JPS6136213A - 口腔用組成物 - Google Patents
口腔用組成物Info
- Publication number
- JPS6136213A JPS6136213A JP59158164A JP15816484A JPS6136213A JP S6136213 A JPS6136213 A JP S6136213A JP 59158164 A JP59158164 A JP 59158164A JP 15816484 A JP15816484 A JP 15816484A JP S6136213 A JPS6136213 A JP S6136213A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- mutans
- formula
- adhesion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 210000000214 mouth Anatomy 0.000 title description 13
- 208000002925 dental caries Diseases 0.000 claims abstract description 19
- -1 triterpene compound Chemical class 0.000 claims abstract description 12
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims abstract description 5
- 230000002378 acidificating effect Effects 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 18
- 150000001875 compounds Chemical class 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 16
- 229940100243 oleanolic acid Drugs 0.000 abstract description 13
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- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 abstract description 12
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 abstract description 12
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 abstract description 12
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- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 abstract description 9
- MUCRYNWJQNHDJH-OADIDDRXSA-N Ursonic acid Chemical compound C1CC(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C MUCRYNWJQNHDJH-OADIDDRXSA-N 0.000 abstract description 8
- MUCRYNWJQNHDJH-UHFFFAOYSA-N Ursonic acid Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(C)C5C4=CCC3C21C MUCRYNWJQNHDJH-UHFFFAOYSA-N 0.000 abstract description 8
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- 230000001747 exhibiting effect Effects 0.000 abstract description 2
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- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 239000002253 acid Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 12
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- 244000005700 microbiome Species 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- GCGBHJLBFAPRDB-KCVAUKQGSA-N Scutellaric acid Natural products CC1(C)CC[C@@]2(CC[C@@]3(C)[C@@H]4CC[C@H]5[C@@](C)(CO)[C@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2C1)C(=O)O GCGBHJLBFAPRDB-KCVAUKQGSA-N 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- 239000003795 chemical substances by application Substances 0.000 description 7
- 229960003720 enoxolone Drugs 0.000 description 7
- NTWLPZMPTFQYQI-UHFFFAOYSA-N (3alpha)-olean-12-ene-3,23-diol Natural products C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C NTWLPZMPTFQYQI-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- GCGBHJLBFAPRDB-UHFFFAOYSA-N Hederagenin Natural products CC1(C)CCC2(CCC3(C)C4CCC5C(C)(CO)C(O)CCC5(C)C4CC=C3C2C1)C(=O)O GCGBHJLBFAPRDB-UHFFFAOYSA-N 0.000 description 6
- PGOYMURMZNDHNS-MYPRUECHSA-N hederagenin Chemical compound C1C[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PGOYMURMZNDHNS-MYPRUECHSA-N 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 229960001375 lactose Drugs 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 244000215068 Acacia senegal Species 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
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- 150000007524 organic acids Chemical class 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- RIXNFYQZWDGQAE-DFHVBEEKSA-N (4as,6ar,6as,6br,8ar,10s,12ar,14bs)-10-acetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound C([C@H]1C2=CC[C@H]34)C(C)(C)CC[C@]1(C(O)=O)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](OC(=O)C)C1(C)C RIXNFYQZWDGQAE-DFHVBEEKSA-N 0.000 description 2
- QMHCWDVPABYZMC-UHFFFAOYSA-N 3-Hydroxy-23-oxo-olean-12-en-28-saeure Natural products C1CC(O)C(C)(C=O)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C QMHCWDVPABYZMC-UHFFFAOYSA-N 0.000 description 2
- QMHCWDVPABYZMC-MYPRUECHSA-N 3beta-hydroxy-23-oxoolean-12-en-28-oic acid Chemical compound C1C[C@H](O)[C@@](C)(C=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C QMHCWDVPABYZMC-MYPRUECHSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PAIBKVQNJKUVCE-UHFFFAOYSA-N Gypsogeninsaeure Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C PAIBKVQNJKUVCE-UHFFFAOYSA-N 0.000 description 2
