N 0.000 description 1
- XHRPOTDGOASDJS-XNTGVSEISA-N cholesteryl stearate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)C1 XHRPOTDGOASDJS-XNTGVSEISA-N 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- XEIOPEQGDSYOIH-MURFETPASA-N propan-2-yl (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC(C)C XEIOPEQGDSYOIH-MURFETPASA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 239000002602 strong irritant Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
産業上の利用分野
本発明は、紫外線による皮膚の黒化あるいはシミ、ソバ
カスなどの皮膚の色素沈着を消失、淡色化もしくは予防
する美白化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a whitening cosmetic that eliminates, lightens, or prevents skin darkening caused by ultraviolet rays, or skin pigmentation such as spots and freckles.
従来の技術および町4a
従来、美白化粧料組成物としてはビタミンCおよびその
誘導体、あるいは還元剤、胎盤エキスなどのチロシナー
ゼ活性阻害剤を配合したものが知られている。しかしな
がら、これら従来の美白化粧料は培養細胞によるin
vitroの実験ではメラニン産生抑制作用などを示す
ものの、実際に皮膚に適用した場合、充分な色素沈着の
消失もしくは淡色化などの効果は得られていない。Prior Art and Town 4a Conventionally, whitening cosmetic compositions containing vitamin C and its derivatives, reducing agents, and tyrosinase activity inhibitors such as placenta extract are known. However, these conventional whitening cosmetics are made using cultured cells.
Although it has been shown to inhibit melanin production in vitro experiments, when it is actually applied to the skin, it has not been able to sufficiently eliminate pigmentation or lighten the skin.
本発明は実際に皮膚に適用した場合、副作用がなく優れ
た美白効果を奏しうる化粧料を提供することを目的とす
る。An object of the present invention is to provide a cosmetic that exhibits excellent whitening effects without side effects when actually applied to the skin.
問題点を解決するための手段
本発明者らは、前記目的を達成すべく鋭意研究を重ねた
結果、特定の脂肪酸またはその誘導体にさらにビタミン
E酢酸エステルを組み合わせることにより皮膚の色素沈
着の消失、もしくは淡色化に優れた相乗的な効果があら
れれることを見いだし、本発明を完成するに至った。Means for Solving the Problems As a result of extensive research to achieve the above object, the present inventors have found that by combining a specific fatty acid or its derivative with vitamin E acetate, the skin pigmentation disappears. Alternatively, the present inventors have discovered that a synergistic effect excellent in lightening the color can be achieved, and have completed the present invention.
すなわち本発明は、
(、L)ビタミンE酢酸エステル、および(b)炭素数
18〜22かつ分子構造中の不飽和結合数が2以上の遊
離脂肪酸、その塩、あるいは一価または二価アルコール
とのエステルを配合したことを特徴とする美白化粧料を
提供するものである。That is, the present invention comprises (L) vitamin E acetate, and (b) a free fatty acid having 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure, a salt thereof, or a monohydric or dihydric alcohol. The object of the present invention is to provide a whitening cosmetic characterized by containing an ester of.
本発明組成物に配合されるビタミンE酢酸エステルは、
従来血行増進剤として公知の油溶性物質であるが、他の
活性成分と組み合わせて皮膚に対し相乗的な美白効果を
示すことについては知られていない。The vitamin E acetate blended into the composition of the present invention is
Although it is an oil-soluble substance that is conventionally known as a blood circulation enhancer, it is not known that it exhibits a synergistic whitening effect on the skin when combined with other active ingredients.
ビタミンE酢酸エステルの化粧料組成物中における配合
mは0.1〜10重量%であるのが好ましい。The content m of vitamin E acetate in the cosmetic composition is preferably 0.1 to 10% by weight.
