JPH03209305A - Beautifying cosmetic - Google Patents

Abstract

PURPOSE:To obtain beautifying cosmetics exhibiting excellent synergistic effects to elimination of pigmentation of skin or making pale and further suppressed in stimulation, etc., by combining 2-hydroxy-4-methoybenzophenone with a specific fatty acid or derivative thereof. CONSTITUTION:The beatifying cosmetics obtained by combining a free 18-22C fatty acid having >=2 unsaturated bond numbers in molecular structure, salt thereof or ester (e.g. linoleic acid) of monovalent or bivalent alcohol therewith with 2-hydroxy-4-methoxybenzophenone. The blend amount of free fatty acid, salt thereof or ester thereof in the cosmetics is preferably about 0.1-10wt.% and blend amount of 2-hydroxy-4-methoxybenzophenone is preferably about 0.001-10wt.%. The cosmetics eliminate blackening or pigmentation of skin by ultraviolet ray or make pale or prevent these changes and exhibit excellent beautifying effects.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a whitening cosmetic that eliminates, lightens, or prevents skin darkening or skin pigmentation such as spots and freckles caused by ultraviolet rays.

BACKGROUND TECHNOLOGY AND PROBLEMS Conventionally, whitening cosmetic compositions containing vitamin C and derivatives thereof, reducing agents, and tyrosinase activity inhibitors such as placenta extract are known. However, these conventional whitening cosmetics are made using cultured cells.
Although in vitro experiments have shown that it suppresses melanin production, when it is actually applied to the skin, it does not sufficiently eliminate pigmentation or lighten the color, and there are problems with side effects such as irritation.

Means for Solving the Problems As a result of extensive research into whitening cosmetics, the present inventors unexpectedly found that by combining a specific fatty acid or its derivative with 2-hydroxy-4-methoxybenzophenone, skin whitening cosmetics can be improved. The present inventors have discovered that a synergistic effect that is excellent in eliminating pigmentation or lightening the color of the skin, and that a skin-whitening cosmetic with suppressed irritation can be obtained, leading to the completion of the present invention.

That is, the present invention provides: (a) 2-hydroxy-4-methoxybenzophenone;
and (b) provides a whitening cosmetic containing a free fatty acid having 18 to 22 carbon atoms and 2 or more unsaturated bonds in its molecular structure, a salt thereof, or an ester with a monohydric or dihydric alcohol. It is something to do.

2-Hydroquine-4- blended into the whitening cosmetic of the present invention
Methoxybenzophenone is a cosmetic raw material conventionally known as an ultraviolet absorber, but it is not yet known that it exhibits a synergistic whitening effect on the skin when combined with other active ingredients.

In the present invention, from the viewpoint of whitening effect, it is preferable to blend 2-hydroquine-4-methoxybenzophenone in an amount of 0001 to 10% by weight based on the total amount of the cosmetic.

When blending linoleic acid and the like in the cosmetic composition of the present invention, it is preferable to use purified linoleic acid. Representative examples of the whitening cosmetics of the present invention having 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure include all
I! Examples of fatty acids include gamma fatty acid, arachidonic acid, and eicosapentaenoic acid, and one or more of these may be used.

These fatty acids are usually released from triglycerides in animal and vegetable oils and fats, but triglycerides themselves do not exhibit excellent pigmentation and lightening effects in animal tests, unlike free fatty acids and their alkyl esters. Also,
Some animal and vegetable oils and fats contain saturated fatty acids such as valmitic acid and stearic acid, but these saturated fatty acids do not exhibit a pigmentation-suppressing effect, and in some cases may even promote melanin production. Therefore, it is preferable to use sufficiently purified fatty acids.

Examples of the salts of these fatty acids include alkali metal salts such as sodium salts and potassium salts, amino acid salts such as arginine salts and lysine salts, and amine salts such as triethanolamine salts and monoethanolamine salts.

