JPS63201114A - Hair tonic composition - Google Patents
Hair tonic compositionInfo
- Publication number
- JPS63201114A JPS63201114A JP3429287A JP3429287A JPS63201114A JP S63201114 A JPS63201114 A JP S63201114A JP 3429287 A JP3429287 A JP 3429287A JP 3429287 A JP3429287 A JP 3429287A JP S63201114 A JPS63201114 A JP S63201114A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- acid monoglyceride
- oleic acid
- composition
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 230000001256 tonic effect Effects 0.000 title abstract description 7
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims abstract description 20
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims abstract description 20
- WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 11
- 208000001840 Dandruff Diseases 0.000 abstract description 7
- 241001465754 Metazoa Species 0.000 abstract description 7
- 210000004761 scalp Anatomy 0.000 abstract description 5
- 230000005722 itchiness Effects 0.000 abstract 2
- 238000013329 compounding Methods 0.000 abstract 1
- 230000003450 growing effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- 239000003205 fragrance Substances 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003779 hair growth Effects 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 201000004384 Alopecia Diseases 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- 208000024963 hair loss Diseases 0.000 description 6
- 230000003676 hair loss Effects 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 235000015961 tonic Nutrition 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000003660 hair regeneration Effects 0.000 description 3
- 235000019388 lanolin Nutrition 0.000 description 3
- 229940039717 lanolin Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- GVJHHUAWPYXKBD-QLVXXPONSA-N (S,R,R)-alpha-tocopherol Chemical compound [H][C@@](C)(CCCC(C)C)CCC[C@@]([H])(C)CCC[C@@]1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C GVJHHUAWPYXKBD-QLVXXPONSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- ZVTDEEBSWIQAFJ-KHPPLWFESA-N 2-hydroxypropyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C)O ZVTDEEBSWIQAFJ-KHPPLWFESA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 208000006981 Skin Abnormalities Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔利用分野〕
本発明はオレイン酸モノグリセリドまたはリノール酸モ
ノグリセリドを有効成分とする養毛組成物に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Application] The present invention relates to a hair nourishing composition containing oleic acid monoglyceride or linoleic acid monoglyceride as an active ingredient.
（従来技術〕
従来から各種の養毛組成物が脱毛の予防および治療、ふ
けやかゆみの抑制等に用いられいるが、これらの症状の
原因や発生機作が十分には解明されていないこともあっ
て、脱毛を抑制して発毛、養毛を促進し、さらには、ふ
けやかゆみを抑制するのに有効な薬剤は未だ見出されて
いない。(Prior art) Various hair nourishing compositions have been used to prevent and treat hair loss, suppress dandruff and itching, etc., but the causes and mechanisms of occurrence of these symptoms are not fully understood. However, no drug has yet been found that is effective in suppressing hair loss, promoting hair growth and growth, and further suppressing dandruff and itch.
近年、脂肪酸やそのグリセリンエステルの特定の化合物
が、がなりの効果があることが報告されている（特開昭
５９−１４１５１４．特開昭５９−１５２３０７．特開
昭５９−１５２３０８．特開昭５９〜１５２３０８．特
開昭５９−１７２４１０、特開昭５９−１７２４１１．
特開昭６１１８７０９．特開昭５９−２７０９ ） 。In recent years, it has been reported that certain compounds such as fatty acids and their glycerin esters have an anti-inflammatory effect. 59-152308. JP-A-59-172410, JP-A-59-172411.
Japanese Patent Publication No. 6118709. JP-A-59-2709).
しかしながら、上記発明は安全性の点で疑問があり、効
果の面からも十分とは言いがたい。However, the above invention is questionable in terms of safety and cannot be said to be sufficient in terms of effectiveness.
本発明者らは、安全性の高い、より有効なる養毛組成物
が切望されていることにかんがみさらなる研−究を遂行
し、その結果オレイン酸モノグリセリドまたはリノール
酸モノグリセリドが顕著な効果があることを見出し本発
明を完成した。In view of the need for a highly safe and more effective hair nourishing composition, the present inventors conducted further research and found that oleic acid monoglyceride or linoleic acid monoglyceride had remarkable effects. They found this and completed the present invention.
