JPS6026381B2 - ４−ヒドロキシベンゾフエノン類の塩基性エ−テルおよびその製法 - Google Patents
４−ヒドロキシベンゾフエノン類の塩基性エ−テルおよびその製法Info
- Publication number
- JPS6026381B2 JPS6026381B2 JP56018891A JP1889181A JPS6026381B2 JP S6026381 B2 JPS6026381 B2 JP S6026381B2 JP 56018891 A JP56018891 A JP 56018891A JP 1889181 A JP1889181 A JP 1889181A JP S6026381 B2 JPS6026381 B2 JP S6026381B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hydroxybenzophenones
- producing
- penzophenones
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NPFYZDNDJHZQKY-UHFFFAOYSA-N 4-Hydroxybenzophenone Chemical class C1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 NPFYZDNDJHZQKY-UHFFFAOYSA-N 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title description 19
- 150000003839 salts Chemical class 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 150000002170 ethers Chemical class 0.000 claims description 4
- 229910052736 halogen Chemical group 0.000 claims description 4
- 150000002367 halogens Chemical group 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- RUETVLNXAGWCDS-UHFFFAOYSA-N (4-chlorophenyl)-(4-hydroxyphenyl)methanone Chemical compound C1=CC(O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 RUETVLNXAGWCDS-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 1
- -1 filter Substances 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000003944 halohydrins Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19887A/80 | 1980-02-13 | ||
| IT19887/80A IT1147311B (it) | 1980-02-13 | 1980-02-13 | Eteri basici di 4-idrossi-benzofenoni con attivita' quali agenti betabloccanti e relativi procedimento di preparazione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56128742A JPS56128742A (en) | 1981-10-08 |
| JPS6026381B2 true JPS6026381B2 (ja) | 1985-06-24 |
Family
ID=11162071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56018891A Expired JPS6026381B2 (ja) | 1980-02-13 | 1981-02-10 | ４−ヒドロキシベンゾフエノン類の塩基性エ−テルおよびその製法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4376788A (enExample) |
| JP (1) | JPS6026381B2 (enExample) |
| AT (1) | AT374450B (enExample) |
| CA (1) | CA1138897A (enExample) |
| DE (1) | DE3104785A1 (enExample) |
| ES (1) | ES498846A0 (enExample) |
| FR (1) | FR2475540A1 (enExample) |
| GB (1) | GB2068963B (enExample) |
| IT (1) | IT1147311B (enExample) |
| ZA (1) | ZA81946B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208911A (ja) * | 1987-02-26 | 1988-08-30 | Atsugi Motor Parts Co Ltd | 圧力制御弁 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2660198T3 (es) | 2009-07-30 | 2018-03-21 | Igm Group B.V. | Macrofotoiniciadores |
| BR112012020628B1 (pt) | 2010-02-23 | 2019-12-10 | Coloplast As | fotoiniciador de éter polialquílico, uso de um fotoiniciador de éter polialquílico, e, método para curar uma composição de matriz |
| CN102971345A (zh) | 2010-06-22 | 2013-03-13 | 科洛普拉斯特公司 | 来自基于聚烷基醚的光引发剂的亲水性凝胶 |
| SG186779A1 (en) | 2010-06-22 | 2013-02-28 | Coloplast As | Skin-friendly adhesives from polyalkylether-based photoinitiators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3102839A (en) * | 1960-03-04 | 1963-09-03 | West Laboratories Inc | Germicidal compositions |
| LU53667A1 (enExample) * | 1966-07-26 | 1968-11-29 | ||
| GB1185044A (en) * | 1966-11-03 | 1970-03-18 | Ici Ltd | Alkanolamine Derivatives |
| US3553332A (en) * | 1967-06-27 | 1971-01-05 | Hoffmann La Roche | Anti-tubercular benzophenone derivatives |
| SE372762B (enExample) * | 1969-05-21 | 1975-01-13 | Haessle Ab | |
