JPS6237631B2 - - Google Patents

Info

Publication number
JPS6237631B2
JPS6237631B2 JP54089886A JP8988679A JPS6237631B2 JP S6237631 B2 JPS6237631 B2 JP S6237631B2 JP 54089886 A JP54089886 A JP 54089886A JP 8988679 A JP8988679 A JP 8988679A JP S6237631 B2 JPS6237631 B2 JP S6237631B2
Authority
JP
Japan
Prior art keywords
benzodiazepine
pyrrolo
acrylamide
methyl
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54089886A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5615289A (en
Inventor
Yasuo Ueda
Masao Kagitani
Eiji Sako
Tadakazu Suyama
Nobuhiko Komatsu
Daisuke Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GC Biopharma Corp
Original Assignee
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Korea filed Critical Green Cross Corp Korea
Priority to JP8988679A priority Critical patent/JPS5615289A/ja
Priority to SE8001458A priority patent/SE436882B/sv
Priority to CA000346511A priority patent/CA1152985A/en
Priority to US06/127,984 priority patent/US4309437A/en
Priority to GB8008033A priority patent/GB2053894B/en
Priority to NL8001531A priority patent/NL8001531A/nl
Priority to LU82272A priority patent/LU82272A1/fr
Priority to DE3010544A priority patent/DE3010544C2/de
Priority to FR8006153A priority patent/FR2461711A1/fr
Priority to BE0/199851A priority patent/BE882305A/fr
Priority to CH2187/80A priority patent/CH648848A5/de
Publication of JPS5615289A publication Critical patent/JPS5615289A/ja
Publication of JPS6237631B2 publication Critical patent/JPS6237631B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP8988679A 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3 Granted JPS5615289A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3
SE8001458A SE436882B (sv) 1979-07-17 1980-02-25 1h-pyrrolo /2,1-c//1,4/bensodiazepin-2-akrylamidforeningar, forfarande for deras framstellning och farmaceutisk komposition
CA000346511A CA1152985A (en) 1979-07-17 1980-02-27 Benzodiazepine compounds
US06/127,984 US4309437A (en) 1979-07-17 1980-03-04 Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof
GB8008033A GB2053894B (en) 1979-07-17 1980-03-10 Benzodiazepines processes for producing them and compositions containing them
NL8001531A NL8001531A (nl) 1979-07-17 1980-03-14 Nieuwe benzodiazepineverbindingen.
LU82272A LU82272A1 (fr) 1979-07-17 1980-03-19 Nouveau compose du benzodiazepine
DE3010544A DE3010544C2 (de) 1979-07-17 1980-03-19 1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien
FR8006153A FR2461711A1 (fr) 1979-07-17 1980-03-19 Composes du 1h-pyrrolo-(2,1-c) (1,4) benzodiazepine-2-acrylamide, leur procede de preparation et compositions pharmaceutiques en contenant
BE0/199851A BE882305A (fr) 1979-07-17 1980-03-19 Nouveaux composes de benzodiazepine
CH2187/80A CH648848A5 (de) 1979-07-17 1980-03-20 1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-acrylsaeureamid-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Publications (2)

Publication Number Publication Date
JPS5615289A JPS5615289A (en) 1981-02-14
JPS6237631B2 true JPS6237631B2 (enExample) 1987-08-13

Family

ID=13983232

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8988679A Granted JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Country Status (11)

