JPS61122209A - Cosmetic composition for preventing skins from staining and spotting - Google Patents

Abstract

PURPOSE:The titled composition that is obtained by adding a powder and/or extract of ginseng to a composition for preventing skins from staining, containing essences of specific plants such as Moutan cortex, thus showing increased absorbability through skins and strengthened effect of preventing skins from staining. CONSTITUTION:The objective composition which is used as a cosmetic or lotion for preventing skins from staining is prepared by adding (A) a powder and/or essence of ginseng and/or nontoxicated Aconiti Tuber for accelerating absorption of components B through skins to (B) extracts of herbs having activity of preventing skins from staining such as Moutan Cortex, Paeoniae Radix, Ceranii Herba, Burdock, Coicis Semen, Seseleos Radix, Scutellariae Radix, Glycyrrrhizc Radix, Purrariae Radix, preferably extracts from Moutan cortex, etc., containing gallic acids, especially compounds of formula I or formula Ii (G is gallic acid).

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention relates to a stain-preventing cosmetic composition, and the purpose thereof is to use it as a lotion or auxiliary skin cosmetic to have an extremely high stain-preventing effect and to obtain the essential ingredients contained therein. The main ingredient is a specific plant that has traditionally been allowed to be added to food as an oral herbal medicine or a food additive, or an extract containing a gallic acid compound, which is a specific component in that specific plant, and in addition to this main ingredient, these ingredients An anti-stain product with excellent absorption and an extremely high anti-stain effect, which is characterized by containing as essential ingredients at least a plant powder of ginseng, detoxified aconite, and/or an extract thereof. An object of the present invention is to provide a cosmetic composition.

(Prior Art and Its Disadvantages) Conventionally, anti-blemish cosmetics such as sunscreen creams contain medicinal ingredients that inhibit tyrosinase activity, such as placenta.

This placenta is an extract of the human body's placenta, which is difficult to obtain, and because it is obtained from the placenta as a raw material, its supply is limited and it is extremely expensive. .

The medicinal effect of placenta is mainly to inhibit the activity of tyrosinase, an enzyme that produces melanin from tyrosine, and by inhibiting the activity of tyrosinase, it prevents melanin pigment from being deposited on the skin, thereby reducing age spots. It is thought to have the effect of suppressing the occurrence of.

However, a substitute for this tyrosinase that has an effect comparable to that of tyrosinase has not yet been found.

In light of the above-mentioned circumstances, the inventors conducted extensive research and identified a stain-preventing cosmetic composition that is easily available from placenta, has excellent tyrosinase activity inhibiting ability, and also contains highly safe ingredients. It has already been discovered and revealed that extracts extracted from plants and specific components thereof have the ability to inhibit tyrosinase activity to the same extent as placenta, but this invention further improves the skin absorption ability of this previously disclosed invention. The aim is to further improve the stain prevention effect.

(Solution Means) This invention further deepens the research on this extract by extracting from a specific plant a component that has the ability to inhibit tyrosinase activity to the same extent as placenta, which is the result of the previously disclosed research by the inventors. This invention has been completed as a result of the above, and the present invention is based on an extract of at least one of button skin, peony, gennoshoko, gopoushi, yokuinin, boufu, scutellariae, horse chestnut, cuckoo, licorice, and pear fruit, or from button skin and peony. The extracted following formula (1
) or (2), an extract containing a gallic acid compound as shown in (2), and a powder of at least one plant among ginseng and detoxified aconite, which promotes the skin absorption of these ingredients, and/or an extract thereof as essential ingredients. The present invention relates to a stain-preventing cosmetic composition containing:

What is the button skin used in this invention? - Paeoniaceae Paenoi
amoutan 51m5) is dried root bark.

The peony (medicine) used in this invention is the dried or steam-dried root of the peony (Paeonia 1actiflora), a perennial plant of the Paeonaceae family (Paeoniaceae), which has traditionally been used as an analgesic in Chinese medicine. means.

