JPS61271249A - 光学活性α−クロルカルボン酸エステルの精製方法 - Google Patents
光学活性α−クロルカルボン酸エステルの精製方法Info
- Publication number
- JPS61271249A JPS61271249A JP11457585A JP11457585A JPS61271249A JP S61271249 A JPS61271249 A JP S61271249A JP 11457585 A JP11457585 A JP 11457585A JP 11457585 A JP11457585 A JP 11457585A JP S61271249 A JPS61271249 A JP S61271249A
- Authority
- JP
- Japan
- Prior art keywords
- acid ester
- acid
- chlorocarboxylic
- optically
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alpha-chlorocarboxylic acid ester Chemical class 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 8
- 238000004821 distillation Methods 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract description 10
- 150000007514 bases Chemical class 0.000 abstract description 9
- 230000003287 optical effect Effects 0.000 abstract description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract description 5
- 239000003054 catalyst Substances 0.000 abstract description 5
- 239000007809 chemical reaction catalyst Substances 0.000 abstract description 3
- 150000003903 lactic acid esters Chemical class 0.000 abstract description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract description 3
- 150000003980 alpha-chlorocarboxylic acids Chemical class 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012045 crude solution Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000006340 racemization Effects 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000001577 simple distillation Methods 0.000 description 4
- LPEKGGXMPWTOCB-GSVOUGTGSA-N methyl (R)-lactate Chemical compound COC(=O)[C@@H](C)O LPEKGGXMPWTOCB-GSVOUGTGSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010701 ester synthesis reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- JLEJCNOTNLZCHQ-UHFFFAOYSA-N methyl 2-chloropropanoate Chemical compound COC(=O)C(C)Cl JLEJCNOTNLZCHQ-UHFFFAOYSA-N 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11457585A JPS61271249A (ja) | 1985-05-28 | 1985-05-28 | 光学活性α−クロルカルボン酸エステルの精製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11457585A JPS61271249A (ja) | 1985-05-28 | 1985-05-28 | 光学活性α−クロルカルボン酸エステルの精製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61271249A true JPS61271249A (ja) | 1986-12-01 |
| JPH051775B2 JPH051775B2 (enrdf_load_stackoverflow) | 1993-01-11 |
Family
ID=14641268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11457585A Granted JPS61271249A (ja) | 1985-05-28 | 1985-05-28 | 光学活性α−クロルカルボン酸エステルの精製方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61271249A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009025169A1 (ja) * | 2007-08-17 | 2009-02-26 | Central Glass Company, Limited | 光学活性α－フルオロカルボン酸エステルの精製方法 |
-
1985
- 1985-05-28 JP JP11457585A patent/JPS61271249A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009025169A1 (ja) * | 2007-08-17 | 2009-02-26 | Central Glass Company, Limited | 光学活性α－フルオロカルボン酸エステルの精製方法 |
| JP2009067776A (ja) * | 2007-08-17 | 2009-04-02 | Central Glass Co Ltd | 光学活性α−フルオロカルボン酸エステルの精製方法 |
| US8748653B2 (en) | 2007-08-17 | 2014-06-10 | Central Glass Company, Limited | Method for purification of optically active α-fluorocarboxylic acid esters |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH051775B2 (enrdf_load_stackoverflow) | 1993-01-11 |
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