Furthermore, examples of the alkyl ester of the fatty acid include esters with m alcohols such as methanol, ethanol, and isopropyl alcohol, and esters with dihydric alcohols such as ethylene glycol, propylene glycol, and 1,3-butylene glycol.

The content of these free fatty acids, salts, or esters in cosmetics is preferably 0.1 to 10% by weight. If the amount is less than 0.1% by weight, there will be no effect of lightening pigmentation, while if it exceeds 10% by weight, irritation will be strong.

Next, we will show the results of evaluating various ingredients for their pigmentation elimination or lightening effects and their effects on suppressing skin irritation caused by fatty acids.

Test method: Experiment I The backs of JY-3 yarn-colored guinea pigs were pricked and exposed to ultraviolet light (U).
V8 intensity: IJ/(1,31 was irradiated and pigmentation was obtained after 1 week. Next, 2-hydroxy-
Samples prepared by dissolving various components including 4-methoxybenzophenone and linoleic acid in ethanol were cumulatively applied for 4 weeks. To evaluate the lightening of pigmentation, the degree of pigmentation in the area to which the specimen has not been applied (unapplied) is set to 0, and the degree of pigmentation is judged with the naked eye according to the degree of lightening according to the criteria shown below. went.

Judgment criteria· 0: No lightening of pigmentation is observed.

1: Slight lightening of pigmentation is observed.

2: Moderate lightening of pigmentation is observed.

3: Significant lightening of pigmentation is observed.

The results are shown in Tables 1 and 2 below.

As is clear from Tables 1 and 2, 2-hydroxy-4-methoxybenzophenone alone did not cause any lightening of pigmentation, and the number of carbon atoms and unsaturated bonds in the molecular structure was 18 to 22 and 2 or more. When the free fatty acid, its salt, or alkyl ester is blended alone, there is only slight lightening of the pigmentation. On the other hand, when 2-hydroxy-4-methoxy-benzophenone and the fatty acid or its derivative are used in combination, significant pigmentation is observed.

Experiment 2 Using a patch test plaster on the inner side of the upper arm of 10 healthy subjects, two samples containing 2-hydroxy-4-methoxybenzophenone and linoleic acid as an essence base were applied.
An occluded patch was applied for 4 hours. As a method for evaluating the degree of skin irritation, erythema and edema were determined visually according to the criteria shown below.

Judgment criteria: 0: No change 0.5: Indistinct erythema l: Clear erythema 2: Erythema and edema The average of the judgment measurements of 10 people was multiplied by 100, and the result was determined as a skin disorder failure, and the results are shown in Table 3. show.

As is clear from Table 3, 2-hydroxy-4=methoxybenzophenone has an effect of suppressing skin irritation caused by fatty acids.

Thus, the whitening cosmetic of the present invention contains 2-hydroxy-4
-Methoxybenzophenone and the fatty acid or its derivatives are combined with other desired ingredients by a known method to produce a lotion, cosmetic oil, cream, milky lotion, bag, powder, or the like.

Other ingredients are not particularly limited, and any known ingredients may be added as appropriate, depending on the type of cosmetic, within a range that does not impair performance.

In addition, conventionally used melanin production inhibitors (vitamin C1 placenta extract), ultraviolet absorbers, ultraviolet scattering agents, anti-inflammatory agents, antioxidants, etc. may be further added.

Example Next, the present invention will be explained in more detail with reference to Examples.

Example 1 (Lotion) 2-Hydroxy-4-methoxy-benzophenone Linoleic acid Glycerin Ethanol Polyoxyethylene Hydrogenated castor oil Methyl paraoxybenzoate Citrate Sodium citrate Fragrance Water-soluble Blasenta extract 0.3 0.5 6.0 8 .0 0.8 0.05 0.05 0.07 0.1 2.0 Purified water with glycerin, citric acid, sodium citrate,
Dissolve the water-soluble placenta extract. Separately in ethanol 2-hydroxy-4-methoxybenzophenone, linoleic acid, polyoxyethylene hydrogenated castor oil (60E, O
), methylparaben, and fragrance were dissolved, added to the purified aqueous solution, solubilized, and filtered to obtain a lotion.

