GB1495680A - 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes - Google Patents

1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes

Info

Publication number
GB1495680A
GB1495680A GB26407/75A GB2640775A GB1495680A GB 1495680 A GB1495680 A GB 1495680A GB 26407/75 A GB26407/75 A GB 26407/75A GB 2640775 A GB2640775 A GB 2640775A GB 1495680 A GB1495680 A GB 1495680A
Authority
GB
United Kingdom
Prior art keywords
formula
prepared
compounds
june
aminopropanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26407/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB26407/75A priority Critical patent/GB1495680A/en
Priority to SE7606707A priority patent/SE426237B/en
Priority to NL7606354A priority patent/NL7606354A/en
Priority to DK262776A priority patent/DK145041C/en
Priority to ZA763514A priority patent/ZA763514B/en
Priority to JP51068826A priority patent/JPS525749A/en
Priority to AU14910/76A priority patent/AU503182B2/en
Priority to IE1292/76A priority patent/IE43119B1/en
Priority to FR7618231A priority patent/FR2314711A1/en
Priority to CH783576A priority patent/CH601186A5/xx
Priority to DE19762627210 priority patent/DE2627210A1/en
Priority to LU75199A priority patent/LU75199A1/xx
Priority to BE168117A priority patent/BE843170A/en
Priority to US05/860,303 priority patent/US4201790A/en
Publication of GB1495680A publication Critical patent/GB1495680A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1495680 1 - (2 - Benzoylphenoxy) - 2 - hydroxy-3-aminopropanes MAY & BAKER Ltd 16 June 1976 [20 June 1975] 26407/75 Heading C2C Novel compounds of Formula I (wherein R<SP>1</SP> represents an isopropyl, t-butyl or 2-phenylethyl group, R<SP>2</SP> represents a methyl group or a chlorine atom, n represents 1 or 2 and m represents 0, 1 or 2) and non-toxic acid addition salts thereof where it is to be understood that when m represents 2 then the substitutents represented by the symbol R<SP>2</SP> may be the same or different are prepared by reaction of a compound of Formula II with an amine R<SP>1</SP>NH 2 . Intermediates of Formula II above are prepared from compounds of Formula IV with epichlorohydrin. Phenols of Formula IV are prepared by Fries rearrangement of the substituted benzoyloxy compounds prepared by acylation of the unsubstituted phenols. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having vascular #-andrenoceptor blocking activity comprise an above novel compound and a carrier or diluent.
GB26407/75A 1975-06-20 1975-06-20 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes Expired GB1495680A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB26407/75A GB1495680A (en) 1975-06-20 1975-06-20 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes
SE7606707A SE426237B (en) 1975-06-20 1976-06-11 PROCEDURE FOR PREPARING NEW BENZOPHENON DERIVATIVES
NL7606354A NL7606354A (en) 1975-06-20 1976-06-11 METHOD OF PREPARING A MEDICINAL PRODUCT AND OF NEW BENZOPHEN DERIVATIVES.
DK262776A DK145041C (en) 1975-06-20 1976-06-11 METHOD OF ANALOGUE FOR PREPARING A BENZOPHENO DERIVATIVE OR ACID ADDITION SALTS THEREOF
ZA763514A ZA763514B (en) 1975-06-20 1976-06-14 New benzophenone derivatives
JP51068826A JPS525749A (en) 1975-06-20 1976-06-14 Novel bezophenone derivatives
AU14910/76A AU503182B2 (en) 1975-06-20 1976-06-15 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes
IE1292/76A IE43119B1 (en) 1975-06-20 1976-06-15 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes
FR7618231A FR2314711A1 (en) 1975-06-20 1976-06-16 NEW DERIVATIVES OF BENZOPHENONE
CH783576A CH601186A5 (en) 1975-06-20 1976-06-18
DE19762627210 DE2627210A1 (en) 1975-06-20 1976-06-18 NEW BENZOPHENONE DERIVATIVES
LU75199A LU75199A1 (en) 1975-06-20 1976-06-18
BE168117A BE843170A (en) 1975-06-20 1976-06-18 NEW DERIVATIVES OF BENZOPHENONE
US05/860,303 US4201790A (en) 1975-06-20 1977-12-14 Benzophenone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26407/75A GB1495680A (en) 1975-06-20 1975-06-20 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes

Publications (1)

Publication Number Publication Date
GB1495680A true GB1495680A (en) 1977-12-21

Family

ID=10243171

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26407/75A Expired GB1495680A (en) 1975-06-20 1975-06-20 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes

Country Status (13)

Country Link
JP (1) JPS525749A (en)
AU (1) AU503182B2 (en)
BE (1) BE843170A (en)
CH (1) CH601186A5 (en)
DE (1) DE2627210A1 (en)
DK (1) DK145041C (en)
FR (1) FR2314711A1 (en)
GB (1) GB1495680A (en)
IE (1) IE43119B1 (en)
LU (1) LU75199A1 (en)
NL (1) NL7606354A (en)
SE (1) SE426237B (en)
ZA (1) ZA763514B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1147311B (en) * 1980-02-13 1986-11-19 Stabil Bioterapico Farmachim BASIC ETHERS OF 4-HYDROXY-BENZOFENONES WITH ACTIVITIES SUCH AS BETABLOCCANT AGENTS AND RELATED PREPARATION PROCEDURE
SE9101509D0 (en) * 1991-05-17 1991-05-17 Karobio Ab RECEPTOR LIGANDS

Also Published As

Publication number Publication date
SE426237B (en) 1982-12-20
NL7606354A (en) 1976-12-22
IE43119B1 (en) 1980-12-17
DK145041B (en) 1982-08-09
DE2627210A1 (en) 1976-12-30
FR2314711B1 (en) 1978-12-15
SE7606707L (en) 1976-12-21
DK262776A (en) 1976-12-21
AU503182B2 (en) 1979-08-23
DK145041C (en) 1983-01-10
FR2314711A1 (en) 1977-01-14
IE43119L (en) 1976-12-20
CH601186A5 (en) 1978-06-30
AU1491076A (en) 1977-12-22
BE843170A (en) 1976-12-20
LU75199A1 (en) 1977-03-15
ZA763514B (en) 1977-05-25
JPS525749A (en) 1977-01-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee