JP2644353B2 - Whitening cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic that eliminates, darkens, or prevents skin blackening due to ultraviolet rays or skin pigmentation such as spots and freckles.

2. Description of the Related Art Conventionally, as a whitening cosmetic composition, a composition containing a tyrosinase activity inhibitor such as vitamin C and a derivative thereof, a reducing agent, and a placenta extract is known. However, these conventional whitening cosmetics are in v
Although itroin exhibits an inhibitory effect on melanin production in the experiment of itro, when it is actually applied to the skin, sufficient effects such as disappearance of pigmentation or lightening are not obtained, and there are problems of side effects such as irritation.

Means for Solving the Problems The present inventors have conducted intensive studies on whitening cosmetics, and have also obtained a combination of a specific fatty acid or a derivative thereof and 2-hydroxy-4-methoxybenzophenone, The present inventors have found that a synergistic effect excellent in the disappearance of pigmentation or lightening is obtained, and that a whitening cosmetic product with suppressed irritation and the like can be obtained, thereby completing the present invention.

That is, the present invention provides: (a) 2-hydroxy-4-methoxybenzophenone,
And (b) having 18 to 22 carbon atoms and 2 unsaturated bonds in the molecular structure.
A whitening cosmetic comprising the above free fatty acid, a salt thereof, or an ester with a monohydric or dihydric alcohol is provided.

2-hydroxy-4 compounded in the whitening cosmetic composition of the present invention
-Methoxybenzophenone is a cosmetic raw material conventionally known as an ultraviolet absorber, but it is not yet known to exhibit a synergistic whitening effect on the skin in combination with other active ingredients.

In the present invention, from the viewpoint of a whitening effect, it is preferable to add the 2-hydroxy-4-methoxybenzophenone at a ratio of 0.001 to 10% by weight based on the total amount of the cosmetic. In blending linoleic acid and the like in the cosmetic of the present invention, it is preferable to use a purified product. Typical examples of the whitening cosmetic of the present invention having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in the molecular structure include the free fatty acid γ.
-Linolenic acid, arachidonic acid, eicosapentaenoic acid and the like, and one or more of these are used.

These fatty acids are usually released from triglycerides in animal and vegetable oils and fats, but triglycerides themselves do not show an excellent pigmentation and lightening effect in animal tests and the like like free fatty acids and alkyl esters thereof. In addition, some animal and vegetable fats and oils contain saturated fatty acids such as partimic acid and stearic acid. However, these saturated fatty acids do not show a pigmentation-suppressing effect, and may increase melanin production in some cases. Therefore, it is preferable to use a sufficiently purified fatty acid.

Examples of the salts of these fatty acids include alkali metal salts such as sodium salt and potassium salt, amino acid salts such as arginine salt and lysine salt, and amine salts such as triethanolamine salt and monoethanolamine salt.

Further, examples of the alkyl ester of the fatty acid include an ester with a monohydric alcohol such as methanol, ethanol, and isopropyl alcohol, and an ester with a dihydric alcohol such as ethylene glycol, propylene glycol, and 1,3-butylene glycol.

The amount of these free fatty acids, salts or esters in cosmetics is preferably 0.1 to 10% by weight.
When the amount is less than 0.1% by weight, there is no lightening effect of pigmentation, and when the amount exceeds 10% by weight, irritation is strong.

Next, the results of evaluating the effects of various components on the disappearance or lightening of pigmentation and on the effect of suppressing fatty acid irritation by skin are shown.

Test method: Experiment 1 Shaving the back of JY-3 brown guinea pig,
B intensity: 1 J / cm ² ), and one week later, pigmentation was obtained.
Next, samples obtained by dissolving various components such as 2-hydroxy-4-methoxybenzophenone and linoleic acid in ethanol were cumulatively applied to this site for 4 weeks. The pigmentation lightening was evaluated by setting the degree of pigmentation of a part to which the sample was not applied (uncoated) to 0, and visually determining the degree of pigmentation according to the following criteria based on the degree of the lightening. went.

Judgment criteria: 0: No lightening of pigmentation was observed.

-1: slight fading of pigmentation is observed.

