JP5399701B2 - Whitening skin external preparation and skin whitening method - Google Patents

Description

  The present invention relates to a novel skin external preparation for whitening and a skin whitening method.

Conventionally, esters of higher fatty acids have been widely used in skin external preparations as agents that contribute to the stabilization of the system, such as surfactants. For example, an external preparation for skin containing fatty acid esters has been proposed for the purpose of improving formulation stability (Patent Document 1). Further, an active ingredient carrier containing a sucrose ester type nonionic surfactant containing a saturated or unsaturated fatty acid having 12 to 22 carbon atoms as a component of a film is disclosed, and its use in cosmetics is also proposed (patent) Reference 2).
In addition, it has also been proposed to blend higher fatty acids and derivatives thereof as active ingredients such as whitening agents into an external preparation for skin, for example, having 18 to 22 carbon atoms and an unsaturated number of 2 or more in the molecular structure. Whitening cosmetics containing fatty acids such as linoleic acid, salts thereof, or esters thereof with mono- or dihydric alcohols as active ingredients have been proposed (Patent Document 3). Moreover, whitening cosmetics (patent document 4) containing fatty acids such as linoleic acid and an oil-soluble extract extracted from licorice have been proposed.
Japanese Patent Laid-Open No. 9-294927 Japanese Patent No. 3414752 JP 63-284109 A JP-A-5-194176

However, when linoleic acid, a salt thereof or an ester thereof with alcohol is actually added to the external preparation for skin, odor and discoloration are likely to occur over time, and there is a problem in terms of storage stability.
Accordingly, the present invention provides an external preparation for skin that has no (or less) odor and discoloration over time, has good storage stability, and exhibits the same whitening effect as when linoleic acid is blended. Is an issue.

As a result of searching for a compound having an excellent whitening effect similar to linoleic acid, the present inventors have found that sucrose linoleic acid ester in which sucrose and linoleic acid are ester-bonded has an excellent whitening effect similar to linoleic acid. I found out to play. In addition, sucrose linoleic acid ester has obtained the knowledge that it has a much higher transdermal absorption effect than free fatty acids and is also excellent in stability in the preparation, and further studies are made based on these findings. The present invention has been completed.
That is, this invention provides the skin external preparation for whitening which contains a sucrose linoleic acid ester as an active ingredient in order to solve the said subject.

  The number of ester bonds in one molecule of the sucrose linoleic acid ester used in the external preparation for skin of the present invention is not particularly limited, and is a monoester, a diester, and a plurality of tri, tetra, or more esters. Any of polyester bodies having a bond (hereinafter, an ester body containing 3 or more ester bonds may be referred to as “polyester body”), or a mixture of two or more selected from these. Good. As a preferred embodiment of the present invention, the sucrose linoleic acid ester contains 20% by mass or more of a diester, and the skin whitening agent for whitening; the sucrose linoleic acid ester contains 20% by mass or more of a monoester. And a skin external preparation for skin whitening, wherein the sucrose linoleic acid ester contains 20% by mass or more of a diester and 20% by mass or more of a monoester.

Further, the skin whitening external preparation of the present invention preferably further contains at least one whitening agent other than sucrose linoleic acid ester, and the whitening agent is ascorbic acid and its derivatives, arbutin and ellagic acid. It is preferably at least one selected from
In another aspect, the present invention provides a skin whitening method using sucrose linoleic acid ester as an active ingredient; and a method for producing a whitening cosmetic comprising adding sucrose linoleic acid ester. .

  According to the present invention, there is provided an external preparation for skin that has no (or less) odor and discoloration over time, has good storage stability, and has the same excellent whitening effect as when linoleic acid is blended. Can do.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after. Regarding numerical values, “above” means the numerical value and a range exceeding the numerical value, and “below” means the numerical value and a range less than the numerical value.
The present invention relates to a whitening skin external preparation containing sucrose linoleic acid ester as an active ingredient. Sucrose has eight hydroxyl groups that can be esterified with the carboxyl group of linoleic acid. The sucrose linoleic acid ester used in the present invention may be any of a monoester, a diester, and a polyester, or may be a mixture containing two or three of these in a predetermined ratio. Good. Further, the hydroxyl group at any position of sucrose may be ester-bonded to the carboxyl group of linoleic acid.

