JPS62126186A - イソフラボン誘導体含有溶液の製造方法 - Google Patents
イソフラボン誘導体含有溶液の製造方法Info
- Publication number
- JPS62126186A JPS62126186A JP26612585A JP26612585A JPS62126186A JP S62126186 A JPS62126186 A JP S62126186A JP 26612585 A JP26612585 A JP 26612585A JP 26612585 A JP26612585 A JP 26612585A JP S62126186 A JPS62126186 A JP S62126186A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- organic solvent
- resin
- water
- isoflavone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930012930 isoflavone derivative Natural products 0.000 title claims abstract description 22
- 150000002515 isoflavone derivatives Chemical class 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 229920005989 resin Polymers 0.000 claims abstract description 21
- 239000011347 resin Substances 0.000 claims abstract description 21
- 239000003960 organic solvent Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000012046 mixed solvent Substances 0.000 claims abstract description 6
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 5
- 239000000057 synthetic resin Substances 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 17
- 238000001179 sorption measurement Methods 0.000 claims description 15
- 235000020712 soy bean extract Nutrition 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 12
- 235000010469 Glycine max Nutrition 0.000 abstract description 9
- 244000068988 Glycine max Species 0.000 abstract description 9
- 238000010828 elution Methods 0.000 abstract description 7
- 239000003463 adsorbent Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 16
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 8
- 235000007240 daidzein Nutrition 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 6
- OZBAVEKZGSOMOJ-MIUGBVLSSA-N glycitin Chemical compound COC1=CC(C(C(C=2C=CC(O)=CC=2)=CO2)=O)=C2C=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OZBAVEKZGSOMOJ-MIUGBVLSSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 4
- 235000006539 genistein Nutrition 0.000 description 4
- 229940045109 genistein Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical class C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 description 3
- XJTZHGNBKZYODI-UHFFFAOYSA-N Glycitin Natural products OCC1OC(Oc2ccc3OC=C(C(=O)c3c2CO)c4ccc(O)cc4)C(O)C(O)C1O XJTZHGNBKZYODI-UHFFFAOYSA-N 0.000 description 3
- 235000015429 Mirabilis expansa Nutrition 0.000 description 3
- 244000294411 Mirabilis expansa Species 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000013536 miso Nutrition 0.000 description 3
- 239000002952 polymeric resin Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- ZCOLJUOHXJRHDI-FZHKGVQDSA-N Genistein 7-O-glucoside Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)c1cc(O)c2C(=O)C(c3ccc(O)cc3)=COc2c1 ZCOLJUOHXJRHDI-FZHKGVQDSA-N 0.000 description 2
- CJPNHKPXZYYCME-UHFFFAOYSA-N Genistin Natural products OCC1OC(Oc2ccc(O)c3OC(=CC(=O)c23)c4ccc(O)cc4)C(O)C(O)C1O CJPNHKPXZYYCME-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- YCUNGEJJOMKCGZ-UHFFFAOYSA-N Pallidiflorin Natural products C1=CC(OC)=CC=C1C1=COC2=CC=CC(O)=C2C1=O YCUNGEJJOMKCGZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 239000012156 elution solvent Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26612585A JPS62126186A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26612585A JPS62126186A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS62126186A true JPS62126186A (ja) | 1987-06-08 |
JPH0421670B2 JPH0421670B2 (enrdf_load_stackoverflow) | 1992-04-13 |
Family
ID=17426672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP26612585A Granted JPS62126186A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS62126186A (enrdf_load_stackoverflow) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07506822A (ja) * | 1992-05-19 | 1995-07-27 | ノボゲン リサーチ ピーティーワイ リミッテッド | フィト−エストロゲン,類似体またはその代謝産物を含有する健康補助剤 |
US5919921A (en) * | 1996-06-11 | 1999-07-06 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US6004558A (en) * | 1998-02-25 | 1999-12-21 | Novogen, Inc. | Methods for treating cancer with legume plant extracts |
