JPS5488295A - Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative - Google Patents

Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative

Info

Publication number
JPS5488295A
JPS5488295A JP15439677A JP15439677A JPS5488295A JP S5488295 A JPS5488295 A JP S5488295A JP 15439677 A JP15439677 A JP 15439677A JP 15439677 A JP15439677 A JP 15439677A JP S5488295 A JPS5488295 A JP S5488295A
Authority
JP
Japan
Prior art keywords
formycin
phosphate
cyclic phosphate
alkylformycin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15439677A
Other languages
Japanese (ja)
Other versions
JPS612072B2 (en
Inventor
Sumio Umezawa
Hamao Umezawa
Kenji Kawamura
Osamu Makabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP15439677A priority Critical patent/JPS5488295A/en
Publication of JPS5488295A publication Critical patent/JPS5488295A/en
Publication of JPS612072B2 publication Critical patent/JPS612072B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:Compounds of the formula (R1 is NH2, OH; R2 is H, alkyl) and their salts.
EXAMPLE: N2-methylformycin-3',5'-cyclic phosphate.
USE: Antibiotics, anticarsinostatics, biochemical reagents, their synthetic intermediates, they have similar structure to cyclicadenosin monophosphate.
PREPARATION: The reaction of one of formycin derivatives as formycin, formycin B or N2-alkylformycin with POCl3 is effected in a solvent as trimethyl phosphate to form formycin 5'-phosphate, which is heated in an appropriate solvent in the presence of a dehydration agent to yield the compound of the formula. N2-alkylformycin is prepared by alkylating a product from formycin and an alkali metal hydroxide with an alkyl iodide.
COPYRIGHT: (C)1979,JPO&Japio
JP15439677A 1977-12-23 1977-12-23 Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative Granted JPS5488295A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15439677A JPS5488295A (en) 1977-12-23 1977-12-23 Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15439677A JPS5488295A (en) 1977-12-23 1977-12-23 Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative

Publications (2)

Publication Number Publication Date
JPS5488295A true JPS5488295A (en) 1979-07-13
JPS612072B2 JPS612072B2 (en) 1986-01-22

Family

ID=15583218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15439677A Granted JPS5488295A (en) 1977-12-23 1977-12-23 Formycin 3',5'-cyclic phosphate and its n2-alkyl derivative

Country Status (1)

Country Link
JP (1) JPS5488295A (en)

Also Published As

Publication number Publication date
JPS612072B2 (en) 1986-01-22

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