- YAGYBNOEVSEGSL-UHFFFAOYSA-N Phytolaccinic acid Chemical compound C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=O)OC)(C)CC5C4=CCC3C21C YAGYBNOEVSEGSL-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
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- 108010080698 Peptones Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZZTYPLSBNNGEIS-OPAXANQDSA-N Pomolic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C ZZTYPLSBNNGEIS-OPAXANQDSA-N 0.000 description 1
- JYEJQUHSBMDABO-SYKQLJDKSA-N Pomolic acid Natural products C[C@@H]1CC[C@@]2(CC[C@H]3[C@@H]4CC[C@H]5C(C)(C)[C@@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2[C@]1(C)O)C(=O)O JYEJQUHSBMDABO-SYKQLJDKSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- UWSHDAOEAKIXMQ-UHFFFAOYSA-J [Th+4].S(=O)(=O)(OCCCCCCCCCCCC)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-] Chemical compound [Th+4].S(=O)(=O)(OCCCCCCCCCCCC)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-].C(CCCCCCCCCCC)OS(=O)(=O)[O-] UWSHDAOEAKIXMQ-UHFFFAOYSA-J 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000000397 acetylating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005428 food component Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- XTLWNMXYCHABQH-UHFFFAOYSA-N germanicol Natural products CC1(C)CCC2(C)CCC3(C)C(CCC4(C)C5(C)CCC(O)C(C)(C)C5CCC34C)C2=C1 XTLWNMXYCHABQH-UHFFFAOYSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000001279 glycosylating effect Effects 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 102100039604 mRNA guanylyltransferase Human genes 0.000 description 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- WRZYGPIFICWRCG-OOFFSTKBSA-M sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trih Chemical compound [Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O WRZYGPIFICWRCG-OOFFSTKBSA-M 0.000 description 1
- MOCOXAJEZKHXSF-IHMBCTQLSA-M sodium;(2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound [Na+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MOCOXAJEZKHXSF-IHMBCTQLSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- GGGUGZHBAOMSFJ-GADYQYKKSA-N taraxerol Chemical compound CC([C@@H]1CC2)(C)[C@@H](O)CC[C@]1(C)[C@@H]1[C@]2(C)C2=CC[C@@]3(C)CCC(C)(C)C[C@H]3[C@]2(C)CC1 GGGUGZHBAOMSFJ-GADYQYKKSA-N 0.000 description 1
- HYTFUKZLSYXRDX-UHFFFAOYSA-N taraxerol Natural products CC1CCCC2C3(C)CCC4(C)C5CC(C)(C)CCC5(C)C=CC4(C)C3C(O)CC12C HYTFUKZLSYXRDX-UHFFFAOYSA-N 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59158164A JPS6136213A (ja) | 1984-07-27 | 1984-07-27 | 口腔用組成物 |
| US06/754,300 US4606911A (en) | 1984-07-27 | 1985-07-15 | Pharmaceutical composition for the prevention of dental caries |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59158164A JPS6136213A (ja) | 1984-07-27 | 1984-07-27 | 口腔用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6136213A true JPS6136213A (ja) | 1986-02-20 |
| JPS6326083B2 JPS6326083B2 (enExample) | 1988-05-27 |
Family
ID=15665665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59158164A Granted JPS6136213A (ja) | 1984-07-27 | 1984-07-27 | 口腔用組成物 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US4606911A (enExample) |
| JP (1) | JPS6136213A (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01290619A (ja) * | 1988-05-19 | 1989-11-22 | Hokkaido Togyo Kk | 口腔用組成物の製造法 |
| JPH01308219A (ja) * | 1988-01-14 | 1989-12-12 | Warner Lambert Co | 口腔用組成物 |
| JPH02129211A (ja) * | 1988-11-09 | 1990-05-17 | Yasuji Otsuka | 非複屈折性材料 |
| WO1992009553A1 (fr) * | 1990-11-21 | 1992-06-11 | Hokkaidosugar Co., Ltd. | Composition de triterpene pentacyclique, soluble dans l'eau, et production de cette composition |
| KR100414833B1 (ko) * | 2001-02-21 | 2004-01-16 | 학교법인연세대학교 | 약용식물로부터 분리한 트리터펜계 화합물을 함유하는충치 예방용 항균 조성물 |
| JP2022163809A (ja) * | 2021-04-15 | 2022-10-27 | ライオン株式会社 | 口腔菌叢改善剤 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04106489U (ja) * | 1991-02-27 | 1992-09-14 | 日本農薬株式会社 | 可搬式乾燥装置 |
| JPH0532992U (ja) * | 1991-10-07 | 1993-04-30 | 北斗工機株式会社 | 穀類乾燥用通風装置 |
| GR1001287B (el) * | 1992-04-10 | 1993-07-30 | Georgios Kallimanis | Μεθοδος παρασκευης φαρμακου για τη θεραπεια των ουλιτιδων. |
| US5405604A (en) * | 1992-10-16 | 1995-04-11 | The Procter & Gamble Company | Concentrated mouthrinse for efficient delivery of antimicrobials |
