JPS6160697A - 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法 - Google Patents

新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法

Info

Publication number
JPS6160697A
JPS6160697A JP60187555A JP18755585A JPS6160697A JP S6160697 A JPS6160697 A JP S6160697A JP 60187555 A JP60187555 A JP 60187555A JP 18755585 A JP18755585 A JP 18755585A JP S6160697 A JPS6160697 A JP S6160697A
Authority
JP
Japan
Prior art keywords
nucleic acid
partner
acid sequence
formula
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60187555A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0578320B2 (OSRAM
Inventor
ヘルマン・グラーフ
ヘルムート・レンツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS6160697A publication Critical patent/JPS6160697A/ja
Publication of JPH0578320B2 publication Critical patent/JPH0578320B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP60187555A 1984-08-28 1985-08-28 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法 Granted JPS6160697A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843431536 DE3431536A1 (de) 1984-08-28 1984-08-28 Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren
DE3431536.5 1984-08-28

Publications (2)

Publication Number Publication Date
JPS6160697A true JPS6160697A (ja) 1986-03-28
JPH0578320B2 JPH0578320B2 (OSRAM) 1993-10-28

Family

ID=6244044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60187555A Granted JPS6160697A (ja) 1984-08-28 1985-08-28 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法

Country Status (6)

Country Link
EP (1) EP0173251B1 (OSRAM)
JP (1) JPS6160697A (OSRAM)
AT (1) ATE48141T1 (OSRAM)
AU (1) AU582380B2 (OSRAM)
CA (1) CA1242657A (OSRAM)
DE (2) DE3431536A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01215300A (ja) * 1988-01-12 1989-08-29 Boehringer Mannheim Gmbh ハイブリツド形成による定義された配列の核酸の検出方法
JPH0731194B2 (ja) * 1988-01-12 1995-04-10 ベーリンガー マンハイム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 核酸の検出法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365595A4 (en) * 1987-06-26 1990-06-05 Du Pont AFFINITY EXTRACTION OF CONTAMINANT SEQUENCES FROM RECOMBINANT CLONED NUCLEIC ACIDS USING CAPTURE PEARLS.
ATE192465T1 (de) * 1987-10-28 2000-05-15 Florey Howard Inst Oligonucleotid-polyamid konjugate
US5525465A (en) * 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
US5354657A (en) * 1988-01-12 1994-10-11 Boehringer Mannheim Gmbh Process for the highly specific detection of nucleic acids in solid
FR2627590A1 (fr) * 1988-02-24 1989-08-25 Ire Celltarg Sa Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation
FR2634211B1 (fr) * 1988-07-13 1992-06-26 Lebacq Philippe Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede
FR2644163B2 (fr) * 1988-07-13 1994-09-30 Bioprobe Systems Sa Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede
DE3836656A1 (de) * 1988-10-27 1990-05-03 Boehringer Mannheim Gmbh Neue digoxigenin-derivate und ihre verwendung
US5356773A (en) * 1989-05-16 1994-10-18 Kinetic Investments Limited Generation of unidirectional deletion mutants
DE3916595A1 (de) * 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
DE69033546T2 (de) * 1989-10-13 2000-09-21 Zeneca Ltd., London Sonden
US5677440A (en) * 1990-07-16 1997-10-14 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
EP0752474A1 (en) 1995-07-07 1997-01-08 Boehringer Mannheim Gmbh Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins
WO1997003348A1 (en) * 1995-07-13 1997-01-30 Immunological Associates Of Denver Self-contained device integrating nucleic acid extraction, amplification and detection
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
US20020146728A1 (en) 1998-12-03 2002-10-10 Tanja Ligensa IGF-1 receptor interacting proteins
EP1099757B1 (en) 1999-11-11 2010-02-24 F. Hoffmann-La Roche Ag Process for the determination of CTp11 and for determining whether a tumor sample has metatastic potential
JP2004500852A (ja) 2000-05-19 2004-01-15 エフ．　ホフマン−ラ　ロシュ　アーゲー ヒト腫瘍細胞においてダウンレギュレートされる核酸の使用による、試料の殺腫瘍能を決定するためのプロセス
CN101951509B (zh) 2004-11-19 2012-05-23 松下电器产业株式会社 运动图像编码方法以及运动图像解码方法
EP1862804B1 (en) 2005-03-14 2010-05-05 Link Genomics, Inc. Method for diagnosis of prostate cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209297A (en) * 1981-04-17 1982-12-22 Univ Yale Modified nucleotide, manufacture and use
JPS5962600A (ja) * 1982-06-23 1984-04-10 エンゾ・バイオケム・インコ−ポレ−テツド 修飾ヌクレオチド

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
EP0135587B2 (en) * 1983-02-22 2002-12-18 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
FR2558172B1 (fr) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209297A (en) * 1981-04-17 1982-12-22 Univ Yale Modified nucleotide, manufacture and use
JPS5962600A (ja) * 1982-06-23 1984-04-10 エンゾ・バイオケム・インコ−ポレ−テツド 修飾ヌクレオチド

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01215300A (ja) * 1988-01-12 1989-08-29 Boehringer Mannheim Gmbh ハイブリツド形成による定義された配列の核酸の検出方法
JPH0731194B2 (ja) * 1988-01-12 1995-04-10 ベーリンガー マンハイム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 核酸の検出法

Also Published As

Publication number Publication date
CA1242657A (en) 1988-10-04
DE3431536A1 (de) 1986-03-13
EP0173251A3 (en) 1986-10-29
EP0173251B1 (de) 1989-11-23
DE3574383D1 (en) 1989-12-28
ATE48141T1 (de) 1989-12-15
JPH0578320B2 (OSRAM) 1993-10-28
AU4648485A (en) 1986-03-06
AU582380B2 (en) 1989-03-23
EP0173251A2 (de) 1986-03-05

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