JPS5615289A - Novel benzodiazepinnbased compound 3 - Google Patents

Novel benzodiazepinnbased compound 3

Info

Publication number
JPS5615289A
JPS5615289A JP8988679A JP8988679A JPS5615289A JP S5615289 A JPS5615289 A JP S5615289A JP 8988679 A JP8988679 A JP 8988679A JP 8988679 A JP8988679 A JP 8988679A JP S5615289 A JPS5615289 A JP S5615289A
Authority
JP
Japan
Prior art keywords
formula
compound shown
compound
acyl
benzodiazepinnbased
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8988679A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6237631B2 (enExample
Inventor
Yasuo Ueda
Masao Kagitani
Eiji Sako
Tadakazu Suyama
Nobuhiko Komatsu
Daisuke Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp Japan
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan
Priority to JP8988679A priority Critical patent/JPS5615289A/ja
Priority to SE8001458A priority patent/SE436882B/sv
Priority to CA000346511A priority patent/CA1152985A/en
Priority to US06/127,984 priority patent/US4309437A/en
Priority to GB8008033A priority patent/GB2053894B/en
Priority to NL8001531A priority patent/NL8001531A/nl
Priority to DE3010544A priority patent/DE3010544C2/de
Priority to LU82272A priority patent/LU82272A1/fr
Priority to BE0/199851A priority patent/BE882305A/fr
Priority to FR8006153A priority patent/FR2461711A1/fr
Priority to CH2187/80A priority patent/CH648848A5/de
Publication of JPS5615289A publication Critical patent/JPS5615289A/ja
Publication of JPS6237631B2 publication Critical patent/JPS6237631B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP8988679A 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3 Granted JPS5615289A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3
SE8001458A SE436882B (sv) 1979-07-17 1980-02-25 1h-pyrrolo /2,1-c//1,4/bensodiazepin-2-akrylamidforeningar, forfarande for deras framstellning och farmaceutisk komposition
CA000346511A CA1152985A (en) 1979-07-17 1980-02-27 Benzodiazepine compounds
US06/127,984 US4309437A (en) 1979-07-17 1980-03-04 Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof
GB8008033A GB2053894B (en) 1979-07-17 1980-03-10 Benzodiazepines processes for producing them and compositions containing them
NL8001531A NL8001531A (nl) 1979-07-17 1980-03-14 Nieuwe benzodiazepineverbindingen.
DE3010544A DE3010544C2 (de) 1979-07-17 1980-03-19 1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien
LU82272A LU82272A1 (fr) 1979-07-17 1980-03-19 Nouveau compose du benzodiazepine
BE0/199851A BE882305A (fr) 1979-07-17 1980-03-19 Nouveaux composes de benzodiazepine
FR8006153A FR2461711A1 (fr) 1979-07-17 1980-03-19 Composes du 1h-pyrrolo-(2,1-c) (1,4) benzodiazepine-2-acrylamide, leur procede de preparation et compositions pharmaceutiques en contenant
CH2187/80A CH648848A5 (de) 1979-07-17 1980-03-20 1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-acrylsaeureamid-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Publications (2)

Publication Number Publication Date
JPS5615289A true JPS5615289A (en) 1981-02-14
JPS6237631B2 JPS6237631B2 (enExample) 1987-08-13

Family

ID=13983232

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8988679A Granted JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Country Status (11)

Country Link
US (1) US4309437A (enExample)
JP (1) JPS5615289A (enExample)
BE (1) BE882305A (enExample)
CA (1) CA1152985A (enExample)
CH (1) CH648848A5 (enExample)
DE (1) DE3010544C2 (enExample)
FR (1) FR2461711A1 (enExample)
GB (1) GB2053894B (enExample)
LU (1) LU82272A1 (enExample)
NL (1) NL8001531A (enExample)
SE (1) SE436882B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60168512U (ja) * 1985-03-25 1985-11-08 株式会社栗田機械製作所 圧搾濾板の圧搾膜検査装置
JP2008536905A (ja) * 2005-04-21 2008-09-11 スピロゲン リミティッド ピロロベンゾジアゼピン

