JPS6245877B2 - - Google Patents
Info
- Publication number
- JPS6245877B2 JPS6245877B2 JP53097457A JP9745778A JPS6245877B2 JP S6245877 B2 JPS6245877 B2 JP S6245877B2 JP 53097457 A JP53097457 A JP 53097457A JP 9745778 A JP9745778 A JP 9745778A JP S6245877 B2 JPS6245877 B2 JP S6245877B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- oxazolidinyl
- bis
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 72
- 229910052757 nitrogen Inorganic materials 0.000 claims description 59
- 150000001875 compounds Chemical class 0.000 claims description 48
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 26
- -1 acetyloxy, pivalyloxy, 3,5-dinitrobenzoyloxy Chemical group 0.000 claims description 23
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- UIBHKZCMOPHOOT-UHFFFAOYSA-N NP(N)(=O)NCl Chemical compound NP(N)(=O)NCl UIBHKZCMOPHOOT-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims description 14
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 13
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 239000012442 inert solvent Substances 0.000 claims description 10
- 125000004423 acyloxy group Chemical group 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 9
- 125000003277 amino group Chemical group 0.000 claims description 8
- 229930182555 Penicillin Natural products 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims description 7
- DMSZORWOGDLWGN-UHFFFAOYSA-N ctk1a3526 Chemical compound NP(N)(N)=O DMSZORWOGDLWGN-UHFFFAOYSA-N 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 6
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 6
- 150000001734 carboxylic acid salts Chemical class 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 229940049954 penicillin Drugs 0.000 claims description 6
- 229930186147 Cephalosporin Natural products 0.000 claims description 5
- 150000001540 azides Chemical group 0.000 claims description 5
- 229940124587 cephalosporin Drugs 0.000 claims description 5
- 150000001780 cephalosporins Chemical class 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims description 4
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims description 3
- 150000007942 carboxylates Chemical class 0.000 claims description 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 3
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 claims description 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- CVXYZHAGJIKAIF-UHFFFAOYSA-N ctk1a4618 Chemical compound NNP(N)(N)=O CVXYZHAGJIKAIF-UHFFFAOYSA-N 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 230000000269 nucleophilic effect Effects 0.000 claims description 2
- 229950008644 adicillin Drugs 0.000 claims 2
- MIFYHUACUWQUKT-GPUHXXMPSA-N penicillin N Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-GPUHXXMPSA-N 0.000 claims 2
- SEPPVOUBHWNCAW-FNORWQNLSA-N (E)-4-oxonon-2-enal Chemical compound CCCCCC(=O)\C=C\C=O SEPPVOUBHWNCAW-FNORWQNLSA-N 0.000 claims 1
- LLBZPESJRQGYMB-UHFFFAOYSA-N 4-one Natural products O1C(C(=O)CC)CC(C)C11C2(C)CCC(C3(C)C(C(C)(CO)C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)CO5)OC5C(C(OC6C(C(O)C(O)C(CO)O6)O)C(O)C(CO)O5)OC5C(C(O)C(O)C(C)O5)O)O4)O)CC3)CC3)=C3C2(C)CC1 LLBZPESJRQGYMB-UHFFFAOYSA-N 0.000 claims 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 claims 1
- 239000000243 solution Substances 0.000 description 49
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 42
- 238000002329 infrared spectrum Methods 0.000 description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
- 230000008018 melting Effects 0.000 description 14
- 238000002844 melting Methods 0.000 description 14
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 13
- 239000002904 solvent Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 10
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 8
- 229960000583 acetic acid Drugs 0.000 description 7
- 239000012362 glacial acetic acid Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 229910052698 phosphorus Inorganic materials 0.000 description 6
- 239000011574 phosphorus Substances 0.000 description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000005711 Benzoic acid Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 150000003931 anilides Chemical class 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
- 239000012038 nucleophile Substances 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 150000003952 β-lactams Chemical class 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- CJVGKCYUGBXLME-UHFFFAOYSA-N 1,3-oxazolidin-2-one Chemical compound O=C1NCCO1.O=C1NCCO1 CJVGKCYUGBXLME-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- VYWYYJYRVSBHJQ-UHFFFAOYSA-N 3,5-dinitrobenzoic acid Chemical compound OC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 VYWYYJYRVSBHJQ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- YVHRWUNRJIZXJI-UHFFFAOYSA-N N(=[N+]=[N-])NP(=O)(N)N Chemical compound N(=[N+]=[N-])NP(=O)(N)N YVHRWUNRJIZXJI-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229960001413 acetanilide Drugs 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- XEXVABHBBLCIKD-UHFFFAOYSA-N n-diaminophosphinothioylethanamine Chemical compound CCNP(N)(N)=S XEXVABHBBLCIKD-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000004454 trace mineral analysis Methods 0.000 description 2
- WYMQKAMZLHAMDC-UHFFFAOYSA-N (2-diaminophosphorylhydrazinyl)benzene Chemical compound NP(N)(=O)NNC1=CC=CC=C1 WYMQKAMZLHAMDC-UHFFFAOYSA-N 0.000 description 1
- FCMALWMMDFDDQH-UHFFFAOYSA-N (diaminophosphorylamino) benzoate Chemical compound C(C1=CC=CC=C1)(=O)ONP(=O)(N)N FCMALWMMDFDDQH-UHFFFAOYSA-N 0.000 description 1
- GFMPXASHWPERMV-UHFFFAOYSA-N (dithiocyanatoamino) thiocyanate Chemical group N#CSN(SC#N)SC#N GFMPXASHWPERMV-UHFFFAOYSA-N 0.000 description 1
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 1
- OTLNPYWUJOZPPA-UHFFFAOYSA-N 4-nitrobenzoic acid Chemical compound OC(=O)C1=CC=C([N+]([O-])=O)C=C1 OTLNPYWUJOZPPA-UHFFFAOYSA-N 0.000 description 1
- IYYXFBWNHYAWMD-UHFFFAOYSA-N CONP(=O)(N)N Chemical compound CONP(=O)(N)N IYYXFBWNHYAWMD-UHFFFAOYSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- CEKVYISSINZLOG-UHFFFAOYSA-N N-diaminophosphorylthiohydroxylamine Chemical compound NP(N)(=O)NS CEKVYISSINZLOG-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000004703 alkoxides Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
- MNNDDJIKWGFEJB-UHFFFAOYSA-N benzoic acid;n,n-diethylethanamine Chemical compound CCN(CC)CC.OC(=O)C1=CC=CC=C1 MNNDDJIKWGFEJB-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- ZTIMKJROOYMUMU-UHFFFAOYSA-N butyl n-phenylcarbamate Chemical group CCCCOC(=O)NC1=CC=CC=C1 ZTIMKJROOYMUMU-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- HDFRDWFLWVCOGP-UHFFFAOYSA-N carbonothioic O,S-acid Chemical group OC(S)=O HDFRDWFLWVCOGP-UHFFFAOYSA-N 0.000 description 1
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical group [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
