KR101308871B1 - Skin-whitening agent for external application to the skin, and method for whitening the skin - Google Patents

Abstract

The present invention relates to a whitening skin external preparation containing sucrose linoleic acid ester as an active ingredient.

Description

Skin-whitening agent for external application to the skin, and method for whitening the skin}

The present invention relates to a novel skin whitening agent for whitening and a method for whitening skin.

Conventionally, esters of higher fatty acids are widely used in external preparations for skin as agents, for example, surfactants and the like, which contribute to stabilization of a system. For example, for the purpose of improving formulation stability, a skin external preparation containing fatty acid esters is proposed (Patent Document 1). Moreover, the active ingredient carrier which contains the sucrose ester type nonionic surfactant containing a C12-C22 saturated or unsaturated fatty acid as a component of a film | membrane is disclosed, and the use for cosmetics is also proposed (patent document 2).

In addition, it is also proposed to formulate itself, such as higher fatty acids and derivatives thereof, into the external preparation for skin as an active ingredient such as a whitening agent, for example, fatty acids such as linoleic acid having 18 to 22 carbon atoms and 2 or more unsaturated atoms in the molecular structure, There is proposed a whitening cosmetic containing a salt thereof or an ester with a monohydric or dihydric alcohol as an active ingredient (Patent Document 3). Moreover, the whitening cosmetics (patent document 4) containing fatty acids, such as linoleic acid, and the oil-soluble extract extracted from licorice is proposed.

Patent Document 1: Japanese Patent Application Laid-Open No. 9-294927

Patent Document 2: Japanese Patent No. 3414752

Patent Document 3: Japanese Patent Application Laid-Open No. 63-284109

Patent Document 4: Japanese Patent Application Laid-Open No. 5-194176

DISCLOSURE OF INVENTION

Problems to be solved by the invention

However, when linoleic acid, its salt, or its ester with alcohol is actually blended into the external preparation for skin, it tends to cause discoloration and discoloration over time, and there is a problem in terms of storage stability.

Therefore, an object of the present invention is to provide a skin external preparation which has no (or less) discoloration and discoloration with time, has good storage stability, and exhibits the same excellent whitening effect as when linoleic acid is blended.

Means for solving the problem

The present inventors searched for compounds exhibiting an excellent whitening effect, such as linoleic acid, and found that sucrose linoleic acid esters in which sucrose and linoleic acid are ester-linked show the same excellent whitening effect as linoleic acid. In addition, sucrose linoleic acid ester was found to have a noticeably higher transdermal absorption effect than free fatty acids, and also excellent stability in the formulation. Based on these findings, further studies were completed to complete the present invention.

That is, this invention provides the whitening skin external preparation containing sucrose linoleic acid ester as an active ingredient in order to solve the said subject.

The number of ester bonds in one molecule of the sucrose linoleic acid ester used in the external preparation for skin of the present invention is not particularly limited, and it is a polyester having a monoester body, a diester body, and a plurality of tri, tetra or more ester bonds. Either an ester body (Hereinafter, an ester body containing 3 or more ester bonds may be called a "polyester body") may be sufficient, and 2 or more types of mixtures selected from these may be sufficient. As a preferable aspect of this invention, the said skin external preparation for whitening whose said sucrose linoleic acid ester contains 20 mass% or more of diester bodies; The whitening skin external preparation, wherein the sucrose linoleic acid ester contains 20% by mass or more of a monoester; And the external skin preparation for whitening wherein the sucrose linoleic acid ester contains 20% by mass or more of a diester body and 20% by mass or more of a monoester body.

In addition, the skin external preparation for whitening of the present invention preferably further contains one or more of whitening agents other than sucrose linoleic acid ester, and the whitening agent is ascorbic acid and its derivatives, arbutin and ellagic acid. It is preferable that it is 1 or more types chosen from.

Moreover, from another viewpoint, According to this invention, the skin whitening method using sucrose linoleic acid ester as an active ingredient; And a method for producing a cosmetic for whitening comprising adding sucrose linoleic acid ester.