Country Link
US (1) US4309437A (enExample)
JP (1) JPS5615289A (enExample)
BE (1) BE882305A (enExample)
CA (1) CA1152985A (enExample)
CH (1) CH648848A5 (enExample)
DE (1) DE3010544C2 (enExample)
FR (1) FR2461711A1 (enExample)
GB (1) GB2053894B (enExample)
LU (1) LU82272A1 (enExample)
NL (1) NL8001531A (enExample)
SE (1) SE436882B (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214774A (en) * 1983-02-10 1986-12-02 Yusei Shiraga Benzodiazepine derivative
JPS59152329A (ja) * 1983-02-17 1984-08-31 Green Cross Corp:The 局所障害抑制剤
JPS60168512U (ja) * 1985-03-25 1985-11-08 株式会社栗田機械製作所 圧搾濾板の圧搾膜検査装置
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
ES2260570T3 (es) * 1998-08-27 2006-11-01 Spirogen Limited Pirrolobenziodiazepinas dimericas.
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
ES2398975T3 (es) * 2004-03-01 2013-03-25 Spirogen Sàrl Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
EP1723152B1 (en) * 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
ES2338696T3 (es) * 2005-04-21 2010-05-11 Spirogen Limited Pirrolobenzodiazepinas.
GB0813432D0 (en) * 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
US9399641B2 (en) 2011-09-20 2016-07-26 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
CA2850264C (en) 2011-10-14 2019-11-05 Medimmune Limited Pyrrolobenzodiazepines
AU2012322934B2 (en) 2011-10-14 2016-09-08 Medimmune Limited Pyrrolobenzodiazepines
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
JP6166728B2 (ja) 2011-10-14 2017-07-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピンの製造に有用な合成方法及び中間体
IN2014MN02175A (enExample) 2012-04-30 2015-08-28 Ucl Business Plc
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
PT2906248T (pt) 2012-10-12 2019-03-04 Medimmune Ltd Pirrolobenzodiazepinas e conjugados das mesmas
KR101995620B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
PT2906253T (pt) 2012-10-12 2018-11-05 Medimmune Ltd Conjugados de anticorpo anti-psma de pirrolobenzodiazepina
DK2839860T3 (da) 2012-10-12 2019-06-17 Medimmune Ltd Pyrrolobenzodiazepiner og konjugater deraf
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
BR112015008238A2 (pt) 2012-10-12 2017-11-28 Adc Therapeutics Sarl conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2017201132A2 (en) 2016-05-18 2017-11-23 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS61795B1 (sr) 2017-02-08 2021-06-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin antitela
SMT202200490T1 (it) 2017-04-18 2023-01-13 Medimmune Ltd Coniugati di pirrolobenzodiazepina
WO2018193102A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
SI3668874T1 (sl) 2017-08-18 2022-04-29 Medimmune Limited Pirolobenzodiazepinski konjugati
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN113631560B (zh) 2019-03-15 2025-02-18 麦迪穆有限责任公司 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
USD925487S1 (en) * 2019-10-22 2021-07-20 Lg Electronics Inc. Audio player

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523941A (en) * 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

Also Published As

Publication number Publication date
DE3010544A1 (de) 1981-01-29
JPS5615289A (en) 1981-02-14
CA1152985A (en) 1983-08-30
GB2053894A (en) 1981-02-11
FR2461711B1 (enExample) 1983-05-13
SE8001458L (sv) 1981-01-18
CH648848A5 (de) 1985-04-15
US4309437A (en) 1982-01-05
SE436882B (sv) 1985-01-28
FR2461711A1 (fr) 1981-02-06
LU82272A1 (fr) 1980-07-01
DE3010544C2 (de) 1982-07-01
GB2053894B (en) 1983-04-20
NL8001531A (nl) 1981-01-20
BE882305A (fr) 1980-07-16

Similar Documents

Publication Publication Date Title
US4309437A (en) Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof
DE69522490T2 (de) Platinkomplexe
CH515910A (de) Verfahren zur Herstellung von neuen Tetrahydro-sulfamylchinazolinonen und ihrer Salze
JP6084680B2 (ja) 抗寄生虫薬セラメクチンの新規合成方法
JPS60258183A (ja) １４‐ヒドロキシ‐モルフイナンアルカロイドの脱アルキル化方法
DE2149750A1 (de) Erythromycin-Derivate
KR920002298B1 (ko) 샤르트류신 유도체 또는 그염의 제조방법
EP0080819A1 (en) 11-0-Alkylerythromycin A derivatives
DE2463173C2 (de) Zwischenprodukte 1,3-Dithiolanyl(2)- und 1,3-Dithianyl(2)-Verbindungen
DD228259A5 (de) Verfahren zur herstellung von 7-acylamino-9a-methoxymitosanen
JPS642593B2 (enExample)
DE69511993T2 (de) Antineoplastische Cyclolignan-Derivate
EP0139859B1 (de) 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln
Wood Jr et al. The Preparation of Crystalline 2-O-Methylsulfonyl-D-arabinose and Some of Its Derivatives
DE1232577B (de) Verfahren zur Herstellung von delta 4,9-3-Oxo-11beta-hydroperoxy-19-nor-steroiden
Djerassi et al. Studies in Organic Sulfur Compounds. V. 1 Synthesis of 21-Thiolacetates of Adrenal Cortical Hormones
DE2501861C2 (de) 3,4,6-Tri-O-acyl-2-desoxy-2-nicotinoylamino-1-O-nicotinoyl-β-D-glucopyranosen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US3912767A (en) Novel sulfonate esters of 2-hydroxy-3-(methylthio)-1,4-naphthoquinone
CH615182A5 (enExample)
JPS6152839B2 (enExample)
JPH0357915B2 (enExample)
DE2256866C3 (de) Verfahren zur Herstellung von 17 alpha- oder 17beta-Hydroxy-Verbindungen der 20-Ketopregnan- oder -17alpha-pregnanreihe
US4061639A (en) Quinolinesulfonyl compounds
DE3051054C2 (enExample)
JPS61103881A (ja) ４−チアゾリジノン誘導体及びその製造方法