JPS60260546A - 高血圧症治療用テトラヒドロナフタレノール類 - Google Patents

高血圧症治療用テトラヒドロナフタレノール類

Info

Publication number
JPS60260546A
JPS60260546A JP60106806A JP10680685A JPS60260546A JP S60260546 A JPS60260546 A JP S60260546A JP 60106806 A JP60106806 A JP 60106806A JP 10680685 A JP10680685 A JP 10680685A JP S60260546 A JPS60260546 A JP S60260546A
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
tetrahydro
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP60106806A
Other languages
English (en)
Japanese (ja)
Inventor
カーネイル・エス・アトウオール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS60260546A publication Critical patent/JPS60260546A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP60106806A 1984-05-17 1985-05-17 高血圧症治療用テトラヒドロナフタレノール類 Pending JPS60260546A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61125884A 1984-05-17 1984-05-17
US611258 1984-05-17

Publications (1)

Publication Number Publication Date
JPS60260546A true JPS60260546A (ja) 1985-12-23

Family

ID=24448300

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60106806A Pending JPS60260546A (ja) 1984-05-17 1985-05-17 高血圧症治療用テトラヒドロナフタレノール類

Country Status (13)

Country Link
EP (1) EP0163458A1 (enExample)
JP (1) JPS60260546A (enExample)
KR (1) KR910002944B1 (enExample)
AU (1) AU573828B2 (enExample)
DK (1) DK219885A (enExample)
ES (2) ES8701144A1 (enExample)
FI (1) FI851969A7 (enExample)
GR (1) GR851204B (enExample)
HU (1) HUT38298A (enExample)
IL (1) IL75224A (enExample)
NZ (1) NZ212112A (enExample)
PT (1) PT80481B (enExample)
ZA (1) ZA853759B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007045847A (ja) * 1994-05-03 2007-02-22 Aventis Pharma Sa エリスロマイシン誘導体の製造中間体

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE56944T1 (de) * 1986-07-28 1990-10-15 Whitby Research Inc Substituierte 2-aminotetraline.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267373A (en) * 1972-07-03 1981-05-12 E. R. Squibb & Sons, Inc. 5,6,7,8-Tetrahydronaphthalene hypotensive agents
US3930022A (en) * 1972-07-03 1975-12-30 Squibb & Sons Inc Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia
GB1442851A (en) * 1973-07-09 1976-07-14 Squibb & Sons Inc Substituted cyclic polymethylene phenols
AU8194275A (en) * 1974-06-17 1976-12-16 Takeda Chemical Industries Ltd Aminotetralin compounds
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
NZ213651A (en) * 1984-10-11 1989-07-27 Hoffmann La Roche Tetrahydronapthalene derivatives and medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007045847A (ja) * 1994-05-03 2007-02-22 Aventis Pharma Sa エリスロマイシン誘導体の製造中間体

Also Published As

Publication number Publication date
KR850008659A (ko) 1985-12-21
ES552087A0 (es) 1987-05-01
FI851969A0 (fi) 1985-05-17
AU573828B2 (en) 1988-06-23
KR910002944B1 (ko) 1991-05-11
FI851969L (fi) 1985-11-18
NZ212112A (en) 1988-10-28
PT80481A (en) 1985-06-01
ES543242A0 (es) 1986-11-16
PT80481B (en) 1987-01-15
AU4254785A (en) 1985-11-21
HUT38298A (en) 1986-05-28
ES8705363A1 (es) 1987-05-01
IL75224A (en) 1988-11-15
GR851204B (enExample) 1985-11-25
DK219885A (da) 1985-11-18
ZA853759B (en) 1986-01-29
FI851969A7 (fi) 1985-11-18
DK219885D0 (da) 1985-05-17
EP0163458A1 (en) 1985-12-04
ES8701144A1 (es) 1986-11-16
IL75224A0 (en) 1985-09-29

Similar Documents

Publication Publication Date Title
CZ280532B6 (cs) Pyridinové a pyridin-N-oxidové deriváty diaryl-methyl-piperidinů nebo piperazinů, jejich použití a způsob jejich přípravy, farmaceutický prostředek je obsahující
JP2007506715A (ja) ガンマセクレターゼ阻害剤
CZ201799A3 (cs) 6-Fenylpyridin-2-ylaminové deriváty, farmaceutické kompozice na jejich bázi a způsoby léčení
ZA200602448B (en) Thrombin receptor antagonists
UA55461C2 (uk) 2-амінопіридини, які мають циклоконденсовані замісники, як інгібітори оксиду азоту синтази, фармацевтичні композиції, способи лікування або попередження хворобливих станів та спосіб інгібування оксиду азоту синтази
JP2776919B2 (ja) フルオキセチン類似体
EP0637586A1 (en) 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors
JPH05213872A (ja) メタノアントラセン化合物、該化合物を含有する精神病治療用医薬調剤および上記化合物の製造方法ならびに中間体
JP2501298B2 (ja) モルフアナン類のｏ−アリ―ルエ―テル
JPH10504820A (ja) Ｎ−置換されたフェノチアジン類の使用
EP0411912B1 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
JPH05213751A (ja) 一連のアレコロンおよびイソアレコロンのニコチン様活性
KR910005854B1 (ko) 헤테로사이클릭 그룹을 함유하는 이미다조 퀴놀린 유도체의 제조방법
CA2048959C (en) 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
EP0703232B1 (en) 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors
JP5491524B2 (ja) エタンアミン化合物及びうつ病を処置するためのその使用
EP0077536B1 (en) 2'-substituted-spiro(benzofuran-2(3h),1'-cycloalkanes), a process for preparing same, pharmaceutical compositions containing such compounds and their use as medicaments
JPH0559117B2 (enExample)
Cohen et al. Antiplasmodial action and chemical constitution. Part I. Cinchona alkaloidal derivatives and allied substances
JPS63225358A (ja) シクロペンタ〔ｂ〕キノリン誘導体
KR910002944B1 (ko) 테트라히드로나프탈레놀 유도체 및 그의 제조 방법
NL8302776A (nl) Moederkoornalkaloiden en werkwijzen voor hun bereiding en toepassing.
KR0148365B1 (ko) 4,5,5a,6-테트라하이드로-3H-이소옥사졸로[5,4,3-kl]아크리딘 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
AU687414B2 (en) Piperidinyl substituted methanoanthracenes as D1/D2-antagonists and 5HT2-serotanin-antagonists
CH594667A5 (en) Hexahydro-2H-pyrazolo(4,3-C) pyridine derivs