- 150000001913 cyanates Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- AVBGNFCMKJOFIN-UHFFFAOYSA-N triethylammonium acetate Chemical compound CC(O)=O.CCN(CC)CC AVBGNFCMKJOFIN-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Description
æ¬çºæã¯æ¬¡ã®äžè¬åŒ
ïŒåŒäžã®R1ïŒR2ïŒR3åã³R4ã¯æ°ŽçŽ ãççŽ åå
æ°ïŒãïŒã®ã¢ã«ãã«åã³ããšãã«ããæã矀ãã
éžæããåºã瀺ããã¯èŠªæ žç眮æã«ããå°å ¥ã
åŸãåºã瀺ãïŒã§è¡šããããçååç©ã«é¢ããã
ã®ã§ãããæ¬çºæã¯ãŸããããååç©ã®è£œé æ¹æ³
ã«ãé¢ãããã®ã§ããã 詳述ãããšãèŠªæ žç眮æã«ããå°å ¥ãåŸãåº
ã¯ãããã²ã³ãã¢ãžãïŒN3ïŒåºãã¢ããåºãã¡ã«
ã«ããåºãã¢ã·ã«ãªãã·åºãã«ã«ããã·ã«åºåã³
ã¢ã«ã³ãã·ãåºããéžæãããã®ã§ãããããã²
ã³ãšã¢ãžãïŒN3ïŒåºã®å Žåã«ã¯ãæ¬çºæååç©ã¯
ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâãª
ã³ïŒããã²ã³ãã¹ãã«ã¢ãããšïŒ®ïŒNâ²âãã¹â
ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒã¢ãžããã¹
ãã«ã¢ããã§ããã以äžåè ãClâSPOïŒïŒžïŒ
ClïŒãšç§°ããåŸè ãN3âSPOïŒïŒžïŒN3ïŒãšç§°ã
ããããçã®ååç©ã¯ã以äžSPOãšç¥ç§°ãã察称
ãã¹ããªã«ãªããµãŸãªãžãã³ã®åæäœãæ§æã
ããããã«ãã¯ãç°¡æåã®çºããªããµãŸãªãžãã³
åºãOXAãšç¥èšãããšãåŒã®ååç©ã¯æ¬¡ã®è¡š
çŸ ã§è¡šããããããã®è¡šçŸã¯ç¡å·®å¥ã«çšããããã ãããã®ç©è³ªã®å©ç¹ã¯ãããçã®ç©è³ªãåºæ±ãª
æè¡ççšéãæãã掻æ§åæ©èœãäŸãã°ç¹ã«ã«ã«
ããã·ã«ãã¢ãããããããã·ã«åã³ããªãŒã«åº
çã®çºã®é©ãã¹ãèœåãæããããšãä»ãèŠåºã
ããäºå®ã«åºããã®ã§ããããŸãã掻æ§åé床ã¯
ããçã®ç©è³ªã®åã ã«ãã€ãŠç°ãªãããããçã®
ç©è³ªã®åºæ±ãªäœçšåéã¯ããçåŒã®ååç©ãã
å·¥æ¥çè«žæ¹æ³ã«çšããããåæåã³ãã®æè¡å·¥
åŠãäŸãã°äººéåã³åç©ã®è¬åçæ²»çççšéãæ
ããããã·ãªã³ãã»ãã¢ãã¹ããªã³ã®åéã«ãã
ã䟡å€æãè¬åãšããäºå®ã«åºããã®ã§ããã æ¬çºæã«ãããŠã¯ãåè¿°ã®åŒïŒäœãã¯èŠªæ ž
ç眮æã«ããå°å ¥ãåŸãåè¿°ã®åºã瀺ãïŒã®ïŒ°â
眮æïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒãã¹ãã«ã¢ããã®è£œé ã«ãããã 次ã®äžè¬åŒ ïŒåŒäžã®R5åã³R6ã¯åè¿°ã®æå³ãæããR1ïŒ
R2ïŒR3åã³R4åºããéžæãããã®ã瀺ãïŒã§è¡š
ãããããªããµãŸãªãžãã³ã®å°ããšãïŒåœé以äž
ãäžæŽ»æ§æº¶åªäžã§äºå¡©åçãšåå¿ãããå Žåã«ã
ã€ãŠã¯ããã«çææ··åç©ãäžæŽ»æ§æº¶åªäžã§èŠªæ žå€
ãšåå¿ãããŠåŒã®ååç©ãåŸããããæ¢ç¥æè¡
ã«ããåé¢ããã äºå¡©åçãšã®åå¿ã¯åºæ±ãªç¯å²å ã®æž©åºŠïŒâ15
âã100âïŒã§è¡ãªãããšãã§ããæ··åç©ãèŠªæ ž
å€ãšåå¿ãããåã«æ°Žãã¢ã«ã³ãŒã«åã¯ã«ã«ãã³
é žå¡©ãæ··åç©ã«æ·»å ããããšãã§ãããèŠªæ žå€ãš
ããŠã¯ç¹ã«ã¢ãžåãããªãŠã ãããããã·ã«åºã
ã¢ãã³åºãããã©ãžã³åºåã¯ã¡ã«ã«ããåºãæã
ãååç©åã¯ã«ã«ãã³é žå¡©å¥œãŸããã¯ããªãšãã«
ã¢ãã³ãçšããããšãã§ããã æ¬çºæã«ãããŠã¯åŒã®ååç©ïŒäœãR5åã³
R6ã¯æ°ŽçŽ ååã瀺ãïŒãäžæŽ»æ§æº¶åªãäŸãã°å¡©
åã¡ãã¬ã³ãã¢ã»ããããªã«åã¯ãããã¡ã¿ã³äž
ã§äºå¡©åçãšåå¿ãããŠåŒã®ååç©ïŒäœã
R1ïŒR2ïŒR3åã³R4ã¯æ°ŽçŽ ã瀺ããã¯åè¿°ãã
ãšåããã®ã瀺ãïŒãåŸãã ãŸããæ¬çºæã«ãããŠã¯åŒã®ååç©ïŒäœã
R5åã³R6ã¯æ°ŽçŽ ã瀺ãïŒã®ïŒåœéãäžæŽ»æ§æº¶åª
äŸãã°å¡©åã¡ãã«äžã§å ãäºå¡©åçãšåå¿ããã
ç¶ãåŸåŸããâããªã¯ããâãã¹ãããŠã âïŒ
âãªããµãŸãªãžãã³å¡©åç©ãããã«åŒã®ååç©
ïŒäœãR5åã³R6ã¯æ°ŽçŽ ã§ããããšã奜ãŸããïŒã®
ïŒåœéãšåå¿ãããŠåŒã®ååç©ïŒäœãã¯åè¿°
ãããšåããã®ã瀺ãïŒãåŸãã æ¬çºæã®ç®çã®äžã€ã¯æ¬¡ã®ãã®ã®è£œé ã«ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¯ãããã¹ãã«ã¢ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ãžããã¹ãã«ã¢ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã«ã³ãã·ãã¹ãã«ã¢ããã ãã®å Žåã¢ã«ã³ãã·åºã¯èèªãè³éŠæåã¯è€
çŽ ç°åŒã¢ã«ã³ãŒã«ã«ç±æ¥ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ãããã¹ãã«ã¢ããããã®å Žåã¢ã
ãåºã¯èèªæå¡©åºãè³éŠæå¡©åºãè€çŽ ç°åŒå¡©
åºãïŒâã¢ããããã·ã©ã³é žã®ã«ã«ããã·ãšã¹
ãã«åã¯ïŒâã¢ããã»ãã¢ãã¹ãã©ã³é žã®ã«ã«
ããã·ãšã¹ãã«ã«ç±æ¥ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¡ã«ã«ãããã¹ãã«ã¢ããããã®å Žå
ã¡ã«ã«ããåºã¯èèªæãè³éŠæåã¯è€çŽ ç°åŒã®
ããªãŒã«ã«ç±æ¥ããã æ¬çºæã®ããã«ä»ã®ç®çã¯ãã¯ãããã¹ãã«ã¢
ãããã«ã«ãã³é žå¡©ãšåå¿ãããŠæ¬¡ã®ãã®ãåŸã
ã«ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã¢ã·ã«ãªãã·åºã¯èèªæãè³éŠæåã¯è€çŽ ç°
åŒã®ã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ããã·ãªã³ã®ïŒ£âïŒäœã«ã
ãã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ã»ãã¢ãã¹ããªã³ã®ïŒ£âïŒ
äœã«ããã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·åºã¯ããã·ãªã³ã®ïŒ£âïŒäœã«ãã
åŽéã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ã»ãã¢ãã¹ããªã³ã®ïŒ£âïŒ
äœã«ããåŽéã«ç±æ¥ããã ãããŠæ¬çºææ¹æ³ã¯ããã²ã³åçïŒã¢ã«ã«å¯Ÿã
ïŒã¢ã«ã®OXAã®ååŠéè«çæ¯ãçšããâããª
ã¯ããâãã¹ãããŠã âïŒâãªããµãŸãªãžãã³å¡©
åç©ã®åé¢åã¯çŽæ¥ã®ç¹ã§ç°ãªãïŒã€ã®éžæçæ¹
æ³ã«ããã系統å³ïŒ¡ã«ç€ºãé åºã«åŸã€ãŠåŒã®å
åç©ã補é ããã«ãããäœãã®å Žåã§ãå¡©åç©ã¯
ã¢ãžãåºåã¯ä»ã®èŠªæ žå€ãšäº€æããŠåŒã®ååç©
ãçæããã åœæ¥æè¡è ã«ã¯ïŒžãä»ã®èŠªæ žå€äŸãã°ããªã·ã¢
ããŒããã·ã¢ããŒãããããªããããåç©ãèå
ç©åã³æ²åç©äŸãã°ClâSPOãšããã²ã³ãšã®çž
äºåå¿ããçæãããã®ã瀺ãåŸãããšã¯èªæã§
ãããã âSPOã補é ããå®çšçæ¹æ³ã®äžã€ã¯ãïŒåœ
éã®OXAã®æº¶æ¶²ãäžæŽ»æ§æº¶åªäžã§ïŒã¢ã«ã®äºå¡©
åçãšåå¿ããããã®åå¿ãåžžæž©ïŒ20ã25âïŒã§
è¡ãªãæ¹æ³ã§ãããé©åœãªæº¶åªã¯äŸãã°é極æ§ã
ããã³æº¶åªãšããŠå¡©åã¡ãã¬ã³ãïŒïŒïŒâãžã¡ã
ãã·ãšã¿ã³ããããã¡ã¿ã³åã³ã¢ã»ããããªã«ã§
ãããç¶ãåŸæº¶åªãæžå§äžã§é€å»ããæ®çç©ãç³»
çµ±å³ïŒ¡ã«ç€ºããåå¿ã®ååŠéè«ã«ãã瀺ãããçš
床ã®éã§ïŒãïŒâã®æ°Žãšåå¿ãããã åŒã®ååç©ã溶解ããªãäžæŽ»æ§æº¶åªäŸãã°
ïŒïŒïŒâãžã¡ããã·ãšã¿ã³äžã«åžéããæ°Žãçšã
ãŠåŠçãããšäžãã奜䟿å®ã§ããããã®ç®çã®çº
ã«ãã¯ãé©åœãªã®ã¯ãžãªããµã³ãããã©ãããã
ã©ã³åã³ã€ãœãããããŒã«ã§ãããããçã®ãã®
ã¯åžå Žã§å ¥æå¯èœã§äœã³ã¹ãã®è£œåã§ããå©ç¹ã
äžããã ããã«ä»ã®è£œé æ¹æ³ã¯ç³»çµ±å³ïŒ¡ã«ç€ºãããã«ã
äºãã¹ãã€ã³åœç¹èš±ç¬¬444470å·ã«èšè¿°ãããŠãã
ããã«åã¯ãããã¡ã¿ã³æº¶æ¶²äžã§ãã®åœåå Žæã§
ïŒâããªãããã¹ãããŠã âïŒâãªããµãŸãªãžã
ã³ãã©ã€ãã補é ãã次ãã§OXAãæ·»å ãåè¿°
ããåŠãããŠé²è¡ããæ¹æ³ã§ãããåçã¯37ã80
ïŒ ã§ãããã溶åªã枩床åã³æ¬¡ã®å æ°Žå解åŠçã«
ãã€ãŠç°ãªãããŸã転åãäžåäžçžäžåã¯åäžçž
äžã§è¡ãªããåŠãã«ãã€ãŠç°ãªãã ããã«ä»ã®è£œé æ¹æ³ã¯ã調ç¯ããéã®æ°Žãåå¿
ç²åæãå«æãã溶液ã«æ·»å ããããšã«ããéæ
ãããåå¿äœã®åœåå Žæã§ã®è£œé ã§ããã ClâSPOã¯ãããã¡ã¿ã³ã®æº¶æ¶²ãšã¢ã«ã«ãªé
å±å¥œãŸããã¯ãããªãŠã åã¯ã«ãªãŠã ã®ã¢ãžãã
çšãããšãåªããåçã§N3âSPOã«å®¹æã«è»¢å
ãããããããN3âSPOã¯æº¶åªã®é€å»ãšæ¬¡ã®å
æ¶åºã«ããåé¢ãããã N3âSPOã®å©ç¹ã®äžéšã¯ãN3âSPOãã«ã«ã
ãã·ã¬ãŒããšåå¿ããŠçžå¿ããã¢ã·ã«ã¢ãžããäž
ããããšã®å®¹æããšããã®ã¢ã·ã«ã¢ãžããå ç±äž
ã§ã€ãœã·ã¢ããŒããçæããããã«ããåºæ±ãªç¯
å²ã®åæå¯èœæ§ãéãç¹ã«ããã ããçã®ååç©ã¯äœãã匷åãªé«åºŠã«ææãªå
å¿äœã§ãããããçã®çµæã¯ç³»çµ±å³ïŒ¢ã«ç€ºãããŠ
ãããåå³ã«ãããŠç€ºãæ°èŠSPOèªå°äœã¯åŒã®
補åã®éèŠæ§ã瀺ããããã¯ãã®äžé£ã®äžéäœå
å¿äœããèªå°ãããåŒã®è£œåã®çšéãšãã¢ã
ããã¢ãžããããã©ãžãåã³ãšã¹ãã«ã®è£œé ã®çº
ã®çžå¿ããå·¥çšã®æè¡ãšå®çšäžã®ç®çããã¯ãã
çãå¿ ãããåé¢ããªããŠãè¯ãããšã«ããçºã§
ããããã®ç®çã®çºã次ã«ç³»çµ±å³ïŒ¢ã瀺ãã 系統å³ïŒ¢ã®ïœãšïœã®å·¥çšã®ã©ã¡ããåããã¯ã
亀æãããšããåºãæããååç©ã®åå¿æ§ãšæ§é
ã«ãã€ãŠç°ãªããã¢ãããšãšã¹ãã«ã®åæãæã
å Žåã«ã¯ãïœå·¥çšã®æ¹ãå€å€§ã®éžææ§ãšåå¿é床
ã®èŠ³ç¹ããæšè³ãããã ããæ ãæ¬çºæã®ç¯å²ã¯åŒã®ååç©ã§ïŒžãå
ã«ããã²ã³åã¯ã¢ãžãåºã瀺ããã®ã®ã¿ã«éãã
ãªãã§ãçâ眮æïŒNâ²âãã¹âïŒïŒâãªããµãŸ
ãªãžãã«âïŒâãªã³ïŒãã¹ãã«ã¢ããã®è£œé æ¹æ³
ãåŒã®ååç©ã§ïŒžãããã²ã³ãã¢ãžããã¢ã
ããã¢ã«ã³ãã·ãã¡ã«ã«ãããã«ã«ããã·ã¬ãŒ
ãããããªããããªã·ã¢ããŒããã·ã¢ããŒããã
ãã©ãžãããæã矀ããéžæãããã®ã瀺ããã®
ã«ãé©çšããããã®åå¿åªè³ªããåŒã®ååç©ã
åé¢ãããçºã«åŠçã§ããããšãæãã¯ãšã¹ã
ã«ãã¢ããåã³ããã©ãžãïŒããçã¯èšå·ïŒžâ
SPOãå©çšããŠRNHâSPOãââSPOã
RCOOâSPOçãšè¡šãåŸãïŒã®è£œé ã«çŽæ¥äœ¿çšã
åŸãããšãä»ãç解ãããã§ãããã奜é©ãªãªã
ãµåºã®äžã€ã¯ïŒâãªããµãŸãªãžãã³ã§ããããã
ã¯å®äŸ¡ã§åžå Žã§å ¥æãåŸã補åã®çºã§ããã æ¬çºæã®ç®çãäžããè¯ãç解ãåŸãããã«ã
ãçºãâSPOååç©ã®è¥å¹²ã®è£œé äŸãšãè¥å¹²ã®
ãã®ã¯èªå°äœã®çæã«å°é£ãçããæ¢ç¥ã®é žãçš
ãããšã¹ãã«ãã¢ããåã³ããã©ãžãã®è£œé æã«
âSPOååç©ãçšããè¥å¹²ã®äŸã次ã®ç¬¬ïŒè¡šã«
瀺ãã
æ°ïŒãïŒã®ã¢ã«ãã«åã³ããšãã«ããæã矀ãã
éžæããåºã瀺ããã¯èŠªæ žç眮æã«ããå°å ¥ã
åŸãåºã瀺ãïŒã§è¡šããããçååç©ã«é¢ããã
ã®ã§ãããæ¬çºæã¯ãŸããããååç©ã®è£œé æ¹æ³
ã«ãé¢ãããã®ã§ããã 詳述ãããšãèŠªæ žç眮æã«ããå°å ¥ãåŸãåº
ã¯ãããã²ã³ãã¢ãžãïŒN3ïŒåºãã¢ããåºãã¡ã«
ã«ããåºãã¢ã·ã«ãªãã·åºãã«ã«ããã·ã«åºåã³
ã¢ã«ã³ãã·ãåºããéžæãããã®ã§ãããããã²
ã³ãšã¢ãžãïŒN3ïŒåºã®å Žåã«ã¯ãæ¬çºæååç©ã¯
ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâãª
ã³ïŒããã²ã³ãã¹ãã«ã¢ãããšïŒ®ïŒNâ²âãã¹â
ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒã¢ãžããã¹
ãã«ã¢ããã§ããã以äžåè ãClâSPOïŒïŒžïŒ
ClïŒãšç§°ããåŸè ãN3âSPOïŒïŒžïŒN3ïŒãšç§°ã
ããããçã®ååç©ã¯ã以äžSPOãšç¥ç§°ãã察称
ãã¹ããªã«ãªããµãŸãªãžãã³ã®åæäœãæ§æã
ããããã«ãã¯ãç°¡æåã®çºããªããµãŸãªãžãã³
åºãOXAãšç¥èšãããšãåŒã®ååç©ã¯æ¬¡ã®è¡š
çŸ ã§è¡šããããããã®è¡šçŸã¯ç¡å·®å¥ã«çšããããã ãããã®ç©è³ªã®å©ç¹ã¯ãããçã®ç©è³ªãåºæ±ãª
æè¡ççšéãæãã掻æ§åæ©èœãäŸãã°ç¹ã«ã«ã«
ããã·ã«ãã¢ãããããããã·ã«åã³ããªãŒã«åº
çã®çºã®é©ãã¹ãèœåãæããããšãä»ãèŠåºã
ããäºå®ã«åºããã®ã§ããããŸãã掻æ§åé床ã¯
ããçã®ç©è³ªã®åã ã«ãã€ãŠç°ãªãããããçã®
ç©è³ªã®åºæ±ãªäœçšåéã¯ããçåŒã®ååç©ãã
å·¥æ¥çè«žæ¹æ³ã«çšããããåæåã³ãã®æè¡å·¥
åŠãäŸãã°äººéåã³åç©ã®è¬åçæ²»çççšéãæ
ããããã·ãªã³ãã»ãã¢ãã¹ããªã³ã®åéã«ãã
ã䟡å€æãè¬åãšããäºå®ã«åºããã®ã§ããã æ¬çºæã«ãããŠã¯ãåè¿°ã®åŒïŒäœãã¯èŠªæ ž
ç眮æã«ããå°å ¥ãåŸãåè¿°ã®åºã瀺ãïŒã®ïŒ°â
眮æïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒãã¹ãã«ã¢ããã®è£œé ã«ãããã 次ã®äžè¬åŒ ïŒåŒäžã®R5åã³R6ã¯åè¿°ã®æå³ãæããR1ïŒ
R2ïŒR3åã³R4åºããéžæãããã®ã瀺ãïŒã§è¡š
ãããããªããµãŸãªãžãã³ã®å°ããšãïŒåœé以äž
ãäžæŽ»æ§æº¶åªäžã§äºå¡©åçãšåå¿ãããå Žåã«ã
ã€ãŠã¯ããã«çææ··åç©ãäžæŽ»æ§æº¶åªäžã§èŠªæ žå€
ãšåå¿ãããŠåŒã®ååç©ãåŸããããæ¢ç¥æè¡
ã«ããåé¢ããã äºå¡©åçãšã®åå¿ã¯åºæ±ãªç¯å²å ã®æž©åºŠïŒâ15
âã100âïŒã§è¡ãªãããšãã§ããæ··åç©ãèŠªæ ž
å€ãšåå¿ãããåã«æ°Žãã¢ã«ã³ãŒã«åã¯ã«ã«ãã³
é žå¡©ãæ··åç©ã«æ·»å ããããšãã§ãããèŠªæ žå€ãš
ããŠã¯ç¹ã«ã¢ãžåãããªãŠã ãããããã·ã«åºã
ã¢ãã³åºãããã©ãžã³åºåã¯ã¡ã«ã«ããåºãæã
ãååç©åã¯ã«ã«ãã³é žå¡©å¥œãŸããã¯ããªãšãã«
ã¢ãã³ãçšããããšãã§ããã æ¬çºæã«ãããŠã¯åŒã®ååç©ïŒäœãR5åã³
R6ã¯æ°ŽçŽ ååã瀺ãïŒãäžæŽ»æ§æº¶åªãäŸãã°å¡©
åã¡ãã¬ã³ãã¢ã»ããããªã«åã¯ãããã¡ã¿ã³äž
ã§äºå¡©åçãšåå¿ãããŠåŒã®ååç©ïŒäœã
R1ïŒR2ïŒR3åã³R4ã¯æ°ŽçŽ ã瀺ããã¯åè¿°ãã
ãšåããã®ã瀺ãïŒãåŸãã ãŸããæ¬çºæã«ãããŠã¯åŒã®ååç©ïŒäœã
R5åã³R6ã¯æ°ŽçŽ ã瀺ãïŒã®ïŒåœéãäžæŽ»æ§æº¶åª
äŸãã°å¡©åã¡ãã«äžã§å ãäºå¡©åçãšåå¿ããã
ç¶ãåŸåŸããâããªã¯ããâãã¹ãããŠã âïŒ
âãªããµãŸãªãžãã³å¡©åç©ãããã«åŒã®ååç©
ïŒäœãR5åã³R6ã¯æ°ŽçŽ ã§ããããšã奜ãŸããïŒã®
ïŒåœéãšåå¿ãããŠåŒã®ååç©ïŒäœãã¯åè¿°
ãããšåããã®ã瀺ãïŒãåŸãã æ¬çºæã®ç®çã®äžã€ã¯æ¬¡ã®ãã®ã®è£œé ã«ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¯ãããã¹ãã«ã¢ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ãžããã¹ãã«ã¢ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã«ã³ãã·ãã¹ãã«ã¢ããã ãã®å Žåã¢ã«ã³ãã·åºã¯èèªãè³éŠæåã¯è€
çŽ ç°åŒã¢ã«ã³ãŒã«ã«ç±æ¥ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ãããã¹ãã«ã¢ããããã®å Žåã¢ã
ãåºã¯èèªæå¡©åºãè³éŠæå¡©åºãè€çŽ ç°åŒå¡©
åºãïŒâã¢ããããã·ã©ã³é žã®ã«ã«ããã·ãšã¹
ãã«åã¯ïŒâã¢ããã»ãã¢ãã¹ãã©ã³é žã®ã«ã«
ããã·ãšã¹ãã«ã«ç±æ¥ããã ïœ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¡ã«ã«ãããã¹ãã«ã¢ããããã®å Žå
ã¡ã«ã«ããåºã¯èèªæãè³éŠæåã¯è€çŽ ç°åŒã®
ããªãŒã«ã«ç±æ¥ããã æ¬çºæã®ããã«ä»ã®ç®çã¯ãã¯ãããã¹ãã«ã¢
ãããã«ã«ãã³é žå¡©ãšåå¿ãããŠæ¬¡ã®ãã®ãåŸã
ã«ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã¢ã·ã«ãªãã·åºã¯èèªæãè³éŠæåã¯è€çŽ ç°
åŒã®ã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ããã·ãªã³ã®ïŒ£âïŒäœã«ã
ãã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ã»ãã¢ãã¹ããªã³ã®ïŒ£âïŒ
äœã«ããã«ã«ãã³é žã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·åºã¯ããã·ãªã³ã®ïŒ£âïŒäœã«ãã
åŽéã«ç±æ¥ããã ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããããã®å Ž
åã«ã«ããã·ã«åºã¯ã»ãã¢ãã¹ããªã³ã®ïŒ£âïŒ
äœã«ããåŽéã«ç±æ¥ããã ãããŠæ¬çºææ¹æ³ã¯ããã²ã³åçïŒã¢ã«ã«å¯Ÿã
ïŒã¢ã«ã®OXAã®ååŠéè«çæ¯ãçšããâããª
ã¯ããâãã¹ãããŠã âïŒâãªããµãŸãªãžãã³å¡©
åç©ã®åé¢åã¯çŽæ¥ã®ç¹ã§ç°ãªãïŒã€ã®éžæçæ¹
æ³ã«ããã系統å³ïŒ¡ã«ç€ºãé åºã«åŸã€ãŠåŒã®å
åç©ã補é ããã«ãããäœãã®å Žåã§ãå¡©åç©ã¯
ã¢ãžãåºåã¯ä»ã®èŠªæ žå€ãšäº€æããŠåŒã®ååç©
ãçæããã åœæ¥æè¡è ã«ã¯ïŒžãä»ã®èŠªæ žå€äŸãã°ããªã·ã¢
ããŒããã·ã¢ããŒãããããªããããåç©ãèå
ç©åã³æ²åç©äŸãã°ClâSPOãšããã²ã³ãšã®çž
äºåå¿ããçæãããã®ã瀺ãåŸãããšã¯èªæã§
ãããã âSPOã補é ããå®çšçæ¹æ³ã®äžã€ã¯ãïŒåœ
éã®OXAã®æº¶æ¶²ãäžæŽ»æ§æº¶åªäžã§ïŒã¢ã«ã®äºå¡©
åçãšåå¿ããããã®åå¿ãåžžæž©ïŒ20ã25âïŒã§
è¡ãªãæ¹æ³ã§ãããé©åœãªæº¶åªã¯äŸãã°é極æ§ã
ããã³æº¶åªãšããŠå¡©åã¡ãã¬ã³ãïŒïŒïŒâãžã¡ã
ãã·ãšã¿ã³ããããã¡ã¿ã³åã³ã¢ã»ããããªã«ã§
ãããç¶ãåŸæº¶åªãæžå§äžã§é€å»ããæ®çç©ãç³»
çµ±å³ïŒ¡ã«ç€ºããåå¿ã®ååŠéè«ã«ãã瀺ãããçš
床ã®éã§ïŒãïŒâã®æ°Žãšåå¿ãããã åŒã®ååç©ã溶解ããªãäžæŽ»æ§æº¶åªäŸãã°
ïŒïŒïŒâãžã¡ããã·ãšã¿ã³äžã«åžéããæ°Žãçšã
ãŠåŠçãããšäžãã奜䟿å®ã§ããããã®ç®çã®çº
ã«ãã¯ãé©åœãªã®ã¯ãžãªããµã³ãããã©ãããã
ã©ã³åã³ã€ãœãããããŒã«ã§ãããããçã®ãã®
ã¯åžå Žã§å ¥æå¯èœã§äœã³ã¹ãã®è£œåã§ããå©ç¹ã
äžããã ããã«ä»ã®è£œé æ¹æ³ã¯ç³»çµ±å³ïŒ¡ã«ç€ºãããã«ã
äºãã¹ãã€ã³åœç¹èš±ç¬¬444470å·ã«èšè¿°ãããŠãã
ããã«åã¯ãããã¡ã¿ã³æº¶æ¶²äžã§ãã®åœåå Žæã§
ïŒâããªãããã¹ãããŠã âïŒâãªããµãŸãªãžã
ã³ãã©ã€ãã補é ãã次ãã§OXAãæ·»å ãåè¿°
ããåŠãããŠé²è¡ããæ¹æ³ã§ãããåçã¯37ã80
ïŒ ã§ãããã溶åªã枩床åã³æ¬¡ã®å æ°Žå解åŠçã«
ãã€ãŠç°ãªãããŸã転åãäžåäžçžäžåã¯åäžçž
äžã§è¡ãªããåŠãã«ãã€ãŠç°ãªãã ããã«ä»ã®è£œé æ¹æ³ã¯ã調ç¯ããéã®æ°Žãåå¿
ç²åæãå«æãã溶液ã«æ·»å ããããšã«ããéæ
ãããåå¿äœã®åœåå Žæã§ã®è£œé ã§ããã ClâSPOã¯ãããã¡ã¿ã³ã®æº¶æ¶²ãšã¢ã«ã«ãªé
å±å¥œãŸããã¯ãããªãŠã åã¯ã«ãªãŠã ã®ã¢ãžãã
çšãããšãåªããåçã§N3âSPOã«å®¹æã«è»¢å
ãããããããN3âSPOã¯æº¶åªã®é€å»ãšæ¬¡ã®å
æ¶åºã«ããåé¢ãããã N3âSPOã®å©ç¹ã®äžéšã¯ãN3âSPOãã«ã«ã
ãã·ã¬ãŒããšåå¿ããŠçžå¿ããã¢ã·ã«ã¢ãžããäž
ããããšã®å®¹æããšããã®ã¢ã·ã«ã¢ãžããå ç±äž
ã§ã€ãœã·ã¢ããŒããçæããããã«ããåºæ±ãªç¯
å²ã®åæå¯èœæ§ãéãç¹ã«ããã ããçã®ååç©ã¯äœãã匷åãªé«åºŠã«ææãªå
å¿äœã§ãããããçã®çµæã¯ç³»çµ±å³ïŒ¢ã«ç€ºãããŠ
ãããåå³ã«ãããŠç€ºãæ°èŠSPOèªå°äœã¯åŒã®
補åã®éèŠæ§ã瀺ããããã¯ãã®äžé£ã®äžéäœå
å¿äœããèªå°ãããåŒã®è£œåã®çšéãšãã¢ã
ããã¢ãžããããã©ãžãåã³ãšã¹ãã«ã®è£œé ã®çº
ã®çžå¿ããå·¥çšã®æè¡ãšå®çšäžã®ç®çããã¯ãã
çãå¿ ãããåé¢ããªããŠãè¯ãããšã«ããçºã§
ããããã®ç®çã®çºã次ã«ç³»çµ±å³ïŒ¢ã瀺ãã 系統å³ïŒ¢ã®ïœãšïœã®å·¥çšã®ã©ã¡ããåããã¯ã
亀æãããšããåºãæããååç©ã®åå¿æ§ãšæ§é
ã«ãã€ãŠç°ãªããã¢ãããšãšã¹ãã«ã®åæãæã
å Žåã«ã¯ãïœå·¥çšã®æ¹ãå€å€§ã®éžææ§ãšåå¿é床
ã®èŠ³ç¹ããæšè³ãããã ããæ ãæ¬çºæã®ç¯å²ã¯åŒã®ååç©ã§ïŒžãå
ã«ããã²ã³åã¯ã¢ãžãåºã瀺ããã®ã®ã¿ã«éãã
ãªãã§ãçâ眮æïŒNâ²âãã¹âïŒïŒâãªããµãŸ
ãªãžãã«âïŒâãªã³ïŒãã¹ãã«ã¢ããã®è£œé æ¹æ³
ãåŒã®ååç©ã§ïŒžãããã²ã³ãã¢ãžããã¢ã
ããã¢ã«ã³ãã·ãã¡ã«ã«ãããã«ã«ããã·ã¬ãŒ
ãããããªããããªã·ã¢ããŒããã·ã¢ããŒããã
ãã©ãžãããæã矀ããéžæãããã®ã瀺ããã®
ã«ãé©çšããããã®åå¿åªè³ªããåŒã®ååç©ã
åé¢ãããçºã«åŠçã§ããããšãæãã¯ãšã¹ã
ã«ãã¢ããåã³ããã©ãžãïŒããçã¯èšå·ïŒžâ
SPOãå©çšããŠRNHâSPOãââSPOã
RCOOâSPOçãšè¡šãåŸãïŒã®è£œé ã«çŽæ¥äœ¿çšã
åŸãããšãä»ãç解ãããã§ãããã奜é©ãªãªã
ãµåºã®äžã€ã¯ïŒâãªããµãŸãªãžãã³ã§ããããã
ã¯å®äŸ¡ã§åžå Žã§å ¥æãåŸã補åã®çºã§ããã æ¬çºæã®ç®çãäžããè¯ãç解ãåŸãããã«ã
ãçºãâSPOååç©ã®è¥å¹²ã®è£œé äŸãšãè¥å¹²ã®
ãã®ã¯èªå°äœã®çæã«å°é£ãçããæ¢ç¥ã®é žãçš
ãããšã¹ãã«ãã¢ããåã³ããã©ãžãã®è£œé æã«
âSPOååç©ãçšããè¥å¹²ã®äŸã次ã®ç¬¬ïŒè¡šã«
瀺ãã
ãè¡šã
ãè¡šã
ãè¡šã
ç¹ã«éèŠãªãã®ã¯ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµ
ãŸãªãžãã«âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢
ããã§ãããããã¯åªããååŠç掻æ§ãæããã
ããã«ãããçã®ååç©ã¯å®¹æã«è£œé ããããšã
ã§ãããäŸãã°ClâSPOã¯ïŒâãªããµãŸãªãžã
ã³ãšäºå¡©åçãšã®åå¿æ··åç©ã«å¯Ÿããæ°Žã®äœçš
ãšãããã«ç¶ãããã·ã©ã³é žãŸãã¯ã»ãã¢ãã¹ã
ã©ã³é žããã¹ã¢ã»ããã·ã»ãã¢ãã¹ãã©ã³é žãã
ã³ãããçã®èªå°äœã®äœçšãšãäºãããçãçšã
ãŠäžæŽ»æ§æº¶åªäŸãã°å¡©åã¡ãã¬ã³äžã§ã¢ãã³å¡©å¥œ
ãŸããã¯ããªãšãã«ã¢ãã³ãçæããããšã«ãã
補é ãããããã®åå¿ã¯ã¢ã·ã«ãªãã·ãã¹ãã«ã¢
ããã®æº¶æ¶²ãŸãã¯æåºç©ãçæããããšãã§ãã
äœãã®å Žåã§ãã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã¯æº¶
åªã®èžçºã«ãããŸãã¯æº¶æ¶²ã®å Žåã«ã¯ïœâããã¿
ã³ã«ããæåºãšæçµçéã«ããåé¢ããããšã
ã§ãããããçã¯äœããã«ã«ããã«åºã®äœçœ®ã«å¯Ÿ
ããã«ã«ããã·ã«åºã®ç¹è²æãèµ€å€ç·ã¹ãã¯ãã«
ã瀺ãããã®ã¹ãã¯ãã«ã¯Î²âã©ã¯ã¿ã æ žã«çžå¿
ããèªåå€ããé¢ããŠããããã®èªåã¯ååå ã®
çã®ååšã«äŸããã®ã§ããã æ¬çºæã次ã«äŸã«ã€ãããã«è©³çŽ°ã«èª¬æããã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 5.4ïœïŒ6.21ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãž
ãã³ã60mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã20âã®æº¶æ¶²