Effects of the Invention

According to the present invention, it is possible to provide an external preparation for skin that has no (or less) discoloration and discoloration with time, has good storage stability, and exhibits the same excellent whitening effect as when linoleic acid is blended.

Carrying out the invention  Best form for

Hereinafter, the present invention will be described in detail. In addition, in this specification, "-" shall mean the range containing the numerical value before and behind that. In addition, with respect to a numerical value, "above" means the numerical value and the range exceeding the numerical value, and "less than" means the numerical value and the range below the numerical value.

The present invention relates to a whitening skin external preparation containing sucrose linoleic acid ester as an active ingredient. Sucrose has eight hydroxyl groups which can be ester-bonded with the carboxyl group of linoleic acid. The sucrose linoleic acid ester used in the present invention may be any of a monoester, a diester, and a polyester, or may be a mixture containing two or three of them in a predetermined ratio. In addition, the hydroxyl group in any position of sucrose may be ester-bonded with the carboxyl group of linoleic acid.

The sucrose linoleic acid ester can be produced by a general esterification reaction. For example, a catalyst such as sucrose, linoleic acid or alcohol esters of linoleic acid (for example, methyl linoleate) and potassium hydrogen carbonate is dissolved in an organic solvent such as dimethyl sulfoxide (DMSO) to proceed with esterification. Then, it is obtained by removing organic solvents, such as DMSO, and water washing etc. according to the objective. Citric acid anhydride etc. may be added for catalyst neutralization. At the time of esterification progress, you may heat or cool as needed, and you may stir the reaction liquid. By adjusting the addition amount of sucrose and linoleic acid, or adjusting reaction conditions, such as temperature, the sucrose linoleic acid ester which contains a monoester body, a diester body, and a polyester body in a predetermined ratio is obtained, for example. When isolating a monoester body, a diester body, and various polyester bodies, or when preparing sucrose linoleic acid ester of a different composition ratio, a mixture of the monoester body, diester body, and polyester body obtained by esterification reaction It is preferable to refine | purify by column chromatography. In addition, although the unreacted sucrose may be contained in the product obtained, you may mix | blend as it is in a skin external preparation as it is, and may remove and mix | blend by the said purification method etc., and may mix | blend.

Among the esters of sucrose and linoleic acid, from the viewpoint of low cytotoxicity and high whitening effect, the diester is preferred, and it is preferable to use a sucrose linoleic acid ester containing a large number of diesters. It is preferable that the sucrose linoleic acid ester to be used contains 20 mass% or more of diester bodies, It is more preferable to contain 30 mass% or more, It is further more preferable that 50 mass% or more is contained. On the other hand, since the monoester is inferior to the diester from the viewpoint of cytotoxicity, and the whitening effect is the highest, the monoester is preferably contained to some extent in the sucrose linoleic acid ester to be used. It is preferable that the sucrose linoleic acid ester to be used contains 20 mass% or more of monoester bodies, It is more preferable to contain 30 mass% or more, It is further more preferable to contain 40 mass% or more.

Sucrose linoleic acid ester is different in the state at normal temperature according to the degree of esterification and composition ratios, such as a mono, di, and a polyester body, and exists in the form of solid-paste. For example, when the ratio of a monoester body becomes high, it becomes a solid at normal temperature, and when a ratio of di or a polyester body becomes high, it becomes a paste form. Any of these forms may be sufficient, and the ratio of a mono, di, and polyester body may be adjusted so that it may become a form which is easy to mix | blend according to the dosage form of a skin external preparation.

The preferred range of the sucrose linoleic acid ester content in the whitening skin external preparation of the present invention varies depending on the formulation of the skin external preparation and the composition ratio of mono, di, and polyester bodies of sucrose linoleic acid ester, but in general, the total mass of the external preparation for skin It is preferable that it is 0.01-20 mass% in it, and it is more preferable that it is 0.1-5 mass%. If the content of the sucrose linoleic acid ester is in the above range, it does not produce a sticky feeling due to the blending of the sucrose linoleic acid ester, resulting in a skin external preparation having an excellent whitening effect. Moreover, as mentioned above, the preferable range of sucrose linoleic acid ester content also changes according to the formulation of the external preparation for skin, For example, in the form of a lotion, 0.01-3 mass% is preferable, and 0.1-1 mass% is more preferable. . Moreover, in the form of an emulsion, 0.01-15 mass% is preferable, and 0.5-10 mass% is more preferable. Moreover, in the form of a cream, 0.01-20 mass% is preferable, and 0.5-15 mass% is more preferable.

