JP2614474B2 - Whitening cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic which eliminates, pales or prevents skin blackening due to ultraviolet rays or skin pigmentation such as spots and freckles.

2. Description of the Related Art Conventionally, as a whitening cosmetic composition, a composition containing vitamin C and a derivative thereof, or a tyrosinase activity inhibitor such as a reducing agent or a placenta extract is known. However, these conventional whitening cosmetics are based on cultured cells.
In vitro experiments show an inhibitory effect on melanin production, but when actually applied to the skin, sufficient effects such as disappearance of pigmentation or lightening have not been obtained.

An object of the present invention is to provide a cosmetic that can exhibit an excellent whitening effect without side effects when actually applied to the skin.

Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, disappearance of skin pigmentation by further combining various components with a specific fatty acid or a derivative thereof,
Alternatively, they have found that a synergistic effect excellent in lightening is obtained, and have completed the present invention.

That is, the present invention provides (a) a free fatty acid having 18 to 22 carbon atoms and an unsaturated bond number in a molecular structure of 2 or more, a salt thereof, or an ester with a monohydric or dihydric alcohol, (b) a placenta extract, Kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxine and its derivatives, tranexamic acid and its derivatives, arbutin, photosensitizer, sulfur, sodium chondroitin sulfate, 4-hydroxycinnamic acid And at least one component selected from the group consisting of carrot extract.

Fatty acids having 18 to 22 carbon atoms, such as linoleic acid and γ-linolenic acid, which are blended in the composition of the present invention, and having an unsaturated bond number of 2 or more in the molecular structure are contained in vegetable oils and fats. I have. However, these fatty acids rarely exist in a free state, and most of them exist in a triglyceride state. Such a triglyceride does not exhibit an excellent pigmentation and lightening effect in animal tests and the like, as in the case of a free fatty acid or an alkyl ester thereof. Similarly, the effect of inhibiting the pigmentation is not observed even with saturated fatty acids such as palmitic acid and stearic acid, and in some cases, the production of melanin is enhanced. Since such saturated fatty acids are contained in a large amount in vegetable oils and fats and oils, it is preferable to use purified fatty acids when blending linoleic acid in the cosmetic of the present invention.

Representative examples of the free fatty acid having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in the molecular structure to be incorporated in the whitening cosmetic composition of the present invention include linoleic acid, linoleic acid, α-
Examples thereof include linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid, arachidonic acid, and eicosapentaenoic acid. One or more of these are used.

Examples of the salts of these free fatty acids include metal salts such as sodium salt and potassium salt, amino acid salts such as arginine salt and lysine salt, and amine salts such as triethanolamine salt and monoethanolamine salt.

Further, examples of the alkyl ester of the free fatty acid include an ester with a monohydric alcohol such as methanol, ethanol and isopropyl alcohol, and an ester with a dihydric alcohol such as ethylene glycol, propylene glycol and 1,3-butylene glycol. Can be

The amount of these free fatty acids, salts or esters in cosmetics is preferably 0.1 to 10% by weight.
When the amount is less than 0.1% by weight, there is no lightening effect of pigmentation, and when the amount exceeds 10% by weight, the skin becomes irritating.

On the other hand, the components to be added to the composition of the present invention together with the fatty acids and the like, or esters, placenta extract, succinic acid and its salts or esters, glucosamine and its salts or esters, azelaic acid and its salts or esters, retinol and its Esters, pyridoxine and salts or esters thereof, tranexamic acid and salts or esters thereof, arbutin, photosensitizer, sulfur, chondroitin sulfate, 4-hydroxycinnamic acid, and carrot extract. One or more of these are blended. The content of these components in the cosmetic composition is preferably 0.1 to 10% by weight. If the amount is less than 0.1% by weight, there is no lightening effect of pigmentation, while if it exceeds 10% by weight, irritation is strong, which is not preferable for use.

It has not been known that a combination of these active ingredients and the above-mentioned fatty acids exhibits a synergistic whitening effect on the skin.

Next, the results of evaluating the effect of various active ingredients on the disappearance of pigmentation or lightening are shown.

