JPS6257631B2 - - Google Patents

Info

Publication number
JPS6257631B2
JPS6257631B2 JP53016013A JP1601378A JPS6257631B2 JP S6257631 B2 JPS6257631 B2 JP S6257631B2 JP 53016013 A JP53016013 A JP 53016013A JP 1601378 A JP1601378 A JP 1601378A JP S6257631 B2 JPS6257631 B2 JP S6257631B2
Authority
JP
Japan
Prior art keywords
trifluoromethyl
bis
quinolinemethanol
piperidyl
hydrogenation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53016013A
Other languages
English (en)
Japanese (ja)
Other versions
JPS53103478A (en
Inventor
Gureete Gyuntaa
Mitsuto Toomasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS53103478A publication Critical patent/JPS53103478A/ja
Publication of JPS6257631B2 publication Critical patent/JPS6257631B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP1601378A 1977-02-17 1978-02-16 Method of producing erythro alphaa22piperidyl 2*88bis*trifluoromethyl**44quinolinemethanol Granted JPS53103478A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76981677A 1977-02-17 1977-02-17

Publications (2)

Publication Number Publication Date
JPS53103478A JPS53103478A (en) 1978-09-08
JPS6257631B2 true JPS6257631B2 (cg-RX-API-DMAC10.html) 1987-12-02

Family

ID=25086585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1601378A Granted JPS53103478A (en) 1977-02-17 1978-02-16 Method of producing erythro alphaa22piperidyl 2*88bis*trifluoromethyl**44quinolinemethanol

Country Status (9)

Country Link
JP (1) JPS53103478A (cg-RX-API-DMAC10.html)
AT (1) AT358044B (cg-RX-API-DMAC10.html)
BE (1) BE864002A (cg-RX-API-DMAC10.html)
CH (2) CH640530A5 (cg-RX-API-DMAC10.html)
DE (1) DE2806909A1 (cg-RX-API-DMAC10.html)
FR (1) FR2381044A1 (cg-RX-API-DMAC10.html)
GB (1) GB1594282A (cg-RX-API-DMAC10.html)
IT (1) IT1158450B (cg-RX-API-DMAC10.html)
NL (1) NL7801787A (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0234129U (cg-RX-API-DMAC10.html) * 1989-05-25 1990-03-05

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2940443A1 (de) * 1979-10-05 1981-04-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
DE3038504A1 (de) 1980-10-11 1982-06-03 Basf Ag, 6700 Ludwigshafen Neue 4-chinolinmethanderivate, ihre herstellung und verwendung zur darstellung von substanzen mit arzneimittelwirkung
US4507482A (en) * 1982-04-14 1985-03-26 Hoffmann-La Roche Inc. Purification of mefloquin hydrochloride
DK160499C (da) * 1982-09-10 1991-08-26 Hoffmann La Roche Fremgangsmaade til fremstilling af mefloquin og mellemprodukt til anvendelse herved
HUT54363A (en) * 1989-07-25 1991-02-28 Alkaloida Vegyeszeti Gyar Process for producing pyridyl-methyl-quinolin derivatives
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH590275A5 (cg-RX-API-DMAC10.html) * 1970-03-16 1977-07-29 Hoffmann La Roche
CH605916A5 (cg-RX-API-DMAC10.html) * 1973-12-07 1978-10-13 Hoffmann La Roche

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0234129U (cg-RX-API-DMAC10.html) * 1989-05-25 1990-03-05

Also Published As

Publication number Publication date
ATA113378A (de) 1980-01-15
AT358044B (de) 1980-08-11
DE2806909C2 (cg-RX-API-DMAC10.html) 1988-04-07
IT7820331A0 (it) 1978-02-16
JPS53103478A (en) 1978-09-08
NL7801787A (nl) 1978-08-21
FR2381044B1 (cg-RX-API-DMAC10.html) 1983-06-10
GB1594282A (en) 1981-07-30
IT1158450B (it) 1987-02-18
CH640530A5 (en) 1984-01-13
DE2806909A1 (de) 1978-08-24
CH640531A5 (en) 1984-01-13
FR2381044A1 (fr) 1978-09-15
BE864002A (fr) 1978-08-16

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