In order to use button skin (Bodanpi) or peony (Xunyaku) used in this invention as a compounding ingredient according to this invention, it is recommended to use an extract extracted with water, water-soluble alcohol (ethanol or methanol), or acetone. desirable.

This extraction method involves drying and pulverizing peonies or peonies, degreasing them with a degreasing solvent, or adding 3 to 10 times the volume of water-soluble alcohol (without degreasing).
ethanol or methanol) or acetone (concentration: 5
0x or less) as an extraction solvent under reflux,
Extract while heating for about 2 hours.

Then, the extraction solvent is distilled off under reduced pressure to dryness or
Concentrate to about 0-175.

Even at this stage, this component can be an essential component used in this invention.

If necessary, this powder or extract is hydrolyzed with a 5χIICI solution or the like.

Although this hydrolysis step is not always necessary, if it is necessary to take out gallic acid alone, this hydrolysis step is added to separate glucose and gallic acid.

The button skin (Paeoniacea) obtained in this way
A stain-preventing cosmetic composition according to the present invention is prepared by using an extract containing a gallic acid compound represented by the preceding formula (1) or (2) extracted from Paeonia lactiflora and Paeonia lactiflora. These extracts or gallic acid compounds are 10mg = 1000mg as extract content.
Mix to the desired extent.

Further, one or more of these extracts may be mixed and blended.

Gennoshoko used in this invention is also known as “
It is a perennial herb of the Phyllantaceae family that is so famous as an anti-diarrheal agent that it is called ``the current evidence'', and it is used by drying it.

The burdock (half) used in this invention is a member of the Asteraceae family (Comp) whose root is commonly used as a vegetable.

s i tae) perennial half (Arctii Fru
ctus) is the dried mature fruit.

Yokuinin used in this invention is a member of the Poaceae family (Graminaceae).
inae) Coix lacryma-
jobi L.

var, ma-yuen 5 tapf) is the dried mature seed from which the seed coat has been removed.

The bofuu used in this invention is a member of the Apiaceae family (Umbel family).
Liferae's Boufuu (Ledebouriel)
It refers to the dried roots of plants such as La 5eseloides W,).

The scutellariae used in this invention is a member of the Lamiaceae family (Labiaceae).
tae) Scutllaria bai
Calensis Georgf) dried root.

Horse chestnut fleas (Hachi esculu) used in this invention.
s Gurbinata Balune) is a fruit of the family Cucurbitaceae, and usually refers to the extract of this fruit.

The cacao used in this invention is a member of the Fabaceae (Legum) family.
inosae) scum (Pueraria 1obat)
It refers to the dried roots of a O,).

The licorice used in this invention is from the Fabaceae family (L.
It refers to the dried perennial roots of the genus Eguminosae.

The pear fruit used in this invention refers to the fruit of a deciduous tree belonging to the Rosaceae family, Pear genus.

It is desirable to use an extract extracted with water or water-soluble alcohol (ethanol) as the above-mentioned ingredients used in this invention.

These extracts are at least 10 mg to 100 mg as an extract when blended into a stain-preventing cosmetic composition.
Mix to the desired extent.

Further, it is desirable that these extracts be mixed in an amount of at least IM or more.

Panax ginseng (Pana spp.) used in this invention
chinseng Nees) is a member of the Araliaceae family (Araxaceae).
This refers to the root of the so-called Panax ginseng, which is a plant (A. In this invention, it is believed that the roots of such ginseng can be effectively used, but the above-ground parts and all parts can be used without being limited to the roots.

Detoxified aconite (^conitu) used in this invention
m chinense 5ieb, et Zucc,)
What is Aconitum chinense?
5ieb, et Zucc,).

Incidentally, aconite (Aconitum chinens)
e 5ieb, et Zucc,) is a family of Ranunculaceae (
It is a perennial plant of the Acon i tum) family that is generally cultivated, and its common name is aconite.

All related plants such as Aconite and its relatives, such as Aconite, Octopus, Aconite, and Aconite, can be preferably used, and dried tuberous roots of such plants can be preferably used.

