JPS567787A - Novel mitomycin and its preparation - Google Patents

Novel mitomycin and its preparation

Info

Publication number
JPS567787A
JPS567787A JP8080979A JP8080979A JPS567787A JP S567787 A JPS567787 A JP S567787A JP 8080979 A JP8080979 A JP 8080979A JP 8080979 A JP8080979 A JP 8080979A JP S567787 A JPS567787 A JP S567787A
Authority
JP
Japan
Prior art keywords
formula
substituted
compound shown
preparation
mitomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8080979A
Other languages
Japanese (ja)
Other versions
JPS626556B2 (en
Inventor
Kazumichi Kono
Masaji Kasai
Kimikatsu Shirahata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP8080979A priority Critical patent/JPS567787A/en
Priority to EP79102497A priority patent/EP0008021B1/en
Priority to DE7979102497T priority patent/DE2966984D1/en
Priority to US06/126,346 priority patent/US4374774A/en
Publication of JPS567787A publication Critical patent/JPS567787A/en
Publication of JPS626556B2 publication Critical patent/JPS626556B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A mitomycin shown by the formula I [X is (substituted)amino, hydroxy, etc; Y is H, -COR1[R1 is H, (substituted)alkyl, (substituted)aryl, -CH2 CH2Z(Z is alkyloxycarbonyl, acyl, etc.,)]; with respect to RA and RB, RA is H and RB, is -CH2OH, etc., RA and RB form =CH2; with the proviso that when RA is H and RB is -CH2OH, Y is -CH2CH2Z, and when RA is H and RB is -CH2OSO2R2, Y is H or -CH2CH2Z].
EXAMPLE: A 1a-N-acetyl-10-decarbamoyloxy-9-dehydromitomycin C.
USE: Having antibacterial activity. An intermediate for a bactericide, detergent, other useful compounds.
PROCESS: For example, a compound shown by the formula III is subjected to dealkylation (or dearylation) and sulfon oxidation to give a compound shown by the formula IV, which is submitted to deacylation to prepare a compound shown by the formula V.
COPYRIGHT: (C)1981,JPO&Japio
JP8080979A 1978-07-18 1979-06-28 Novel mitomycin and its preparation Granted JPS567787A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP8080979A JPS567787A (en) 1979-06-28 1979-06-28 Novel mitomycin and its preparation
EP79102497A EP0008021B1 (en) 1978-07-18 1979-07-17 New mitomycins and processes for production thereof
DE7979102497T DE2966984D1 (en) 1978-07-18 1979-07-17 New mitomycins and processes for production thereof
US06/126,346 US4374774A (en) 1979-03-13 1980-03-03 Mitomycins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8080979A JPS567787A (en) 1979-06-28 1979-06-28 Novel mitomycin and its preparation

Publications (2)

Publication Number Publication Date
JPS567787A true JPS567787A (en) 1981-01-27
JPS626556B2 JPS626556B2 (en) 1987-02-12

Family

ID=13728787

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8080979A Granted JPS567787A (en) 1978-07-18 1979-06-28 Novel mitomycin and its preparation

Country Status (1)

Country Link
JP (1) JPS567787A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US5577081A (en) * 1994-07-21 1996-11-19 Mitsubishi Nuclear Fuel Co. Method of forming grids for nuclear fuel assembly and grids formed by same method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
EP0284380B1 (en) * 1987-03-25 1992-06-10 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US5577081A (en) * 1994-07-21 1996-11-19 Mitsubishi Nuclear Fuel Co. Method of forming grids for nuclear fuel assembly and grids formed by same method

Also Published As

Publication number Publication date
JPS626556B2 (en) 1987-02-12

Similar Documents

Publication Publication Date Title
JPS5615289A (en) Novel benzodiazepinnbased compound 3
JPS567787A (en) Novel mitomycin and its preparation
IE791199L (en) N,n'-bis£(n-cyano-n'-alkynyl)methanimidamidyl|¹cystamines.
AU548292B2 (en) 3-3-demethyl derivatives of istamycin b series compounds
IE780186L (en) Imidazopyridazines
GB2118546B (en) 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives
JPS5424882A (en) Novel heterocyclic compounds and their preparation
JPS53132584A (en) 18-cyano-18-substituted amino-18-deoxy-macrolide anibiotic substance derivative
ES8603434A1 (en) 1,2,4-Triazolylpropanols, and their production and use.
JPS545981A (en) Carbostyryl derivatives
JPS5287173A (en) 4-(pyridyl-2-oxy)phynoxyalkanecarboxylic acid compounds
ES8706646A1 (en) Cyclopropane derivates.
JPS532476A (en) Synthesis of 4-substituted-dithio-2-azetidinone derivatives
BR9100488A (en) PROCESS FOR THE PREPARATION OF COMPOUNDS, COMPOSITION FOR COMBATING OR INHIBITING AN INFESTATION BY MICROORGANISMS
JPS5441384A (en) Preparation of 2-deoxy-d-glucose
JPS5538301A (en) New derivative of antibiotics fortimicin and its preparation
JPS53133229A (en) Novel disazo compounds and their preparation
JPS57176979A (en) Novel derivative of secalonic acid and its preparation
JPS5422353A (en) 2-chloro-2-cyano-7-alkylidene-bicyclo(2,2,1)-5-heptene and its preparation
JPS5412355A (en) Alkyl cyclohexyldichlorosilane compounds and their preparation
JPS55100384A (en) Cephalosporin analog
JPS5373560A (en) Spiro compound
JPS5533431A (en) Derivative of antibiotic ps-7 and its preparation
JPS5488295A (en) Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative
JPS5439088A (en) Novel antibacterial agents