JPS6172773A - ピペラジン誘導体およびこれを含有する血管拡張剤 - Google Patents

ピペラジン誘導体およびこれを含有する血管拡張剤

Info

Publication number
JPS6172773A
JPS6172773A JP59194253A JP19425384A JPS6172773A JP S6172773 A JPS6172773 A JP S6172773A JP 59194253 A JP59194253 A JP 59194253A JP 19425384 A JP19425384 A JP 19425384A JP S6172773 A JPS6172773 A JP S6172773A
Authority
JP
Japan
Prior art keywords
piperazine
formula
disorder
trimethoxyphenyl
piperazine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59194253A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03390B2 (enExample
Inventor
Toshio Wakabayashi
若林　利生
Yasuhiro Kumonaka
恭裕 雲中
Yasushi Suwabe
諏訪部　泰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP59194253A priority Critical patent/JPS6172773A/ja
Priority to US06/776,625 priority patent/US4656172A/en
Priority to DE8585111697T priority patent/DE3566257D1/de
Priority to EP85111697A priority patent/EP0175331B1/en
Publication of JPS6172773A publication Critical patent/JPS6172773A/ja
Publication of JPH03390B2 publication Critical patent/JPH03390B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59194253A 1984-09-17 1984-09-17 ピペラジン誘導体およびこれを含有する血管拡張剤 Granted JPS6172773A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59194253A JPS6172773A (ja) 1984-09-17 1984-09-17 ピペラジン誘導体およびこれを含有する血管拡張剤
US06/776,625 US4656172A (en) 1984-09-17 1985-09-16 1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted carbonylmethyl)-piperazines having vasodilating activity
DE8585111697T DE3566257D1 (en) 1984-09-17 1985-09-16 Piperazine derivatives
EP85111697A EP0175331B1 (en) 1984-09-17 1985-09-16 Piperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59194253A JPS6172773A (ja) 1984-09-17 1984-09-17 ピペラジン誘導体およびこれを含有する血管拡張剤

Publications (2)

Publication Number Publication Date
JPS6172773A true JPS6172773A (ja) 1986-04-14
JPH03390B2 JPH03390B2 (enExample) 1991-01-07

Family

ID=16321538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59194253A Granted JPS6172773A (ja) 1984-09-17 1984-09-17 ピペラジン誘導体およびこれを含有する血管拡張剤

Country Status (4)

Country Link
US (1) US4656172A (enExample)
EP (1) EP0175331B1 (enExample)
JP (1) JPS6172773A (enExample)
DE (1) DE3566257D1 (enExample)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR58316E (fr) * 1948-05-12 1953-11-18 Récipient avec couvercle à pointes intérieures et bec verseur adaptable à toutes les boîtes de conserves de liquides
US3410857A (en) * 1964-10-12 1968-11-12 Endo Lab 2-amino ethyl pyrrol-3-yl ketones
US3407199A (en) * 1966-01-18 1968-10-22 Endo Lab Tertiaryamino ethyl or propyl pyrrol-2-yl ketones
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
JPS5888370A (ja) * 1981-11-19 1983-05-26 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
IT1151104B (it) * 1982-02-04 1986-12-17 Delalande Sa Impiego terapeutico di derivati (1-cinnamoil oppure 1-fenetil-carbonil)piperazinici
JPS58172380A (ja) * 1982-04-05 1983-10-11 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリ−トメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
JPS58189170A (ja) * 1982-04-30 1983-11-04 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
JPS58194873A (ja) * 1982-05-11 1983-11-12 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルメチル置換ピペラジン誘導体

Also Published As

Publication number Publication date
EP0175331A1 (en) 1986-03-26
DE3566257D1 (en) 1988-12-22
EP0175331B1 (en) 1988-11-17
JPH03390B2 (enExample) 1991-01-07
US4656172A (en) 1987-04-07

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