Example 2 (cosmetic oil) Ingredients Combination! (Weight%) 2-hydroxy-4-methoxy-1,0 benzophenone ethyl linoleate 1.0 ascorbyl palmitate 0.2 retinol acetate
0.3 Cholesteryl stearate
1.0 Olive oil 2.0 Squalane Other ingredients were uniformly dissolved in the remaining squalane to obtain a cosmetic oil.

Example 3 (cream) Ingredients Amount (wt%) Ingredients (A
) 2-Hydroxy-4-methoxy-1,0 benzophenone γ-lylunic acid 2.0 Ascorbyl stearate 1.0 White beeswax cetanol stearate myristate Isopropyl lanolin Liquid paraffin Self-emulsifying monostearate Glyceryl monostearate Polyoxyethylene Sorbitan (20E, 0.) Propyl paraoxybenzoate component (B) Methylpropylene glycol paraoxybenzoate fragrance 4.0 2.0! , 0 5.0 2.0 9.0 3.0 1.5 0.1 0.2 5.0 0.2 Component (A) is dissolved by heating and maintained at 80°C. Separately, component (B) excluding perfume is dissolved by heating and maintained at 80° C., and component (A) is added to this with stirring and mixed thoroughly. The mixture was further cooled while stirring, a flavoring agent was added, and the mixture was further cooled to obtain a cream.

Example 4 (emulsion) Component Amount (wt%) Component (A
) 2-hydroxy-4-methoxy-0,5 benzophenone isopropyl linoleate 2.0 stearyl glycyrrhetinate 0.1 liquid paraffin
5.0 Vaseline 2
．． 0 Beeswax 1,0 Sorbitan sesquioleate 2.0 Component (B) Polyoxyethylene 2.5 Oleyl ether (20E, O,) Ethyl paraoxybenzoate 0.2 Propylene glycol 5.0 Carboxy vinyl polymer 0.5 Hydroxylation Potassium 0.
5 fragrance 0.2 purified water
The remaining component (A) is heated at 80°C, and the remaining component (B) excluding the fragrance is heated separately (80°C) and dissolved.
) while stirring and mix thoroughly. Next, the mixture was cooled while stirring, perfume was added, and the mixture was further cooled to obtain a milky lotion.

Example 5 (back) Ingredients Amount (wt%) 2-hydroxy-4-methoxy-0,3 benzophenone linoleic acid 3.0 Water-soluble placenta extract 2.0 Vinyl acetate-styrene copolymer ■0.0 polyvinyl alcohol
10.0 Sorbit 5.0 Titanium oxide 8.0 Kaolin
7.0 ethanol
5.0 fragrance
2.0% Ethyl oxybenzoate 0.2
Purified ice Uniformly dissolve the remaining 2-hydroxy-4-methoxybenzophenone, linoleic acid, fragrance, and ethanol. This is vinyl acetate.
Add styrene copolymer, polyvinyl alcohol, sorbitol, titanium oxide, and kaolin to a uniform mixture. To this, a solution in which water-soluble placenta extract and ethyl roseoxybenzoate were uniformly dissolved in purified water was added and mixed uniformly to obtain a pack.

Example 6 (powder) Ingredients Amount (% by weight) 2-hydroxy-4-methoxy-0,3 benzophenone linoleic acid 2.0 Dextrin 95.0 Talc
2.0 Decaglyceryl stearate
1.02-Hydroxy-4-methoxybenzophenone, linoleic acid and decaglyceryl stearate were heated and dissolved, maintained at 70°C, and gradually added to the mixture of dextrin and talc with stirring to obtain a powder.

Effect of the invention

Claims (1)

[Claims] (1) (a) 2-hydroxy-4-methoxybenzophenone, and (b) free fatty acids having 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure, their salts, or monohydric or dihydric alcohols. A whitening cosmetic characterized by containing an ester of.