The external skin preparation of the present invention may be an emulsified skin external preparation, and in such a case, any of the W / O type and the O / W type may be used. Sucrose linoleic acid ester can be added to any of an aqueous phase and an oil phase, and it is a useful agent also in the point which makes preparation of a skin external preparation easy.

In the present invention, sucrose linoleic acid ester is used as an active ingredient of the skin external preparation for whitening, that is, a whitening agent. In addition, in this specification, the term "whitening" shall be used in the meaning which includes not only the effect which whitens skin but the effect which suppresses blackening of skin, for example, pigmentation, such as a blemish and freckles, is used. Not only the effect to improve but also the effect of suppressing pigmentation shall be included. Although the details of the mechanism in which the sucrose linoleic acid ester exhibits a whitening effect are not clear, it is inferred that the sucrose linoleic acid ester is due to its ability to promote degradation of tyrosinase protein that promotes the synthesis of melanin.

The external preparation for skin of this invention may contain the other active ingredient with sucrose linoleic acid ester. In particular, in combination with other whitening agents, the whitening effect is higher, which is preferable. Moreover, when combined with a whitening agent which exhibits a whitening effect by a mechanism different from the above-mentioned mechanism of sucrose linoleic acid ester, the effect is synergistically increased. It is preferable because it can. Here, the outline of the mechanism of skin blackening is that the expression of tyrosinase gene in melanocytes is increased by stimulation such as melanocyte activating factor secreted from ultraviolet rays or keratinocytes, and the tyrosinase protein is synthesized. It is thought that melanin is synthesize | combined from tyrosine by the enzymatic reaction of a cinase protein, melanin is transferred to keratinocytes, and the color of skin is blackened. As a conventionally known whitening agent, agents which exhibit a whitening effect by the following mechanisms are known, respectively;

(1) inhibits the action of melanocyte activating factors on melanocytes,

(2) inhibits the activity of tyrosinase protein in melanocytes,

(3) promotes the degradation of tyrosinase protein,

(4) inhibits oxidation during synthesis from tyrosine to melanin.

As mentioned above, sucrose linoleic acid ester is estimated to suppress melanin synthesis by the mechanism of (3), and shows a whitening effect. Therefore, it is preferable to combine with the whitening agent which shows a whitening effect by the mechanism of (1), (2), and (4), and in connection with a mechanism, the whitening agent which shows the whitening effect by the mechanism of (2) or (4) More preferably in combination with. As a whitening agent which shows a whitening effect by the mechanism of (1), t-AMCHA (t-4-aminomethyl cyclohexane carboxylic acid), chamomile ET, etc. are mentioned. As a whitening agent which shows a whitening effect by the mechanism of (2), arbutin, ellagic acid, rucinol (4-n-butyl resorcinol), t-AMCHA, ascorbic acid, and its derivative (s) are mentioned. Ascorbic acid and its derivatives are mentioned as a whitening agent which shows the whitening effect by the mechanism of (4). Especially, it is preferable to combine with 1 or more types chosen from arbutin, ellagic acid, ascorbic acid, and its derivative (s). Preferred examples of the derivatives of ascorbic acid include ascorbic acid phosphate ester magnesium salts, ascorbic acid phosphate ester sodium salts, ascorbic acid palmitic acid esters, ascorbic acid glucosides, and ascorbic acid ethyl.

The external preparation for skin of the present invention includes, in addition to the above essential ingredients, various components commonly used in cosmetics, quasi-drugs, and external medicines, that is, water, alcohols, emulsions, surfactants, thickeners, powders, chelating agents, pH adjusters, and various pharmaceutical agents. , Plants and microorganism-derived extracts, pharmaceuticals and the like can be appropriately added within a range that does not impair the effects of the present invention. Examples of various agonists include antioxidants, cell activators, anti-inflammatory agents, anti-UV agents, and the like. The medicinal agents may be used in combination to further enhance the effect of the present invention or to add other effects. .