US6083553A (en) * | 1998-06-05 | 2000-07-04 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US6132795A (en) * | 1998-03-15 | 2000-10-17 | Protein Technologies International, Inc. | Vegetable protein composition containing an isoflavone depleted vegetable protein material with an isoflavone containing material |
US6146668A (en) * | 1997-04-28 | 2000-11-14 | Novogen, Inc. | Preparation of isoflavones from legumes |
US6340703B1 (en) | 1997-05-01 | 2002-01-22 | Novogen, Inc. | Treatment or prevention of osteoporosis |
KR100347668B1 (ko) * | 2000-03-24 | 2002-08-07 | 주식회사 유젠바이오 | 개선된 이소플라본 추출 방법 |
US6444239B2 (en) | 2000-01-28 | 2002-09-03 | Kikkoman Corporation | Process for producing isoflavone aglycone-containing composition |
JP2002308868A (ja) * | 2001-04-12 | 2002-10-23 | Morita Kk | オルトジヒドロキシ構造を有するイソフラボン化合物の製造方法 |
US6479054B1 (en) | 1998-09-21 | 2002-11-12 | Showa Sangyo Co., Ltd. | Process for obtaining genistin-rich isoflavone composition |
WO2003000674A1 (en) * | 2001-06-21 | 2003-01-03 | Fuji Oil Company,Limited | Process for producing soluble isoflavone-containing composition |
US6544566B1 (en) | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
US6599536B1 (en) | 1998-03-26 | 2003-07-29 | Novogen Research Pty Ltd | Therapy of estrogen-associated disorders |
US6649648B1 (en) | 1996-08-30 | 2003-11-18 | Novogen Research Pty Limited | Therapeutic methods and compositions involving isoflavones |
US6703051B1 (en) | 1998-10-13 | 2004-03-09 | Solae, Llc | Process for separating and recovering protein and isoflavones from a plant material |
US7015339B2 (en) | 2001-07-24 | 2006-03-21 | Cargill, Incorporated | Process for isolating phenolic compounds |
US7285297B1 (en) | 1999-04-23 | 2007-10-23 | Archer-Daniels-Midland Company | Method of reducing low density liproprotein cholesterol concentration |
US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
US7560131B2 (en) | 2002-12-24 | 2009-07-14 | Fuji Oil Company, Limited | High solubility composition with high isoflavone concentration and process of producing same |
US7713940B2 (en) | 2003-05-20 | 2010-05-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Water-soluble isoflavone composition, process for producing the same, and use thereof |
US7993684B2 (en) | 2003-09-19 | 2011-08-09 | Sunstar Inc. | Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein |
CN102206209A (zh) * | 2011-04-12 | 2011-10-05 | 聊城大学 | 从大豆中提取分离大豆异黄酮单体化合物的方法 |
CN103788156A (zh) * | 2014-02-24 | 2014-05-14 | 聊城大学 | 一种分离纯化大豆异黄酮单体化合物的方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107096514B (zh) * | 2017-06-16 | 2019-09-27 | 江苏科技大学 | 一种中空结构的硼酸基氧化锡印迹复合纳米微球、其制备方法及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5133167A (enrdf_load_stackoverflow) * | 1974-06-05 | 1976-03-22 | Sarubadooru Montagyuto Gy Hose | |
JPS59187746A (ja) * | 1983-04-11 | 1984-10-24 | Hayashibara Biochem Lab Inc | 飲食物とその製造方法 |
-
1985
- 1985-11-28 JP JP26612585A patent/JPS62126186A/ja active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5133167A (enrdf_load_stackoverflow) * | 1974-06-05 | 1976-03-22 | Sarubadooru Montagyuto Gy Hose | |
JPS59187746A (ja) * | 1983-04-11 | 1984-10-24 | Hayashibara Biochem Lab Inc | 飲食物とその製造方法 |
Cited By (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642212B1 (en) | 1992-05-19 | 2003-11-04 | Novogen Research Pty. Ltd. | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
US6562380B1 (en) | 1992-05-19 | 2003-05-13 | Novogen Research Pty Limited | Methods for treating or reducing prediposition to breast cancer, pre-menstrual syndrome or symptoms associated with menopause by administration of phyto-estrogen |
JPH07506822A (ja) * | 1992-05-19 | 1995-07-27 | ノボゲン リサーチ ピーティーワイ リミッテッド | フィト−エストロゲン,類似体またはその代謝産物を含有する健康補助剤 |
USRE40792E1 (en) | 1992-05-19 | 2009-06-23 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
US6987098B2 (en) | 1992-05-19 | 2006-01-17 | Novogen Research Pty. Ltd. | Health supplement |