  The sucrose linoleic acid ester can be produced by a general esterification reaction. For example, sucrose, linoleic acid, or an alcohol ester of linoleic acid (for example, methyl linoleate) and a catalyst such as potassium hydrogen carbonate are dissolved in an organic solvent such as dimethyl sulfoxide (DMSO) to advance the esterification reaction. Thereafter, an organic solvent such as DMSO is removed and, if desired, obtained by washing with water. Anhydrous citric acid or the like may be added for catalyst neutralization. When the esterification reaction proceeds, if necessary, it may be heated or cooled, and the reaction solution may be stirred. By adjusting the amount of sucrose and linoleic acid charged, or by adjusting the reaction conditions such as temperature, for example, a sucrose linoleic acid ester containing a monoester body, a diester body and a polyester body in a desired ratio can get. When isolating monoesters, diesters and various polyesters, or when preparing sucrose linoleic acid esters with different composition ratios, the monoesters, diesters and polyesters obtained by the esterification reaction The mixture is preferably purified by column chromatography or the like. In addition, the product obtained may contain unreacted sucrose, but it may be blended in the skin external preparation as it is, or may be blended after being removed by the purification method or the like. .

  Of the ester bodies of sucrose and linoleic acid, diester bodies are preferred in terms of low cytotoxicity and high whitening effect, and sucrose linoleic acid esters containing a large amount of diester bodies are preferably used. The sucrose linoleic acid ester to be used preferably contains 20% by mass or more of a diester, more preferably 30% by mass or more, and still more preferably 50% by mass or more. On the other hand, monoesters are inferior to diesters from the viewpoint of cytotoxicity, but have the highest whitening effect, and therefore are preferably contained to some extent in the sucrose linoleate used. The sucrose linoleic acid ester to be used preferably contains 20% by mass or more of a monoester, more preferably 30% by mass or more, and further preferably 40% by mass or more.

  The sucrose linoleic acid ester varies in the state at room temperature depending on the degree of esterification and the composition ratio of mono-, di-, and polyester bodies, and exists in a solid to paste form. For example, when the ratio of the monoester body becomes high, it becomes solid at room temperature, and when the ratio of the di- or polyester body becomes high, it becomes a paste. This form may be any, and the ratio of the mono-, di-, and polyester bodies may be adjusted so that the form can be easily blended according to the dosage form of the external preparation for skin.

  The preferred range of the content of sucrose linoleic acid ester in the whitening skin external preparation of the present invention varies depending on the dosage form of the external skin preparation and the composition ratio of mono-, di- and polyester bodies of sucrose linoleic acid ester. However, generally, it is preferably 0.01 to 20% by mass and more preferably 0.1 to 5% by mass in the total mass of the external preparation for skin. When the content of the sucrose linoleic acid ester is within the above range, the skin external preparation has an excellent whitening effect without causing a sticky feeling due to the blending of the sucrose linoleic acid ester. In addition, as described above, the preferable range of the content of sucrose linoleic acid ester varies depending on the dosage form of the external preparation for skin, for example, in the form of a skin lotion, preferably 0.01 to 3% by mass, 1% by mass is more preferable. Moreover, 0.01-15 mass% is preferable in the form of an emulsion, and 0.5-10 mass% is more preferable. Moreover, in the form of a cream, 0.01-20 mass% is preferable and 0.5-15 mass% is more preferable.

  In addition, the skin external preparation of the present invention may be an emulsified skin external preparation, and in such a case, either the W / O type or the O / W type may be used. Sucrose linoleic acid ester can be added to both the aqueous phase and the oil phase, and is also a useful agent in terms of facilitating preparation of a skin external preparation.

  In the present invention, sucrose linoleic acid ester is used as an active ingredient of a skin whitening external preparation, that is, a whitening agent. In the present specification, the term “whitening” is used to include not only the effect of whitening the skin but also the effect of suppressing the blackening of the skin. For example, it includes not only the effect of improving pigmentation such as stains and freckles but also the effect of suppressing pigmentation. The details of the mechanism of whitening effect of sucrose linoleate are not clear, but it is assumed that sucrose linoleate has the ability to promote degradation of tyrosinase protein that promotes melanin synthesis. The

