JPS606946B2 - Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法 - Google Patents

Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法

Info

Publication number
JPS606946B2
JPS606946B2 JP49027745A JP2774574A JPS606946B2 JP S606946 B2 JPS606946 B2 JP S606946B2 JP 49027745 A JP49027745 A JP 49027745A JP 2774574 A JP2774574 A JP 2774574A JP S606946 B2 JPS606946 B2 JP S606946B2
Authority
JP
Japan
Prior art keywords
diphenylpropyl
mol
piverazine
moles
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP49027745A
Other languages
English (en)
Japanese (ja)
Other versions
JPS50121285A (enExample
Inventor
忠之 鈴木
敏治 恵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Priority to JP49027745A priority Critical patent/JPS606946B2/ja
Priority to US05/555,827 priority patent/US3957790A/en
Priority to DE19752511022 priority patent/DE2511022C3/de
Priority to FR7507614A priority patent/FR2263775A1/fr
Publication of JPS50121285A publication Critical patent/JPS50121285A/ja
Publication of JPS606946B2 publication Critical patent/JPS606946B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP49027745A 1974-03-12 1974-03-12 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法 Expired JPS606946B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP49027745A JPS606946B2 (ja) 1974-03-12 1974-03-12 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法
US05/555,827 US3957790A (en) 1974-03-12 1975-03-06 N-(3,3-diphenylpropyl)-n'-aralkyl-substituted piperazines
DE19752511022 DE2511022C3 (de) 1974-03-12 1975-03-11 N-(3,3-Diphenylpropyl)-N' -benzylpiperazine
FR7507614A FR2263775A1 (enExample) 1974-03-12 1975-03-11

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49027745A JPS606946B2 (ja) 1974-03-12 1974-03-12 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法

Publications (2)

Publication Number Publication Date
JPS50121285A JPS50121285A (enExample) 1975-09-23
JPS606946B2 true JPS606946B2 (ja) 1985-02-21

Family

ID=12229554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP49027745A Expired JPS606946B2 (ja) 1974-03-12 1974-03-12 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法

Country Status (3)

Country Link
US (1) US3957790A (enExample)
JP (1) JPS606946B2 (enExample)
FR (1) FR2263775A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53112886A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
JPS53112887A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
IT1156989B (it) * 1978-04-27 1987-02-04 Geymonat Sud Spa Procedimento per la preparazione della i.4 bis piperonil piperazina e dei composti analoghi
ATE10193T1 (de) * 1980-06-16 1984-11-15 Ab Ferrosan Diphenylbutyl-1-acylpiperazine.
HU186656B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
WO1990013539A1 (fr) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. Nouveaux derives de piperazine a substitution n et medicament de traitement des troubles fonctionnels du cerveau
JP2679872B2 (ja) * 1989-04-28 1997-11-19 明治製菓株式会社 Ｎ−置換ピペラジン誘導体を含む脳機能障害改善剤

Also Published As

Publication number Publication date
DE2511022A1 (de) 1975-09-18
FR2263775A1 (enExample) 1975-10-10
DE2511022B2 (de) 1976-09-30
JPS50121285A (enExample) 1975-09-23
US3957790A (en) 1976-05-18

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