すなわち、本発明はオレイン酸モノグリセリドまたはリ
ノール酸モノグリセリドを有効成分とする養毛組成物で
ある。That is, the present invention is a hair nourishing composition containing oleic acid monoglyceride or linoleic acid monoglyceride as an active ingredient.
本発明の有効成分であるオレイン酸モノグリセリドまた
はリノール酸モノグリセリドは、化粧料分野において湿
潤剤としての用途は知られていたが、ふけやかゆみの抑
−１効果及び養毛効果や育毛効果があることは新規な事
項である。Oleic acid monoglyceride or linoleic acid monoglyceride, which is the active ingredient of the present invention, has been known to be used as a humectant in the cosmetics field, but it is also known that it has a suppressive effect on dandruff and itch, and a hair nourishing effect. is a new matter.
一方、本発明に係わる上記物質は、人体に対して毒性を
有しないことから、養毛組成物への配合比は特に限定さ
れず、随意に選択することができる。しかしながら養毛
組成物の基材への溶解ならびに分散させるといった実際
面から０．０１重量％ないし１０重機影の配合比が好ま
しい。On the other hand, since the above substances according to the present invention are not toxic to the human body, the blending ratio in the hair growth composition is not particularly limited and can be selected as desired. However, from the practical point of view of dissolving and dispersing the hair nourishing composition in the base material, a blending ratio of 0.01% by weight to 10% by weight is preferred.
この発明の養毛組成物に使用する基材としては、化粧料
に常用されている任意のものを使用することができ、例
えば、蒸留水やエタノール、グリセリン、エチレングリ
コール等の多価アルコール類、油脂類、界面活性剤など
を使用することができる。また、この発明の効果を損な
わない限りにおいて従来の養毛組成物や整髪組成物に使
用されている公知の諸成分を含有せしめることができ、
これらの成分としては、例えばトコフェノール、ホルモ
ン類、ビタミン類、アミノ酸類、生薬エキス類、湿潤剤
、香料等を挙げることができる。As the base material used in the hair growth composition of this invention, any base material commonly used in cosmetics can be used, such as distilled water, polyhydric alcohols such as ethanol, glycerin, and ethylene glycol, Oils and fats, surfactants, etc. can be used. In addition, various known ingredients used in conventional hair nourishing compositions and hair styling compositions may be included as long as they do not impair the effects of the present invention.
Examples of these components include tocophenols, hormones, vitamins, amino acids, crude drug extracts, humectants, fragrances, and the like.
本発明の養毛組成物の網形はへアートニンク、ヘアーク
リーム、ヘアーローション、シャンプー、リンス、ポマ
ード、エアーゾル等の常用のものとすることができる。The net shape of the hair nourishing composition of the present invention can be those commonly used in hair tonics, hair creams, hair lotions, shampoos, conditioners, pomades, aerosols, and the like.
本発明の養毛組成物をヒトの頭皮または動物の皮膚に適
用した場合、強力な養毛効果を発揮する、すなわち、こ
の発明の組成物を頭皮に適用した場合、抜は毛、脱毛が
抑制され、産毛化した頭髪が健全化し、また毛の伸長速
度が顕著に１：昇する、またふけの発生が抑制され、か
ゆみが防止される。更に、この発明の化粧料を動物に適
用した場合、毛の伸長速度が顕著に上昇する。When the hair growth composition of the present invention is applied to the human scalp or animal skin, it exhibits a strong hair growth effect, that is, when the composition of the present invention is applied to the scalp, hair loss and hair loss are suppressed. This makes the hair on the scalp healthy, the growth rate of the hair increases significantly, and the occurrence of dandruff is suppressed and itching is prevented. Furthermore, when the cosmetic composition of the present invention is applied to animals, the rate of hair growth is significantly increased.