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214774A (en) * 1983-02-10 1986-12-02 Yusei Shiraga Benzodiazepine derivative
JPS59152329A (ja) * 1983-02-17 1984-08-31 Green Cross Corp:The 局所障害抑制剤
ATE320436T1 (de) * 1998-08-27 2006-04-15 Spirogen Ltd Dimere pyrrolobenzodiazepine
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
PT2270010E (pt) * 2004-03-01 2012-03-12 Spirogen Ltd Derivados de 11-hidroxi-5h-pirrolo[2,1-c][1,4]benzodiazepin- 5-ona como intermediários chave para a preparação de pirrolobenzodiazepinas substituídas em c2
WO2005085260A1 (en) * 2004-03-09 2005-09-15 Spirogen Limited Pyrrolobenzodiazepines
GB0813432D0 (en) * 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
CN103987718A (zh) 2011-09-20 2014-08-13 斯皮罗根有限公司 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
AU2012322933B2 (en) 2011-10-14 2017-02-02 Medimmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN103998449A (zh) 2011-10-14 2014-08-20 斯皮罗根有限公司 吡咯并苯并二氮杂卓
CN103998450B (zh) 2011-10-14 2017-03-08 麦迪穆有限责任公司 吡咯并苯并二氮杂卓
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
NZ701478A (en) 2012-04-30 2016-08-26 Medimmune Ltd Pyrrolobenzodiazepines
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
HRP20180945T1 (hr) 2012-10-12 2018-08-10 Adc Therapeutics Sa Konjugati protutijelo-pirolobenzodiazepin
CA2885305C (en) 2012-10-12 2019-11-12 Spirogen Sarl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
LT2906251T (lt) 2012-10-12 2017-12-11 Adc Therapeutics Sa Pirolobenzodiazepino-anti-cd22 antikūno konjugatai
PT2906253T (pt) 2012-10-12 2018-11-05 Medimmune Ltd Conjugados de anticorpo anti-psma de pirrolobenzodiazepina
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
RS58921B1 (sr) 2012-10-12 2019-08-30 Medimmune Ltd Pirolobenzodiazepini i njihovi konjugati
CN104703630A (zh) 2012-10-12 2015-06-10 斯皮罗根有限公司 吡咯并苯并二氮杂卓及其结合物
HRP20182129T1 (hr) 2012-10-12 2019-02-08 Adc Therapeutics Sa Konjugati protutijelo - pirolobenzodiazepin
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR20170101895A (ko) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 접합체
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2017201132A2 (en) 2016-05-18 2017-11-23 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
JP7049276B2 (ja) 2016-06-24 2022-04-06 メルサナ セラピューティクス インコーポレイテッド ピロロベンゾジアゼピンおよびその結合体
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
SI3544636T1 (sl) 2017-02-08 2021-08-31 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
HRP20221063T1 (hr) 2017-04-18 2022-11-11 Medimmune Limited Konjugati pirolobenzodiazepina
WO2018193102A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
ES2988683T3 (es) 2017-06-14 2024-11-21 Adc Therapeutics Sa Pautas posológicas para la administración de un CAF anti-CD19
JP7220203B2 (ja) 2017-08-18 2023-02-09 メドイミューン・リミテッド ピロロベンゾジアゼピン複合体
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN113631560B (zh) 2019-03-15 2025-02-18 麦迪穆有限责任公司 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
USD925487S1 (en) * 2019-10-22 2021-07-20 Lg Electronics Inc. Audio player

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523941A (en) * 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60168512U (ja) * 1985-03-25 1985-11-08 株式会社栗田機械製作所 圧搾濾板の圧搾膜検査装置
JP2008536905A (ja) * 2005-04-21 2008-09-11 スピロゲン リミティッド ピロロベンゾジアゼピン

Also Published As

Publication number Publication date
FR2461711A1 (fr) 1981-02-06
US4309437A (en) 1982-01-05
JPS6237631B2 (enExample) 1987-08-13
FR2461711B1 (enExample) 1983-05-13
DE3010544A1 (de) 1981-01-29
CA1152985A (en) 1983-08-30
GB2053894B (en) 1983-04-20
CH648848A5 (de) 1985-04-15
GB2053894A (en) 1981-02-11
DE3010544C2 (de) 1982-07-01
SE436882B (sv) 1985-01-28
BE882305A (fr) 1980-07-16
LU82272A1 (fr) 1980-07-01
NL8001531A (nl) 1981-01-20
SE8001458L (sv) 1981-01-18

Similar Documents

Publication Publication Date Title
JPS5615289A (en) Novel benzodiazepinnbased compound 3
IE791753L (en) Complexes of 6-hydroxyalkyl purines
GB1459830A (en) Process for the preparation of thiocarbamic acid o-esters
JPS5671075A (en) Novel imidazole derivative
IE791199L (en) N,n'-bis£(n-cyano-n'-alkynyl)methanimidamidyl|¹cystamines.
JPS5511506A (en) Preparation of cysteamine or cystamine
JPS5645460A (en) Novel imidazolyl sulfonate derivative
IL63008A0 (en) Hydrocarbon soluble sodium alkyls and their manufacture
JPS53132584A (en) 18-cyano-18-substituted amino-18-deoxy-macrolide anibiotic substance derivative
JPS567787A (en) Novel mitomycin and its preparation
JPS5461148A (en) Sulfamoylphenylcarbonates and miticide containing the same
JPS5387370A (en) Preparation of penicillamine derivative
JPS53102986A (en) Metal complex of cyclodextrin derivative
JPS5653682A (en) Production of novel rifamycin derivative
JPS5632472A (en) Preparation of chemotherapeutically useful salicylic acid double salt
JPS5439029A (en) Nitro compounds
JPS5540617A (en) Mitomycin derivative
JPS5673069A (en) Pyrazolecarboxylic acid derivative
JPS5592363A (en) New 2-azetidinone derivative
JPS5538301A (en) New derivative of antibiotics fortimicin and its preparation
IE781705L (en) Phenylurea derivatives
JPS5490117A (en) Benzenesulfonamide derivatives and fungicides containing the same
GB1375799A (enExample)
JPS56142272A (en) Hydrazinopyridazine derivative
JPS5538353A (en) Alpha-isopropyl-4-chlorophenylacetamide derivative and its preparation and acaricide containing the same.