JPS6245879B2 - - Google Patents

Info

Publication number
JPS6245879B2
JPS6245879B2 JP54113470A JP11347079A JPS6245879B2 JP S6245879 B2 JPS6245879 B2 JP S6245879B2 JP 54113470 A JP54113470 A JP 54113470A JP 11347079 A JP11347079 A JP 11347079A JP S6245879 B2 JPS6245879 B2 JP S6245879B2
Authority
JP
Japan
Prior art keywords
androstane
dipiperidino
methobromide
acid
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54113470A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5535098A (en
Inventor
Kureigu Kaariru Ian
Surei Toomasu
Samyueru Saueji Deiuido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of JPS5535098A publication Critical patent/JPS5535098A/ja
Publication of JPS6245879B2 publication Critical patent/JPS6245879B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
JP11347079A 1978-09-05 1979-09-04 16 betaamonoquaternary ammonium derivative acid addition salt of 2 beta*16 betaabiss piperidinooandrostane and medicine containing it Granted JPS5535098A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7835667 1978-09-05

Publications (2)

Publication Number Publication Date
JPS5535098A JPS5535098A (en) 1980-03-11
JPS6245879B2 true JPS6245879B2 (https=) 1987-09-29

Family

ID=10499453

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11347079A Granted JPS5535098A (en) 1978-09-05 1979-09-04 16 betaamonoquaternary ammonium derivative acid addition salt of 2 beta*16 betaabiss piperidinooandrostane and medicine containing it

Country Status (20)

Country Link
US (2) US4237126A (https=)
EP (1) EP0008824B1 (https=)
JP (1) JPS5535098A (https=)
AR (1) AR228728A1 (https=)
AT (1) ATE921T1 (https=)
AU (1) AU526270B2 (https=)
CA (1) CA1134813A (https=)
DE (1) DE2962627D1 (https=)
DK (1) DK159119C (https=)
ES (1) ES483894A1 (https=)
FI (1) FI66881C (https=)
GR (1) GR72520B (https=)
HU (1) HU181847B (https=)
IE (1) IE50376B1 (https=)
IL (1) IL58080A (https=)
NO (1) NO151367C (https=)
NZ (1) NZ191462A (https=)
PH (1) PH16041A (https=)
PT (1) PT70126A (https=)
ZA (1) ZA794371B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
US5238957A (en) * 1988-07-07 1993-08-24 Presidenza Del Consiglio Dei Ministri-Uffico Del Ministro Per Il Coordinamento Delle Iniziative Per La Ricerca Scientifica E Tecnologica Esters of 2,2-dimethyl-cyclopropane-carboxylic acid
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
US5767112A (en) * 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
US5553456A (en) * 1995-05-17 1996-09-10 Ramco, Inc. Clathrate freeze desalination apparatus and method
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
HU0402017D0 (en) * 2004-10-07 2004-12-28 Richter Gedeon Vegyeszet Environment-friend process for the synthesis of quaternary ammonio-steroids
WO2006038047A1 (en) * 2004-10-07 2006-04-13 Richter Gedeon Vegyészeti Gyár Rt. Environment-friend process for the synthesis of quaternary ammonio-steroιds
WO2006113462A2 (en) * 2005-04-15 2006-10-26 Lyotropic Therapeutics, Inc. Formulations of quaternary ammonium neuromuscular blocking agents
DE102005030423A1 (de) * 2005-06-30 2007-01-04 Inresa Arzneimittel Gmbh Neue Formulierung für Vecuroniumbromid
ATE554769T1 (de) 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2022078483A1 (zh) * 2020-10-15 2022-04-21 江苏恩华络康药物研发有限公司 甾体季铵化合物及其制备方法、制剂和用途
CN116925171B (zh) * 2023-07-10 2025-06-27 时森海(杭州)医药科技有限公司 含环丙甲基甾体类季铵盐化合物、中间体及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
US4177190A (en) * 1975-08-01 1979-12-04 Richter Gedeon Vegyeszeti Gyar Rt. Diamino-androstanes and a process for the preparation of the said compounds
HU172522B (hu) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh 2beta, 16beta-diamino-androstana i ikh chetvertichnykh solej

Also Published As

Publication number Publication date
ATE921T1 (de) 1982-05-15
EP0008824A1 (en) 1980-03-19
IE50376B1 (en) 1986-04-16
GR72520B (https=) 1983-11-16
FI66881B (fi) 1984-08-31
NZ191462A (en) 1982-03-16
IL58080A0 (en) 1979-12-30
AU526270B2 (en) 1982-12-23
NO151367C (no) 1985-03-27
US4297351A (en) 1981-10-27
US4237126A (en) 1980-12-02
DK361779A (da) 1980-03-06
NO792810L (no) 1980-03-06
CA1134813A (en) 1982-11-02
EP0008824B1 (en) 1982-04-28
DE2962627D1 (en) 1982-06-09
HU181847B (en) 1983-11-28
PH16041A (en) 1983-06-02
JPS5535098A (en) 1980-03-11
IL58080A (en) 1982-12-31
FI792745A7 (fi) 1980-03-06
PT70126A (en) 1979-09-01
AU5034879A (en) 1980-03-13
DK159119C (da) 1991-03-11
IE791593L (en) 1980-03-05
NO151367B (no) 1984-12-17
DK159119B (da) 1990-09-03
AR228728A1 (es) 1983-04-15
ZA794371B (en) 1980-08-27
ES483894A1 (es) 1980-09-01
FI66881C (fi) 1984-12-10

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