CN109157448A - A kind of Saussurea involucrata extract and its preparing the application in cosmetics - Google Patents
A kind of Saussurea involucrata extract and its preparing the application in cosmetics Download PDFInfo
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- CN109157448A CN109157448A CN201811150858.0A CN201811150858A CN109157448A CN 109157448 A CN109157448 A CN 109157448A CN 201811150858 A CN201811150858 A CN 201811150858A CN 109157448 A CN109157448 A CN 109157448A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses a kind of Saussurea involucrata extracts, the Saussurea involucrata extract by weight percentage containing 0.5%~1.2% Syringin, 7%~17% chlorogenic acid and 8%~25% rutin, Saussurea involucrata extract obtains in the steps below: S1, taking saussurea involucrata, it crushes, it places into extractor, ethyl alcohol extracts, combined extract；S2, extracting solution is filtered, is cooling, being centrifuged to obtain supernatant；S3, supernatant is taken, is concentrated to give concentrate；S4, above-mentioned concentrate addition macroreticular resin is taken to be purified, it is eluted again with ethyl alcohol, Fractional Collections efflux, dried cream powder is made in efflux concentration thick paste, obtain Saussurea involucrata extract, supernatant is concentrated using MVR evaporator in the present invention, it runs smoothly, high degree of automation, low-power consumption, low operating cost, and simple process, it is practical, sub-load service performance is excellent, and Saussurea involucrata extract has in cosmetics absorbs the functions such as ultraviolet light, anti-radiation, anti-inflammatory and antalgic and anti-aging.
Description
Technical field
Technical field more particularly to a kind of saussurea involucrata the present invention relates to Saussurea involucrata extract and its in cosmetic applications are extracted
Object and its preparing the application in cosmetics.
Background technique
Saussurea involucrata is the important medicinal plant of China western part alpine region, and saussurea involucrata is warm-natured, mildly bitter flavor, enters liver,spleen,kidney warp, tool
There is dispelling cold and removing dampness, blood circulation, strengthening tendons and supporing Yang, anti-inflammatory and antalgic, shrink the functions such as uterus, is clinically used for treatment rheumatism joint
The diseases such as inflammation, women's cold and pain in the lower abdomen, amenorrhoea, measles without adequate eruption, lung cold cough, impotence, high mountain be inadaptable.Saussurea involucrata is carried out both at home and abroad
In-depth study mainly contains the chemistry such as Phenylpropanoid Glycosides, flavones, alkaloid, terpene, lactone, polysaccharide, volatile oil, steroidal in saussurea involucrata
Ingredient, modern pharmacology experiment show that general flavone in saussurea involucrata, Phenylpropanoid Glycosides are main actives.
Saussurea involucrata extract exists in cosmetics to be widely applied, but is existed when concentration in Saussurea involucrata extract
Concentrated cost is high, energy consumption is high, and the disadvantage that the degree of automation is low.
Therefore, it is used to solve above-mentioned ask we have proposed a kind of Saussurea involucrata extract and its preparing the application in cosmetics
Topic.
Summary of the invention
The purpose of the present invention is to solve concentrated costs existing in the prior art high, energy consumption height and the degree of automation
Low disadvantage, and a kind of Saussurea involucrata extract that proposes and its preparing the application in cosmetics.
A kind of Saussurea involucrata extract, the Saussurea involucrata extract by weight percentage containing 0.5%~1.2% Syringin,
7%~17% chlorogenic acid and 8%~25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, the second for being 60%~90% with concentration
6~12 times of amounts of alcohol are extracted 2~4 times, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 3500r/
Min~5000r/min is centrifuged 10~20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, concentration time is 20~30 minutes, obtains every milliliter containing life
The concentrate of medicine 0.1g~0.5g；
S4, above-mentioned concentrate tune pH value is taken to be 1~5, addition macroreticular resin is purified, and loading volume is 3BV~6BV,
Water removal solution impurity is sloughed with 3BV~6BV acid-water washing, then is eluted with ethyl alcohol, Fractional Collections efflux, efflux adds
It is concentrated in MVR evaporator, being concentrated into temperature is 20 DEG C, the thick paste or dried cream powder is made that relative density is 1.05~1.20,
Obtain Saussurea involucrata extract.
Preferably, 6~12 times of amounts of ethyl alcohol extraction 2~4 times for being 60%~90% with concentration in the S1, every time 1~3
Hour.
Preferably, macroreticular resin is one of AB-8, D101, HPD100, HPD400 and HPD600, column in the S2
Diameter height compares for 1:5~1:9.
Preferably, temperature is 50~70 DEG C when evaporation when being concentrated in MVR evaporator in the S3.
Preferably, washing steps are twice, to use the ethyl alcohol and 2BV~6BV of 2BV~6BV 30% respectively in the S4
50% ethyl alcohol is eluted.
Preferably, the Saussurea involucrata extract is applied to absorb the makeup of ultraviolet light, anti-radiation, anti-inflammatory and antalgic and anti-aging
Product.