US5919921A (en) * | 1996-06-11 | 1999-07-06 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US5990291A (en) * | 1996-06-11 | 1999-11-23 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US6680381B1 (en) | 1996-06-11 | 2004-01-20 | Solae, Llc | Recovery of isoflavones from soy molasses |
US6664382B2 (en) | 1996-06-11 | 2003-12-16 | Solae, Llc | Recovery of isoflavones from soy molasses |
US6323018B1 (en) | 1996-06-11 | 2001-11-27 | Protein Technologies Int'l Lnc. | Recovery of isoflavones from soy molasses |
US6706292B2 (en) | 1996-06-11 | 2004-03-16 | Solae, Llc | Recovery of isoflavones from soy molasses |
US6495141B2 (en) | 1996-06-11 | 2002-12-17 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US6649648B1 (en) | 1996-08-30 | 2003-11-18 | Novogen Research Pty Limited | Therapeutic methods and compositions involving isoflavones |
US7202273B2 (en) | 1996-08-30 | 2007-04-10 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
US6146668A (en) * | 1997-04-28 | 2000-11-14 | Novogen, Inc. | Preparation of isoflavones from legumes |
US6340703B1 (en) | 1997-05-01 | 2002-01-22 | Novogen, Inc. | Treatment or prevention of osteoporosis |
US6004558A (en) * | 1998-02-25 | 1999-12-21 | Novogen, Inc. | Methods for treating cancer with legume plant extracts |
US6132795A (en) * | 1998-03-15 | 2000-10-17 | Protein Technologies International, Inc. | Vegetable protein composition containing an isoflavone depleted vegetable protein material with an isoflavone containing material |
US6599536B1 (en) | 1998-03-26 | 2003-07-29 | Novogen Research Pty Ltd | Therapy of estrogen-associated disorders |
US6083553A (en) * | 1998-06-05 | 2000-07-04 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
US6479054B1 (en) | 1998-09-21 | 2002-11-12 | Showa Sangyo Co., Ltd. | Process for obtaining genistin-rich isoflavone composition |
US6703051B1 (en) | 1998-10-13 | 2004-03-09 | Solae, Llc | Process for separating and recovering protein and isoflavones from a plant material |
US6579534B2 (en) | 1999-04-23 | 2003-06-17 | Solae, Llc | Composition containing soy hypocotyl material and plant sterol for reducing LDL-cholesterol |
US6572876B2 (en) | 1999-04-23 | 2003-06-03 | Solae, Llc | Administering a composition containing plant sterol, soy protein and isoflavone for reducing LDL-cholesterol |
US6544566B1 (en) | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
US6669952B2 (en) | 1999-04-23 | 2003-12-30 | Solae, Llc | Composition containing isoflavone material and plant sterol for reducing LDL-cholesterol |
US7285297B1 (en) | 1999-04-23 | 2007-10-23 | Archer-Daniels-Midland Company | Method of reducing low density liproprotein cholesterol concentration |
US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
US6444239B2 (en) | 2000-01-28 | 2002-09-03 | Kikkoman Corporation | Process for producing isoflavone aglycone-containing composition |
KR100347668B1 (ko) * | 2000-03-24 | 2002-08-07 | 주식회사 유젠바이오 | 개선된 이소플라본 추출 방법 |
US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
JP2002308868A (ja) * | 2001-04-12 | 2002-10-23 | Morita Kk | オルトジヒドロキシ構造を有するイソフラボン化合物の製造方法 |
WO2003000674A1 (en) * | 2001-06-21 | 2003-01-03 | Fuji Oil Company,Limited | Process for producing soluble isoflavone-containing composition |
US7015339B2 (en) | 2001-07-24 | 2006-03-21 | Cargill, Incorporated | Process for isolating phenolic compounds |
US7560131B2 (en) | 2002-12-24 | 2009-07-14 | Fuji Oil Company, Limited | High solubility composition with high isoflavone concentration and process of producing same |
US7713940B2 (en) | 2003-05-20 | 2010-05-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Water-soluble isoflavone composition, process for producing the same, and use thereof |
US7993684B2 (en) | 2003-09-19 | 2011-08-09 | Sunstar Inc. | Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein |
CN102206209A (zh) * | 2011-04-12 | 2011-10-05 | 聊城大学 | 从大豆中提取分离大豆异黄酮单体化合物的方法 |
CN103788156A (zh) * | 2014-02-24 | 2014-05-14 | 聊城大学 | 一种分离纯化大豆异黄酮单体化合物的方法 |
Also Published As
Publication number | Publication date |
---|---|
JPH0421670B2 (enrdf_load_stackoverflow) | 1992-04-13 |
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