The external preparation for skin of the present invention may contain other medicinal ingredients together with sucrose linoleic acid ester. In particular, it is preferable to combine with other whitening agents because the whitening effect is higher, and when combined with a whitening agent that exhibits a whitening effect by a mechanism different from the above estimated mechanism of sucrose linoleic acid ester, the effect is synergistically enhanced. This is preferable. Here, the outline of the mechanism of skin blackening is that tyrosinase protein expression is increased in melanocytes by the stimulation of melanocyte activator secreted from ultraviolet rays and keratinocytes, and tyrosinase protein is synthesized. It is thought that melanin is synthesized from tyrosine by the reaction, and then melanin is transferred to keratinocytes, and the skin color becomes black. As conventionally known whitening agents, agents that exhibit a whitening effect by the following mechanisms are known, respectively;
(1) inhibits melanocyte activator from acting on melanocytes,
(2) inhibits the activity of tyrosinase protein in melanocytes,
(3) promote the degradation of tyrosinase protein,
(4) Suppresses oxidation during synthesis from tyrosine to melanin.
As described above, it is speculated that sucrose linoleic acid ester suppresses the synthesis of melanin by the mechanism of (3) and exhibits a whitening effect. Therefore, it is preferable to combine it with a whitening agent that exhibits a whitening effect by the mechanism of (1), (2), and (4). From the relationship of the mechanism, a whitening agent that exhibits a whitening effect by the mechanism of (2) or (4) It is more preferable to combine with. Examples of the whitening agent that exhibits a whitening effect by the mechanism (1) include t-AMCHA (t-4-aminomethyl-cyclohexanecarboxylic acid), chamomile ET, and the like. Examples of the whitening agent having a whitening effect by the mechanism (2) include arbutin, ellagic acid, lucinol (4-n-butylresorcinol), t-AMCHA, ascorbic acid and derivatives thereof. Examples of the whitening agent having a whitening effect by the mechanism (4) include ascorbic acid and its derivatives. Among them, it is preferable to combine with at least one selected from arbutin, ellagic acid, ascorbic acid and derivatives thereof. Preferable examples of the derivatives of ascorbic acid include ascorbic acid phosphate magnesium salt, ascorbic acid phosphate sodium salt, ascorbyl palmitate, ascorbic acid glucoside, and ethyl ascorbate.

  In addition to the above essential components, the external preparation for skin of the present invention includes various components that are usually used in cosmetics, quasi-drugs, external medicines, etc., that is, water, alcohol, oils, surfactants, thickeners. Agents, powders, chelating agents, pH adjusting agents, various medicinal agents, extracts derived from animals, plants and microorganisms, fragrances, and the like can be added as appropriate within the range not impairing the effects of the present invention. Examples of the various medicinal agents include antioxidants, cell activators, anti-inflammatory agents, UV inhibitors, and the like, and these medicinal agents are used in combination to further enhance the effects of the present invention, or other effects. Further, it may be added.

  The form of the external preparation for skin of the present invention is not particularly limited, and examples thereof include emulsions, creams, lotions, packs, cleaning agents, makeup cosmetics, dispersions, ointments, liquids, aerosols, patches, cataplasms, liniments. Any form of cosmetic, such as an agent, may be an external medicine.

The present invention will be described more specifically with reference to the following examples. However, the scope of the present invention is not limited to the following examples.
[Example 1: Preparation of sucrose linoleic acid ester]
First, 76 parts by mass of sucrose, 64 parts by mass of methyl linoleate, 190 parts by mass of dimethyl sulfoxide (DMSO) and 2 to 2.5 parts by mass of a catalyst (potassium hydrogencarbonate) were placed in a reaction vessel. The esterification reaction between sugar and linoleic acid was allowed to proceed. After completion of the reaction, anhydrous citric acid was added to neutralize the catalyst, DMSO was removed, and then washed with water to obtain a product (sample 1).
This product was fractionated by reversed-phase column chromatography (eluent: ethanol → hexane), and the fractions were mixed to obtain Samples 2 to 4 having the compositions shown in Table 1, respectively.
About the obtained samples 1-4, the composition of monoester, diester, and polyester was investigated by the eartro scan analysis method (TLC / FID analysis method), and the result calculated | required by the mass% when the whole was set to 100 is represented. It was shown in 1. In addition, the thin layer automatic detection apparatus Iatron scan TH-10 of Yatron Co., Ltd. was used for the analysis.

[Example 2: Melanin production inhibitory effect]
An appropriate amount of the medium was collected in two 6-well petri dishes, seeded with mouse-derived B16 melanoma cells, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5 v / v%. On the next day, a sample preparation solution in which each sample was dissolved in ethanol so that the final concentration was a predetermined concentration was added and mixed. As a control, only a solution (ethanol) was added and mixed. On the fifth day of culture, the medium is changed, and the sample preparation solution is added again. On the next day, the medium was removed, the cells were washed with a phosphate buffer in one petri dish, and then collected, and the degree of whitening of the cultured B16 melanoma cells was visually evaluated according to the following criteria.
(Criteria)
++: Extremely white relative to the control.
+: Clearly white relative to the control.
±: Slightly white with respect to the control.
-: The same black color as the control.