The detoxified aconite used in this invention is preferably a detoxified aconite tuberous root.

That is, such aconite generally contains alkaloids such as aconitine or atisnene, and such alkaloids are particularly toxic, such as paralyzing the respiratory center, causing heart failure, paralyzing the circulatory system, and impairing sensory and motor nerves. It has toxic effects such as paralysis.

Therefore, in the present invention, detoxified products from which alkaloids such as aconitine or atisnene have been removed can be suitably used.

This detoxification method means that these alkaloids are soluble in chloroform, so the alkaloids can be removed by immersing them in chloroform. Detoxification methods can be adopted such as soaking in salt water and then drying or semi-drying, and products detoxified by such methods can be used.

In order to incorporate such ginseng or detoxified aconite into the stain-preventing cosmetic composition according to the present invention, ginseng or detoxified aconite may be made into fine powder as it is, or it may be mixed with water or hot water (120 ml).
-150'c) and then concentrated under reduced pressure to about 10χ, dry extract of this concentrate, dry powder or 'a
It may be used as a shrunken extract.

In this invention, the pharmacological explanation of why ginseng or detoxified aconite promoted the skin absorption of the ingredients is still unclear, but this is the inventor's reasoning. According to the authors, these ingredients act on cell membranes to produce CAMP (cyclic adenosine-3', 5'-phosphate), which activates intracellular protein kinases and activates the activated protein kinases. We believe that this may have the effect of improving the physiological functions of proteins in cell membranes, thereby increasing the permeability of cell membrane components.

In addition, in this invention, 50 parts per 100 parts of the compounded ingredients.
~300 parts (as a powder, in the case of an extract, half the amount of powder is sufficient) of ginseng or detoxified aconite may be blended.

In order to prepare the stain-preventing cosmetic composition according to the present invention using the above ingredients and absorption enhancer, other ingredients such as moisturizers, softeners, solvents, oils and fats, fragrances, antioxidants, etc. may be added as appropriate. Mix.

(Effects) As detailed above, the stain-preventing cosmetic composition according to the present invention can be applied to button skin, peonies, burdock, burdock,
Yokuinin, Bofuu, Scutellariae, Toyochinomi,
A stain-preventing cosmetic composition containing, as essential ingredients, an extract of at least one of Cucumber, Licorice, and Pear fruits, and a powder of at least one of plants such as Ginseng and detoxified aconite, and/or an extract thereof. Therefore, if used as a lotion or auxiliary skin cosmetic, it will have an extremely high stain suppression effect, and its essential ingredients can be found in or in specific plants that have been allowed to be added to foods as oral herbal medicines or food additives. It is an extract containing gallic acid compound, which is a specific component of ginseng, and is extremely safe.In addition to this main component, it also contains powder of at least one plant such as ginseng and detoxified aconite, which promotes skin absorption of these components. And/or because it contains this extracted extract as an essential component, these stain-preventing ingredients are absorbed well into the skin, resulting in a stain-preventing cosmetic composition with an extremely high stain-preventing effect.

Next, the effects of this invention will be made clearer by describing Examples, Comparative Examples, and Test Examples of this invention.

Examples and comparative examples A stain prevention lotion with the following composition was prepared.

In addition, in this composition, (A) button skin, (13) rhododendron, (C) scutellariae, (b) 50% ethanol extract, (E) gennoshoko, (F) burdock, (G) toyotochinomi, CII) Kakkon, (1) Gennoshoko uses 3Ox ethanol extract, (J) Licorice, (K) Pear fruit uses water extract, and (L)
Gallic acid (formula (1)) and (M) gallic acid (formula (2)) were used.

Detoxified aconite powder or ginseng powder was added in an amount three times that of the extract.

As the ginseng powder, a freeze-dried product of a commercially available concentrated ginseng strain (Korean Ginseng Products Corporation type) was used, and as the detoxified aconite, a commercially available ginseng was pulverized as it was.