ã«6.24ïœïŒïŒã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»
å ããé»è²æº¶æ¶²ãåŸãããã®æº¶æ¶²ã¯ïŒååŸå€éã®
æåºç©ãçæãããããã20ã25âã§12æéãã
æ··ããéæµäžã§ïŒæéããæ··ããå šäœã§ã¯ãªãè©
䟡ã§ãã溶液ãåŸããç¶ãåŸæº¶åªãæžå§äžã§é€å»
ããŠæ²¹ç¶ç©ãåŸããããïŒâã«å·åŽã20mlã®æ¥µã
ãŠäœæž©ã®æ°Žãæ¿ããããæ··ããªããæ·»å ãããæ··
åç©ãè¿ éã«å¥ãã10mlã®ïŒïŒïŒâãžã¡ããã·
ãšã¿ã³ãçšããŠæŽæµãããåé2.8ïœïŒ37ïŒ ïŒãè
ç¹191ã193âã 埮éåæïŒC6H8O5N2ClPïŒ ïŒ£   èšç®å€ 28.27 3.14 10.99 å®æž¬å€ 28.19 3.08 10.89ïŒïŒ ïŒ äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïœïŒ8.05ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã20âã®80mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ããïŒïœ
ïŒ4.3ã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å ããŠå š
äœæº¶æ¶²ãšæ¬¡ã®æåºç©ãåŸããæ··åç©ã20ã25âã§
22æéããæ··ãã溶åªãæžå§äžã§é§éããŠæ²¹ç¶ç©
ãåŸãããã«10mlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã
æ·»å ãããæ··åç©ãïŒâã«å·åŽããã次ãã§ïŒå
éã«äºã€ãŠïŒmlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ãšïŒ
mlã®æ°Žãšã®æº¶æ¶²ã滎å ããã枩床ã¯ïŒãïŒâã«ä¿
æãããåŸããåºåœ¢ç©ãå¥ã10mlã®ïŒïŒïŒâãž
ã¡ããã·ãšã¿ã³ãçšããŠæŽæµãããåé6.0ïœ
ïŒ55ïŒ ïŒã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 34.8ïœïŒ40ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã380mlã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ã«ã
41.7ïœïŒ20ã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å
ãã溶液ãšããããã®æº¶æ¶²ã20ã25âã§ïŒæéã
ãæ··ãã40ã45âã§ããã«ïŒæéããæ··ãããïŒ
âã«å·åŽåŸã15mlã®æ°Žãš50mlã®ïŒïŒïŒâãžã¡ãã
ã·ãšã¿ã³ãšã®æ··å液ãïŒåéã§æ·»å ãããç¶ãåŸ
溶åªãæžå§äžã§é§éãçœè²æ®çç©ãåŸããããã
10mlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®æ·»å ã«ããæ¶
åºããããããå¥ããïŒïŒïŒâãžã¡ããã·ãšã¿
ã³ãçšããŠæŽæµãã50âã®ç空äžã§ä¹Ÿç¥ããCl
âSPOååç©40.64ïœïŒåç80ïŒ ïŒãåŸãããã®
ãã®ã¯åŸ®éåææ³ã«ããåæå€ãšäžèŽããã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ãããã¡ã¿ã³ã®ä»£ãã«ã¢ã»ããããªã«ãçšããŠ
äŸïŒã®åŠçãè¡ãªãã65ïŒ ã®åçïŒåé32.02
ïœïŒãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ æ°Žã®ä»£ãã«15mlã®ã¡ã¿ããŒã«ãçšããŠäŸïŒã®åŠ
çãè¡ãªãã54ïŒ ïŒ27.43ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ æ°Žæ§æº¶æ¶²ã®ä»£ãã«2.4ïœã®æ°·é ¢é žããã³5.6mlã®
ããªãšãã«ã¢ãã³ã10mlã®ïŒïŒïŒâãžã¡ããã·ãš
ã¿ã³ã«æº¶è§£ãã溶液ãçšããŠäŸïŒã®åŠçãè¡ãª
ãã50ïŒ ïŒ5.46ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ å¡©åã¡ãã¬ã³ã®ä»£ãã«ã¢ã»ããããªã«ãçšãã
ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ãžãªããµã³ã
çšããŠäŸïŒã®åŠçãè¡ãªãã60ïŒ ïŒ6.44ïœïŒã®å
çãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ããã©ãã
ããã©ã³ãçšããŠäŸïŒã®åŠçãè¡ãªãã78ïŒ
ïŒ39.62ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ã€ãœããã
ããŒã«ãçšããŠäŸïŒã®åŠçãè¡ãªãã35ïŒ ïŒ2.67
ïœïŒã®åçãåŸãã äŸ 10 0.87ïœïŒïŒã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã10mlã®20âã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã2.08ïœ
ïŒïŒã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å ããã
ïŒåéããæ··ããåŸå€éã®æåºç©ãçæãããç¶
ãåŸããã«ïŒã»ã³ãã¢ã«ã®ïŒâãªããµãŸãªãžãã³
ïŒ0.87ïœïŒãæ·»å ããäŸïŒã®åŠçãè¡ãªããåå
ç©ClâSPOãåæ§ãªåçã§åé¢ããã äŸ 11 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 1.74ïœïŒïŒã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã10mlã®ã¢ã»ããããªã«ã«æº¶è§£ãã2.08ïœã®äº
å¡©åçãäžåºŠã«æ·»å ããé»è²ã®å šäœæº¶æ¶²ãåŸãã
溶液ã20ã25âã§12æéããæ··ããïŒæééæµå
ç±ãããç¶ãåŸïŒâã«å·åŽãã0.2mlã®æ°ŽïŒçŽïŒ
ã»ã³ãã¢ã«ïŒã滎å ããŠãïŒã»ã³ãã¢ã«ïŒ2.54
ïœïŒã®ClâSPOãåŸãã äŸ 12 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ãžããã¹ãã«ã¢ããïŒN3âSPOïŒ 5.08ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã50mlã®40
âã®ãããã¡ã¿ã³ã«æº¶è§£ãã1.95ïœïŒïŒã»ã³ãã¢
ã«ïŒã®ã¢ãžåãããªãŠã ãæ·»å ãããæ··åç©ã70
âã§ïŒæéããæ··ããããããéãã溶åªã50
âã®æžå§äžã§é§éããçœè²åºåœ¢ç©ãåŸããéé
5.6ïœãåç97ïŒ ãããããšã¿ããŒã«ãŸãã¯ïŒïŒ
ïŒâãžã¡ããã·ãšã¿ã³äžã§åæ¶åºãããèç¹97ã
99âãèµ€å€ç·ã¹ãã¯ãã«ã¯2190cm-1ã§N3ãã³ãã
1770cm-1ã§ã«ã«ããã«ãã³ããååšããã 埮éåæïŒC6H8O5N5PïŒ ïŒ£   èšç®å€ 27.58 3.06 26.81 å®æž¬å€ 27.41 2.97 26.43ïŒïŒ ïŒ äŸ 13 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ãžããã¹ãã«ã¢ããïŒN3âSPOïŒ ãããã¡ã¿ã³ã®ä»£ãã«75mlã®ã¢ã»ããããªã«ã
çšããŠäŸ12ã®åŠçãè¡ãªãã4.75ïœã®N3âSPOã
åŸããåçã¯91ïŒ ã§ãã€ãã1.3ïœã®N3âSPOè©Š
æã0.7mlã®ããªãšãã«ã¢ãã³ïŒTEAïŒãš0.61ïœ
ã®å®æ¯éŠé žãšå ±ã«16mlã®ç¬¬ïŒçŽãã¿ããŒã«äžã«å
åºãããæ··åç©ãéæµå ç±äžã§ïŒæéããæ··ã
ãããããŠåŸã溶液ã®èµ€å€ç·ã¹ãã¯ãã«ã¯N3ã
ã³ããååšããªãããšã瀺ãããæ°Žã溶液ã«æ·»å
ããŠããæ··ãã25mlã®ãã³ãŒã³ãæ·»å ããã溶液
ãæ°ŽãçšããŠæŽæµãã次ãã§é£œåéçé žå¡©æº¶æ¶²ã
çšããŠæŽæµããæåŸã«æ°ŽãçšããŠæŽæµããããã³
ãŒã³ãç¡«é žãããªãŠã äžã§ä¹Ÿç¥ããã溶液ãæžå§
äžã§èžçºä¹ŸåºãããåŸããåºåœ¢ç©ãïœâãããµã³
äžã§åæ¶åºããèç¹134ã136âã®ç¬¬ïŒçŽããã«ã
ãšãã«ã«ã«ãã¡ãŒããåŸããåç70ïŒ ãèµ€å€ç·ã¹
ãã¯ãã«ã§ã¯1690cm-1ã®ãšããã«ã«ã«ããã«ã®ã
ã³ããã3320cm-1ã®ãšããã«NHã®ãã³ããååš
ããŠããã åè¿°ã®æè¡ã«åŸããäžã€å®æ¯éŠé žã®ä»£ãã«0.84
ïœã®ãã©ãããå®æ¯éŠé žãçšãã第ïŒçŽããã«ã
ã©ãããããšãã«ã«ã«ãã¡ãŒããåŸããèç¹112
ã114âåç65ïŒ ãèµ€å€ç·ã¹ãã¯ãã«ïŒ3280cm-1
ã§NHã®ãã³ãã1690cm-1ã§ã«ã«ããã«ã®ãã³
ãã äŸ 14 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ã»ãã«ãªãã·ãã¹ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
å¡©åã¡ãã¬ã³ã«æžæ¿ãã0.30mlã®æ°·é ¢é žãš0.7ml
ã®ããªãšãã«ã¢ãã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£
ãã溶液ãããã«æ·»å ããããã®æ··åç©ãå®å šãª
溶液ãåŸãããšãªã20ã25âã§30åããæ··ããã
1770cm-1ã§ã®SPOã®ã«ã«ããã«ã®ãã³ãã¯å¯æº¶éš
åã®èµ€å€ç·ã¹ãã¯ãã«ïŒæº¶æ¶²ã«ã€ããŠå®æœïŒã«ã¯
ç¡ãã€ããã1670cm-1ããã³1735cm-1ã«ã¯é¡èšã®
ååç©ã«çžå¿ãããã³ããååšããŠãããäžæº¶è§£
éšåãå¥ããŠ0.7ïœã®äžèšçæç©ãåŸãããã®
ãã®ã®èµ€å€ç·ã¹ãã¯ãã«ïŒå¡©åã¡ãã¬ã³æº¶æ¶²ã«ã€
ããŠïŒã¯é¡èšã®ååç©ã®ããã«éããããšãã§ã
ããèç¹240ã242âã ã¢ã»ãã¢ããªããåŸãããã«ãæžæ¿æ¶²ïŒããæ
éãããŠããªããã®ïŒã«ã0.5mlïŒçŽ0.5ã»ã³ã
ã¢ã«ïŒã®ã¢ããªã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ã
ã溶液ãæ·»å ããæ··åç©ãïŒæé氷氎济äžã§ãã
æ··ããããã«0.7mlïŒ0.5ã»ã³ãã¢ã«ïŒã®TEAãïŒ
mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ã挞次添å ã
ããæçµPHã¯4.5ã§ãã€ããæ··åç©ãPH1.5ã«é žæ§
åãããææ©ç©çžãé§éããç¡«é žãããªãŠã äžã§
也ç¥ãã也åºããŠã¢ã»ãã¢ããªããåç94ïŒ ã§åŸ
ããèç¹114âã äŸ 15 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãããªã«ãªãã·ãã¹ãã«ã¢ãã äŸ14ã®åŠçã«åŸããäœãæ°·é ¢é žã®ä»£ãã«0.51ïœ
ã®ãããªã³é žãçšããå®å šãªæº¶æ¶²ãåŸãããã®ã
ã®ã®èµ€å€ç·ã¹ãã¯ãã«ã¯1770cm-1ã§ã«ã«ããã«ã®
ãã³ããååšããªãããšã瀺ãã1760cm-1ããã³
1730cm-1ã§ãã³ããåºçŸããããšã瀺ããã ç¶ãåŸã0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢ããªã³
ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»å ãã
äŸ14ã«èšããåŠãããŠåŠçãè¡ãªã€ããéãšä¹Ÿ
ç¥åŸãã¢ããªããåç78ïŒ ã§åŸããèç¹129âã äŸ 16 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒïŒïŒïŒâãžããããã³ãŸã€ã«ãªãã·ãã¹
ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
ãããã¡ã¿ã³äžã«æžæ¿ããããã«1.06ïœïŒ0.5ã»
ã³ãã¢ã«ïŒã®ïŒïŒïŒâãžãããå®æ¯éŠé žãš0.7ml
ã®ããªãšãã«ã¢ãã³ãïŒmlã®ãããã¡ã¿ã³ã«æº¶è§£
ãã溶液ãæ·»å ãããæ··åç©ã20ã25âã§15åé
ããæ··ããå®å šãªæº¶æ¶²ãåŸãã 溶液ã«ã€ããŠè¡ãªã€ãèµ€å€ç·ã¹ãã¯ãã«ã¯1770
cm-1ã§ã®ã«ã«ããã«ã®ãã³ãã®äžåšãšã1755cm-1
1735cm-1ã§ã®ãã³ãã®åºçŸã瀺ãããç¶ãåŸãã
ãã«0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢ããªã³ãïŒml
ã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ãæ·»å ããäŸ14ã«
èšããåŠãåŠçãè¡ãªã€ããã¢ããªããåç90ïŒ
ã§åŸããèç¹234âã äŸ 17 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãã³ãŸã€ã«ãªãã·ãã¹ãã«ã¢ãã äŸ14ã®åŠçã«åŸããäœãæ°·é ¢é žã®ä»£ãã«0.62ïœ
ïŒ0.5ã»ã³ãã¢ã«ïŒã®å®æ¯éŠé žãçšããå®å šãªæº¶æ¶²
ãåŸãããã®ãã®ã®èµ€å€ç·ã¹ãã¯ãã«ã¯1770cm-1
ã§ã®ã«ã«ããã«ã®ãã³ãã®äžåšãšã1730cm-1ãã