一方、本発明組成物に配合されるリノール酸、γ−リル
ン酸など炭素数18〜22を有し、かつ分子構造中の不
飽和結合数が2以上の脂肪酸は、植物油脂および動物油
脂に含まれている。しかし、これら脂肪酸は遊離の状態
で存在することは少なく、そのほとんどはトリグリセリ
ドの状態で存在する。このようなトリグリセリドは、遊
離の脂肪酸もしくはそのアルキルエステルのごとく動物
試験等において優れた色素沈着淡色化作用は認められな
い。また、パルミチン酸、ステアリン酸などの飽和脂肪
酸にあっても同様に色素沈着抑制効果は認められず、場
合によっては逆にメラニン産生を先進する。かかる飽和
脂肪酸は、植物油脂お上・び動物油脂に多量にふくまれ
ているため、本発明化粧料におけるリノール酸などの配
合にあたっては精製したものを用いることが好ましい。On the other hand, fatty acids having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in the molecular structure, such as linoleic acid and γ-lylunic acid, which are blended into the composition of the present invention, are contained in vegetable oils and animal fats. It is. However, these fatty acids rarely exist in a free state, and most of them exist in the form of triglycerides. Such triglycerides, unlike free fatty acids or their alkyl esters, have not been shown to have excellent pigmentation and lightening effects in animal tests. Similarly, saturated fatty acids such as palmitic acid and stearic acid do not have the same effect on suppressing pigmentation, and in some cases may even promote melanin production. Since such saturated fatty acids are contained in large amounts in vegetable oils, animal fats and oils, it is preferable to use purified fatty acids when blending linoleic acid and the like in the cosmetic composition of the present invention.
本発明の美白化粧料に配合される炭素数18〜22かつ
分子構造中の不飽和結合数が2以上の遊離脂肪酸の代表
的なものとしては、リノール酸、リノエライジン酸、α
−リルン酸、γ−リルン酸、ジホモ−γ−リルン酸、ア
ラキドン酸、エイコサペンタエン酸などが挙げられ、こ
れらの1種また2種以上が用いられる。Typical free fatty acids with 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure that are incorporated into the whitening cosmetics of the present invention include linoleic acid, linoleaidic acid, α
-lyllunic acid, γ-lyllunic acid, dihomo-γ-lyllunic acid, arachidonic acid, eicosapentaenoic acid, etc., and one or more of these may be used.
また、これら遊離脂肪酸の塩としては、ナトリウム塩、
カリウム塩などの金属塩、アルギニン塩、リジン塩など
のアミノ酸塩、トリエタノールアミン塩、モノエタノー
ルアミン塩等のアミン塩などが挙げられる。In addition, as salts of these free fatty acids, sodium salts,
Examples include metal salts such as potassium salts, amino acid salts such as arginine salts and lysine salts, and amine salts such as triethanolamine salts and monoethanolamine salts.
さらに、前記遊離脂肪酸のアルキルエステルとしては、
メタノール、エタノール、イソプロピルアルコールなど
の一価アルコールとのエステル、エヂレングリコール、
プロピレングリコール、1.3−ブチレングリコールな
どの二価のアルコールとのエステルなどが挙げられる。Furthermore, as the alkyl ester of the free fatty acid,
Esters with monohydric alcohols such as methanol, ethanol, isopropyl alcohol, ethylene glycol,
Examples include esters with dihydric alcohols such as propylene glycol and 1,3-butylene glycol.
これら遊離脂肪酸、塩、またはエステルの化粧料中にお
ける配合量は、0.1〜10重量%であるのが好ましい
。かかる配合量が、0.1重量%未満であると、色素沈
着の淡色化効果がなく、−方、10重量%を越えると、
刺激性が強い。The content of these free fatty acids, salts, or esters in cosmetics is preferably 0.1 to 10% by weight. If the amount is less than 0.1% by weight, there is no effect of lightening the pigmentation, while if it exceeds 10% by weight,
Strong irritant.
つぎに各種活性成分についてその色素沈着の消失もしく
は淡色化の作用を評価した結果を示す。 試験方法;
English系茶色モルモットの背部を刺毛して紫外
線(UV8強度:IJ/cm”)を照射し、1週間後に
色素沈着を得た。つぎに、この部位にビタミンE酢酸エ
ステル、リノール酸をはじめとする成分をエタノールに
溶解した検体を4週間累積塗布した。色素沈着の淡色化
を評価する方法として、検体を塗布していない部位(無
塗布)の色素沈着度をOとし、その淡色化の度合いによ
り、以下に示す判定基準に従い、色素沈着度を肉眼判定
した。Next, the results of evaluating various active ingredients for their pigmentation disappearing or lightening effects are shown. Test method: The back of an English brown guinea pig was pricked and irradiated with ultraviolet rays (UV8 intensity: IJ/cm"), and pigmentation was obtained one week later. Next, vitamin E acetate and linoleic acid were applied to this area. A sample prepared by dissolving ingredients such as According to the degree of pigmentation, the degree of pigmentation was visually judged according to the criteria shown below.
