JPS6044318B2 - ステロイダル〔１６ａ，１７‐ｂ〕ナフタリン類の製法 - Google Patents
ステロイダル〔１６ａ，１７‐ｂ〕ナフタリン類の製法Info
- Publication number
- JPS6044318B2 JPS6044318B2 JP50141543A JP14154375A JPS6044318B2 JP S6044318 B2 JPS6044318 B2 JP S6044318B2 JP 50141543 A JP50141543 A JP 50141543A JP 14154375 A JP14154375 A JP 14154375A JP S6044318 B2 JPS6044318 B2 JP S6044318B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- chloroform
- compound
- hydrogen
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 150000002790 naphthalenes Chemical class 0.000 title claims description 4
- 230000003637 steroidlike Effects 0.000 title claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 20
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 9
- 150000003431 steroids Chemical class 0.000 claims description 8
- 125000004423 acyloxy group Chemical group 0.000 claims description 7
- -1 benzocyclobutene compound Chemical class 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Substances ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 7
- OQNGCCWBHLEQFN-UHFFFAOYSA-N chloroform;hexane Chemical compound ClC(Cl)Cl.CCCCCC OQNGCCWBHLEQFN-UHFFFAOYSA-N 0.000 description 7
- 239000012299 nitrogen atmosphere Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- SKCNIGRBPJIUBQ-UHFFFAOYSA-N chloroform;ethyl acetate Chemical compound ClC(Cl)Cl.CCOC(C)=O SKCNIGRBPJIUBQ-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- UMIVXZPTRXBADB-UHFFFAOYSA-N benzocyclobutene Chemical compound C1=CC=C2CCC2=C1 UMIVXZPTRXBADB-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KDCIHNCMPUBDKT-UHFFFAOYSA-N hexane;propan-2-one Chemical compound CC(C)=O.CCCCCC KDCIHNCMPUBDKT-UHFFFAOYSA-N 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Chemical group 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- FJIDKRPZJBUHME-UHFFFAOYSA-N bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile Chemical compound C1=CC=C2C(C#N)CC2=C1 FJIDKRPZJBUHME-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- NWSBNVVOFKKFNV-UHFFFAOYSA-N chloroform;oxolane Chemical compound ClC(Cl)Cl.C1CCOC1 NWSBNVVOFKKFNV-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- ZRSDQBKGDNPFLT-UHFFFAOYSA-N ethanol;oxolane Chemical compound CCO.C1CCOC1 ZRSDQBKGDNPFLT-UHFFFAOYSA-N 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 150000003128 pregnanes Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/526,866 US3937720A (en) | 1974-11-25 | 1974-11-25 | Steroidal[16α,17-β]naphthalenes |
| US526866 | 1990-05-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5176258A JPS5176258A (en) | 1976-07-01 |
| JPS6044318B2 true JPS6044318B2 (ja) | 1985-10-02 |
Family
ID=24099134
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50141543A Expired JPS6044318B2 (ja) | 1974-11-25 | 1975-11-25 | ステロイダル〔１６ａ，１７‐ｂ〕ナフタリン類の製法 |
| JP59191428A Granted JPS6163693A (ja) | 1974-11-25 | 1984-09-11 | ステロイダル〔１６α，１７−ｂ〕ナフタリン類の製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59191428A Granted JPS6163693A (ja) | 1974-11-25 | 1984-09-11 | ステロイダル〔１６α，１７−ｂ〕ナフタリン類の製法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3937720A (en, 2012) |
| JP (2) | JPS6044318B2 (en, 2012) |
| BE (1) | BE835912A (en, 2012) |
| CA (1) | CA1055014A (en, 2012) |
| CH (1) | CH608813A5 (en, 2012) |
| DE (1) | DE2551562C2 (en, 2012) |
| DK (1) | DK528575A (en, 2012) |
| FR (1) | FR2291762A1 (en, 2012) |
| GB (1) | GB1512400A (en, 2012) |
| HU (1) | HU173528B (en, 2012) |
| IE (1) | IE43305B1 (en, 2012) |
| NL (1) | NL7513392A (en, 2012) |
| SE (1) | SE412241B (en, 2012) |
| ZA (1) | ZA757055B (en, 2012) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091036A (en) * | 1977-05-12 | 1978-05-23 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives |
| US4164504A (en) * | 1978-06-26 | 1979-08-14 | E. R. Squibb & Sons, Inc. | Steroidal[16α,17-b]naphthaleno-21-carboxylic acid esters |
| US4213912A (en) * | 1979-04-26 | 1980-07-22 | E. R. Squibb & Sons, Inc. | Process for preparing steroidal [16α,17-d]cyclohexene-21-carboxylic acid esters |
| US4447426A (en) * | 1982-01-18 | 1984-05-08 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
| US4391755A (en) * | 1982-01-18 | 1983-07-05 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
-
1974
- 1974-11-25 US US05/526,866 patent/US3937720A/en not_active Expired - Lifetime
-
1975
- 1975-11-07 IE IE2443/75A patent/IE43305B1/en unknown
- 1975-11-07 CA CA239,195A patent/CA1055014A/en not_active Expired
- 1975-11-10 ZA ZA00757055A patent/ZA757055B/xx unknown
- 1975-11-13 GB GB46902/75A patent/GB1512400A/en not_active Expired
- 1975-11-17 DE DE2551562A patent/DE2551562C2/de not_active Expired
- 1975-11-17 NL NL7513392A patent/NL7513392A/xx not_active Application Discontinuation
- 1975-11-24 SE SE7513200A patent/SE412241B/xx not_active IP Right Cessation
- 1975-11-24 CH CH7515209A patent/CH608813A5/xx not_active IP Right Cessation
- 1975-11-24 DK DK528575A patent/DK528575A/da unknown
- 1975-11-24 HU HU75SU905A patent/HU173528B/hu not_active IP Right Cessation
- 1975-11-25 BE BE162152A patent/BE835912A/xx not_active IP Right Cessation
- 1975-11-25 JP JP50141543A patent/JPS6044318B2/ja not_active Expired
- 1975-11-25 FR FR7536002A patent/FR2291762A1/fr active Granted
-
1984
- 1984-09-11 JP JP59191428A patent/JPS6163693A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1512400A (en) | 1978-06-01 |
| JPH0364509B2 (en, 2012) | 1991-10-07 |
| HU173528B (hu) | 1979-06-28 |
| US3937720A (en) | 1976-02-10 |
| DK528575A (da) | 1976-05-26 |
| ZA757055B (en) | 1976-10-27 |
| FR2291762B1 (en, 2012) | 1980-05-30 |
| CH608813A5 (en, 2012) | 1979-01-31 |
| IE43305B1 (en) | 1981-01-28 |
| JPS6163693A (ja) | 1986-04-01 |
| BE835912A (fr) | 1976-05-25 |
| IE43305L (en) | 1976-05-25 |
| AU8662275A (en) | 1977-05-19 |
| DE2551562A1 (de) | 1976-05-26 |
| FR2291762A1 (fr) | 1976-06-18 |
| CA1055014A (en) | 1979-05-22 |
| JPS5176258A (en) | 1976-07-01 |
| NL7513392A (nl) | 1976-05-28 |
| SE7513200L (sv) | 1976-05-26 |
| SE412241B (sv) | 1980-02-25 |
| DE2551562C2 (de) | 1985-05-09 |
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