ã³1755cm-1ã§ã®ãã³ãã®åºçŸãšã瀺ããã ç¶ãåŸãããã«0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢
ããªã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»
å ããäŸ14ã«èšããåŠçãç¶ãããéããã³ä¹Ÿ
ç¥åŸã¢ããªããåç85ïŒ ã§åŸããèç¹162ã164â äŸ 18 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ããã¢ã»ãã«ã¢ãããã¹ã¢ã»ããã·ã»
ãã¢ãã¹ãã©ãã€ã«ãªãã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.46ïœã®ã¯ããã¢ã»ãã«ã¢ãã
âãã¹ã¢ã»ããã·ã»ãã¢ãã¹ãã©ã³é žãçšããŠäŸ
14ã®åŠçãè¡ãªããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-
ïŒãïŒÎ²âã©ã¯ã¿ã ïŒã1755cm-1ããã³1735cm-1ã®
ãã³ããååšãã溶液ãåŸãã äŸ 19 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ããã¢ã»ãã¢ããããã·ã©ãã€ã«ãªã
ã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.45ïœã®ïŒâã¯ããã¢ã»ãã«ã¢
ããâããã·ã©ã³é žãçšããŠäŸ14ã®åŠçãè¡ãª
ããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-1ïŒÎ²âã©ã¯ã¿
ã ïŒã1760cm-1ããã³1740cm-1ã®ãã³ããååšã
ã溶液ãåŸãã äŸ 20 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒããšãã«ã¢ã»ãã¢ããã»ãã¢ãã¹ãã©ã
ã€ã«ãªãã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.98ïœã®ããšãã«ã¢ã»ãã¢ãã
âã»ãã¢ãã¹ãã©ã³é žãçšããŠäŸ14ã®åŠçãè¡ãª
ããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-1ïŒÎ²âã©ã¯ã¿
ã ïŒã1760cm-1ããã³1740cm-1ã®ãã³ããååšã
ã溶液ãåŸãã äŸ 21 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒââããšãã«ã¢ãããã¹ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
å¡©åã¡ãã¬ã³ã«æžæ¿ããæžæ¿æ¶²ã«ãïŒmlã®ã¢ããª
ã³ãš0.7mlã®ããªãšãã«ã¢ãã³ã10mlã®å¡©åã¡ã
ã¬ã³ã«æº¶è§£ãã20âã®æº¶æ¶²ãæ·»å ãããïŒæé20
ã25âã§ããæ··ããåŸå®å šãªæº¶æ¶²ãåŸããææ©ç©
çžãé žæ§æ°ŽãçšããŠæœåºããç¡æ°Žç¡«é žãããªãŠã
äžã§ä¹Ÿç¥ããæžå§äžã§æ¿çž®ãããæ®çç©ã¯0.9ïœ
ã®é¡èšã®ååç©ãäžãããåç56ïŒ ãèç¹195ã
198âãèµ€å€ç·ã¹ãã¯ãã«ïŒ ã¯3190cm-1ã§ïŒ®â
ã®ãã³ããååšãã1770cm-1ã§ã«ã«ããã«ã®ãã³
ããååšãããããã«ã0.62ïœã®å®æ¯éŠé žãš0.7
mlã®ããªãšãã«ã¢ãã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶
解ãã溶液ããã®ïŒ®âããšãã«ã¢ãããã¹ãã«ã¢
ãã溶液ã«æ·»å ãã20ã25âã§48æéããæ··ã
ããïŒãïŒâã§é žæ§æ°ŽãçšããŠæœåºåŸçžå¿ããã¢
ããªããåŸããåç51ïŒ ãèç¹162ã164âã äŸ 22 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒããšãã«ããã©ãžããã¹ãã«ã¢ãã 2.54ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®å¡©
åã¡ãã¬ã³ã«æžæ¿ããæžæ¿æ¶²ã«ã1.08ïœïŒïŒã»ã³
ãã¢ã«ïŒã®ããšãã«ããã©ãžã³ãïŒmlã®å¡©åã¡ã
ã¬ã³ã«æº¶è§£ãã溶液ã挞次ã«æ·»å ããç¶ãåŸ1.4
mlã®ããªãšãã«ã¢ãã³ãæ³šå ¥ããæ··åç©ãåžžæž©ã§
60åããæ··ããé¡èšã®ååç©ã®æº¶æ¶²ãåŸãã åè¿°ã®æº¶æ¶²ã«ãïŒã»ã³ãã¢ã«ã®ããªãšãã«ã¢ã
ã³ãã³ãŸãšãŒãã10mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã
溶液ãæ·»å ãããããæ··ããåžžæž©ã§ïŒæéç¶ãã
次ãã§ããšãã«ããã©ãžããåé¢ãããåç59
ïŒ ãèç¹108âã äŸ 23 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¡ããã·ãã¹ãã«ã¢ãã 1.27ïœã®ClâSPOã10mlã®å¡©åã¡ãã¬ã³ã«æžæ¿
ããæžæ¿æ¶²ã«ãïŒmlã®ã¡ã¿ããŒã«ãš0.7mlã®ããª
ãšãã«ã¢ãã³ãšããæã溶液ãæ·»å ããã20ã25
âã§90åããæ··ããç¶ããïŒãïŒâã§é žæ§æº¶æ¶²ã
åŸããææ©ç©çžãç¡æ°Žç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ãã溶åªãæžå§äžã§é§éãã0.8ïœã®ã¡ãã«ãšã¹
ãã«ãåŸããåç64ïŒ ãèç¹83ã84âãèµ€å€ç·ã¹
ãã¯ãã«ã¯1760cm-1ã§ã«ã«ããã«ã®ãã³ãã瀺ã
ãã ClâSPOã®å¯æº¶ååŸã1.06ïœã®ïŒïŒïŒâãžãã
ãå®æ¯éŠé žãš0.7mlã®ããªãšãã«ã¢ãã³ãïŒmlã®
å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»å ãããããæ··
ãã20ã25âã§72æéç¶ããææ©ç©çžãé žæ§æ°Žã
çšããŠæœåºããããããç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ãã溶åªãæžå§äžã§é§éãã0.52ïœã®ãšã¹ãã«ã
åŸããåç52ïŒ ãèç¹105ã106âãèµ€å€ç·ã¹ãã¯
ãã«ã¯1725cm-1ã§ã«ã«ããã«ã®ãã³ãã瀺ããã äŸ 24 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãšãã«ããªãã¹ãã«ã¢ãã 2.54ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã40âã§10
mlã®ãããã¡ã¿ã³ã«æº¶è§£ããã1.26ïœïŒ1.5ã»ã³
ãã¢ã«ïŒã®ãããªãŠã ããªãšãã¬ãŒããæ·»å ã
ããããæ··ãã70âã§ïŒæéç¶ãããæ··åç©ã
éããŠãšãã«ããªãã¹ãã«ã¢ããã®æº¶æ¶²ãåŸãã
ãã«ïŒã»ã³ãã¢ã«ã®é ¢é žããªãšãã«ã¢ãã³ãïŒml
ã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ã滎å ããããã
æ··ãã20ã25âã§ïŒæéç¶ãããšã¹ãã«ãåç62
ïŒ ã§åŸãã沞ç¹116ã117âãæ¯é0.9755ã äŸ 25 ïŒNâ²âãã¹âïŒïŒâã¡ãã«âïŒâãªããµãŸãª
ãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâã¡ãã«âïŒ
âãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ã®åçã§åé¢ããããã®
ãã®ã®ç¹æ§ãèµ€å€ç·ã¹ãã¯ãã«åæã§è©Šéšãããš
ãããçã®ååšãšã«ã«ããã«ã«ããç¹å®ã®èªåå€
ã瀺ããã äŸ 26 ïŒNâ²âãã¹âïŒïŒâãšãã«âïŒâãªããµãŸãª
ãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâãšãã«âïŒ
âãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ãªåçã§åé¢ããããã®
ãã®ã¯çã®ååšãšã«ã«ããã·ã«ã®ååšã«ããèµ€å€
ç·ã¹ãã¯ãã«ã§ã®ç¹å®ã®èªåå€ã«ç¹è²ãæããŠã
ãã äŸ 27 ïŒNâ²âãã¹âïŒïŒâã¡ãã«âïŒâãšãã«âïŒ
âãªããµãŸãªãžãã«âïŒâãªã³ïŒã¯ãããã¹ã
ã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâã¡ãã«âïŒ
âãšãã«âïŒâãªããµãŸãªãžãã³ãçšããŠäŸïŒã®
åŠçãè¡ãªããé¡èšã®ååç©ãåæ§ã¯åçã§åé¢
ããããã®ãã®ã¯èµ€å€ç·ã¹ãã¯ãã«ã«ãããšãç
ãšã«ã«ããã·ã«ã®ååšã«èµ·å ããèªåå€ã«ç¹è²ã
æããŠããã äŸ 28 ïŒNâ²âãã¹âïŒïŒâããšãã«âïŒâãªããµãŸ
ãªãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâããšãã«â
ïŒâãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ãªåçã§åé¢ããããã®
ãã®ãèµ€å€ç·ã¹ãã¯ãã«ã§åæãããšãããã«ã«
ããã«ãšçã«èµ·å ããèªåå€ã«ç¹è²ãæããŠã
ãã æ¬çºæãããçã®äŸã®ã¿ã«éå®ããããã®ã§ãª
ããæ¬çºæã®åºæ±ãªç²Ÿç¥ãšèŠéãéžè±ããããšãª
ãçš®ã ã®å€æŽãšä¿®æŽãå¯èœãªããšå¿è«ã§ããã
ãŸãªãžãã«âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢
ããã§ãããããã¯åªããååŠç掻æ§ãæããã
ããã«ãããçã®ååç©ã¯å®¹æã«è£œé ããããšã
ã§ãããäŸãã°ClâSPOã¯ïŒâãªããµãŸãªãžã
ã³ãšäºå¡©åçãšã®åå¿æ··åç©ã«å¯Ÿããæ°Žã®äœçš
ãšãããã«ç¶ãããã·ã©ã³é žãŸãã¯ã»ãã¢ãã¹ã
ã©ã³é žããã¹ã¢ã»ããã·ã»ãã¢ãã¹ãã©ã³é žãã
ã³ãããçã®èªå°äœã®äœçšãšãäºãããçãçšã
ãŠäžæŽ»æ§æº¶åªäŸãã°å¡©åã¡ãã¬ã³äžã§ã¢ãã³å¡©å¥œ
ãŸããã¯ããªãšãã«ã¢ãã³ãçæããããšã«ãã
補é ãããããã®åå¿ã¯ã¢ã·ã«ãªãã·ãã¹ãã«ã¢
ããã®æº¶æ¶²ãŸãã¯æåºç©ãçæããããšãã§ãã
äœãã®å Žåã§ãã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã¯æº¶
åªã®èžçºã«ãããŸãã¯æº¶æ¶²ã®å Žåã«ã¯ïœâããã¿
ã³ã«ããæåºãšæçµçéã«ããåé¢ããããšã
ã§ãããããçã¯äœããã«ã«ããã«åºã®äœçœ®ã«å¯Ÿ
ããã«ã«ããã·ã«åºã®ç¹è²æãèµ€å€ç·ã¹ãã¯ãã«
ã瀺ãããã®ã¹ãã¯ãã«ã¯Î²âã©ã¯ã¿ã æ žã«çžå¿
ããèªåå€ããé¢ããŠããããã®èªåã¯ååå ã®
çã®ååšã«äŸããã®ã§ããã æ¬çºæã次ã«äŸã«ã€ãããã«è©³çŽ°ã«èª¬æããã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 5.4ïœïŒ6.21ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãž
ãã³ã60mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã20âã®æº¶æ¶²
ã«6.24ïœïŒïŒã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»
å ããé»è²æº¶æ¶²ãåŸãããã®æº¶æ¶²ã¯ïŒååŸå€éã®
æåºç©ãçæãããããã20ã25âã§12æéãã
æ··ããéæµäžã§ïŒæéããæ··ããå šäœã§ã¯ãªãè©
䟡ã§ãã溶液ãåŸããç¶ãåŸæº¶åªãæžå§äžã§é€å»
ããŠæ²¹ç¶ç©ãåŸããããïŒâã«å·åŽã20mlã®æ¥µã
ãŠäœæž©ã®æ°Žãæ¿ããããæ··ããªããæ·»å ãããæ··
åç©ãè¿ éã«å¥ãã10mlã®ïŒïŒïŒâãžã¡ããã·
ãšã¿ã³ãçšããŠæŽæµãããåé2.8ïœïŒ37ïŒ ïŒãè
ç¹191ã193âã 埮éåæïŒC6H8O5N2ClPïŒ ïŒ£   èšç®å€ 28.27 3.14 10.99 å®æž¬å€ 28.19 3.08 10.89ïŒïŒ ïŒ äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïœïŒ8.05ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã20âã®80mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ããïŒïœ
ïŒ4.3ã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å ããŠå š
äœæº¶æ¶²ãšæ¬¡ã®æåºç©ãåŸããæ··åç©ã20ã25âã§
22æéããæ··ãã溶åªãæžå§äžã§é§éããŠæ²¹ç¶ç©
ãåŸãããã«10mlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã
æ·»å ãããæ··åç©ãïŒâã«å·åŽããã次ãã§ïŒå
éã«äºã€ãŠïŒmlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ãšïŒ
mlã®æ°Žãšã®æº¶æ¶²ã滎å ããã枩床ã¯ïŒãïŒâã«ä¿
æãããåŸããåºåœ¢ç©ãå¥ã10mlã®ïŒïŒïŒâãž
ã¡ããã·ãšã¿ã³ãçšããŠæŽæµãããåé6.0ïœ