判定基準;
0 色素沈着の淡色化が認められない
−1わずかに色素沈着の淡色化が認められる−2 中等
度の色素沈着の淡色化が認められる−3 顕著な色素沈
着の淡色化が認められる結果を次の第1表および第2表
に示す。Judgment criteria: 0 No lightening of pigmentation is observed - 1 Slight lightening of pigmentation is observed - 2 Moderate lightening of pigmentation is observed - 3 Significant lightening of pigmentation is observed The results are shown in Tables 1 and 2 below.
第 1 表 (2週間塗布後の色素沈着度)酢酸エステ
ル 0.1 0 −リノール酸
0.5 −1 −2リノエライジン
酸 〃0−1
γ−リルン酸 〃−1−2
アラキドン酸 〃0−1
α−リルン酸 〃−1−2
エイコサ
ペンクエン酸 〃0−l
ドコサ
ヘキサエン酸 〃0−1
リノール酸エチル 〃0−1
第 2 表 (4週間塗布後の色素沈着度)酢酸エステ
ル 0.1 0 −リノール酸
0.5 −2 −3リノエライジ
ン酸 〃−1−3
7−リルン酸 〃−2−3
アラキドン酸 −2−3α−リルン酸
〃−2−3
リノール酸エチル 〃−1−3
第1表および第2表より明らかなごとく、ビタミンE酢
酸エステル単独では色素沈着の淡色化は認められず、ま
た炭素数18〜22かつ分子構造中の不飽和結合数が2
以上の遊離脂肪酸、その塩あるいはアルキルエステルを
単独で配合した場合は、色素沈着の淡色化はわずかであ
る。これらに対して、ビタミンE酢酸エステルと前記脂
肪酸あるいはその誘導体を併用した場合は、顕著な色素
沈着の淡色化が認められる。Table 1 (Degree of pigmentation after 2 weeks of application) Acetate ester 0.1 0-Linoleic acid
0.5 -1 -2 Linoelaidic acid 〃0-1 γ-Lilunic acid 〃-1-2 Arachidonic acid 〃0-1 α-Lilunic acid 〃-1-2 Eicosapencitric acid 〃0-l Docosahexaenoic acid 〃 0-1 Ethyl linoleate 〃0-1 Table 2 (Degree of pigmentation after 4 weeks of application) Acetate ester 0.1 0-linoleic acid
Table 1 and As is clear from Table 2, no lightening of pigmentation was observed when using vitamin E acetate alone, and the number of unsaturated bonds in the molecular structure was 18-22 and 2.
When the above free fatty acids, their salts, or alkyl esters are blended alone, the pigmentation becomes slightly lighter. On the other hand, when vitamin E acetate and the aforementioned fatty acids or derivatives thereof are used in combination, a remarkable lightening of the pigmentation is observed.
本発明の美白化粧料は、公知の方法により、化粧水、化
粧用油、クリーム、乳液、バック、パウダーなどの形態
に製造される。The whitening cosmetic of the present invention is manufactured in the form of lotion, cosmetic oil, cream, milky lotion, bag, powder, etc. by a known method.
さらに本発明の化粧料には、その種類に応じ性能を損な
わない範囲において、適宜公知の成分を配合することが
できる。Further, the cosmetic composition of the present invention may contain any known ingredients as appropriate, depending on the type thereof, within a range that does not impair performance.
なお、従来から使用されているメラニン産生抑制剤(ビ
タミンC1胎盤抽出物)、紫外線吸収剤、紫外線散乱剤
、抗炎症剤、抗酸化剤などを配合しても良い。Note that conventionally used melanin production inhibitors (vitamin C1 placenta extract), ultraviolet absorbers, ultraviolet scattering agents, anti-inflammatory agents, antioxidants, and the like may be added.
実施例 つぎに本発明を実施例によりさらに具体的に説明する。Example Next, the present invention will be explained in more detail with reference to Examples.