The form of the external preparation for skin of the present invention is not particularly limited, and, for example, milky lotion, cream, lotion, pack, cleanser, makeup cosmetic, dispersion, ointment, liquid, aerosol, patch, patch, liner, etc. These may be cosmetics of any form, or may be external medicines.

Although an Example is given to the following and this invention is demonstrated to it further more concretely, the scope of the present invention is not limited to the following Example.

Example 1 Preparation of Sucrose Linoleic Acid Ester

First, 76 parts by mass of sucrose, 64 parts by mass of methyl linoleate, 190 parts by mass of dimethyl sulfoxide (DMSO) and 2 to 2.5 parts by mass of catalyst (potassium carbonate) were added, and esterification reaction of sucrose and linoleic acid was carried out. Proceeded. After completion | finish of reaction, citric acid anhydride was added for catalyst neutralization, DMSO was removed, and it washed with water, and obtained the product (sample 1).

The product was fractionated by reversed phase column chromatography (eluent was ethanol → hexane), and each fraction was mixed to obtain Samples 2 to 4 of the compositions shown in Table 1, respectively.

About the obtained samples 1-4, the composition of the monoester, diester, and polyester was investigated by the Iatroscan analysis method (TLC / FID analysis method), and it calculated | required by the mass% when the whole was set to 100. The results are shown in Table 1. In addition, the thin layer automatic detection apparatus Iyatroscan TH-10 of Yatron, Ltd. was used for the analysis.

Example 2: Melanin Production Inhibition Effect

A medium was collected in two 6-well chalets, mouse-derived B16 melanoma cells were seeded, and allowed to stand at 37 ° C. and carbon dioxide concentration of 5 v / v%. The next day, each sample was mixed and mixed with a sample preparation dissolved in ethanol such that the final concentration was a predetermined concentration. In addition, the control was added and mixed only with solution (ethanol). The medium was changed on the 5th day of culture, and the sample preparation was added again. The following day, the medium was removed, the cells were washed with phosphate buffer for one chalet, and recovered. The whiteness of the B16 melanoma cultured cells was visually evaluated based on the following criteria.

(Criteria)

++: Extremely white compared to the control.

+: Clearly white compared to the control.

±: slightly white compared to control.

-: Black same as contrast.

For the remaining one chalet, cells were fixed in formalin, followed by addition of 1% crystal violet solution and staining. The viable cell number (A) and control cell number (B) for each sample concentration were measured by a monocell, and cell viability was calculated by the ratio (A) / (B)%.

Evaluation of whitening degree and cell viability at the concentration of each sample is shown in Table 2 below.

From the above results, all of the samples 1 to 4 of the sucrose linoleic acid ester exhibited a high melanin production inhibitory ability equivalent to linoleic acid. In particular, Sample 2 in which the proportion of the monoester was 20% by mass or more, Sample 3 in which the ratio of the diester was in the range of 20% by mass or more, and Sample 1 in which both the proportions were in excess of 20% by mass showed particularly high melanin production inhibitory ability.

Example 3: Human UV-induced Pigment Deposition Inhibition Test

Cream 1 containing 1% by mass of sample 1 prepared in Example 1 and cream 2 containing 1% by mass of sample 1 and 3% by mass of arbutin were prepared. In addition, the cream 3 which mix | blended only 3 mass% of arbutin and the blank cream which did not mix | blend both sample 1 and arbutin were prepared for comparison, respectively. The composition of each cream is shown in Table 3, respectively. Each was prepared by the following manufacturing method.

A. The components 4-7 are mixed and melted by heating at 70 degreeC.

B. After mixing the components 1 to 3, the mixture is warmed to 70 ° C, emulsified with A, and the components 8 to 11 are added and mixed.

C. The components 12-14 are mixed and melt | dissolved, it adds to B, and mixes uniformly.

D. C was filled in a container to obtain a test cream.

Four places of the upper arm inner part of the subject were irradiated with ultraviolet rays of about 1 MED for 3 days (from day 1 to day 3) to artificially form pigmentation.