ïŒ55ïŒ ïŒã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 34.8ïœïŒ40ã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã380mlã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ã«ã
41.7ïœïŒ20ã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å
ãã溶液ãšããããã®æº¶æ¶²ã20ã25âã§ïŒæéã
ãæ··ãã40ã45âã§ããã«ïŒæéããæ··ãããïŒ
âã«å·åŽåŸã15mlã®æ°Žãš50mlã®ïŒïŒïŒâãžã¡ãã
ã·ãšã¿ã³ãšã®æ··å液ãïŒåéã§æ·»å ãããç¶ãåŸ
溶åªãæžå§äžã§é§éãçœè²æ®çç©ãåŸããããã
10mlã®ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®æ·»å ã«ããæ¶
åºããããããå¥ããïŒïŒïŒâãžã¡ããã·ãšã¿
ã³ãçšããŠæŽæµãã50âã®ç空äžã§ä¹Ÿç¥ããCl
âSPOååç©40.64ïœïŒåç80ïŒ ïŒãåŸãããã®
ãã®ã¯åŸ®éåææ³ã«ããåæå€ãšäžèŽããã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ãããã¡ã¿ã³ã®ä»£ãã«ã¢ã»ããããªã«ãçšããŠ
äŸïŒã®åŠçãè¡ãªãã65ïŒ ã®åçïŒåé32.02
ïœïŒãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ æ°Žã®ä»£ãã«15mlã®ã¡ã¿ããŒã«ãçšããŠäŸïŒã®åŠ
çãè¡ãªãã54ïŒ ïŒ27.43ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ æ°Žæ§æº¶æ¶²ã®ä»£ãã«2.4ïœã®æ°·é ¢é žããã³5.6mlã®
ããªãšãã«ã¢ãã³ã10mlã®ïŒïŒïŒâãžã¡ããã·ãš
ã¿ã³ã«æº¶è§£ãã溶液ãçšããŠäŸïŒã®åŠçãè¡ãª
ãã50ïŒ ïŒ5.46ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ å¡©åã¡ãã¬ã³ã®ä»£ãã«ã¢ã»ããããªã«ãçšãã
ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ãžãªããµã³ã
çšããŠäŸïŒã®åŠçãè¡ãªãã60ïŒ ïŒ6.44ïœïŒã®å
çãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ããã©ãã
ããã©ã³ãçšããŠäŸïŒã®åŠçãè¡ãªãã78ïŒ
ïŒ39.62ïœïŒã®åçãåŸãã äŸ ïŒ ïŒ®ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ ïŒïŒïŒâãžã¡ããã·ãšã¿ã³ã®ä»£ãã«ã€ãœããã
ããŒã«ãçšããŠäŸïŒã®åŠçãè¡ãªãã35ïŒ ïŒ2.67
ïœïŒã®åçãåŸãã äŸ 10 0.87ïœïŒïŒã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã10mlã®20âã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã2.08ïœ
ïŒïŒã»ã³ãã¢ã«ïŒã®äºå¡©åçãäžåºŠã«æ·»å ããã
ïŒåéããæ··ããåŸå€éã®æåºç©ãçæãããç¶
ãåŸããã«ïŒã»ã³ãã¢ã«ã®ïŒâãªããµãŸãªãžãã³
ïŒ0.87ïœïŒãæ·»å ããäŸïŒã®åŠçãè¡ãªããåå
ç©ClâSPOãåæ§ãªåçã§åé¢ããã äŸ 11 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ãããã¹ãã«ã¢ããïŒClâSPOïŒ 1.74ïœïŒïŒã»ã³ãã¢ã«ïŒã®ïŒâãªããµãŸãªãžã
ã³ã10mlã®ã¢ã»ããããªã«ã«æº¶è§£ãã2.08ïœã®äº
å¡©åçãäžåºŠã«æ·»å ããé»è²ã®å šäœæº¶æ¶²ãåŸãã
溶液ã20ã25âã§12æéããæ··ããïŒæééæµå
ç±ãããç¶ãåŸïŒâã«å·åŽãã0.2mlã®æ°ŽïŒçŽïŒ
ã»ã³ãã¢ã«ïŒã滎å ããŠãïŒã»ã³ãã¢ã«ïŒ2.54
ïœïŒã®ClâSPOãåŸãã äŸ 12 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ãžããã¹ãã«ã¢ããïŒN3âSPOïŒ 5.08ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã50mlã®40
âã®ãããã¡ã¿ã³ã«æº¶è§£ãã1.95ïœïŒïŒã»ã³ãã¢
ã«ïŒã®ã¢ãžåãããªãŠã ãæ·»å ãããæ··åç©ã70
âã§ïŒæéããæ··ããããããéãã溶åªã50
âã®æžå§äžã§é§éããçœè²åºåœ¢ç©ãåŸããéé
5.6ïœãåç97ïŒ ãããããšã¿ããŒã«ãŸãã¯ïŒïŒ
ïŒâãžã¡ããã·ãšã¿ã³äžã§åæ¶åºãããèç¹97ã
99âãèµ€å€ç·ã¹ãã¯ãã«ã¯2190cm-1ã§N3ãã³ãã
1770cm-1ã§ã«ã«ããã«ãã³ããååšããã 埮éåæïŒC6H8O5N5PïŒ ïŒ£   èšç®å€ 27.58 3.06 26.81 å®æž¬å€ 27.41 2.97 26.43ïŒïŒ ïŒ äŸ 13 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ãžããã¹ãã«ã¢ããïŒN3âSPOïŒ ãããã¡ã¿ã³ã®ä»£ãã«75mlã®ã¢ã»ããããªã«ã
çšããŠäŸ12ã®åŠçãè¡ãªãã4.75ïœã®N3âSPOã
åŸããåçã¯91ïŒ ã§ãã€ãã1.3ïœã®N3âSPOè©Š
æã0.7mlã®ããªãšãã«ã¢ãã³ïŒTEAïŒãš0.61ïœ
ã®å®æ¯éŠé žãšå ±ã«16mlã®ç¬¬ïŒçŽãã¿ããŒã«äžã«å
åºãããæ··åç©ãéæµå ç±äžã§ïŒæéããæ··ã
ãããããŠåŸã溶液ã®èµ€å€ç·ã¹ãã¯ãã«ã¯N3ã
ã³ããååšããªãããšã瀺ãããæ°Žã溶液ã«æ·»å
ããŠããæ··ãã25mlã®ãã³ãŒã³ãæ·»å ããã溶液
ãæ°ŽãçšããŠæŽæµãã次ãã§é£œåéçé žå¡©æº¶æ¶²ã
çšããŠæŽæµããæåŸã«æ°ŽãçšããŠæŽæµããããã³
ãŒã³ãç¡«é žãããªãŠã äžã§ä¹Ÿç¥ããã溶液ãæžå§
äžã§èžçºä¹ŸåºãããåŸããåºåœ¢ç©ãïœâãããµã³
äžã§åæ¶åºããèç¹134ã136âã®ç¬¬ïŒçŽããã«ã
ãšãã«ã«ã«ãã¡ãŒããåŸããåç70ïŒ ãèµ€å€ç·ã¹
ãã¯ãã«ã§ã¯1690cm-1ã®ãšããã«ã«ã«ããã«ã®ã
ã³ããã3320cm-1ã®ãšããã«NHã®ãã³ããååš
ããŠããã åè¿°ã®æè¡ã«åŸããäžã€å®æ¯éŠé žã®ä»£ãã«0.84
ïœã®ãã©ãããå®æ¯éŠé žãçšãã第ïŒçŽããã«ã
ã©ãããããšãã«ã«ã«ãã¡ãŒããåŸããèç¹112
ã114âåç65ïŒ ãèµ€å€ç·ã¹ãã¯ãã«ïŒ3280cm-1
ã§NHã®ãã³ãã1690cm-1ã§ã«ã«ããã«ã®ãã³
ãã äŸ 14 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ã»ãã«ãªãã·ãã¹ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
å¡©åã¡ãã¬ã³ã«æžæ¿ãã0.30mlã®æ°·é ¢é žãš0.7ml
ã®ããªãšãã«ã¢ãã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£
ãã溶液ãããã«æ·»å ããããã®æ··åç©ãå®å šãª
溶液ãåŸãããšãªã20ã25âã§30åããæ··ããã
1770cm-1ã§ã®SPOã®ã«ã«ããã«ã®ãã³ãã¯å¯æº¶éš
åã®èµ€å€ç·ã¹ãã¯ãã«ïŒæº¶æ¶²ã«ã€ããŠå®æœïŒã«ã¯
ç¡ãã€ããã1670cm-1ããã³1735cm-1ã«ã¯é¡èšã®
ååç©ã«çžå¿ãããã³ããååšããŠãããäžæº¶è§£
éšåãå¥ããŠ0.7ïœã®äžèšçæç©ãåŸãããã®
ãã®ã®èµ€å€ç·ã¹ãã¯ãã«ïŒå¡©åã¡ãã¬ã³æº¶æ¶²ã«ã€
ããŠïŒã¯é¡èšã®ååç©ã®ããã«éããããšãã§ã
ããèç¹240ã242âã ã¢ã»ãã¢ããªããåŸãããã«ãæžæ¿æ¶²ïŒããæ
éãããŠããªããã®ïŒã«ã0.5mlïŒçŽ0.5ã»ã³ã
ã¢ã«ïŒã®ã¢ããªã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ã
ã溶液ãæ·»å ããæ··åç©ãïŒæé氷氎济äžã§ãã
æ··ããããã«0.7mlïŒ0.5ã»ã³ãã¢ã«ïŒã®TEAãïŒ
mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ã挞次添å ã
ããæçµPHã¯4.5ã§ãã€ããæ··åç©ãPH1.5ã«é žæ§
åãããææ©ç©çžãé§éããç¡«é žãããªãŠã äžã§
也ç¥ãã也åºããŠã¢ã»ãã¢ããªããåç94ïŒ ã§åŸ
ããèç¹114âã äŸ 15 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãããªã«ãªãã·ãã¹ãã«ã¢ãã äŸ14ã®åŠçã«åŸããäœãæ°·é ¢é žã®ä»£ãã«0.51ïœ
ã®ãããªã³é žãçšããå®å šãªæº¶æ¶²ãåŸãããã®ã
ã®ã®èµ€å€ç·ã¹ãã¯ãã«ã¯1770cm-1ã§ã«ã«ããã«ã®
ãã³ããååšããªãããšã瀺ãã1760cm-1ããã³
1730cm-1ã§ãã³ããåºçŸããããšã瀺ããã ç¶ãåŸã0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢ããªã³
ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»å ãã
äŸ14ã«èšããåŠãããŠåŠçãè¡ãªã€ããéãšä¹Ÿ
ç¥åŸãã¢ããªããåç78ïŒ ã§åŸããèç¹129âã äŸ 16 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒïŒïŒïŒâãžããããã³ãŸã€ã«ãªãã·ãã¹
ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
ãããã¡ã¿ã³äžã«æžæ¿ããããã«1.06ïœïŒ0.5ã»
ã³ãã¢ã«ïŒã®ïŒïŒïŒâãžãããå®æ¯éŠé žãš0.7ml
ã®ããªãšãã«ã¢ãã³ãïŒmlã®ãããã¡ã¿ã³ã«æº¶è§£
ãã溶液ãæ·»å ãããæ··åç©ã20ã25âã§15åé
ããæ··ããå®å šãªæº¶æ¶²ãåŸãã 溶液ã«ã€ããŠè¡ãªã€ãèµ€å€ç·ã¹ãã¯ãã«ã¯1770
cm-1ã§ã®ã«ã«ããã«ã®ãã³ãã®äžåšãšã1755cm-1
1735cm-1ã§ã®ãã³ãã®åºçŸã瀺ãããç¶ãåŸãã
ãã«0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢ããªã³ãïŒml
ã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ãæ·»å ããäŸ14ã«
èšããåŠãåŠçãè¡ãªã€ããã¢ããªããåç90ïŒ
ã§åŸããèç¹234âã äŸ 17 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãã³ãŸã€ã«ãªãã·ãã¹ãã«ã¢ãã äŸ14ã®åŠçã«åŸããäœãæ°·é ¢é žã®ä»£ãã«0.62ïœ
ïŒ0.5ã»ã³ãã¢ã«ïŒã®å®æ¯éŠé žãçšããå®å šãªæº¶æ¶²
ãåŸãããã®ãã®ã®èµ€å€ç·ã¹ãã¯ãã«ã¯1770cm-1
ã§ã®ã«ã«ããã«ã®ãã³ãã®äžåšãšã1730cm-1ãã
ã³1755cm-1ã§ã®ãã³ãã®åºçŸãšã瀺ããã ç¶ãåŸãããã«0.5mlïŒçŽ0.5ã»ã³ãã¢ã«ïŒã®ã¢
ããªã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»
å ããäŸ14ã«èšããåŠçãç¶ãããéããã³ä¹Ÿ
ç¥åŸã¢ããªããåç85ïŒ ã§åŸããèç¹162ã164â äŸ 18 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ããã¢ã»ãã«ã¢ãããã¹ã¢ã»ããã·ã»
ãã¢ãã¹ãã©ãã€ã«ãªãã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.46ïœã®ã¯ããã¢ã»ãã«ã¢ãã
âãã¹ã¢ã»ããã·ã»ãã¢ãã¹ãã©ã³é žãçšããŠäŸ
14ã®åŠçãè¡ãªããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-
ïŒãïŒÎ²âã©ã¯ã¿ã ïŒã1755cm-1ããã³1735cm-1ã®
ãã³ããååšãã溶液ãåŸãã äŸ 19 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¯ããã¢ã»ãã¢ããããã·ã©ãã€ã«ãªã
ã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.45ïœã®ïŒâã¯ããã¢ã»ãã«ã¢
ããâããã·ã©ã³é žãçšããŠäŸ14ã®åŠçãè¡ãª
ããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-1ïŒÎ²âã©ã¯ã¿
ã ïŒã1760cm-1ããã³1740cm-1ã®ãã³ããååšã
ã溶液ãåŸãã äŸ 20 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒããšãã«ã¢ã»ãã¢ããã»ãã¢ãã¹ãã©ã
ã€ã«ãªãã·ãã¹ãã«ã¢ãã æ°·é ¢é žã®ä»£ãã«1.98ïœã®ããšãã«ã¢ã»ãã¢ãã
âã»ãã¢ãã¹ãã©ã³é žãçšããŠäŸ14ã®åŠçãè¡ãª
ããèµ€å€ç·ã¹ãã¯ãã«ã§1780cm-1ïŒÎ²âã©ã¯ã¿
ã ïŒã1760cm-1ããã³1740cm-1ã®ãã³ããååšã