実施例!(化粧水)
成 分 配合量(重量%)ビタ
ミンE酢酸エステル 0.1リノール酸
0.5グリセリン
6・0エタノール
8.0ポリオキシエチレン硬化ヒマシ油
0.8パラオキシ安息香酸メチル 0.0
5クエン酸 0.05
クエン酸ナトリウム 0.07香料
0.1水溶性プラセ
ンタエキス 2.0精製水
残部精製水にグリセリン、クエン酸、
クエン酸ナトリウム、水溶性ブラセンタエキスを溶解す
る。別個にエタノールにビタミンE酢酸エステル、リノ
ール酸、ポリオキシエチレン硬化ヒマシ油(60E、O
,)、メチルパラベン、香料を溶解し、前記の精製水溶
液に加えて可溶化し、ろ過して化粧水を得た。Example! (Lotion) Ingredients Amount (wt%) Vitamin E acetate 0.1 linoleic acid
0.5 glycerin
6.0 ethanol
8.0 Polyoxyethylene hydrogenated castor oil
0.8 Methyl paraoxybenzoate 0.0
5 Citric acid 0.05
Sodium citrate 0.07 Fragrance 0.1 Water-soluble placenta extract 2.0 Purified water
Glycerin, citric acid, and the remaining purified water
Sodium citrate, dissolve the water-soluble Blacenta extract. Separately in ethanol vitamin E acetate, linoleic acid, polyoxyethylene hydrogenated castor oil (60E, O
), methylparaben, and fragrance were dissolved, added to the purified aqueous solution, solubilized, and filtered to obtain a lotion.
実施例2(化粧用油)
ビタミンE酢酸エステル 0.2リノー
ル酸エチル 1.0パルミチン酸
アスコルビル 0.2酢酸レチノール
0.3ステアリン酸コレステリル
1.0オリーブ油
2.0スクワラン
残部スクワランに他の成分を均一に溶解して化粧用
油を得た。Example 2 (cosmetic oil) Vitamin E acetate 0.2 Ethyl linoleate 1.0 Ascorbyl palmitate 0.2 Retinol acetate
0.3 Cholesteryl stearate 1.0 Olive oil
2.0 squalane
A cosmetic oil was obtained by uniformly dissolving other ingredients in the remaining squalane.
実施例3(クリーム)
成分(A)
ビタミンE酢酸エステル 0,2γ−リ
ルン酸 2.0ステアリン酸ア
スコルビル 1.0サラシミツロウ
4.0セタノール
2・0ステアリン酸
1.0ミリスチン酸イソプロピル
5.0ラノリン 2
.0流動パラフイン 9.0自
己乳化型モノステアリン酸グリセリル 3.0モノステ
アリン酸
ポリオキシエチレンソルビタン(20E、O,) 1
.5パラオキシ安息香酸プロピル 0.1成
分(B)
パラオキシ安息香酸メヂル Q、2プロピ
レングリコール 5.0香料
0,2成分(A)を加熱溶
解し、80℃に保持する。Example 3 (Cream) Ingredients (A) Vitamin E acetate 0,2γ-lylunic acid 2.0 Ascorbyl stearate 1.0 White beeswax
4.0 cetanol
2.0 stearic acid
1.0 Isopropyl myristate
5.0 Lanolin 2
.. 0 Liquid paraffin 9.0 Self-emulsifying glyceryl monostearate 3.0 Polyoxyethylene sorbitan monostearate (20E, O,) 1
.. 5 Propyl paraoxybenzoate 0.1 Ingredient (B) Medyl paraoxybenzoate Q, 2 Propylene glycol 5.0 Fragrance
0.2 component (A) is heated and dissolved and maintained at 80°C.
別に香料を除く成分(B)を加熱溶解して80℃に保ち
、これに前記成分(A)を撹拌しながら加え、充分混合
する。さらに撹拌しながら冷却を行い、香料を加え、さ
らに冷却してクリームを得た。Separately, component (B) excluding perfume is dissolved by heating and maintained at 80° C., and component (A) is added to this with stirring and mixed thoroughly. The mixture was further cooled while stirring, a flavoring agent was added, and the mixture was further cooled to obtain a cream.