本発明の養毛組成物は、ヒト及び動物に対する安全性に
ついて全く問題がない。すなわち、オレイン酸モノグリ
セリドおよびリノール酸モノグリセリドの１０重量％エ
タノール溶液を各々作成し、これらを背部毛を剃ったＣ
３ Ｈ／ Ｈｅ Ｎ Ｃｒ ｊマウス（生後７０日）
１０頭ずつに、ｔＨｔ回７回器日間たり塗布し、エタノ
ールのみを塗布した対照と比較した結果、なんら皮膚の
異常は認められなかった。The hair growth composition of the present invention has no safety problems for humans and animals. That is, 10% by weight ethanol solutions of oleic acid monoglyceride and linoleic acid monoglyceride were each prepared, and these were added to C, whose back hair was shaved.
3H/HeNCrj mouse (70 days old)
tHt was applied to each of 10 animals for 7 days, and compared with a control in which only ethanol was applied, no skin abnormalities were observed.
以下実施例によりさらに詳しく説明する。This will be explained in more detail below with reference to Examples.
１１１− 各種配合例をその網形と共に示す。111- Various formulation examples are shown together with their net shapes.
±人口１ユヘアトニック
オレイン酸モノグリセリド ０．５ ％酢酸ミーα
−トコフェロール０．１ ％パントテニールアルコー
ル ０．１ ％ビオチン ０．００
１ ％メントール ０．１ ％香料
０．２ ％エタノール
７５ ％蒸留水 全！ｔ
１００％とする。±Population 1 Uhair Tonic Oleic Acid Monoglyceride 0.5% Acetate Mi α
-Tocopherol 0.1% Pantothenyl alcohol 0.1% Biotin 0.00
1% menthol 0.1% fragrance 0.2% ethanol
All 75% distilled water! t
Set to 100%.
工Ｎ二主ＩＣ！トニック
リノール酸モノグリセリド ０．５ ％酢酸ｄ−α
−トコフェロール０．１ ％パントテニールアルコー
ル ０．１ ％ビオチン ０．００
１ ％メントール ０．１ ％香料
０．２ ％エタノール
７５ ％蒸留水 全＠１
００％とする。Engineering N two main IC! Tonic linoleic acid monoglyceride 0.5% acetic acid d-α
-Tocopherol 0.1% Pantothenyl alcohol 0.1% Biotin 0.00
1% menthol 0.1% fragrance 0.2% ethanol
75% distilled water total @1
00%.
（Ｂ−１）ヘアクリーム
オレイン酸モノグリセリド ０．５ ％酢ｆＩＩｄ
ｌ−α−トコフェロール０．２ ％流動パラフィン
３３ ％ワセリン
５ ％ミツロウ ５ ％ラノリ
ン ３ ％ポリオキシエチレンソ
ルビタン
セスキオレート ２ ％
香料 ０．２ ％蒸留水
全量１００％とする。(B-1) Hair cream oleic acid monoglyceride 0.5% vinegar fIId
l-α-tocopherol 0.2% liquid paraffin
33% Vaseline
5% beeswax 5% lanolin 3% polyoxyethylene sorbitan sesquiolate 2% fragrance 0.2% distilled water
The total amount is 100%.
（Ｂ−２）ヘアクリーム
リノール酸モノグリセリド ０．５ ％酢酸ミーα
−トコフェロール０．２ ％流動パラフィン
３３ ％ワセリン ５ ％
ミツロウ ５ ％
ラノリン ３ ％
ポリオキシエチレンソルビタン
セスキオレート ２ ％
香料 ０．２ ％ 。(B-2) Hair cream linoleic acid monoglyceride 0.5% acetic acid mea
-Tocopherol 0.2% liquid paraffin
33% petrolatum 5% beeswax 5% lanolin 3% polyoxyethylene sorbitan sesquiolate 2% fragrance 0.2%.
蒸留水 全１１００％とする。Distilled water Total 1100%.
