JP2608745B2 - Whitening cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic which darkens skin by ultraviolet rays or lightens or prevents skin pigmentation such as spots and freckles.

2. Description of the Related Art Conventionally, as a whitening cosmetic composition, a composition containing vitamin C and a derivative thereof, or a tyrosinase activity inhibitor such as a reducing agent or placenta extract is known. However, these conventional whitening cosmetics are in v
Although itroin exhibits an inhibitory effect on melanin production in the experiment of itro, when applied to the skin actually, no effect such as sufficient prevention of pigmentation or lightening is obtained.

An object of the present invention is to provide a cosmetic that can exhibit an excellent whitening effect without side effects when actually applied to the skin.

Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, disappearance or prevention of skin pigmentation by combining an anti-inflammatory agent with a specific fatty acid or a derivative thereof. The present inventors have found that an excellent synergistic effect appears, and have completed the present invention.

That is, the present invention provides: (a) a compound having 18 to 22 carbon atoms and 2 unsaturated bonds in the molecular structure;
One or more compounds selected from the group consisting of the above free fatty acids, salts thereof, and esters with monohydric or dihydric alcohols, and (b) epsilon aminocaproic acid, glycyrrhetinic acid, glycyrrhizic acid, and salts thereof , And derivatives thereof, one or more selected from photosensitizer 301, photosensitizer 401, diphenhydramine hydrochloride, water-soluble azulene, adenosine monophosphate, calamine, purple root extract, Toki extract, mugwort extract and warmoko extract The present invention provides a skin-whitening cosmetic characterized by incorporating a whitening cosmetic.

Fatty acids having 18 to 22 carbon atoms, such as linoleic acid and γ-linolenic acid, which are blended in the composition of the present invention, and having an unsaturated bond number of 2 or more in the molecular structure are contained in vegetable oils and fats. I have. However, these fatty acids rarely exist in a free state, and most of them exist in a triglyceride state. Such a triglyceride does not exhibit an excellent pigmentation and lightening effect in animal tests and the like, as in the case of a free fatty acid or an alkyl ester thereof. Similarly, the effect of inhibiting the pigmentation is not observed even with saturated fatty acids such as palmitic acid and stearic acid, and in some cases, the production of melanin is enhanced. Since such saturated fatty acids are contained in a large amount in vegetable oils and fats and oils, it is preferable to use purified fatty acids when blending linoleic acid in the cosmetic of the present invention.

Representative examples of the free fatty acid having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in the molecular structure to be incorporated in the whitening cosmetic composition of the present invention include linoleic acid, linoleic acid, α-
Examples thereof include linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid, arachidonic acid, and eicosapentaenoic acid. One or more of these are used.

Examples of the salts of these free fatty acids include metal salts such as sodium salt and potassium salt, amino acid salts such as arginine salt and lysine salt, and amine salts such as triethanolamine salt and monoethanolamine salt.

Further, examples of the alkyl ester of the free fatty acid include an ester with a monohydric alcohol such as methanol, ethanol and isopropyl alcohol, and an ester with a dihydric alcohol such as ethylene glycol, propylene glycol and 1,3-butylene glycol. Can be

The amount of these free fatty acids, salts or esters in cosmetics is preferably 0.1 to 10% by weight.
When the amount is less than 0.1% by weight, the effect of suppressing pigmentation is not obtained. On the other hand, when the amount exceeds 10% by weight, irritation becomes strong, which is not preferable in use.

On the other hand, the anti-inflammatory agent blended in the composition of the present invention is generally formulated as a drug having an anti-inflammatory effect in pharmaceuticals, cosmetics, etc., for example, epsilon aminocaproic acid, glycyrrhetinic acid, glycyrrhizic acid, Salts and derivatives thereof, Photosensitizer 301, Photosensitizer 401, diphenhydramine hydrochloride, aqueous azulene (sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate), adenosine monophosphate, calamine (zinc oxide) ,
A purple root extract, a Toki extract, a mugwort extract, a valerian extract and the like can be mentioned, and one or more of these are used.

The amount of these anti-inflammatory agents in the cosmetic composition is 0.
It is preferable because it is 01 to 5.0% by weight.

Heretofore, it has not been known that such anti-inflammatory agents exhibit a synergistic whitening effect on the skin in combination with other active ingredients.