実施例4(乳液)
成分(A)
ビタミンE酢酸エステル 0.2リノール酸
イソプロピル 2.0グリチルレチン酸ステ
アリル 0.1流動パラフイン
5.0ワセリン 2・
0ミツロウ 1.0セスキオ
レイン酸ソルビタン 2.0成分(B)
パラオキシ安息香酸エチル 0.2プロピレン
グリコール 5.0カルボキシビニルポリ
マー 0.5水酸化カリウム
0.5香料 0.2
精製水 残部成分(A)を
80℃にて加熱溶解し、別に加温(80℃)溶解した香
料を除く成分(B)に撹拌しながら加え、充分混合する
。ついで、撹拌しながら冷却を行い、香料を加え、さら
に冷却して乳液を得た。Example 4 (Emulsion) Component (A) Vitamin E acetate 0.2 Isopropyl linoleate 2.0 Stearyl glycyrrhetinate 0.1 Liquid paraffin
5.0 Vaseline 2.
0 Beeswax 1.0 Sorbitan sesquioleate 2.0 Component (B) Ethyl paraoxybenzoate 0.2 Propylene glycol 5.0 Carboxyvinyl polymer 0.5 Potassium hydroxide
0.5 fragrance 0.2
Purified water The remaining component (A) is dissolved by heating at 80°C, and added to the separately heated (80°C) dissolved component (B) excluding the fragrance while stirring, and thoroughly mixed. Next, the mixture was cooled while stirring, perfume was added, and the mixture was further cooled to obtain a milky lotion.
実施例5(パック)
ビタミンE酢酸エステル 0.5リノール酸
3.0水溶性ブラセンタエキ
ス 2.0酢酸ビニル・スチレン共重合体
10.0ポリビニルアルコール 10.0
ソルビツト 5.0酸化チタン
8.0カオリン
7.0エタノール
5.0香料 2
.0パラオキシ安息香酸エチル 0.2精製水
残部ビタミンE酢酸エス
テル、リノール酸、香料およびエタノールを均一に溶解
する。これを酢酸ビニル・スチレン共重合体、ポリビニ
ルアルコール、ソルビット、酸化チタンお上びカオリン
を均一に混和したものに加える。これに、さらに水溶性
プラセンタエキス、パラオキシ安息香酸エチルを精製水
に均一に溶解した溶液を加え、均一に混和しパックを得
た。Example 5 (pack) Vitamin E acetate 0.5 Linoleic acid 3.0 Water-soluble brassenta extract 2.0 Vinyl acetate-styrene copolymer
10.0 Polyvinyl alcohol 10.0
Sorbitto 5.0 Titanium oxide 8.0 Kaolin
7.0 ethanol
5.0 fragrance 2
.. 0 Ethyl paraoxybenzoate 0.2 Purified water Uniformly dissolve the remaining vitamin E acetate, linoleic acid, fragrance, and ethanol. This is added to a uniform mixture of vinyl acetate/styrene copolymer, polyvinyl alcohol, sorbitol, titanium oxide, and kaolin. To this, a solution in which water-soluble placenta extract and ethyl paraoxybenzoate were uniformly dissolved in purified water was added and mixed uniformly to obtain a pack.
実施例6(パウダー)
成 分 配合量(重量%)ビタミンE
酢酸エステル 0.1リノール酸
2.0デキストリン 95.0タ
ルク 2.0ステアリン酸デ
カグリセリル 1.0ビタミンE酢酸エステル、リノ
ール酸およびステアリン酸デカグリセリルを加熱溶解し
、70℃に保持し、これをデキストリンおよびタルクの
混合物に撹拌しながら徐々に加えてパウダーを得た。Example 6 (powder) Ingredients Amount (wt%) Vitamin E
Acetate ester 0.1 linoleic acid
2.0 Dextrin 95.0 Talc 2.0 Decaglyceryl stearate 1.0 Vitamin E acetate, linoleic acid and decaglyceryl stearate are dissolved by heating and kept at 70°C, and this is stirred into the mixture of dextrin and talc. A powder was obtained by gradually adding the powder.
発明の効果
本発明化粧料は、皮膚に適用することにより、特許出願
人 サンスター株式会社Effects of the Invention By applying the cosmetic of the present invention to the skin, the patent applicant: Sunstar Co., Ltd.
