JPS6224075B2 - - Google Patents
Info
- Publication number
- JPS6224075B2 JPS6224075B2 JP54053421A JP5342179A JPS6224075B2 JP S6224075 B2 JPS6224075 B2 JP S6224075B2 JP 54053421 A JP54053421 A JP 54053421A JP 5342179 A JP5342179 A JP 5342179A JP S6224075 B2 JPS6224075 B2 JP S6224075B2
- Authority
- JP
- Japan
- Prior art keywords
- arginine
- argininol
- strain
- brevibacterium
- corynebacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 15
- 229930064664 L-arginine Natural products 0.000 claims description 15
- 235000014852 L-arginine Nutrition 0.000 claims description 15
- UFAABHKZLQFLSG-YFKPBYRVSA-N 2-[(4s)-4-amino-5-hydroxypentyl]guanidine Chemical compound OC[C@@H](N)CCCN=C(N)N UFAABHKZLQFLSG-YFKPBYRVSA-N 0.000 claims description 11
- 241000186216 Corynebacterium Species 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 241000186146 Brevibacterium Species 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 4
- 239000001963 growth medium Substances 0.000 claims description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 6
- 230000004151 fermentation Effects 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 239000004475 Arginine Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 241000319304 [Brevibacterium] flavum Species 0.000 description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 5
- 235000009697 arginine Nutrition 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 4
- 235000011130 ammonium sulphate Nutrition 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 4
- 229960000344 thiamine hydrochloride Drugs 0.000 description 4
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 4
- 239000011747 thiamine hydrochloride Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000807905 Corynebacterium glutamicum ATCC 14067 Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 108010073771 Soybean Proteins Proteins 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- -1 starch hydrolyzate Chemical class 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000003456 ion exchange resin Substances 0.000 description 2
- 229920003303 ion-exchange polymer Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940001941 soy protein Drugs 0.000 description 2
- YYAYLSOQGBAUHK-UHFFFAOYSA-N 2-(1,3-thiazol-2-ylamino)propanoic acid Chemical compound OC(=O)C(C)NC1=NC=CS1 YYAYLSOQGBAUHK-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VZUNGTLZRAYYDE-UHFFFAOYSA-N N-methyl-N'-nitro-N-nitrosoguanidine Chemical compound O=NN(C)C(=N)N[N+]([O-])=O VZUNGTLZRAYYDE-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004306 sulfadiazine Drugs 0.000 description 1
- BRBKOPJOKNSWSG-UHFFFAOYSA-N sulfaguanidine Chemical compound NC(=N)NS(=O)(=O)C1=CC=C(N)C=C1 BRBKOPJOKNSWSG-UHFFFAOYSA-N 0.000 description 1
- 229960004257 sulfaguanidine Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5342179A JPS55148093A (en) | 1979-05-02 | 1979-05-02 | Preparation of l-arginine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5342179A JPS55148093A (en) | 1979-05-02 | 1979-05-02 | Preparation of l-arginine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55148093A JPS55148093A (en) | 1980-11-18 |
| JPS6224075B2 true JPS6224075B2 (da) | 1987-05-26 |
Family
ID=12942369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5342179A Granted JPS55148093A (en) | 1979-05-02 | 1979-05-02 | Preparation of l-arginine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55148093A (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014185430A1 (ja) | 2013-05-13 | 2014-11-20 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0728749B2 (ja) * | 1986-09-22 | 1995-04-05 | 協和醗酵工業株式会社 | Ｌ−アルギニンの製造法 |
| JP5247120B2 (ja) * | 2007-11-02 | 2013-07-24 | 雪印メグミルク株式会社 | Ｌ−オルニチン含有物の製造方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5137348A (da) * | 1974-09-24 | 1976-03-29 | Japan Electronic Control Syst |
-
1979
- 1979-05-02 JP JP5342179A patent/JPS55148093A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5137348A (da) * | 1974-09-24 | 1976-03-29 | Japan Electronic Control Syst |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014185430A1 (ja) | 2013-05-13 | 2014-11-20 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55148093A (en) | 1980-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS6236676B2 (da) | ||
| JPH0488994A (ja) | 発酵法によるｌ―グルタミン酸の製造法 | |
| JPH02186995A (ja) | 発酵法によるｌ‐アルギニンの製造法 | |
| JPS6321479B2 (da) | ||
| JP2810697B2 (ja) | 芳香族アミノ酸の製造法 | |
| JPS6115695A (ja) | 発酵法によるｌ−イソロイシンの製造方法 | |
| JPS6115696A (ja) | 発酵法によるｌ−イソロイシンの製造法 | |
| US5188947A (en) | Process and microorganism for producing l-ornithine by corynebacterium, brevibacterium, or athrobacter | |
| JP3006929B2 (ja) | 発酵法によるｌ−バリンの製造法 | |
| JPS6224074B2 (da) | ||
| JPS6224075B2 (da) | ||
| JP2578463B2 (ja) | 発酵法によるｌ−リジンの製造法 | |
| JPS6241000B2 (da) | ||
| JPS6236672B2 (da) | ||
| JPH0644871B2 (ja) | 発酵法によるｌ−ロイシンの製造法 | |
| US5034319A (en) | Process for producing L-arginine | |
| JPS61119194A (ja) | 発酵法によるｌ−オルニチンの製造法 | |
| JP2995816B2 (ja) | 発酵法によるｌ―リジンの製造法 | |
| JPH0561914B2 (da) | ||
| JPH0594A (ja) | 発酵法によるアントラニル酸の製造法 | |
| JP2817228B2 (ja) | Ｌ―グルタミン酸の製造法 | |
| JPS62265988A (ja) | 発酵法によるｌ−アルギニンの製造法 | |
| JPH0314436B2 (da) | ||
| JPH055476B2 (da) | ||
| JPS58141788A (ja) | 醗酵法によるｌ−グルタミン酸の製造法 |