ã溶液ãåŸãã äŸ 21 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒââããšãã«ã¢ãããã¹ãã«ã¢ãã 1.27ïœïŒ0.5ã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®
å¡©åã¡ãã¬ã³ã«æžæ¿ããæžæ¿æ¶²ã«ãïŒmlã®ã¢ããª
ã³ãš0.7mlã®ããªãšãã«ã¢ãã³ã10mlã®å¡©åã¡ã
ã¬ã³ã«æº¶è§£ãã20âã®æº¶æ¶²ãæ·»å ãããïŒæé20
ã25âã§ããæ··ããåŸå®å šãªæº¶æ¶²ãåŸããææ©ç©
çžãé žæ§æ°ŽãçšããŠæœåºããç¡æ°Žç¡«é žãããªãŠã
äžã§ä¹Ÿç¥ããæžå§äžã§æ¿çž®ãããæ®çç©ã¯0.9ïœ
ã®é¡èšã®ååç©ãäžãããåç56ïŒ ãèç¹195ã
198âãèµ€å€ç·ã¹ãã¯ãã«ïŒ ã¯3190cm-1ã§ïŒ®â
ã®ãã³ããååšãã1770cm-1ã§ã«ã«ããã«ã®ãã³
ããååšãããããã«ã0.62ïœã®å®æ¯éŠé žãš0.7
mlã®ããªãšãã«ã¢ãã³ãïŒmlã®å¡©åã¡ãã¬ã³ã«æº¶
解ãã溶液ããã®ïŒ®âããšãã«ã¢ãããã¹ãã«ã¢
ãã溶液ã«æ·»å ãã20ã25âã§48æéããæ··ã
ããïŒãïŒâã§é žæ§æ°ŽãçšããŠæœåºåŸçžå¿ããã¢
ããªããåŸããåç51ïŒ ãèç¹162ã164âã äŸ 22 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒããšãã«ããã©ãžããã¹ãã«ã¢ãã 2.54ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã10mlã®å¡©
åã¡ãã¬ã³ã«æžæ¿ããæžæ¿æ¶²ã«ã1.08ïœïŒïŒã»ã³
ãã¢ã«ïŒã®ããšãã«ããã©ãžã³ãïŒmlã®å¡©åã¡ã
ã¬ã³ã«æº¶è§£ãã溶液ã挞次ã«æ·»å ããç¶ãåŸ1.4
mlã®ããªãšãã«ã¢ãã³ãæ³šå ¥ããæ··åç©ãåžžæž©ã§
60åããæ··ããé¡èšã®ååç©ã®æº¶æ¶²ãåŸãã åè¿°ã®æº¶æ¶²ã«ãïŒã»ã³ãã¢ã«ã®ããªãšãã«ã¢ã
ã³ãã³ãŸãšãŒãã10mlã®å¡©åã¡ãã¬ã³ã«æº¶è§£ãã
溶液ãæ·»å ãããããæ··ããåžžæž©ã§ïŒæéç¶ãã
次ãã§ããšãã«ããã©ãžããåé¢ãããåç59
ïŒ ãèç¹108âã äŸ 23 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¡ããã·ãã¹ãã«ã¢ãã 1.27ïœã®ClâSPOã10mlã®å¡©åã¡ãã¬ã³ã«æžæ¿
ããæžæ¿æ¶²ã«ãïŒmlã®ã¡ã¿ããŒã«ãš0.7mlã®ããª
ãšãã«ã¢ãã³ãšããæã溶液ãæ·»å ããã20ã25
âã§90åããæ··ããç¶ããïŒãïŒâã§é žæ§æº¶æ¶²ã
åŸããææ©ç©çžãç¡æ°Žç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ãã溶åªãæžå§äžã§é§éãã0.8ïœã®ã¡ãã«ãšã¹
ãã«ãåŸããåç64ïŒ ãèç¹83ã84âãèµ€å€ç·ã¹
ãã¯ãã«ã¯1760cm-1ã§ã«ã«ããã«ã®ãã³ãã瀺ã
ãã ClâSPOã®å¯æº¶ååŸã1.06ïœã®ïŒïŒïŒâãžãã
ãå®æ¯éŠé žãš0.7mlã®ããªãšãã«ã¢ãã³ãïŒmlã®
å¡©åã¡ãã¬ã³ã«æº¶è§£ãã溶液ãæ·»å ãããããæ··
ãã20ã25âã§72æéç¶ããææ©ç©çžãé žæ§æ°Žã
çšããŠæœåºããããããç¡«é žãããªãŠã äžã§ä¹Ÿç¥
ãã溶åªãæžå§äžã§é§éãã0.52ïœã®ãšã¹ãã«ã
åŸããåç52ïŒ ãèç¹105ã106âãèµ€å€ç·ã¹ãã¯
ãã«ã¯1725cm-1ã§ã«ã«ããã«ã®ãã³ãã瀺ããã äŸ 24 ïŒNâ²âãã¹âïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒãšãã«ããªãã¹ãã«ã¢ãã 2.54ïœïŒïŒã»ã³ãã¢ã«ïŒã®ClâSPOã40âã§10
mlã®ãããã¡ã¿ã³ã«æº¶è§£ããã1.26ïœïŒ1.5ã»ã³
ãã¢ã«ïŒã®ãããªãŠã ããªãšãã¬ãŒããæ·»å ã
ããããæ··ãã70âã§ïŒæéç¶ãããæ··åç©ã
éããŠãšãã«ããªãã¹ãã«ã¢ããã®æº¶æ¶²ãåŸãã
ãã«ïŒã»ã³ãã¢ã«ã®é ¢é žããªãšãã«ã¢ãã³ãïŒml
ã®ãããã¡ã¿ã³ã«æº¶è§£ãã溶液ã滎å ããããã
æ··ãã20ã25âã§ïŒæéç¶ãããšã¹ãã«ãåç62
ïŒ ã§åŸãã沞ç¹116ã117âãæ¯é0.9755ã äŸ 25 ïŒNâ²âãã¹âïŒïŒâã¡ãã«âïŒâãªããµãŸãª
ãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâã¡ãã«âïŒ
âãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ã®åçã§åé¢ããããã®
ãã®ã®ç¹æ§ãèµ€å€ç·ã¹ãã¯ãã«åæã§è©Šéšãããš
ãããçã®ååšãšã«ã«ããã«ã«ããç¹å®ã®èªåå€
ã瀺ããã äŸ 26 ïŒNâ²âãã¹âïŒïŒâãšãã«âïŒâãªããµãŸãª
ãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâãšãã«âïŒ
âãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ãªåçã§åé¢ããããã®
ãã®ã¯çã®ååšãšã«ã«ããã·ã«ã®ååšã«ããèµ€å€
ç·ã¹ãã¯ãã«ã§ã®ç¹å®ã®èªåå€ã«ç¹è²ãæããŠã
ãã äŸ 27 ïŒNâ²âãã¹âïŒïŒâã¡ãã«âïŒâãšãã«âïŒ
âãªããµãŸãªãžãã«âïŒâãªã³ïŒã¯ãããã¹ã
ã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâã¡ãã«âïŒ
âãšãã«âïŒâãªããµãŸãªãžãã³ãçšããŠäŸïŒã®
åŠçãè¡ãªããé¡èšã®ååç©ãåæ§ã¯åçã§åé¢
ããããã®ãã®ã¯èµ€å€ç·ã¹ãã¯ãã«ã«ãããšãç
ãšã«ã«ããã·ã«ã®ååšã«èµ·å ããèªåå€ã«ç¹è²ã
æããŠããã äŸ 28 ïŒNâ²âãã¹âïŒïŒâããšãã«âïŒâãªããµãŸ
ãªãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«ã¢ãã ïŒâãªããµãŸãªãžãã³ã®ä»£ãã«ïŒâããšãã«â
ïŒâãªããµãŸãªãžãã³ãçšããŠäŸïŒã®åŠçãè¡ãª
ããé¡èšã®ååç©ãåæ§ãªåçã§åé¢ããããã®
ãã®ãèµ€å€ç·ã¹ãã¯ãã«ã§åæãããšãããã«ã«
ããã«ãšçã«èµ·å ããèªåå€ã«ç¹è²ãæããŠã
ãã æ¬çºæãããçã®äŸã®ã¿ã«éå®ããããã®ã§ãª
ããæ¬çºæã®åºæ±ãªç²Ÿç¥ãšèŠéãéžè±ããããšãª
ãçš®ã ã®å€æŽãšä¿®æŽãå¯èœãªããšå¿è«ã§ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ æ¬¡ã®äžè¬åŒ ïŒåŒäžã®R1ïŒR2ïŒR3åã³R4ã¯æ°ŽçŽ ãççŽ åå
æ°ïŒãïŒã®ã¢ã«ãã«åã³ããšãã«ããæã矀ãã
éžæããåºã瀺ããã¯èŠªæ žç眮æã«ããå°å ¥ã
åŸãåºã§ãã€ãŠããã²ã³ãã¢ãžãåºãã¢ããåºã
ã¡ã«ã«ããåºãã¢ã·ã«ãªãã·åºãã«ã«ããã·ã«åº
åã³ã¢ã«ã³ãã·åºããæã矀ããéžæãããã®ã
瀺ãïŒã§è¡šãããããšãç¹åŸŽãšããâ眮æïŒ
Nâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒ
ãã¹ãã«ã¢ããã ïŒ R1ïŒR2ïŒR3åã³R4ãæ°ŽçŽ ãççŽ ååæ°ïŒã
ïŒã®ã¢ã«ãã«åã³ããšãã«ããéžæããåºã瀺
ããã¯å¡©çŽ ãã¢ãžããã¢ã»ãã«ãªãã·ããããª
ã«ãªãã·ãïŒïŒïŒâãžããããã³ãŸã€ã«ãªãã·ã
ãã³ãŸã€ã«ãªãã·ãã¯ããã¢ã»ãã«ã¢ãããã¹ã¢
ã»ããã·ã»ãã¢ãã¹ãã©ãã€ã«ãªãã·ãã¯ããã¢
ã»ãã¢ããããã·ã©ãã€ã«ãªãã·ãããšãã«ã¢ã»
ãã¢ããã»ãã¢ãã¹ãã©ãã€ã«ãªãã·ãâããš
ãã«ã¢ãããããšãã«ããã©ãžããã¡ããã·åã³
ãšãã«ããªããæã矀ããéžæãããã®ã§ããç¹
èš±è«æ±ã®ç¯å²ïŒèšèŒã®ïŒ°â眮æïŒNâ²âãã¹
ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒãã¹ãã«ã¢
ããã ïŒ R1ïŒR2ïŒR3åã³R4ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®
ç¯å²ïŒèšèŒã®ïŒ°â眮æïŒNâ²âãã¹ïŒïŒâãªã
ãµãŸãªãžãã«âïŒâãªã³ïŒãã¹ãã«ã¢ããã ïŒ ç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®ïŒ®ïŒNâ²âãã¹ïŒïŒ
âãªããµãŸãªãžãã«âïŒâãªã³ïŒã¯ãããã¹ãã«
ã¢ããã ïŒ ç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®ïŒ®ïŒNâ²âãã¹ïŒïŒ
âãªããµãŸãªãžãã«âïŒâãªã³ïŒã¢ãžããã¹ãã«
ã¢ããã ïŒ ã¢ããåºãèèªæå¡©åºãè³éŠæå¡©åºãè€çŽ ç°
åŒå¡©åºãïŒâã¢ããããã·ã©ã³é žã®ã«ã«ããã·ãš
ã¹ãã«åã¯ïŒâã¢ããã»ãã¢ãã¹ãã©ã³é žã®ã«ã«
ããã·ãšã¹ãã«ã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒ
ã®ïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ãããã¹ãã«ã¢ããã ïŒ ã¡ã«ã«ããåºãèèªæãè³éŠæåã¯è€çŽ ç°åŒ
ã®ããªãŒã«ã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®
ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãª
ã³ïŒã¡ã«ã«ãããã¹ãã«ã¢ããã ïŒ ã¢ã·ã«ãªãã·åºãèèªæãè³éŠæåã¯è€çŽ ç°
åŒã®ã«ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒ
ã®ïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã ïŒ ã¢ã·ã«ãªãã·åºãããã·ãªã³ã®ïŒ£âïŒã§ã®ã«
ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®ïŒ®ïŒ
Nâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒ
ã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã ïŒïŒ ã¢ã·ã«ãªãã·åºãã»ãã¢ãã¹ããªã³ã®ïŒ£â
ïŒã§ã®ã«ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèš
èŒã®ïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒ
âãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã ïŒïŒ ã¢ã·ã«ãªãã·åºãããã·ãªã³ã®ïŒ£âïŒã§ã®
åŽéã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®ïŒ®ïŒ
Nâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒ
ã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã ïŒïŒ ã¢ã·ã«ãªãã·åºãã»ãã¢ãã¹ããªã³ã®ïŒ£â
ïŒã§ã®åŽéã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒã®
ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãª
ã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ããã ïŒïŒ ã¢ã«ã³ãã·åºãèèªæãè³éŠæåã¯è€çŽ ç°
åŒã®ã¢ã«ã³ãŒã«ã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒèšèŒ
ã®ïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâ
ãªã³ïŒã¢ã«ã³ãã·ãã¹ãã«ã¢ããã ïŒïŒ 次ã®äžè¬åŒ ïŒåŒäžã®R1ïŒR2ïŒR3åã³R4ã¯æ°ŽçŽ ãççŽ åå
æ°ïŒãïŒã®ã¢ã«ãã«åã³ããšãã«ããæã矀ãã
éžæããåºã瀺ããã¯èŠªæ žç眮æã«ããå°å ¥ã
ãããšãã§ããåºã§ãã€ãŠããã²ã³ãã¢ãžãåºã
ã¢ããåºãã¡ã«ã«ããåºãã¢ã·ã«ãªãã·åºãã«ã«
ããã·ã«åºåã³ã¢ã«ã³ãã·åºããæã矀ããéžæ
ãããã®ã瀺ãïŒã§è¡šãããâ眮æïŒNâ²â
ãã¹ïŒïŒâãªããµãŸãªãžãã«âïŒâãªã³ïŒãã¹ã
ã«ã¢ããã補é ããã«ãããã 次ã®äžè¬åŒ ïŒåŒäžã®R5åã³R6ã¯åè¿°ã®R1ïŒR2ïŒR3åã³R4
ããéžæãããã®ã瀺ãïŒã§è¡šããããªããµãŸãª
ãžãã³ã®å°ãªããšãïŒåœé以äžãäžæŽ»æ§æº¶åªäžã§
äºå¡©åçãšåå¿ãããå Žåã«ãã€ãŠã¯ããã«çæ
æ··åç©ãäžæŽ»æ§æº¶åªäžã§ã¢ãžåãããªãŠã ããã
ããã·ã«åºãæããååç©ãã¢ãã³åºãæããå
åç©ãããã©ãžã³åºãæããååç©ãã¡ã«ã«ãã
åºãæããååç©åã³ã«ã«ãã³é žå¡©ããæã矀ã