| WO1997003088A1 (fr) * | 1995-07-07 | 1997-01-30 | Meiji Seika Kabushiki Kaisha | Derives triterpenes et medicament pour les maladies du foie |
| IT1284604B1 (it) * | 1996-09-27 | 1998-05-21 | Roberto Valducci | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
| US6248309B1 (en) * | 1997-04-04 | 2001-06-19 | Optiva Corporation | Gums containing antimicrobial agents |
| ATE262283T1 (de) * | 2000-02-10 | 2004-04-15 | Loders Croklaan Bv | Fettmischungen mit kristallmodifikatoren |
| WO2002026762A1 (en) * | 2000-09-29 | 2002-04-04 | Regents Of The University Of Minnesota | Triterpenes having antibacterial activity |
| KR100489701B1 (ko) * | 2002-10-09 | 2005-05-16 | 주식회사 태평양 | 고농도의 트리터페노이드를 함유하는 미소화 리포좀 및 그제조방법 |
| WO2005034958A1 (en) * | 2003-10-10 | 2005-04-21 | Sk Chemicals, Co., Ltd. | Triterpene compounds which are effective on improvement of brain function |
| US7604978B2 (en) * | 2004-07-14 | 2009-10-20 | Sequoia Sciences, Inc. | Inhibition of biofilm formation |
| US20060264411A1 (en) * | 2005-05-20 | 2006-11-23 | Eldridge Gary R | Control of biofilm formation |
| US20060014285A1 (en) * | 2004-07-14 | 2006-01-19 | Eldridge Gary R | Methods and compositions for inhibiting biofilms |
| EP1797108A1 (en) * | 2004-09-14 | 2007-06-20 | Gary R. Eldridge | Compounds, compositions and methods for controlling biofilms and bacterial infections |
| US20060134025A1 (en) * | 2004-12-17 | 2006-06-22 | Colgate-Palmolive Company | Oral compositions containing extracts of Rosmarinus and related methods |
| US20060228384A1 (en) * | 2005-04-06 | 2006-10-12 | Sequoia Sciences, Inc. | Control of biofilm with a biofilm inhibitor |
| US20070014739A1 (en) * | 2005-07-14 | 2007-01-18 | Eldridge Gary R | Compositions and methods for controlling biofilms and bacterial infections |
| US8324264B1 (en) | 2011-07-22 | 2012-12-04 | Sequoia Sciences, Inc. | Inhibitors of bacterial biofilms and related methods |
| US20220280403A1 (en) * | 2019-08-23 | 2022-09-08 | Colgate-Palmolive Company | Method to Incorporate Oleanolic Acid into Oral Care Compositions and Oral Care Compositions Based Thereof |
| WO2024228945A1 (en) | 2023-05-03 | 2024-11-07 | Nutrition & Biosciences USA 4, Inc. | Controlling bacterial cell adhesion with alpha-glucan comprising alpha-1,6 glycosidic linkages |
| CN120605220A (zh) * | 2024-03-08 | 2025-09-09 | 高露洁-棕榄公司 | 口腔护理条及其组合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59101417A (ja) * | 1982-12-02 | 1984-06-12 | Lion Corp | 口腔用組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328246A (en) * | 1957-08-20 | 1967-06-27 | Bicrex Lab Ltd | Dental compositions and methods of making same |
| GB923414A (en) * | 1960-04-13 | 1963-04-10 | Laroche Navarron Lab | Therapeutic compositions comprising asiatic and arjunolic acids |
| GB1229562A (enExample) * | 1969-01-17 | 1971-04-28 | ||
| US4022881A (en) * | 1974-06-18 | 1977-05-10 | Beecham Group Limited | Dentifrice |
| IT1075675B (it) * | 1977-03-16 | 1985-04-22 | Isf Spa | Derivati dell'acido oleanoico |
| GB2092442B (en) * | 1981-02-06 | 1984-02-08 | Biorex Laboratories Ltd | Pharmaceutical composition for treating diseases of the oral cavity containing glycyrrhetinic acid or a derivative thereof |
-
1984
- 1984-07-27 JP JP59158164A patent/JPS6136213A/ja active Granted
-
1985
- 1985-07-15 US US06/754,300 patent/US4606911A/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59101417A (ja) * | 1982-12-02 | 1984-06-12 | Lion Corp | 口腔用組成物 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01308219A (ja) * | 1988-01-14 | 1989-12-12 | Warner Lambert Co | 口腔用組成物 |
| JPH01290619A (ja) * | 1988-05-19 | 1989-11-22 | Hokkaido Togyo Kk | 口腔用組成物の製造法 |
| JPH02129211A (ja) * | 1988-11-09 | 1990-05-17 | Yasuji Otsuka | 非複屈折性材料 |
| WO1992009553A1 (fr) * | 1990-11-21 | 1992-06-11 | Hokkaidosugar Co., Ltd. | Composition de triterpene pentacyclique, soluble dans l'eau, et production de cette composition |
| US5314877A (en) * | 1990-11-21 | 1994-05-24 | Hokkaido Sugar Co., Ltd. | Water-soluble pentacyclic triterpene composition and method for producing the same |
| KR100414833B1 (ko) * | 2001-02-21 | 2004-01-16 | 학교법인연세대학교 | 약용식물로부터 분리한 트리터펜계 화합물을 함유하는충치 예방용 항균 조성물 |
| JP2022163809A (ja) * | 2021-04-15 | 2022-10-27 | ライオン株式会社 | 口腔菌叢改善剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6326083B2 (enExample) | 1988-05-27 |
| US4606911A (en) | 1986-08-19 |
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