For the remaining one petri dish, cells were fixed with formalin, and then a 1% crystal violet solution was added and stained. The number of viable cells (A) and the number of control cells (B) for each analyte concentration were measured with a monocellator, and the cell viability was calculated by the ratio of (A) / (B)%.
Table 2 below shows the evaluation of the degree of whitening and the cell growth rate at each concentration of each sample.

ＮＤ：判定不能

ND: Cannot be determined

  From the above results, all samples 1 to 4 of sucrose linoleic acid ester showed a high melanin production inhibitory ability equivalent to linoleic acid. In particular, Sample 2 in which the proportion of monoester is 20% by mass or more, Sample 3 in which the proportion of diester is 20% by mass or more, and Sample 1 in which the proportion of both is 20% by mass or more are particularly high in melanin production. Suppressive ability was shown.

[Example 3: Human UV-induced pigmentation inhibition test]
Cream 1 containing 1% by mass of Sample 1 prepared in Example 1 and Cream 2 containing 1% by mass of Sample 1 and 3% by mass of arbutin were prepared. Moreover, the cream 3 which mix | blended 3 mass% only of arbutin and the blank cream which did not mix | blend both the sample 1 and arbutin were prepared for the comparison, respectively. Table 3 shows the composition of each cream. Each was prepared by the following production method.
A. Ingredients 4-7 are mixed and dissolved by heating at 70 ° C.
B. Components 1 to 3 are mixed, then heated to 70 ° C., A is added and emulsified, and then components 8 to 11 are added and mixed.
C. Components 12 to 14 are mixed and dissolved, added to B, and mixed uniformly.
D. C was filled into a container to obtain a test cream.

Four places on the inner side of the upper arm of the subject were irradiated with ultraviolet rays of about 1 MED for 3 days (from day 1 to day 3) to artificially form pigmentation.
Each cream was applied twice a day for 7 days (from the first day to the seventh day of irradiation) on four irradiated parts.
The ability to suppress human UV-induced pigmentation was evaluated by determining the visual determination on the 7th day after irradiation and cream application, and determining the color difference measurement on the 3rd and 7th days by the following methods. .
-Visual judgment Three skilled judges have compared the degree of pigmentation of a total of four places, the application part of a blank cream, and the application part which applied creams 1-3 about a plurality of subjects, and the difference is 3 Stage (+1, 0, −1: However, the evaluation of “−1” indicates the highest degree of pigmentation due to ultraviolet rays, and the degree of pigmentation decreases as “0” and “+1” indicate normal skin color. It was an evaluation of approaching). The average value of the numerical values of the judge's evaluation (however, the average value obtained by converting the average value of the blank cream application site to 0) was taken as the visual point. The determination was made after the above work was performed for 7 days. The results are shown in Table 4 below.
-Color difference measurement determination The color difference of the application | coating site | part of a blank cream and the site | part which each applied the creams 1-3 was measured using Minolta color difference meter CR-200. The measurement was performed after the above work was performed for 3 days and after 7 days. The results are shown in Table 5 below.

  From the results shown in Tables 4 and 5 above, it can be understood that creams 1 and 2 containing Sample 1 which is a sucrose linoleic acid ester exhibit excellent human UV-induced pigmentation-inhibiting ability. In particular, it can be understood that the cream 2 containing both sucrose linoleic acid ester and arbutin exhibits a far superior ability to suppress human UV-induced pigmentation compared to the cream 3 containing only arbutin.

[Example 4: Evaluation of dullness improvement effect]
The lotions having the compositions shown in Table 6 below were prepared by the following methods.
A. Components 1 to 11 were mixed and dissolved uniformly and heated to 70 ° C.
B. Ingredients 12 to 17 were mixed and dissolved uniformly and heated to 70 ° C.
C. A was added to B, stirred with a homomixer, filled into a container, and a lotion was obtained.

Creams having the compositions shown in Table 7 below were prepared by the following methods.
A. Ingredients 1 to 11 were dissolved by heating at 70 ° C. and mixed uniformly.
B. Ingredients 12 to 20 were dissolved by heating at 70 ° C. and mixed uniformly.
C. B was added to A, stirred and emulsified with a homomixer, and then filled into a container to obtain a W / O type cream.

