JPS61130289A - １３−プロピルベルベリンの塩 - Google Patents

１３−プロピルベルベリンの塩

Info

Publication number
JPS61130289A
JPS61130289A JP59252425A JP25242584A JPS61130289A JP S61130289 A JPS61130289 A JP S61130289A JP 59252425 A JP59252425 A JP 59252425A JP 25242584 A JP25242584 A JP 25242584A JP S61130289 A JPS61130289 A JP S61130289A
Authority
JP
Japan
Prior art keywords
propylberberine
salt
added
precipitated
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59252425A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0469632B2 (OSRAM
Inventor
Tetsuo Ikegawa
哲郎 池川
Fumitake Shimada
文武 島田
Soutetsu Chiyou
丁　宗鉄
Kazuo Kamibaba
和夫 上馬場
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Priority to JP59252425A priority Critical patent/JPS61130289A/ja
Priority to EP85115000A priority patent/EP0184118B1/en
Priority to DE8585115000T priority patent/DE3564434D1/de
Priority to US06/802,447 priority patent/US4761477A/en
Publication of JPS61130289A publication Critical patent/JPS61130289A/ja
Publication of JPH0469632B2 publication Critical patent/JPH0469632B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59252425A 1984-11-29 1984-11-29 １３−プロピルベルベリンの塩 Granted JPS61130289A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59252425A JPS61130289A (ja) 1984-11-29 1984-11-29 １３−プロピルベルベリンの塩
EP85115000A EP0184118B1 (en) 1984-11-29 1985-11-26 13-propylberberine salts
DE8585115000T DE3564434D1 (de) 1984-11-29 1985-11-26 13-propylberberine salts
US06/802,447 US4761477A (en) 1984-11-29 1985-11-27 13-propylberberine salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59252425A JPS61130289A (ja) 1984-11-29 1984-11-29 １３−プロピルベルベリンの塩

Publications (2)

Publication Number Publication Date
JPS61130289A true JPS61130289A (ja) 1986-06-18
JPH0469632B2 JPH0469632B2 (OSRAM) 1992-11-06

Family

ID=17237179

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59252425A Granted JPS61130289A (ja) 1984-11-29 1984-11-29 １３−プロピルベルベリンの塩

Country Status (4)

Country Link
US (1) US4761477A (OSRAM)
EP (1) EP0184118B1 (OSRAM)
JP (1) JPS61130289A (OSRAM)
DE (1) DE3564434D1 (OSRAM)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
FR2728902B1 (fr) * 1994-12-29 1997-01-31 Synthelabo Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique
WO1998012181A1 (en) * 1996-09-23 1998-03-26 Rutgers, The State University Of New Jersey Substituted heterocycles as anti-tumor agents
KR100258849B1 (ko) * 1998-04-24 2000-08-01 박원배 약학적으로 유용한 프로토베르베린염 유도체 및프로토베르베린유도체와 이의 염
KR20000021073A (ko) 1998-09-25 2000-04-15 박원배 콜레스테롤 생합성 저해제
KR20000042507A (ko) * 1998-12-21 2000-07-15 박원배 콜레스테롤 생합성 저해효과를 나타내는 디벤조[a,g]퀴놀리지늄 유도체
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
WO2003047505A2 (en) * 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
MXPA04004607A (es) * 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
AU2002352708A1 (en) 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
KR20050044491A (ko) * 2001-11-14 2005-05-12 루트거스, 더 스테이트 유니버시티 가용화된 토포이소머라제 독
US6992089B2 (en) * 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004014918A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
AU2003265405A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted heterocycles as topoisomerase i targeting agents
WO2004044174A2 (en) 2002-11-12 2004-05-27 Rutgers, The State University Topoisomerase-targeting agents
EP2403856B1 (en) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2208659A1 (en) * 1972-10-19 1974-06-28 Kanebo Ltd 13-Alkyl, alkoxy or allyl berberrubin derivatives - anticancer agents, prepd by demethylation of a 13-subst berberine salt
US3910938A (en) * 1973-01-27 1975-10-07 Kanebo Ltd Berbine derivatives
GB1491358A (en) * 1976-06-04 1977-11-09 Kanebo Ltd Pharmaceutical materials
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩

Also Published As

Publication number Publication date
EP0184118A1 (en) 1986-06-11
DE3564434D1 (de) 1988-09-22
EP0184118B1 (en) 1988-08-17
JPH0469632B2 (OSRAM) 1992-11-06
US4761477A (en) 1988-08-02

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