Next, the results of evaluating the pigmentation inhibiting action of various active ingredients are shown.

Test method: Shaving the back of English brown guinea pig,
VB intensity: 1 J / cm ² ). This operation was repeated for 3 days, during which a sample in which a fatty acid such as linoleic acid or an anti-inflammatory agent was dissolved was applied to the ultraviolet irradiation site. After standing for 10 days, the degree of pigmentation was visually determined according to the following criteria.

Criteria: −: No pigmentation is observed ±: Slight pigmentation is recognized +: Moderate pigmentation is recognized ++: Intense pigmentation is recognized The results are shown in Table 1 below.

As is evident from Table 1, when a free fatty acid having 18 to 22 carbon atoms and an unsaturated bond number in the molecular structure of 2 or more, a salt or an alkyl ester thereof was blended alone, and an anti-inflammatory agent was blended alone. In some cases, the effect of inhibiting pigmentation is slight. On the other hand, when the anti-inflammatory agent and the fatty acid or its derivative are used in combination, a remarkable inhibitory effect on pigmentation is observed.

The whitening cosmetic of the present invention, by a known method, lotion,
It is manufactured in the form of cosmetic oils, creams, emulsions, packs, powders and the like.

Further, the cosmetic of the present invention may be appropriately blended with known components within a range that does not impair the performance according to the type.

A melamine production inhibitor (vitamin C, placenta extract), an ultraviolet absorber, an ultraviolet scattering agent, an antioxidant, and the like, which are conventionally used, may be added.

EXAMPLES Next, the present invention will be described more specifically with reference to examples.

Example 1 (Lotion) Dissolve glycerin, citric acid, sodium citrate, and water-soluble placenta extract in purified water. Separately, allantoin, mugwort extract, linoleic acid, α-
Linolenic acid, polyoxyethylene hydrogenated castor oil (60E.
O.), methylparaben and perfume were dissolved, added to the purified aqueous solution to solubilize, and filtered to obtain a lotion.

Example 2 (cosmetic oil) Other ingredients were uniformly dissolved in squalane to obtain a cosmetic oil.

Example 3 (cream) The component (A) is dissolved by heating and kept at 80 ° C. Separately, the component (B) excluding the fragrance is dissolved by heating and kept at 80 ° C., and the component (A) is added thereto with stirring and mixed well. Cooling was further performed with stirring, a flavor was added, and further cooling was performed to obtain a cream.

Example 4 (Emulsion) Ingredient (A) is heated and melted at 80 ° C and heated separately (80 ° C)
Add to the component (B) excluding the dissolved perfume with stirring and mix well. Then, the mixture was cooled with stirring, a fragrance was added, and the mixture was further cooled to obtain an emulsion.

Example 5 (pack) The purple root extract, allantoin, α-linolenic acid, docosahexaenoic acid, ethyl parahydroxybenzoate, flavor and ethanol are uniformly dissolved. This is added to a homogeneous mixture of vinyl acetate / styrene copolymer, polyvinyl alcohol, sorbit, photosensitizer No. 301 and kaolin. Further, a solution prepared by uniformly dissolving the aqueous placenta extract in purified water was added thereto, and the mixture was uniformly mixed to obtain a pack.

Example 6 (powder) Diphenhydramine hydrochloride, Waremoborg extract, linoleic acid, ethyl linoleate and decaglyceryl stearate were dissolved by heating and maintained at 70 ° C., and this was gradually added to a mixture of dextrin and talc with stirring to obtain a powder.

Effect of the Invention The cosmetic of the present invention, when applied to the skin, eliminates or prevents blackening or pigmentation of the skin due to ultraviolet rays and exhibits an excellent whitening effect.

Claims (1)

(57) [Claims] (1) a free fatty acid having 18 to 22 carbon atoms and having at least 2 unsaturated bonds in the molecular structure, a salt thereof, or an ester with a monohydric or dihydric alcohol; One or more compounds and (b) epsilon aminocaproic acid, glycyrrhetinic acid, glycyrrhizic acid, salts thereof, and derivatives thereof, photosensitizer 301, photosensitizer 401, diphenhydramine hydrochloride, water-soluble azulene, adenosine monophosphate, A whitening cosmetic comprising one or more selected from calamine, purple root extract, Toki extract, mugwort extract, and sagebrush extract.