| SE386892B (sv) * | 1972-07-06 | 1976-08-23 | Haessle Ab | Forfarande for framstellning av oxaminoforeningar |
| US4201790A (en) * | 1975-06-20 | 1980-05-06 | May & Baker Limited | Benzophenone derivatives |
| GB1495680A (en) * | 1975-06-20 | 1977-12-21 | May & Baker Ltd | 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes |
| FR2330383A1 (fr) * | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
-
1980
- 1980-02-13 IT IT19887/80A patent/IT1147311B/it active
-
1981
- 1981-01-27 ES ES498846A patent/ES498846A0/es active Granted
- 1981-02-10 JP JP56018891A patent/JPS6026381B2/ja not_active Expired
- 1981-02-11 FR FR8102669A patent/FR2475540A1/fr active Granted
- 1981-02-11 DE DE19813104785 patent/DE3104785A1/de not_active Withdrawn
- 1981-02-12 CA CA000370708A patent/CA1138897A/en not_active Expired
- 1981-02-12 US US06/233,948 patent/US4376788A/en not_active Expired - Fee Related
- 1981-02-12 GB GB8104471A patent/GB2068963B/en not_active Expired
- 1981-02-12 ZA ZA00810946A patent/ZA81946B/xx unknown
- 1981-02-13 AT AT0068781A patent/AT374450B/de not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208911A (ja) * | 1987-02-26 | 1988-08-30 | Atsugi Motor Parts Co Ltd | 圧力制御弁 |
Also Published As
| Publication number | Publication date |
|---|---|
| US4376788A (en) | 1983-03-15 |
| GB2068963B (en) | 1983-06-02 |
| AT374450B (de) | 1984-04-25 |
| ATA68781A (de) | 1983-09-15 |
| FR2475540B1 (enExample) | 1984-09-14 |
| ES8201120A1 (es) | 1981-12-01 |
| IT8019887A0 (it) | 1980-02-13 |
| CA1138897A (en) | 1983-01-04 |
| FR2475540A1 (fr) | 1981-08-14 |
| JPS56128742A (en) | 1981-10-08 |
| DE3104785A1 (de) | 1982-02-25 |
| GB2068963A (en) | 1981-08-19 |
| ZA81946B (en) | 1982-03-31 |
| IT1147311B (it) | 1986-11-19 |
| ES498846A0 (es) | 1981-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU820659A3 (ru) | Способ получени производных 4-амино- 5-АлКилСульфОНилОАНизАМидОВ, иХ СОлЕй,ОКиСЕй, лЕВО- и пРАВОВРАщАющиХизОМЕРОВ /иХ ВАРиАНТы/ | |
| US4147780A (en) | α-Amino-phosphonous acids for inhibiting bacteria and yeast | |
| DK159264B (da) | Analogifremgangsmaade til fremstilling af d-(threo)-1-aryl-2-acylamido-3-fluor-1-propanolforbindelser | |
| JPS5822119B2 (ja) | ジチオ−ル誘導体 | |
| DK159114B (da) | Benzyldihydrofuropyridinderivater og praeparater indeholdende disse forbindelser | |
| JPS58154538A (ja) | アルキルアミノアルコ−ル誘導体、その製造法、並びに該誘導体を有効成分とする新規薬剤 | |
| US4221795A (en) | Pyridine derivative, its preparation and use | |
| US5084456A (en) | Oxazolopyridine compounds | |
| JPS6026381B2 (ja) | ４−ヒドロキシベンゾフエノン類の塩基性エ−テルおよびその製法 | |
| JPS6340784B2 (enExample) | ||
| US4176193A (en) | Therapeutic isobutyramides | |
| JP2002538101A (ja) | 肥満症を予防または治療するための薬剤の製造における多環式チアゾール系の使用 | |
| CS195332B2 (en) | Method of producing indazolyl-/4/-oxy-propanolamines | |
| JPS59167564A (ja) | スルホニウム化合物 | |
| JPS6334865B2 (enExample) | ||
| FR2460934A1 (fr) | Derives d'isoquinoleine contenant du soufre, procedes pour leur preparation et compositions pharmaceutiques les contenant | |
| CA1040655A (en) | Amine derivatives of azidophenols | |
| US4143143A (en) | Substituted imidazo[5,1-a]isoquinolines | |
| JPS604189B2 (ja) | 抗菌剤およびその製法 | |
| JPH0751572B2 (ja) | 複素環式ジスルフイツド | |
| JPS631314B2 (enExample) | ||
| JPS6411015B2 (enExample) | ||
| US4338320A (en) | Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them | |
| JPS6024100B2 (ja) | アミノプロパノ−ル−誘導体の製法 | |
| KR910002686B1 (ko) | 2-디에틸아미노-1-메틸에틸 시스-1-히드록시-(비시클로헥실)-2-카르복실산염 유도체의 제조방법 |