Claims (1)
が2以上の遊離脂肪酸、その塩、あるいは一価または二
価アルコールとのエステル を配合したことを特徴とする美白化粧料。(1) (a) Vitamin E acetate, and (b) free fatty acids with 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure, their salts, or esters with monohydric or dihydric alcohols. A whitening cosmetic product characterized by the following:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25037487A JPH0193520A (en) | 1987-10-02 | 1987-10-02 | Beautifying and whitening cosmetic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25037487A JPH0193520A (en) | 1987-10-02 | 1987-10-02 | Beautifying and whitening cosmetic |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0193520A true JPH0193520A (en) | 1989-04-12 |
JPH0532366B2 JPH0532366B2 (en) | 1993-05-14 |
Family
ID=17206969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP25037487A Granted JPH0193520A (en) | 1987-10-02 | 1987-10-02 | Beautifying and whitening cosmetic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0193520A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0355842A2 (en) * | 1988-08-26 | 1990-02-28 | Sansho Seiyaku Co., Ltd. | External preparation |
US5607921A (en) * | 1994-01-31 | 1997-03-04 | L'oreal | Stabilized cosmetic or dermatological composition containing several precursors of the same active agent in order to maximize its release, and use thereof |
JP2007047146A (en) * | 2005-07-15 | 2007-02-22 | Yokogawa Electric Corp | Electromagnetic flowmeter |
US7189759B2 (en) | 2001-05-23 | 2007-03-13 | Medicis Pharmaceutical Corporation | Compositions for the treatment of pigmentation disorders and methods for their manufacture |
JP2007240231A (en) * | 2006-03-07 | 2007-09-20 | Yokogawa Electric Corp | Magnetic flowmeter |
WO2008047633A1 (en) * | 2006-10-10 | 2008-04-24 | Maruha Corporation | Aliphatic compound-containing skin whitening agent |
JP2019147770A (en) * | 2018-02-28 | 2019-09-05 | 株式会社コーセー | Cosmetics and skin external preparations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6078911A (en) * | 1983-10-06 | 1985-05-04 | Shiseido Co Ltd | Cosmetic |
JPS60181006A (en) * | 1984-02-27 | 1985-09-14 | Kanebo Ltd | Skin cosmetic |
JPS62106005A (en) * | 1985-11-01 | 1987-05-16 | Sansho Seiyaku Kk | External drug effective to suppress formation of melanine |
-
1987
- 1987-10-02 JP JP25037487A patent/JPH0193520A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6078911A (en) * | 1983-10-06 | 1985-05-04 | Shiseido Co Ltd | Cosmetic |
JPS60181006A (en) * | 1984-02-27 | 1985-09-14 | Kanebo Ltd | Skin cosmetic |
JPS62106005A (en) * | 1985-11-01 | 1987-05-16 | Sansho Seiyaku Kk | External drug effective to suppress formation of melanine |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0355842A2 (en) * | 1988-08-26 | 1990-02-28 | Sansho Seiyaku Co., Ltd. | External preparation |
US5607921A (en) * | 1994-01-31 | 1997-03-04 | L'oreal | Stabilized cosmetic or dermatological composition containing several precursors of the same active agent in order to maximize its release, and use thereof |
US7189759B2 (en) | 2001-05-23 | 2007-03-13 | Medicis Pharmaceutical Corporation | Compositions for the treatment of pigmentation disorders and methods for their manufacture |
JP2007047146A (en) * | 2005-07-15 | 2007-02-22 | Yokogawa Electric Corp | Electromagnetic flowmeter |
JP2007240231A (en) * | 2006-03-07 | 2007-09-20 | Yokogawa Electric Corp | Magnetic flowmeter |
WO2008047633A1 (en) * | 2006-10-10 | 2008-04-24 | Maruha Corporation | Aliphatic compound-containing skin whitening agent |
JP4954988B2 (en) * | 2006-10-10 | 2012-06-20 | 株式会社マルハニチロ水産 | Whitening agent containing aliphatic compounds |
JP2019147770A (en) * | 2018-02-28 | 2019-09-05 | 株式会社コーセー | Cosmetics and skin external preparations |
Also Published As
Publication number | Publication date |
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JPH0532366B2 (en) | 1993-05-14 |
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