Moreover, each cream was apply | coated twice a day for 7 days (until 1st day-7th day of irradiation) to four irradiation parts.

The human UV-induced pigmentation inhibition ability was evaluated by visually determining the color difference measurement on the 7th day from the irradiation and the cream application by the following method on the 3rd and 7th days, respectively.

Visual judgment

Three expert judges compare the degree of pigmentation of the four places of the application part of the blank cream with the application part which apply | coated cream 1-3, respectively, about several subjects, and compare the difference by three steps (+1 , 0, -1: However, evaluation of "-1" showed the highest degree of pigmentation by ultraviolet rays, and the degree of pigmentation was low as it became "0" and "+1", and evaluation approached normal skin color. Is evaluated. The average value of the judge evaluation value (however, the average value converted into 0 as the average value of the application part of the blank cream) was made into the visual point. In addition, determination was performed after performing the said operation for 7 days. The results are shown in Table 4 below.

Color difference measurement judgment

The color difference of the application | coating site | part of the blank cream and the site | part which apply | coated cream 1-3 was measured using the Minolta color-chromaometer CR-200, respectively. The measurement was performed after performing the above work for 3 days and after performing for 7 days. The results are shown in Table 5 below.

From the results shown in Tables 4 and 5 above, it can be understood that creams 1 and 2 containing Sample 1, which is sucrose linoleic acid ester, both exhibited excellent human UV-induced pigmentation inhibition ability. In particular, it can be understood that cream 2 containing both sucrose linoleic acid ester and arbutin exhibits significantly superior human UV-induced pigmentation inhibition ability as compared to cream 3 containing only arbutin.

[Example 4: Evaluation of the dullness improvement effect]

The lotion of the composition shown in following Table 6 was each prepared by the following method.

A. The components 1-11 were melt | dissolved uniformly, and it heated at 70 degreeC.

B. The components 12-17 were mixed and melt | dissolved uniformly, and it heated at 70 degreeC.

C. A was added to B, stirred with a homomixer, and filled into a container to obtain a lotion.

The cream of the composition shown in following Table 7 was respectively prepared by the following method.

A. The components 1-11 were heated and melt | dissolved at 70 degreeC, and were mixed uniformly.

B. The components 12-20 were melt | dissolved by heating at 70 degreeC, and it mixed uniformly.

C. B was added to A, stirred with an homomixer, emulsified, and then filled in a container to obtain a W / O type cream.

Each lotion and each W / O type cream prepared were evaluated according to the following methods and criteria.

(Test method: dullness improvement effect)

About lotion 1 ~ 6 and W / O type creams 4 ~ 7, 10 women aged 35-59 years per panel are used as a panel, and the appropriate amount of the test lotion or cream after face-washing twice a morning and evening for 12 weeks. Was applied to the left half of the face. At the same time, with respect to comparative lotion 7-8 and comparative W / O type creams 8-10, an appropriate amount was applied to the right half of the face in the same manner as above. The dullness improvement effect by application | coating was evaluated according to the following each criteria.

(Evaluation standard)

Dullness improvement effect

<Evaluation> <contents>

Dull skin of the effective skin became inconspicuous.

Dull skin of slightly effective skin is not so noticeable.

There was no change before the invalid use.

<Judgment>

◎: Valid and slightly more than 9 people

(Circle): Effectiveness and slightly effective value 6 or more and 8 or less

(Triangle | delta): Effective and slightly effective, three or more and five or less

×: Valid and slightly less than 2 people

The evaluation results are shown in Tables 6 and 7, respectively.

(Evaluation method regarding skin moisturizing feeling and flexibility)

For each of the samples of the lotion 1-8 and the W / O-type creams 4-10, the sensory tests were performed by the above 10 female panel members for (a) moisturizing feeling of the skin and (b) flexibility of the skin. After the sensory test was used twice a morning and evening for 12 weeks, each sample was evaluated in seven steps based on the following absolute evaluation criteria, and the average value of the rating was further determined based on the following criteria.

