JPS61271982A - モノクロ−ナル抗体 - Google Patents
モノクロ−ナル抗体Info
- Publication number
- JPS61271982A JPS61271982A JP61114952A JP11495286A JPS61271982A JP S61271982 A JPS61271982 A JP S61271982A JP 61114952 A JP61114952 A JP 61114952A JP 11495286 A JP11495286 A JP 11495286A JP S61271982 A JPS61271982 A JP S61271982A
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cell line
- cells
- human
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 104
- 210000004408 hybridoma Anatomy 0.000 claims description 42
- 241000282693 Cercopithecidae Species 0.000 claims description 21
- 210000004698 lymphocyte Anatomy 0.000 claims description 20
- 230000004927 fusion Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 241000282577 Pan troglodytes Species 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 241000288906 Primates Species 0.000 claims description 3
- 230000007910 cell fusion Effects 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 210000000628 antibody-producing cell Anatomy 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 229960005156 digoxin Drugs 0.000 description 16
- 206010035226 Plasma cell myeloma Diseases 0.000 description 14
- 201000000050 myeloid neoplasm Diseases 0.000 description 14
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 10
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 10
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 10
- 108060003951 Immunoglobulin Proteins 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 7
- 102000018358 immunoglobulin Human genes 0.000 description 7
- 229940072221 immunoglobulins Drugs 0.000 description 7
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 241000282668 Cebus Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 239000003855 balanced salt solution Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 2
- 229960005508 8-azaguanine Drugs 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000208011 Digitalis Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 239000012981 Hank's balanced salt solution Substances 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000282560 Macaca mulatta Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000282579 Pan Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- OBATZBGFDSVCJD-UHFFFAOYSA-N de-O-acetyl-lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(O)C1OC1OC(CO)C(O)C(O)C1O OBATZBGFDSVCJD-UHFFFAOYSA-N 0.000 description 2
- 229960001324 deslanoside Drugs 0.000 description 2
- OBATZBGFDSVCJD-LALPQLPRSA-N deslanoside Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OBATZBGFDSVCJD-LALPQLPRSA-N 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- OQUFOZNPBIIJTN-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;sodium Chemical compound [Na].OC(=O)CC(O)(C(O)=O)CC(O)=O OQUFOZNPBIIJTN-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 210000000712 G cell Anatomy 0.000 description 1
- 241000282575 Gorilla Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 description 1
- 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 241000282553 Macaca Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288935 Platyrrhini Species 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229960000648 digitoxin Drugs 0.000 description 1
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000009177 immunoglobulin therapy Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/166—Animal cells resulting from interspecies fusion
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73719685A | 1985-05-23 | 1985-05-23 | |
| US737196 | 1985-05-23 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7197143A Division JPH0841100A (ja) | 1985-05-23 | 1995-07-11 | モノクローナル抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61271982A true JPS61271982A (ja) | 1986-12-02 |
Family
ID=24962960
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61114952A Pending JPS61271982A (ja) | 1985-05-23 | 1986-05-21 | モノクロ−ナル抗体 |
| JP7197143A Pending JPH0841100A (ja) | 1985-05-23 | 1995-07-11 | モノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7197143A Pending JPH0841100A (ja) | 1985-05-23 | 1995-07-11 | モノクローナル抗体 |
Country Status (22)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646041A (en) * | 1987-02-12 | 1997-07-08 | Harfeldt; Elisabeth | Monoclonal antibody to herpes simplex virus and cell line producing same |