The beneficial effects of the present invention are:
1, supernatant is concentrated using MVR evaporator in the present invention, run smoothly, high degree of automation is low
Power consumption, low operating cost, and simple process, practical, sub-load service performance is excellent.
2, Saussurea involucrata extract has absorption ultraviolet light, anti-radiation, anti-inflammatory and antalgic and anti-aging in cosmetics in the present invention
Etc. functions.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one:
A kind of Saussurea involucrata extract, Saussurea involucrata extract is by weight percentage containing 1.2% Syringin, 17% chlorogenic acid
With 25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, with 8 times of the ethyl alcohol amounts that concentration is 70%
Extraction 3 times, 2 hours every time, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 4500r/
Min is centrifuged 20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, temperature is 50 DEG C, and concentration time is 30 minutes, is obtained often
The concentrate of milliliter contained 0.3g；
S4, above-mentioned concentrate tune pH value is taken to be 3, addition macroreticular resin is purified, loading volume 4BV, with 4BV sour water
Elution removal aqueous solution impurity, then eluted twice with the ethyl alcohol of 4BV 30% and the ethyl alcohol of 4BV 50%, Fractional Collections stream
Liquid out, efflux are added in MVR evaporator and are concentrated, be concentrated into temperature be 20 DEG C, relative density be 1.05 thick paste or
Dried cream powder is made to get Saussurea involucrata extract is arrived；
Embodiment two:
A kind of Saussurea involucrata extract, Saussurea involucrata extract is by weight percentage containing 1.2% Syringin, 17% chlorogenic acid
With 25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, with 8 times of the ethyl alcohol amounts that concentration is 70%
Extraction 3 times, 2 hours every time, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 4500r/
Min is centrifuged 20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, temperature is 55 DEG C, and concentration time is 30 minutes, is obtained often
The concentrate of milliliter contained 0.3g；
S4, above-mentioned concentrate tune pH value is taken to be 3, addition macroreticular resin is purified, loading volume 4BV, with 4BV sour water
Elution removal aqueous solution impurity, then eluted twice with the ethyl alcohol of 4BV 30% and the ethyl alcohol of 4BV 50%, Fractional Collections stream
Liquid out, efflux are added in MVR evaporator and are concentrated, be concentrated into temperature be 20 DEG C, relative density be 1.05 thick paste or
Dried cream powder is made to get Saussurea involucrata extract is arrived；
Embodiment three:
A kind of Saussurea involucrata extract, Saussurea involucrata extract is by weight percentage containing 1.2% Syringin, 17% chlorogenic acid
With 25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, with 8 times of the ethyl alcohol amounts that concentration is 70%
Extraction 3 times, 2 hours every time, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 4500r/
Min is centrifuged 20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, temperature is 60 DEG C, and concentration time is 30 minutes, is obtained often
The concentrate of milliliter contained 0.3g；
S4, above-mentioned concentrate tune pH value is taken to be 3, addition macroreticular resin is purified, loading volume 4BV, with 4BV sour water
Elution removal aqueous solution impurity, then eluted twice with the ethyl alcohol of 4BV 30% and the ethyl alcohol of 4BV 50%, Fractional Collections stream
Liquid out, efflux are added in MVR evaporator and are concentrated, be concentrated into temperature be 20 DEG C, relative density be 1.05 thick paste or
Dried cream powder is made to get Saussurea involucrata extract is arrived；
Example IV:
A kind of Saussurea involucrata extract, Saussurea involucrata extract is by weight percentage containing 1.2% Syringin, 17% chlorogenic acid
With 25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, with 8 times of the ethyl alcohol amounts that concentration is 70%
Extraction 3 times, 2 hours every time, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 4500r/
Min is centrifuged 20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, temperature is 65 DEG C, and concentration time is 30 minutes, is obtained often
The concentrate of milliliter contained 0.3g；
S4, above-mentioned concentrate tune pH value is taken to be 3, addition macroreticular resin is purified, loading volume 4BV, with 4BV sour water
Elution removal aqueous solution impurity, then eluted twice with the ethyl alcohol of 4BV 30% and the ethyl alcohol of 4BV 50%, Fractional Collections stream
Liquid out, efflux are added in MVR evaporator and are concentrated, be concentrated into temperature be 20 DEG C, relative density be 1.05 thick paste or
Dried cream powder is made to get Saussurea involucrata extract is arrived；
Embodiment five:
A kind of Saussurea involucrata extract, Saussurea involucrata extract is by weight percentage containing 1.2% Syringin, 17% chlorogenic acid
With 25% rutin, Saussurea involucrata extract obtains in the steps below:
S1, saussurea involucrata is taken, is added in grinding ware and is crushed, is placed into extractor, with 8 times of the ethyl alcohol amounts that concentration is 70%
Extraction 3 times, 2 hours every time, combined extract；
S2, it is added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjusting revolving speed is 4500r/
Min is centrifuged 20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, temperature is 70 DEG C, and concentration time is 30 minutes, is obtained often
The concentrate of milliliter contained 0.3g；
S4, above-mentioned concentrate tune pH value is taken to be 3, addition macroreticular resin is purified, loading volume 4BV, with 4BV sour water
Elution removal aqueous solution impurity, then eluted twice with the ethyl alcohol of 4BV 30% and the ethyl alcohol of 4BV 50%, Fractional Collections stream
Liquid out, efflux are added in MVR evaporator and are concentrated, be concentrated into temperature be 20 DEG C, relative density be 1.05 thick paste or
Dried cream powder is made to get Saussurea involucrata extract is arrived；
Embodiment six: (cosmetics that preparation prevents skin aging)
55 parts of Saussurea involucrata extract made from Example three, and 32 parts of sturgeon roe sauce extract and great Hua cactus is taken to extract
13 parts of object, 10% mixture is taken after mixing, and 25% propylene glycol moisturizer, 24% laureth sodium sulfovinate table is added
Face activating agent, 0.4% preservative and 1.5% xanthan gum thickener, and be added after water mixing to be made and prevent the change of skin aging
Cosmetic.