<Absolute evaluation criteria>

(Rating): (evaluation)

6: very good

5: Good

4: slightly good

3: normal

2: a little bad

1: bad

0: very bad

<Criteria>

(Average value of the ratings): (judgement)

5.0 or more: ◎ (very good)

3.5 or more, less than 5.0: ○ (good)

1.0 or more, less than 3.5: △ (slightly poor)

1.0 or less: × (bad)

The evaluation results are written together in Table 6 and Table 7, respectively.

(Storage stability test (deodorization, discoloration))

For each of the samples of the lotion 1-8 and the W / O-type creams 4-10, after storing for 3 months in a thermostat at 5 ° C and 40 ° C, respectively, the odor and color change with the passage of days were compared. Evaluation was based on the sample of 5 degreeC preservation, and compared with the sample of 40 degreeC preservation about this, and evaluated according to the following evaluation criteria.

(Evaluation standard)

(Double-circle): There is no change (deodoration and discoloration) with a reference product.

(Circle): Although there is a change (smelling and discoloration) slightly compared with a reference product, there is no problem.

X: There exists a change (deodoration, discoloration) clearly compared with a reference | standard article, and it is a problem.

The results are shown in Tables 6 and 7, respectively.

As is clear from the results of Table 6 and Table 7, the lotion 1 to 6 and W / O type creams 4 to 7 of the present invention are excellent in dullness improving effect, storage stability, skin moisturizing property and skin flexibility, Was also good. On the other hand, the lotion 7-8 and W / O type creams 8-10 which are comparative products were not equivalent to this invention product about all the evaluation items.

For example, in the lotions 7 and 8, instead of sucrose linoleic acid esters, sucrose distearic acid esters in which sucrose and stearic acid are ester-bonded, and sucrose dipalmitic acid esters in which sucrose and palmitic acid are ester-bonded, respectively, The dullness improvement effect was not obtained.

In addition, in the W / O creams 8 and 9, instead of sucrose linoleic acid ester, sucrose distearic acid ester and sucrose dipalmitic acid ester were respectively blended, but the same dullness improvement effect as creams 4 to 7 was not obtained. .

In addition, in W / O type cream 10, linoleic acid was blended in place of sucrose linoleic acid ester, but in particular, odor and discoloration were observed, and there was a problem in storage stability.

[Example 5: Preparation of UV-Protection Cosmetic Solution]

The cosmetic liquid of the composition shown in Table 8 was prepared by the following method.

A. The components 1-11 were heated and melt | dissolved at 70 degreeC, and were mixed uniformly.

B. The components 12-18 were heated and melt | dissolved at 70 degreeC, and were mixed uniformly.

C. A was added to B, stirred with a homomixer, and filled into a container to obtain a cosmetic liquid.

The prepared UV protection cosmetic liquid was excellent in the whitening effect and the usability was also favorable. In addition, discoloration and deterioration with time were not observed.

[Example 6: Preparation of Cleansing Cream]

The cleansing cream of the composition shown in Table 9 was prepared by the following method.

A. The components 1-12 were heated and melt | dissolved at 70 degreeC, and were mixed uniformly.

B. The components 13-17 were melt | dissolved by heating at 70 degreeC, and it mixed uniformly.

C. A was added to B, stirred with an homomixer, emulsified, and then filled in a container to obtain a cleansing cream.

The prepared cleansing cream was excellent in the whitening effect and the usability was also good. In addition, discoloration and deterioration with time were not observed.

[Example 7: Formulation of a Pack]

The pack of the composition shown in following Table 10 was prepared by the following method.

A. The components 4-8 are mixed and melted by heating at 70 degreeC.

B. After mixing the components 1 to 3, the mixture was warmed to 70 ° C, emulsified by adding A, and the components 9 to 11 were added and mixed.

C. Add component 12 to B to neutralize, and add components 13 to 15 to mix.

D. C was filled into a container to obtain a pack.

The prepared pack was excellent in the whitening effect and the usability was also favorable. In addition, discoloration and deterioration with time were not observed.