±リーし［クヤンブー
オレイン酸モノグリセリド ０．１ ％ヤシ油
１４ ％オリーブ油
３ ％ヒマシ油 ３ ％水
酸化カリウム ４．７ ％グリセリン
２ ％
エタノール ４ ％へキサメタリン
酸ナトリウム １ ％香料
０．２ ％蒸留水 全量１００％とする
。± Leeshi [Cuyanbu Oleic Acid Monoglyceride 0.1% Coconut Oil
14% olive oil
3% castor oil 3% potassium hydroxide 4.7% glycerin
2% ethanol 4% sodium hexametaphosphate 1% fragrance
0.2% distilled water Make the total amount 100%.
−←仄二二ＬＹ」ンス
オレイン酸モノグリセリド ０．２ ％塩化ステア
リルジメチルベンジル
アンモニウム ８ ％
硫酸ナトリウム ３ ％尿素
２ ％
ラノリン ４ ％モノオレイン酸
プロピレングリコール
ｌ ％
香料 ０．２ ％蒸留水
全量１００％とする。−←组二二LY” oleic acid monoglyceride 0.2% Stearyldimethylbenzylammonium chloride 8% Sodium sulfate 3% Urea
2% Lanolin 4% Propylene Glycol Monooleate l% Fragrance 0.2% Distilled Water
The total amount is 100%.
ＬＬ：１）ポマード
オレイン酸モノグリセリド １ ％モクロウ
１２ ％ヒマシ油
８６．８ ％香料 ０，２
％−（Ｅ−２）ボマ：ユし
リノール酸モノグリセリド １ ％モクロウ
１２ ％ヒマシ油
８６．８ ％香料 ０．２
％（Ｅ−３）ポマード
オレイン酸モノグリセリド ０．５ ％リノール酸
モノグリセリド ０．５ ％モクロウ
１２ ％ヒマシ油 ８６．
８ ％香料 ０．２ ％叉
Ｊ１鍔−一「
実施例１で調整した（Ａ−１）ヘアトニックを、ふけ、
かゆみ、または抜は毛等の症状を呈する１０名の男子（
２９〜５２歳）に１日１〜２回、２〜４１ｄずつ１か月
にわたって投与したところ、次の第−表の結果をえた。LL:1) Pomade oleic acid monoglyceride 1% Mokuro
12% castor oil
86.8% fragrance 0.2
%-(E-2) Boma: Yushilinoleic acid monoglyceride 1% Mokuro
12% castor oil
86.8% fragrance 0.2
% (E-3) Pomade Oleic acid monoglyceride 0.5% Linoleic acid monoglyceride 0.5% Mokuro
12% castor oil 86.
8% fragrance 0.2%
Ten boys with symptoms such as itching or hair loss (
When the drug was administered to patients aged 29 to 52 years old in doses of 2 to 41 d once or twice a day for one month, the results shown in the following table were obtained.
第−表
〔判定基準〕著効：症状の停止があったもの有効：症状
の軽減があったもの
無効：症状の改善がみられないもの
〔注〕−印は症状が投与前よりないもの害１１−ユＬ
実施例１で調整した（Ａ−２）ヘアトニックを、ふけ、
かゆみ、または抜は毛等の症状を呈する１０名の男子（
２９〜４６歳）に１日１〜２回、２〜４１ｄｌずつ１か
月にわたって投与したところ、次の第二表の結果をえた
。Table - Judgment Criteria: Significant response: Symptoms stopped. Effective: Symptoms were reduced. Ineffective: Symptoms did not improve. [Note] - indicates that symptoms are no longer present than before administration. 11-UL The hair tonic (A-2) prepared in Example 1 was used to treat dandruff,
Ten boys with symptoms such as itching or hair loss (
When the drug was administered to patients aged 29 to 46 years old at a dose of 2 to 41 dl once or twice a day for one month, the results shown in Table 2 below were obtained.