Glycerin 58o(χ) Polyethylene glycol 0.2 Surfactant 2゜Ooleyl alcohol 0.1 Ethanol 15.0 Fragrance 0.1 Extract (8) to (M) 0.05 Absorption enhancer
0.15 Coloring agent Purified water Remaining total 100ml Examples (A) to (M) contained all of the above compositions, and Comparative Examples (A) to (M) excluded only the absorption enhancer from the above compositions. I took it as a thing.

In addition, the absorption enhancer in Examples is Example (A) 5.
- (E) used detoxified aconite, and Examples (F) - (M) used ginseng.

Test Example 1 Anti-stain lotions (A) to (M) obtained in the above Examples and Comparative Examples (8) to (M) and conventional examples in which Plan Center was blended without using extracts or absorption enhancers, respectively. Ten women of makeup age each used stain-preventing lotion (
A total of 270 people (18 to 45 years old) used the product daily for two weeks, and the effects thereafter were investigated.

Observations were made to see if the stains were reduced.

The results are shown in Table 1.

(Left below) 1 Example A19 1 Comparative Example A18 1 1 Example BIIO + Comparative Example B19 1 1 Example CI8 1 Comparative Example CI7 11 Example D1
9 1 Comparative Example D18 (1 Example E18 1 Comparative Example E
16! I Example F19 1 Comparative Example F16 1 1 Example G19 1 Comparative Example G17 11 Example H18
1 Comparative Example H151 1 Example 119 1 Comparative Example 117 1 1 Example J19 1 Comparative Example J16 1 1 to Example 17 1 Comparative Example to 16 1 1 Example to 18 (Comparative Example L+7 1'Top! Ink Plate
Any1 Comparative Example M16 1'16 The effective example of the example has a minimum of 70x, and there is also a compounded component that shows an effect of 100x, which shows that it has a better effect than the comparative example and the conventional example.

Test Example 2 The tyrosinase inhibitory activity of the ingredients was determined by quantifying dopachrome (Shimano's method).

L-tyrosine (1 mg/1 ml) 0.5 ml, tyrosinase l m g =4000V/ml) 0.5 ml,
2 ml of phosphate buffer (Pt16.8.0.1M), each component (A) to (M) as an aqueous solution of 0.1χ, 2.0
ml added, relatively hydroquinone 0.01χ and 0.0
Two cases of 01χ and 2 ml each of placenta were added.

The results are summarized in Table 2.

(Left below) Table 2 1 Tyrosinase activity 1%
) l Hydroquinone 0. O1χ 110011 Hydroquinone o, ooiχ1 10 11 Placenter 1 18 11 Extract A
11001 1,, B l 9011〃Cl
701 1〃p l 601'1〃E
l 8011,,F
I 8011〃G I
6011 〃 H1501 1~ i l 80 11
~ J l 40 +1
,,K l 4011〃L
l 601〃 M
As is clear from the results of 80 or more, the stain-preventing cosmetic composition according to the present invention has excellent effects.

Claims (4)

[Claims] (1) An extract of at least one of the following: button peel, peony, gennoshoko, burdock, yokuinin, burdock, scutellariae, horse chestnut, cuckoo, licorice, and pear fruit, and at least one plant among ginseng and detoxified aconite. A stain-preventing cosmetic composition containing a powder and/or an extract thereof as an essential ingredient. (2) The button skin (Paeoniaceae Pae)
noia moutan Sims), Peony (P
2. The stain-preventing cosmetic composition according to claim 1, wherein the extract extracted from Aeonia lactiflora is a gallic acid compound. (3) The stain-preventing cosmetic composition according to claim 1, wherein the gallic acid compound is gallic acid (formula (1)). ▲There are mathematical formulas, chemical formulas, tables, etc.▼Formula (1) (4) Claim 1, wherein the gallic acid compound is a gallic acid compound represented by the following formula (2).
The stain-preventing cosmetic composition described in Section 1. ▲There are mathematical formulas, chemical formulas, tables, etc.▼Formula (2) (G) = gallic acid 1a:n=0 1b:n=1 1c:n=2-5