ãéžæããèŠªæ žå€ãšåå¿ãããŠåŒã®ååç©ã
åŸããããæ¢ç¥æè¡ã«ããåé¢ããããšãç¹åŸŽãš
ããâ眮æïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãž
ãã«âïŒâãªã³ïŒãã¹ãã«ã¢ããã®è£œé æ¹æ³ã ïŒïŒ åŒã®ïŒ°â眮æïŒNâ²âãã¹ïŒïŒâãªã
ãµãŸãªãžãã«âïŒâãªã³ïŒãã¹ãã«ã¢ããã補é
ããã«ããããåŒã®ãªããµãŸãªãžãã³ã®å°ãªã
ãšãïŒåœé以äžãäžæŽ»æ§æº¶åªäžã§â15ãïŒ100â
ã®æž©åºŠã§äºå¡©åçãšåå¿ãããå Žåã«ãã€ãŠã¯ã
ãã«çææ··åç©ãæ°Žãã¢ã«ã³ãŒã«åã¯ã«ã«ãã³é ž
å¡©ã®æ·»å åŸãäžæŽ»æ§æº¶åªäžã§ã¢ãžåãããªãŠã ã
ããããã·ã«åºãæããååç©ãã¢ãã³åºãæã
ãååç©ãããã©ãžã³åºãæããååç©ãã¡ã«ã«
ããåºãæããååç©åã³ã«ã«ãã³é žå¡©ããæã
矀ããéžæããèŠªæ žå€ãšåå¿ãããŠåŒã®ååç©
ãåŸããããæ¢ç¥æè¡ã«ããåé¢ããç¹èš±è«æ±ã®
ç¯å²ïŒïŒèšèŒã®è£œé æ¹æ³ã ïŒïŒ åŒã®ååç©ïŒR5åã³R6ã¯æ°ŽçŽ ã瀺ãïŒ
ãäžæŽ»æ§æº¶åªäŸãã°å¡©åã¡ãã¬ã³ãã¢ã»ããããª
ã«ãïŒïŒïŒâãžã¡ããã·ãšã¿ã³åã¯ãããã¡ã¿ã³
äžã§äºå¡©åçãšåå¿ãããŠåŒã®ååç©ïŒR1ïŒ
R2ïŒR3åã³R4ã¯æ°ŽçŽ ã瀺ããã¯åè¿°ãããšå
ããã®ã瀺ãïŒãåŸãç¹èš±è«æ±ã®ç¯å²ïŒïŒé èšèŒ
ã®è£œé æ¹æ³ã ïŒïŒ åŒã®ååç©ïŒR5åã³R6ã¯æ°ŽçŽ ã瀺ãïŒ
ã®ïŒåœéãäžæŽ»æ§æº¶åªäŸãã°å¡©åã¡ãã¬ã³äžã§å
ãäºå¡©åçãšåå¿ããã次ãã§çæããâããª
ã¯ãããã¹ãããŠã âïŒâãªããµãŸãªãžãã³å¡©å
ç©ãããã«åŒã®ååç©ïŒR5åã³R6ã¯æ°ŽçŽ ã瀺
ãããšã奜ãŸããïŒã®ïŒåœéãšåå¿ãããŠåŒã®
ååç©ãåŸãç¹èš±è«æ±ã®ç¯å²ïŒïŒèšèŒã®è£œé æ¹
æ³ã ïŒïŒ ã¯ãããã¹ãã«ã¢ãããã«ã«ãã³é žå¡©ãšå
å¿ãããŠïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«
âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ãããåŸã
ãã®å Žåã¢ã·ã«ãªãã·åºãèèªæãè³éŠæåã¯è€
çŽ ç°åŒã®ã«ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒ
ïŒèšèŒã®è£œé æ¹æ³ã ïŒïŒ ã¯ãããã¹ãã«ã¢ãããã«ã«ãã³é žå¡©ãšå
å¿ãããŠïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«
âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ãããåŸã
ãã®å Žåã«ã«ããã·ã«åºãããã·ãªã³ã®ïŒ£âïŒã§
ã®ã«ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒïŒèšèŒ
ã®è£œé æ¹æ³ã ïŒïŒ ã¯ãããã¹ãã«ã¢ãããã«ã«ãã³é žå¡©ãšå
å¿ãããŠïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«
âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ãããåŸã
ãã®å Žåã«ã«ããã·ã«åºãã»ãã¢ãã¹ããªã³ã®ïŒ£
âïŒã§ã®ã«ã«ãã³é žã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒ
ïŒèšèŒã®è£œé æ¹æ³ã ïŒïŒ ã¯ãããã¹ãã«ã¢ãããã«ã«ãã³é žå¡©ãšå
å¿ãããŠïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«
âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ãããåŸã
ãã®å Žåã«ã«ããã·ã«åºãããã·ãªã³ã®ïŒ£âïŒã§
ã®åŽéã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒïŒèšèŒã®è£œé
æ¹æ³ã ïŒïŒ ã¯ãããã¹ãã«ã¢ãããã«ã«ãã³é žå¡©ãšå
å¿ãããŠïŒ®ïŒNâ²âãã¹ïŒïŒâãªããµãŸãªãžãã«
âïŒâãªã³ïŒã¢ã·ã«ãªãã·ãã¹ãã«ã¢ãããåŸã
ãã®å Žåã«ã«ããã·ã«åºãã»ãã¢ãã¹ããªã³ã®ïŒ£
âïŒã§ã®åŽéã«ç±æ¥ããç¹èš±è«æ±ã®ç¯å²ïŒïŒèšèŒ
ã®è£œé æ¹æ³ã
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES461552A ES461552A1 (es) | 1977-08-11 | 1977-08-11 | Procedimiento de obtencion de n,n'-bis-(3-oxazolidinil-2- ona)fosforamidas-p-sustituidas. |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5455563A JPS5455563A (en) | 1979-05-02 |
JPS6245877B2 true JPS6245877B2 (ja) | 1987-09-29 |
Family
ID=8474394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9745778A Granted JPS5455563A (en) | 1977-08-11 | 1978-08-11 | Paraasubstituted n*n** biss*33oxazolizinyll22 one* phosphoramide and production thereof |
Country Status (14)
Country | Link |
---|---|
US (1) | US4232162A (ja) |
JP (1) | JPS5455563A (ja) |
AU (1) | AU3879278A (ja) |
BE (1) | BE869135A (ja) |
CH (1) | CH632768A5 (ja) |
DE (1) | DE2833174A1 (ja) |
DK (1) | DK355478A (ja) |
ES (1) | ES461552A1 (ja) |
FI (1) | FI782351A (ja) |
FR (1) | FR2400031A1 (ja) |
GB (1) | GB2002774B (ja) |
IL (1) | IL55237A0 (ja) |
NL (1) | NL7807947A (ja) |
NZ (1) | NZ187846A (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES471783A1 (es) * | 1978-07-15 | 1979-10-16 | Antibioticos Sa | Procedimiento de preparacion de n,n-bis-(3-oxazolidinil-2- ona) fosforanos-p-triclorados para su aplicacion a la obten-cion de amidas y esteres |
CN101747125B (zh) * | 2009-12-25 | 2012-09-05 | äžåœç§åŠé¢é¿æ¥åºçšååŠç 究æ | äžç§èè³çç±»ååç¯çç±»ååç©çå¶å€æ¹æ³ |
-
1977
- 1977-08-11 ES ES461552A patent/ES461552A1/es not_active Expired
-
1978
- 1978-07-12 NZ NZ187846A patent/NZ187846A/xx unknown
- 1978-07-17 GB GB7830079A patent/GB2002774B/en not_active Expired
- 1978-07-19 BE BE189394A patent/BE869135A/xx not_active IP Right Cessation
- 1978-07-24 US US05/927,161 patent/US4232162A/en not_active Expired - Lifetime
- 1978-07-26 NL NL787807947A patent/NL7807947A/xx not_active Application Discontinuation
- 1978-07-27 IL IL55237A patent/IL55237A0/xx unknown
- 1978-07-28 FI FI782351A patent/FI782351A/fi not_active Application Discontinuation
- 1978-07-28 DE DE19782833174 patent/DE2833174A1/de not_active Ceased
- 1978-08-04 CH CH833478A patent/CH632768A5/fr not_active IP Right Cessation
- 1978-08-08 FR FR7823333A patent/FR2400031A1/fr active Granted
- 1978-08-09 AU AU38792/78A patent/AU3879278A/en active Pending
- 1978-08-11 JP JP9745778A patent/JPS5455563A/ja active Granted
- 1978-08-11 DK DK355478A patent/DK355478A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES461552A1 (es) | 1978-06-01 |
US4232162A (en) | 1980-11-04 |
GB2002774B (en) | 1982-03-24 |
DK355478A (da) | 1979-02-12 |
NL7807947A (nl) | 1979-02-13 |
CH632768A5 (fr) | 1982-10-29 |
JPS5455563A (en) | 1979-05-02 |
FR2400031B3 (ja) | 1981-03-27 |
FR2400031A1 (fr) | 1979-03-09 |
NZ187846A (en) | 1980-11-28 |
AU3879278A (en) | 1980-02-14 |
GB2002774A (en) | 1979-02-28 |
DE2833174A1 (de) | 1979-02-22 |
FI782351A (fi) | 1979-02-12 |
BE869135A (fr) | 1978-11-16 |
IL55237A0 (en) | 1978-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR0178542B1 (ko) | ëí°ì€ì¹Žë¥Žë°€ì°ì ìŒë¥, ê·ž ì ì¡°ë°©ë² ë° ê·ž ëí°ì€ì¹Žë¥Žë°€ì°ì ìŒë¥ë¥Œ ì¬ì©íë ìŽìí°ì€ììë€ìŽížë¥ì ì ì¡°ë°©ë² | |
JPS6245877B2 (ja) | ||
JP2965539B2 (ja) | ã¹ã«ããã«ãŠã¬ã¢èªå°äœã®åæäžéäœ | |
JPH061776A (ja) | 眮æãã©ãžã³ã«ã«ããããªã«ã®è£œé æ¹æ³ | |
DK156221B (da) | Fremgangsmaade til fremstilling af penicillansyre- og cephalosporansyrederivater | |
KR101881918B1 (ko) | ìì€ì€í°ìë§ìŽë ì ë첎ì ìë¡ìŽ ì ì¡°ë°©ë² | |
JPS6130576A (ja) | ïŒâã¢ããâïŒâã·ã¢ãããªããžã³ã®è£œæ³ | |
JPH06340623A (ja) | ãã³ãžã«ã³ãã¯é žèªå°äœã®è£œé æ¹æ³ããã³ãã®è£œé äžéäœ | |
KR100288404B1 (ko) | 2-벀조í°ì졞늎 4-ìë¯žë ž-5-íŽë¡ë¡-2-ë©í¡ìí°ì€ë²€ì¡°ììŽíž ë° | |
KR100594568B1 (ko) | ìë¯žë žë ëžëŠ¬ëì° ì ë첎ì ì ì¡°ë°©ë² | |
JP3261454B2 (ja) | ã±ãã³ã€ãã³ååç©ã®è£œé æ¹æ³ | |
KR910006981B1 (ko) | ë¡ì¬í°ë 칎륎복ì€ë ìŽíž ìŒì°ìŒì ìë¡ìŽ ì ì¡°ë°©ë² | |
JPH10287650A (ja) | ïŒâã¯ããã«ã«ããã«âïŒâãããªãžããããªãžã³ãŸãã¯ãã®å¡©é žå¡©ã®è£œé æ¹æ³ | |
JPH06271546A (ja) | ã€ãããŸãªãžã³èªå°äœã®è£œé æ³ | |
KR970001473B1 (ko) | íŒëŒì¡ž ì€í¬ëíŽë¡ëŒìŽë ì ë첎ì ì ì¡°ë°©ë² | |
JP3526606B2 (ja) | â眮æãã©ãžã³ã«ã«ããã·ã¢ããã®è£œé æ¹æ³ | |
JPS62267267A (ja) | ãã©ãŸâã«èªå°äœããã³ãã®è£œé æ³ | |
JPH07258234A (ja) | ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒïŒïŒïœïŒâããªã³é¡ã®è£œé æ³ | |
JPS5916879A (ja) | â眮æã€ãããŸâã«é¡ã®è£œé æ³ | |
JP2019214523A (ja) | ã»ãã«ã«ããžãååç©ã®è£œé æ¹æ³ãããã³ããªã¢ãŸãªãžã³ãžãªã³ååç©ã®è£œé æ¹æ³ | |
JPH0827148A (ja) | ãžãã¢ãŸãªãŠã å¡©ã®è£œé æ¹æ³ | |
JPH0439464B2 (ja) | ||
JPS5888372A (ja) | âã«ã«ãã¢ã€ã«å®æ¯éŠé žã¹ã«ãã€ããèªå°äœã®è£œæ³ | |
JP2007210930A (ja) | ããªãžã³ã¹ã«ãã§ã³ã¢ããååç©ã®è£œé æ¹æ³ | |
JPS6326750B2 (ja) |