-2: Lightening of moderate pigmentation is observed.

−3: Remarkable lightening of pigmentation is observed.

 The results are shown in Tables 1 and 2 below.

As is clear from Tables 1 and 2, 2-hydroxy-4-methoxybenzophenone alone did not show any fading of pigmentation, and had 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure. When only the free fatty acid, its salt or alkyl ester is blended alone, the coloration of pigmentation is slightly reduced. On the other hand, when 2-hydroxy-4-methoxy-benzophenone is used in combination with the above fatty acid or its derivative, remarkable pigmentation is observed.

Experiment 2 A patch test patch containing 2-hydroxy-4-methoxybenzophenone and linoleic acid was used as an essence base on the inner side of the upper arm of 10 healthy subjects.
Closure was applied for 24 hours. As a method for evaluating the degree of skin irritation, erythema and edema were visually determined according to the following criteria.

Criteria 0: No change 0.5: Indistinct erythema 1: Clear erythema 2: Erythema and edema A value obtained by multiplying the average of the measured values of 10 subjects by 100 is defined as a skin damage index, and the results are shown in Table 3.

As is clear from Table 3, 2-hydroxy-4-methoxybenzophenone has an inhibitory effect of fatty acids on skin irritation.

Thus, the whitening cosmetic composition of the present invention comprises 2-hydroxy-
4-Methoxybenzophenone and the fatty acid or a derivative thereof are combined with other desired components by a known method to produce a lotion, a cosmetic oil, a cream, a milky lotion, a pack, a powder and the like.

The other components are not particularly limited, and known components can be appropriately compounded within a range that does not impair the performance according to the type of the cosmetic.

A conventionally used melanin production inhibitor (vitamin C, placenta extract), an ultraviolet absorber, an ultraviolet scattering agent, an anti-inflammatory agent, an antioxidant, and the like may be further added.

EXAMPLES Next, the present invention will be described more specifically with reference to examples.

Dissolve glycerin, citric acid, sodium citrate, and water-soluble placenta extract in purified water. 2-hydroxy-4-methoxybenzophenone separately in ethanol,
Linoleic acid, polyoxyethylene hydrogenated castor oil (60E.
O.), methylparaben and perfume were dissolved, added to the purified aqueous solution to solubilize, and filtered to obtain a lotion.

Other ingredients were uniformly dissolved in squalane to obtain a cosmetic oil.

The component (A) is dissolved by heating and kept at 80 ° C. Separately, the component (B) excluding the fragrance is dissolved by heating and kept at 80 ° C., and the component (A) is added thereto with stirring and mixed well. Cooling was further performed with stirring, a flavor was added, and further cooling was performed to obtain a cream.

The component (A) is heated at 80 ° C., and is separately heated (80 ° C.) and added to the component (B) excluding the dissolved fragrance while stirring, and mixed well. Then, the mixture was cooled with stirring, a fragrance was added, and the mixture was further cooled to obtain an emulsion.

Dissolve 2-hydroxy-4-methoxybenzophenone, linoleic acid, flavor and ethanol uniformly. This is added to a homogeneous mixture of vinyl acetate / styrene copolymer, polyvinyl alcohol, sorbite, titanium oxide and kaolin. To this, a solution in which a water-soluble placenta extract and ethyl parahydroxybenzoate were uniformly dissolved in purified water was added, and the mixture was uniformly mixed to obtain a pack.

2-Hydroxy-4-methoxybenzophenone, linoleic acid and decaglyceryl stearate were dissolved by heating and maintained at 70 ° C, and this was gradually added to a mixture of dextrin and talc with stirring to obtain a powder.

Effect of the Invention The cosmetic of the present invention, when applied to the skin, eliminates, darkens or prevents blackening or pigmentation of the skin due to ultraviolet rays, and exhibits an excellent whitening effect.

Claims (1)

(57) [Claims] (1) 2-hydroxy-4-methoxybenzophenone (a), and (b) a compound having 18 to 22 carbon atoms and an unsaturated bond number of 2 in a molecular structure.
A whitening cosmetic comprising the above free fatty acid, a salt thereof or an ester with a monohydric or dihydric alcohol.