第二表
〔判定基準〕著効：症状の停止トがあったもの有効：症
状の軽減があったもの
無効：症状の改善がみられないもの
〔注］−印は症状が投与前よりないものＸ遣Ｊ１−（ヱ
文λ刃ｉｔ ｔ 、ｇ口υＷ雄のＣ３１１／ｌ１ｅＮＣ
ｒｊマウス（生後５８日目）を用い、小川らの方法〔ノ
ーマル・アンド・アブノーマル・エピデルマル・デイフ
エレンシエーション（Ｎｏｒｍａｌ ａｎｄ Ａｂ
ｎｏｒｍａｌ Ｅｐｉｄｅｒｓａｌ Ｄｉ［ａｒｅ
ｎｔｉａ−ｔｉｏｎ）、Ｍ、５ｅｉｊｉ及び１．＾、Ｒ
ｅｒｎｓＬｅｉｎ １１２集、東大出版会〕に従い実験
を行った。マウスの背部毛を約２Ｘ４Ｃ１１の大きさに
剃り、翌日より１日１回ずつサンプル塗布を連日行い、
皮膚の色がピンクからグレーに変わり始めた部分（毛再
生が始まった部分）の面積比率の変化を求めた。全ての
マウスの毛をそった部分全体に毛再生が認められる迄、
実験を行い、毛再生の早さの比較を行った。Table 2 [Judgment Criteria] Excellent response: Symptoms stopped. Effective: Symptoms were alleviated. Ineffective: Symptoms did not improve. X-Kei J1-(Ebun λ blade it t, g mouth υW male's C311/l1eNC
Using rj mice (58 days old), Ogawa et al.'s method [Normal and Abnormal Epidermal Differentiation (Normal and Ab
Normal Epidermal Di[are
ntia-tion), M, 5eiji and 1. ^,R
The experiment was carried out in accordance with [Erns Lein Vol. 112, University of Tokyo Press]. The hair on the back of the mouse was shaved to a size of approximately 2×4C11, and samples were applied once a day from the next day.
Changes in the area ratio of areas where the skin color began to change from pink to gray (areas where hair regeneration began) were determined. Until hair regrowth was observed in the entire shaved area of all mice.
An experiment was conducted to compare the speed of hair regeneration.
サンプルは、オレイン酸モノグリセリドおよびリノール
酸モノグリセリドをそれぞれ１ｇずつエタノール１５（
ｌｄに溶解し、蒸留水を加えて、２００ａｔに調整した
溶液、２種類を用いた。対照区として７５％エタノール
（７５％ＥｔＯＨ）を用いた、各処理区ともマウス１０
匹ずつを用い、各区の面積比率の平均値を求め、その結
果を第１図および第２図に示す。The samples were 1 g each of oleic acid monoglyceride and linoleic acid monoglyceride in ethanol 15 (
Two types of solutions were used, which were adjusted to 200 at by dissolving it in 1d and adding distilled water. 75% ethanol (75% EtOH) was used as a control group, and each treatment group had 10 mice.
Using each animal, the average value of the area ratio of each area was determined, and the results are shown in FIGS. 1 and 2.
第１図および第２図から明らかなように、オレイン酸モ
ノグリセリド、リノール酸モノグリセリドともに毛の再
生開始時期および完全に回復するまでの期間において顕
著な効果が認められた。As is clear from FIGS. 1 and 2, both oleic acid monoglyceride and linoleic acid monoglyceride had a remarkable effect on the start of hair regeneration and the period until complete recovery.