Each prepared lotion and each W / O type cream was evaluated by the following methods and criteria.
(Test method: Dullness improvement effect)
With regard to lotion 1-6 and W / O type cream 4-7, 10 females aged 35-59 years per panel were used as panels. Appropriate amount was applied to the left half of the face. At the same time, with respect to the comparative lotions 7 to 8 and the comparative W / O creams 8 to 10, an appropriate amount was applied to the right half of the face in the same manner as described above. The dullness improvement effect by application was evaluated according to the following criteria.
(Evaluation criteria)
Dullness improvement effect <Evaluation><Contents>
Effective Skin dullness is not noticeable.
Slightly effective Skin dullness is less noticeable.
Invalid No change from before use.
<Judgment>
◎: Effective and slightly effective is 9 or more ○: Effective and slightly effective is 6 or more and 8 or less △: Effective and slightly effective is 3 or more and 5 or less ×: Effective and slightly effective is 2 or less Evaluation result is shown Shown in 6 and 7, respectively.

(Evaluation method for skin moisturizing feeling and flexibility)
For each sample of lotions 1 to 8 and W / O type creams 4 to 10, a sensory test was conducted by (10) moisturizing feeling of skin and (b) skin flexibility by the 10 female panel members. The sensory test was used twice a day in the morning and at night for 12 weeks, and then each sample was evaluated in 7 stages based on the following absolute evaluation criteria, and the average score was further determined based on the following criteria. .
<Absolute evaluation criteria>
(Score): (Evaluation)
6: Very good 5: Good 4: Somewhat good 3: Normal 2: Somewhat bad 1: Bad 0: Very bad <Criteria>
(Average score): (Judgment)
5.0 or higher: ◎ (very good)
3.5 or more and less than 5.0: ○ (Good)
1.0 or more and less than 3.5: △ (somewhat poor)
Less than 1.0: × (defect)
The evaluation results are shown in Tables 6 and 7, respectively.

(Storage stability test (odour and discoloration))
The samples of lotions 1 to 8 and W / O type creams 4 to 10 were stored in thermostats at 5 ° C. and 40 ° C. for 3 months, respectively, and then the odor and color change due to aging were compared. Evaluation was based on a sample stored at 5 ° C., and a sample stored at 40 ° C. was compared with the sample, and evaluated according to the following evaluation criteria.
(Evaluation criteria)
A: There is no change (odour, discoloration) from the standard product.
○: There is a slight change (odour, discoloration) compared to the standard product, but there is no problem.
X: There is a clear change (odour, discoloration) compared to the standard product, which is a problem.
The results are shown in Table 6 and Table 7, respectively.

As is clear from the results of Tables 6 and 7, the skin lotions 1 to 6 and the W / O creams 4 to 7 that are the products of the present invention have a dullness improving effect, storage stability, skin moisture retention, skin flexibility. It was excellent in the properties and the usability was also good. On the other hand, lotions 7 to 8 and W / O type creams 8 to 10 as comparative products were not equivalent to the products of the present invention for all evaluation items.
For example, in lotions 7 and 8, in place of sucrose linoleate, sucrose distearate in which sucrose and stearic acid are ester-bonded, and sucrose dipalmitate in which sucrose and palmitic acid are ester-bonded Although each ester was blended, the dullness improving effect was not obtained as in skin lotions 1-6.
In addition, in W / O type creams 8 and 9, sucrose distearate and sucrose dipalmitate were blended in place of sucrose linoleate, respectively. The improvement effect was not obtained.
Moreover, in W / O type cream 10, linoleic acid was blended in place of sucrose linoleic acid ester. However, particularly, odor and discoloration were observed, and there was a problem in storage stability.

[Example 5: Preparation of UV-preventing serum]
A cosmetic liquid having the composition shown in Table 8 was prepared by the following method.
A. Ingredients 1 to 11 were dissolved by heating at 70 ° C. and mixed uniformly.
B. Ingredients 12 to 18 were dissolved by heating at 70 ° C. and mixed uniformly.
C. A was added to B, and the mixture was stirred with a homomixer and filled in a container to obtain a serum.

  The prepared UV-preventing cosmetic liquid was excellent in whitening effect and good in use. Further, no discoloration or odor change over time was observed.

[Example 6: Preparation of cleansing cream]
Cleansing creams having the compositions shown in Table 9 were prepared by the following method.
A. Ingredients 1-12 were dissolved by heating at 70 ° C. and mixed uniformly.
B. Ingredients 13 to 17 were dissolved by heating at 70 ° C. and mixed uniformly.
C. A was added to B and stirred and emulsified with a homomixer, and then filled into a container to obtain a cleansing cream.