[Example 8: Formulation of Liquid Foundation]

(Component) Mass%

(1) liquid lanolin 2.0

(2) floating paraffin 5.0

(3) stearic acid 2.0

(4) cetanol 1.0

(5) Self-emulsifying glyceryl monostearate 1.0

(6) paramethoxy cinnamic acid-2-ethylhexyl 8.0

(7) 4-tert-butyl-4'-methoxydibenzoylmethane 2.0

(8) Sample 3 (Prepared in Example 1) 0.5

(9) Methyl paraoxybenzoate 0.1

(10) Glycerin 5.0

(11) Triethanol Amine 1.0

(12) Carboxymethylcellulose 0.2

(13) bentonite 0.5

(14) remaining amount of purified water

(15) Titanium Oxide 6.0

(16) Fine Particle Zinc Oxide 5.0

(17) mica 2.0

(18) Talc 4.0

19. Pigment Color 4.0

20 Golden Extract * 1 0.5

21. Appropriate amount

* 1 Ichimaru Parcos Corporation

(quite)

A. The components (1)-(8) are mixed and dissolved.

B. The components (15)-(19) are added to A, it mixes uniformly, and it maintains at 70 degreeC.

C. The components (9)-(14) are melt | dissolved uniformly and hold | maintain at 70 degreeC.

D. Add B to C and emulsify it uniformly.

After cooling E. D, components (20) and (21) were added to obtain a liquid foundation.

The liquid foundation of Example 8 was a liquid foundation which was excellent in storage stability and excellent in usability with good skin absorption. In addition, by applying the liquid foundation to the skin, there was an excellent whitening effect.

Example 9 Preparation of Sunscreen Latex

(Component) Mass%

(1) polyoxyalkylene-modified organopolysiloxane 1.0

(2) Dimethylpolysiloxane 5.0

(3) octamethylcyclotetrasiloxane 20.0

(4) isononanoic acid isotridecyl 5.0

(5) paramethoxy cinnamic acid-2-ethylhexyl 5.0

(6) Hydrogenated Lecithin * 1 1.0

(7) Sample 4 (Prepared in Example 1) 0.5

(8) Methyl paraoxybenzoate 0.1

(9) Silicon-treated fine particle titanium oxide 10.0

(10) Silicon treated fine particle zinc oxide 10.0

(11) Polystyrene Powder 3.0

(12) trimethylsiloxy silicic acid0.5

(13) dipropylene glycol 3.0

(14) ethyl alcohol 10.0

(15) remaining amount of purified water

(16) sodium chloride 0.2

(17) Hawthorn Extract * 2 1.0

(18) appropriate amount of spices

* 1 Nikko Resinol S-10E made by Nikko Chemicals

* 2 Maruzen Pharmaceutical Co., Ltd.

(quite)

A. The components (1)-(12) are mixed.

B. The components (13)-(16) are mixed.

C. Add B to A and uniformly emulsify.

D. Components (17) and (18) were added to C to obtain a sunscreen emulsion.

The sunscreen latex of Example 9 was excellent in storage stability and the usability with very good skin absorption. In addition, by applying the sunscreen emulsion to the skin, there was an excellent whitening effect.

According to the present invention, it is possible to provide an external preparation for skin such as an emulsion, a cream, a lotion, a pack, a cleaning agent, a makeup cosmetic, etc., which are excellent in whitening effect and also have good stability over time.

Claims (7)

A cosmetic composition for whitening containing sucrose linoleic acid ester as an active ingredient, wherein said sucrose linoleic acid ester contains 20% by mass or more of a diester body. A whitening cosmetic composition comprising sucrose linoleic acid ester as an active ingredient, wherein the sucrose linoleic acid ester contains 20% by mass or more of a monoester. A whitening cosmetic composition comprising sucrose linoleic acid ester as an active ingredient, wherein the sucrose linoleic acid ester contains 20% by mass or more of a monoester body and 20% by mass or more of a diester body. 4. The method according to any one of claims 1 to 3, A whitening cosmetic composition further comprising at least one of whitening agents other than sucrose linoleic acid ester. 5. The method of claim 4, The cosmetic composition for whitening of the said whitening agent is 1 or more types chosen from ascorbic acid and its derivative (s), arbutin, and ellagic acid. A skin whitening method using a cosmetic composition containing sucrose linoleic acid ester as an active ingredient. delete