| IT1226477B (it) * | 1988-07-04 | 1991-01-16 | Genetik Mab S R L | Linee cellulari n omas quale un mezzo per immortalare cellule produttrici di sostanze di qualunque specie animale. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4381292A (en) * | 1980-11-14 | 1983-04-26 | The Board Of Trustees Of The Leland Stanford Jr. University | Anti-human T-lymphocyte monoclonal antibody |
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| CH652145A5 (de) * | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| DE3330160A1 (de) * | 1983-08-20 | 1985-03-07 | Boehringer Ingelheim KG, 6507 Ingelheim | Monoklonaler antikoerper mit hoher affinitaet zum digoxin |
| US4777245A (en) * | 1984-01-06 | 1988-10-11 | Genelabs Incorporated | Non-human primate monoclonal antibodies and methods |
| US4746612A (en) * | 1984-10-12 | 1988-05-24 | Scripps Clinic & Research Foundation | Aotus interspecies hybridomas and monoclonal receptors produced thereby |
-
1986
- 1986-05-13 CH CH192786A patent/CH670098B/de unknown
- 1986-05-15 DE DE3616324A patent/DE3616324C2/de not_active Expired - Fee Related
- 1986-05-19 GB GB8612160A patent/GB2175918B/en not_active Expired
- 1986-05-20 NL NL8601263A patent/NL8601263A/nl not_active Application Discontinuation
- 1986-05-21 NZ NZ216251A patent/NZ216251A/xx unknown
- 1986-05-21 FI FI862131A patent/FI93469C/fi not_active IP Right Cessation
- 1986-05-21 IL IL78871A patent/IL78871A/xx not_active IP Right Cessation
- 1986-05-21 IE IE134786A patent/IE59184B1/en not_active IP Right Cessation
- 1986-05-21 JP JP61114952A patent/JPS61271982A/ja active Pending
- 1986-05-21 AU AU57640/86A patent/AU603985B2/en not_active Ceased
- 1986-05-21 SE SE8602288A patent/SE8602288L/ not_active Application Discontinuation
- 1986-05-22 DK DK240286A patent/DK240286A/da not_active Application Discontinuation
- 1986-05-22 KR KR1019860003999A patent/KR900007950B1/ko not_active Expired
- 1986-05-22 AT AT0135886A patent/AT396936B/de not_active IP Right Cessation
- 1986-05-23 FR FR868607365A patent/FR2587357B1/fr not_active Expired
- 1986-05-23 BE BE1/011495A patent/BE904811A/fr not_active IP Right Cessation
- 1986-05-23 ZA ZA863871A patent/ZA863871B/xx unknown
- 1986-05-23 IT IT48048/86A patent/IT1203789B/it active
- 1986-05-23 LU LU86437A patent/LU86437A1/fr unknown
-
1992
- 1992-03-17 SG SG32392A patent/SG32392G/en unknown
- 1992-05-28 HK HK377/92A patent/HK37792A/xx unknown
- 1992-11-06 CY CY1644A patent/CY1644A/en unknown
-
1995
- 1995-07-11 JP JP7197143A patent/JPH0841100A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Matthew et al. | The production of a monoclonal antibody that blocks the action of a neurite outgrowth-promoting factor | |
| JP2837160B2 (ja) | ヒト腫瘍壊死因子に対するモノクローナル抗体を含有する敗血症治療薬及びリューマチ性疾患治療薬 | |
| US4224404A (en) | Production of specific immune nucleic acids cell dialysates and antibodies | |
| GB2113715A (en) | Process for the production of human mono-clonal antibodies | |
| JPH0367678B2 (enrdf_load_stackoverflow) | ||
| JPH0662844A (ja) | エンドトキシンコアーと反応性のモノクローナル抗体を産生するハイブリドーマ | |
| JPS6229972A (ja) | ウサギモノクロ−ナル抗体産生方法およびその中で用いられる細胞系ならびにそれによつて産生される抗体 | |
| US4752582A (en) | Monoclonal antibodies to human glycophorin A and cell lines for the production thereof | |
| DE69033457T2 (de) | Prohormonspaltungsplatzblockierungsantikörper | |
| EP0142345A2 (en) | Anti-idiotypic vaccine employing anti-idiotypic monoclonal antibodies | |
| WO1983001739A1 (en) | Monoclonal antibodies against brugia malayi | |
| DE3786673T2 (de) | Verfahren zur entfernung unerwünschter zellen aus menschlichen lymphozytenpopulationen, anwendung des verfahrens zur herstellung monoklonaler antikörper und dafür geeigneter kit. | |
| JPS61271982A (ja) | モノクロ−ナル抗体 | |
| JPS61185183A (ja) | 膣トリコモナスに対して細胞溶解性のモノクロ−ナル抗体を産生するハイブリツド細胞系統 | |
| EP0199755A1 (en) | Monoclonal antibodies and their use | |
| EP0529348A1 (de) | Verfahren zur Reinigung von Faktor XIII, monoklonale Antikörper gegen Faktor XIIIA, ihre Herstellung und Verwendung | |
| EP0198001A1 (en) | Monoclonal antibodies and their use | |
| JPS61153569A (ja) | Ｂ型肝炎ウイルス特異性モノクローナル抗体 | |
| JP3036545B2 (ja) | モノクローナル抗体とこれを産生するハイブリドーマ細胞株、およびこれを用いる免疫学的測定法 | |
| EP0204798A1 (en) | Monoclonal antibodies and their use | |
| Pollock | RNA transfer of immunity between inbred strains of mice | |
| SU1726511A1 (ru) | Штамм гибридных культивируемых клеток MUS мUSсULUS L, используемый дл получени моноклональных антител к общим антигенным детерминантам инсулина человека и свиньи | |
| Ménaché et al. | Chicken fibrinogen and human fibrinogen | |
| JPS62180270A (ja) | インタ−フエロン−γの免疫化学的測定法および測定用試薬 | |
| JPH01500722A (ja) | 膵臓α‐アミラーゼに対する抗体の産生及び診断への使用 |