  The prepared cleansing cream had an excellent whitening effect and a good feeling when used. Further, no discoloration or odor change over time was observed.

[Example 7: Preparation of pack]
A pack having the composition shown in Table 10 below was prepared by the following method.
A. Components 4 to 8 are mixed and dissolved by heating at 70 ° C.
B. Components 1 to 3 are mixed and then heated to 70 ° C., A is added and emulsified, and then components 9 to 11 are added and mixed.
C. Component 12 is added to B to neutralize, and components 13 to 15 are added and mixed.
D. C was filled into a container to obtain a pack.

  The prepared pack had an excellent whitening effect and a good feeling when used. Further, no discoloration or odor change over time was observed.

[Example 8: Preparation of liquid foundation]
(Ingredient) Mass%
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4'-methoxydibenzoylmethane
2.0
(8) Sample 3 (prepared in Example 1) 0.5
(9) Methyl paraoxybenzoate 0.1
(10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Purified water remaining amount (15) Titanium oxide 6.0
(16) Fine zinc oxide 5.0
(17) Mica 2.0
(18) Talc 4.0
(19) Color pigment 4.0
(20) Ogon extract * 1 0.5
(21) Fragrance appropriate amount * 1 Made by Ichimaru Falcos

(Manufacturing method)
A. Components (1) to (8) are mixed and dissolved.
B. Ingredients (15) to (19) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (9) to (14) are uniformly dissolved and kept at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (20) and (21) were added to obtain a liquid foundation.

  The liquid foundation of Example 8 was a liquid foundation having excellent storage stability and excellent skin feel and excellent usability. Moreover, there was an excellent whitening effect by applying the above liquid foundation to the skin.

[Example 9: Preparation of sunscreen emulsion]
(Ingredient) Mass%
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Hydrogenated lecithin * 1 1.0
(7) Sample 4 (prepared in Example 1) 0.5
(8) Methyl paraoxybenzoate 0.1
(9) Silicone-treated fine particle titanium oxide 10.0
(10) Silicone-treated fine particle zinc oxide 10.0
(11) Polystyrene powder 3.0
(12) Trimethylsiloxysilicic acid 0.5
(13) Dipropylene glycol 3.0
(14) Ethyl alcohol 10.0
(15) Purified water remaining amount (16) Sodium chloride 0.2
(17) Hawthorn extract * 2 1.0
(18) Fragrance appropriate amount * 1 Nikkor Resinol S-10E manufactured by Nikko Chemicals
* 2 Made by Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Components (1) to (12) are mixed.
B. Components (13) to (16) are mixed.
C. Add B to A and emulsify uniformly.
D. Components (17) and (18) were added to C to obtain a sunscreen emulsion.

  The sunscreen emulsion of Example 9 was excellent in storage stability and very comfortable to use on the skin. Moreover, there was an excellent whitening effect by applying the sunscreen emulsion to the skin.

  ADVANTAGE OF THE INVENTION According to this invention, skin external preparations, such as a milky lotion, a cream, a lotion, a pack, a washing | cleaning agent, and makeup | decoration cosmetics, which are excellent in the whitening effect and favorable with time can be provided.

Claims (6)

An external preparation for skin whitening containing sucrose linoleic acid ester as an active ingredient,
The skin external preparation for whitening in which the said sucrose linoleic acid ester contains 20 mass% or more of diester bodies. An external preparation for skin whitening containing sucrose linoleic acid ester as an active ingredient,
A skin external preparation for whitening, wherein the sucrose linoleic acid ester contains 20% by mass or more of a monoester. An external preparation for skin whitening containing sucrose linoleic acid ester as an active ingredient,
The skin external preparation for whitening in which the said sucrose linoleic acid ester contains 20 mass% or more of monoester bodies, and 20 mass% or more of diester bodies. The skin external preparation for whitening according to any one of claims 1 to 3, further comprising at least one whitening agent other than sucrose linoleic acid ester. The skin external preparation for whitening according to claim 4, wherein the whitening agent is at least one selected from ascorbic acid and derivatives thereof, arbutin and ellagic acid. Skin whitening using sucrose linoleic acid ester as an active ingredient, containing 20% by mass or more of a diester or 20% by mass or more of a monoester, or 20% by mass or more of a monoester and 20% by mass or more of a diester Method (excluding medical practice).