Test method: Shaving the back of English brown guinea pig,
VB intensity: 1 J / cm ² ), and pigmentation was obtained one week later. Next, a sample obtained by dissolving fatty acids such as linoleic acid or other components in ethanol was added to this site.
It was applied cumulatively for a week. As a method for evaluating the lightening of pigmentation, the degree of pigmentation of a part to which a sample is not applied (uncoated) is set to 0, and the degree of pigmentation is visually determined according to the following criterion based on the degree of lightening. did.

Criteria: 0 No lightening of pigmentation is observed -1 Slight fading of pigmentation is observed -2 Lightening of moderate pigmentation is observed -3 Remarkable lightening of pigmentation is observed The results are shown in Table 1 below.

As is clear from Table 1, the active ingredient such as ascorbic acid alone did not show any fading of pigmentation and free fatty acids having 18 to 22 carbon atoms and two or more unsaturated bonds in the molecular structure, and salts thereof. Alternatively, when the alkyl ester is used alone, the coloration of pigmentation is slightly reduced. On the other hand, when the above fatty acids, salts thereof or components such as astell and ascorbic acid are used in combination, remarkable lightening of pigmentation is observed.

The whitening cosmetic of the present invention, by a known method, lotion,
It is manufactured in the form of cosmetic oils, creams, emulsions, packs, powders and the like.

Further, the cosmetic of the present invention may be appropriately blended with known components within a range that does not impair the performance according to the type.

In addition, you may mix the conventionally used ultraviolet absorber, ultraviolet scattering agent, anti-inflammatory agent, antioxidant, etc.

EXAMPLES Next, the present invention will be described more specifically with reference to examples.

Example 1 (Lotion) Dissolve glycerin, citric acid, sodium citrate, and water-soluble placenta extract in purified water. Separately, magnesium ascorbic acid phosphate, linoleic acid, α-linolenic acid, polyoxyethylene hydrogenated castor oil (60E.O.), methylparaben, and fragrance are dissolved in ethanol and added to the purified aqueous solution to solubilize. Filtration gave a lotion.

Example 2 (cosmetic oil) Other ingredients were uniformly dissolved in squalane to obtain a cosmetic oil.

Example 3 (cream) The component (A) is dissolved by heating and kept at 80 ° C. Separately, the component (B) excluding the fragrance is dissolved by heating and kept at 80 ° C., and the component (A) is added thereto with stirring and mixed well. Cooling was further performed with stirring, a flavor was added, and further cooling was performed to obtain a cream.

Example 4 (Emulsion) Ingredient (A) is heated and melted at 80 ° C and heated separately (80 ° C)
Add to the component (B) excluding the dissolved perfume with stirring and mix well. Then, the mixture was cooled with stirring, a fragrance was added, and the mixture was further cooled to obtain an emulsion.

Example 5 (pack) Dissolve sodium chondroitin sulfate, α-linolenic acid, flavor and ethanol uniformly. This is added to a homogeneous mixture of vinyl acetate / styrene copolymer, polyvinyl alcohol, sorbite, titanium oxide and kaolin. Further, a solution obtained by uniformly decomposing a water-soluble placenta extract and ethyl paraoxybenzoate in purified water was added thereto, and the mixture was uniformly mixed to obtain a pack.

Example 6 (powder) Tranexamic acid, sulfur, linoleic acid and decaglyceryl stearate were dissolved by heating and maintained at 70 ° C., and this was gradually added to a mixture of dextrin and talc with stirring to obtain a powder.

Effect of the Invention The cosmetic of the present invention, when applied to the skin, eliminates, darkens or prevents blackening or pigmentation of the skin due to ultraviolet rays, and exhibits an excellent whitening effect.

Claims (1)

(57) [Claims] (1) a free fatty acid having 18 to 22 carbon atoms and having two or more unsaturated bonds in a molecular structure, a salt thereof, or an ester with a monohydric or dihydric alcohol, and (b) a placenta extract. , Kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxine and its derivatives, tranexamic acid and its derivatives, arbutin, photosensitizer, sulfur, sodium chondroitin sulfate, 4-hydroxycinnamic A whitening cosmetic comprising a mixture of one or more components selected from the group consisting of an acid and a carrot extract.