第１図はオレイン酸モノグリセリドをマウスに投与した
場合の効果を示し、第２図は、リノール酸モノグリセリ
ドをマウスに均厚した場合の効果を示す。
特許出願人 サントリー株式会社
特許出願代理人 竹 １）逸 部
秦１ｖＪ
（Ｚ）
黍１っＴ；儀の ｇ欽
奉２図
（〃）
番１フｎ優のＥｒ歓
手続補正書（自発）
昭和６２年ｌＯ月２０日
１、事件の表示
昭和６２年特許ｌ１８１第３４２９２号２、発明の名称
養毛組成物
３、補正をする者
事件との関係 特許出願人
東京都港区元赤坂１丁目２番３号
サントリー株式会社特許情報部
６、補正の内容
（１）明細書の特許請求の範囲を別紙のとおり訂正する
。
（２）明細書第１頁第１７行の「用いられ」の後に、「
て」を挿入する。
（３）明細書第２頁第１３行の「かんがみ」の後に、「
、」を挿入する。
（４）明細書第３頁第１９行の「トコフェノール」を削
除する。
（５）明細書第４真第１１行の「また」の後に「、」を
挿入する。
（６）明細書第４頁第１２行の「また」の後に「、」を
挿入する。
（７）明細書第１１頁第４行の「（２９〜４６歳）」を
「（２５〜４６歳）」に訂正する。
以上
発明の詳細な説明の欄
特許請求の範囲
（１）オレイン酸モノグリセリドまたはリノール酸モノ
グリセリドを有効成分とする養毛組成物。
（２）オレイン酸モノグリセリドまたはリノール酸モノ
グリセリドの配合比が０．０１ないし１０重量％？−夷
至特許請求の範囲第（１１項記載の養毛組成物。FIG. 1 shows the effect when oleic acid monoglyceride is administered to mice, and FIG. 2 shows the effect when linoleic acid monoglyceride is administered to mice in a uniform thickness. Patent Applicant Suntory Ltd. Patent Application Agent Take 1) Itbe Hata 1vJ (Z) Millet 1 T; October 20, 1962 1, Display of the case 1986 Patent 181 No. 34292 2 Name of the invention Hair nourishing composition 3 Person making the amendment Relationship to the case Patent applicant 1-2 Motoakasaka, Minato-ku, Tokyo No. 3 Suntory Limited Patent Information Department 6 Contents of amendment (1) The scope of claims in the specification will be corrected as shown in the attached sheet. (2) After “Used” on page 1, line 17 of the specification, “
Insert "te". (3) After “Kangami” on page 2, line 13 of the specification, “
," is inserted. (4) "Tocopherol" on page 3, line 19 of the specification is deleted. (5) Insert "," after "also" in line 4, line 11 of the specification. (6) Insert "," after "also" on page 4, line 12 of the specification. (7) "(29-46 years old)" on page 11, line 4 of the specification is corrected to "(25-46 years old)". Detailed Description of the Invention Section Claims (1) A hair nourishing composition containing oleic acid monoglyceride or linoleic acid monoglyceride as an active ingredient. (2) Is the blending ratio of oleic acid monoglyceride or linoleic acid monoglyceride 0.01 to 10% by weight? - The hair nourishing composition according to claim 11.
Claims (2)
グリセリドを有効成分とする養毛組成物。(1) A hair nourishing composition containing oleic acid monoglyceride or linoleic acid monoglyceride as an active ingredient.
グリセリドの配合比が０．０１ないし１０重量％である
特許請求の範囲第（１）項記載の養毛組成物。(2) The hair nourishing composition according to claim (1), wherein the blending ratio of oleic acid monoglyceride or linoleic acid monoglyceride is 0.01 to 10% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3429287A JPS63201114A (en) | 1987-02-17 | 1987-02-17 | Hair tonic composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3429287A JPS63201114A (en) | 1987-02-17 | 1987-02-17 | Hair tonic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63201114A true JPS63201114A (en) | 1988-08-19 |
Family
ID=12410079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3429287A Pending JPS63201114A (en) | 1987-02-17 | 1987-02-17 | Hair tonic composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63201114A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0971513A (en) * | 1995-09-07 | 1997-03-18 | Taisho Pharmaceut Co Ltd | Hair tonic |
-
1987
- 1987-02-17 JP JP3429287A patent/JPS63201114A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0971513A (en) * | 1995-09-07 | 1997-03-18 | Taisho Pharmaceut Co Ltd | Hair tonic |
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