JPS5488295A - Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative - Google Patents
Formycin 3',5'-cyclic phosphate and its n2-alkyl derivativeInfo
- Publication number
- JPS5488295A JPS5488295A JP15439677A JP15439677A JPS5488295A JP S5488295 A JPS5488295 A JP S5488295A JP 15439677 A JP15439677 A JP 15439677A JP 15439677 A JP15439677 A JP 15439677A JP S5488295 A JPS5488295 A JP S5488295A
- Authority
- JP
- Japan
- Prior art keywords
- formycin
- phosphate
- cyclic phosphate
- alkylformycin
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Compounds of the formula (R1 is NH2, OH; R2 is H, alkyl) and their salts.
EXAMPLE: N2-methylformycin-3',5'-cyclic phosphate.
USE: Antibiotics, anticarsinostatics, biochemical reagents, their synthetic intermediates, they have similar structure to cyclicadenosin monophosphate.
PREPARATION: The reaction of one of formycin derivatives as formycin, formycin B or N2-alkylformycin with POCl3 is effected in a solvent as trimethyl phosphate to form formycin 5'-phosphate, which is heated in an appropriate solvent in the presence of a dehydration agent to yield the compound of the formula. N2-alkylformycin is prepared by alkylating a product from formycin and an alkali metal hydroxide with an alkyl iodide.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15439677A JPS5488295A (en) | 1977-12-23 | 1977-12-23 | Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15439677A JPS5488295A (en) | 1977-12-23 | 1977-12-23 | Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5488295A true JPS5488295A (en) | 1979-07-13 |
JPS612072B2 JPS612072B2 (en) | 1986-01-22 |
Family
ID=15583218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15439677A Granted JPS5488295A (en) | 1977-12-23 | 1977-12-23 | Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5488295A (en) |
-
1977
- 1977-12-23 JP JP15439677A patent/JPS5488295A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS612072B2 (en) | 1986-01-22 |
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