GB1594282A - Process for the manufacture of mefloquine - Google Patents

Process for the manufacture of mefloquine Download PDF

Info

Publication number
GB1594282A
GB1594282A GB6207/78A GB620778A GB1594282A GB 1594282 A GB1594282 A GB 1594282A GB 6207/78 A GB6207/78 A GB 6207/78A GB 620778 A GB620778 A GB 620778A GB 1594282 A GB1594282 A GB 1594282A
Authority
GB
United Kingdom
Prior art keywords
bis
trifluoromethyl
quinolinemethanol
piperidyl
erythro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6207/78A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1594282A publication Critical patent/GB1594282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
GB6207/78A 1977-02-17 1978-02-16 Process for the manufacture of mefloquine Expired GB1594282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76981677A 1977-02-17 1977-02-17

Publications (1)

Publication Number Publication Date
GB1594282A true GB1594282A (en) 1981-07-30

Family

ID=25086585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6207/78A Expired GB1594282A (en) 1977-02-17 1978-02-16 Process for the manufacture of mefloquine

Country Status (9)

Country Link
JP (1) JPS53103478A (cg-RX-API-DMAC10.html)
AT (1) AT358044B (cg-RX-API-DMAC10.html)
BE (1) BE864002A (cg-RX-API-DMAC10.html)
CH (2) CH640530A5 (cg-RX-API-DMAC10.html)
DE (1) DE2806909A1 (cg-RX-API-DMAC10.html)
FR (1) FR2381044A1 (cg-RX-API-DMAC10.html)
GB (1) GB1594282A (cg-RX-API-DMAC10.html)
IT (1) IT1158450B (cg-RX-API-DMAC10.html)
NL (1) NL7801787A (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429130A (en) 1980-10-11 1984-01-31 Basf Aktiengesellschaft Pyrid-2'-yl-2-trifluoromethyl quinol-4-ylmethanes

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2940443A1 (de) * 1979-10-05 1981-04-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
US4507482A (en) * 1982-04-14 1985-03-26 Hoffmann-La Roche Inc. Purification of mefloquin hydrochloride
DK160499C (da) * 1982-09-10 1991-08-26 Hoffmann La Roche Fremgangsmaade til fremstilling af mefloquin og mellemprodukt til anvendelse herved
JPH0234129U (cg-RX-API-DMAC10.html) * 1989-05-25 1990-03-05
HUT54363A (en) * 1989-07-25 1991-02-28 Alkaloida Vegyeszeti Gyar Process for producing pyridyl-methyl-quinolin derivatives
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH590274A5 (cg-RX-API-DMAC10.html) * 1970-03-16 1977-07-29 Hoffmann La Roche
CH605916A5 (cg-RX-API-DMAC10.html) * 1973-12-07 1978-10-13 Hoffmann La Roche

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429130A (en) 1980-10-11 1984-01-31 Basf Aktiengesellschaft Pyrid-2'-yl-2-trifluoromethyl quinol-4-ylmethanes

Also Published As

Publication number Publication date
DE2806909A1 (de) 1978-08-24
FR2381044B1 (cg-RX-API-DMAC10.html) 1983-06-10
CH640530A5 (en) 1984-01-13
FR2381044A1 (fr) 1978-09-15
IT7820331A0 (it) 1978-02-16
JPS53103478A (en) 1978-09-08
AT358044B (de) 1980-08-11
ATA113378A (de) 1980-01-15
CH640531A5 (en) 1984-01-13
NL7801787A (nl) 1978-08-21
IT1158450B (it) 1987-02-18
BE864002A (fr) 1978-08-16
DE2806909C2 (cg-RX-API-DMAC10.html) 1988-04-07
JPS6257631B2 (cg-RX-API-DMAC10.html) 1987-12-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930216