By one~embodiment of embodiment three it is found that temperature when being concentrated using MVR evaporator deposits the quality of concentration
It is centainly influencing, specific experiment situation is as shown in the table:
As seen from the above table, temperature of the MVR evaporator when being concentrated has a certain impact to the quality of concentration, and 60
DEG C or so be optimum temperature.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of Saussurea involucrata extract, which is characterized in that the Saussurea involucrata extract is by weight percentage containing 0.5%~1.2%
Syringin, 7%~17% chlorogenic acid and 8%~25% rutin, Saussurea involucrata extract obtain in the steps below:
S1, take saussurea involucrata, be added in grinding ware and crushed, placed into extractor, with concentration be 60%~90% ethyl alcohol 6~
12 times of amounts are extracted 2~4 times, combined extract；
S2, be added in centrifuge to extracting solution filtering, cooling, then by extracting solution after cooling, adjustings revolving speed for 3500r/min~
5000r/min is centrifuged 10~20 minutes, obtains supernatant after static；
S3, supernatant is taken, is added in MVR evaporator and is concentrated, concentration time is 20~30 minutes, obtains every milliliter contained
The concentrate of 0.1g~0.5g；
S4, above-mentioned concentrate tune pH value is taken to be 1~5, addition macroreticular resin is purified, and loading volume is 3BV~6BV, uses 3BV
~6BV acid-water washing sloughs water removal solution impurity, then is eluted with ethyl alcohol, Fractional Collections efflux, and efflux adds MVR steaming
It is concentrated in hair device, being concentrated into temperature is 20 DEG C, the thick paste or dried cream powder is made to get arriving that relative density is 1.05~1.20
Saussurea involucrata extract.
2. a kind of Saussurea involucrata extract according to claim 1, which is characterized in that using concentration in the S1 is 60%~90%
6~12 times of amounts of ethyl alcohol extract 2~4 times, every time 1~3 hour.
3. a kind of Saussurea involucrata extract according to claim 1, which is characterized in that in the S2 macroreticular resin be AB-8,
One of D101, HPD100, HPD400 and HPD600, column diameter height compare for 1:5~1:9.
4. a kind of Saussurea involucrata extract according to claim 1, which is characterized in that carried out in MVR evaporator in the S3
Temperature is 50~70 DEG C when evaporation when concentration.
5. a kind of Saussurea involucrata extract according to claim 1, which is characterized in that washing steps are twice, to divide in the S4
It is not eluted using the ethyl alcohol of the ethyl alcohol of 2BV~6BV 30% and 2BV~6BV 50%.
6. a kind of Saussurea involucrata extract is preparing the application in cosmetics, which is characterized in that the Saussurea involucrata extract is applied to absorb
The cosmetics of ultraviolet light, anti-radiation, anti-inflammatory and antalgic and anti-aging.
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| CN201811150858.0A CN109157448A (en) | 2018-09-29 | 2018-09-29 | A kind of Saussurea involucrata extract and its preparing the application in cosmetics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113768811A (en) * | 2021-10-18 | 2021-12-10 | 天津尚美化妆品有限公司 | Application of syringin in preparation of composition for improving skin elasticity and wrinkle |
| CN115028751A (en) * | 2022-06-15 | 2022-09-09 | 中国科学院新疆理化技术研究所 | Preparation method and application of saussurea involucrate polysaccharide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113768811A (en) * | 2021-10-18 | 2021-12-10 | 天津尚美化妆品有限公司 | Application of syringin in preparation of composition for improving skin elasticity and wrinkle |
| CN115028751A (en) * | 2022-06-15 | 2022-09-09 | 中国科学院新疆理化技术研究所 | Preparation method and application of saussurea involucrate polysaccharide |
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