JPS60185799A - ヒト癌壊死因子 - Google Patents

ヒト癌壊死因子

Info

Publication number
JPS60185799A
JPS60185799A JP59043617A JP4361784A JPS60185799A JP S60185799 A JPS60185799 A JP S60185799A JP 59043617 A JP59043617 A JP 59043617A JP 4361784 A JP4361784 A JP 4361784A JP S60185799 A JPS60185799 A JP S60185799A
Authority
JP
Japan
Prior art keywords
ala
gly
glu
val
scr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59043617A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0157955B2 (el
Inventor
Masaaki Yamada
正明 山田
Taiji Furuya
古谷　泰治
Mitsue Notake
野竹　三津恵
Junichi Yamagishi
山岸　純一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP59043617A priority Critical patent/JPS60185799A/ja
Priority to EP85102093A priority patent/EP0155549B1/en
Priority to DE8585102093T priority patent/DE3582183D1/de
Priority to AT85102093T priority patent/ATE61817T1/de
Priority to DE1999175063 priority patent/DE19975063I2/de
Priority to AU39448/85A priority patent/AU584608B2/en
Priority to PH31937A priority patent/PH22108A/en
Priority to CA000475653A priority patent/CA1341240C/en
Priority to KR1019850001374A priority patent/KR920010225B1/ko
Priority to HU85828A priority patent/HU202921B/hu
Priority to ES540939A priority patent/ES8802159A1/es
Priority to DK100985A priority patent/DK172013B1/da
Priority to SU853869300A priority patent/SU1614765A3/ru
Publication of JPS60185799A publication Critical patent/JPS60185799A/ja
Priority to ES550939A priority patent/ES8703490A1/es
Publication of JPH0157955B2 publication Critical patent/JPH0157955B2/ja
Priority to US08/084,445 priority patent/US5288852A/en
Priority to NL990034C priority patent/NL990034I2/nl
Priority to FR99C0037C priority patent/FR99C0037I2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
JP59043617A 1984-03-06 1984-03-06 ヒト癌壊死因子 Granted JPS60185799A (ja)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP59043617A JPS60185799A (ja) 1984-03-06 1984-03-06 ヒト癌壊死因子
EP85102093A EP0155549B1 (en) 1984-03-06 1985-02-26 Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
DE8585102093T DE3582183D1 (de) 1984-03-06 1985-02-26 Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
AT85102093T ATE61817T1 (de) 1984-03-06 1985-02-26 Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
DE1999175063 DE19975063I2 (de) 1984-03-06 1985-02-26 DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.
AU39448/85A AU584608B2 (en) 1984-03-06 1985-03-01 DNA encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
PH31937A PH22108A (en) 1984-03-06 1985-03-04 Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
CA000475653A CA1341240C (en) 1984-03-06 1985-03-04 Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
HU85828A HU202921B (en) 1984-03-06 1985-03-05 Process for producing coding dns for human tumor necrosis factor the corresponding polypeptide with utilizing them and pharmaceutical compositions containing this polypeptide as active component
KR1019850001374A KR920010225B1 (ko) 1984-03-06 1985-03-05 인간암괴사인자 및 그를 코우드하는 dna의 제법
ES540939A ES8802159A1 (es) 1984-03-06 1985-03-05 Un procedimiento de producir un acido desoxirribonucleico (adn)que tiene o contiene una secuencia de base que codificaun polipeptido de factor de necrosis tumoral de humano
DK100985A DK172013B1 (da) 1984-03-06 1985-03-05 DNA, vektor indeholdende dette DNA, vært transformeret med vektoren,polypeptid indeholdt i DNA'et og salt deraf, aggregat indeholdende polypeptidet samt pharmaceutisk sammensætning indeholdende polypeptidet eller aggregatet.
SU853869300A SU1614765A3 (ru) 1984-03-06 1985-03-05 Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека
ES550939A ES8703490A1 (es) 1984-03-06 1986-01-16 Un procedimiento para producir un polipeptido que tiene o contiene un polipeptido de factor de necrosis de tumor humano
US08/084,445 US5288852A (en) 1984-03-06 1993-07-01 Human tumor necrosis factor polypeptides
NL990034C NL990034I2 (nl) 1984-03-06 1999-10-12 DNA dat codeert voor humane tumor necrosis faktor en humane tumor necrosis faktor polypeptide.
FR99C0037C FR99C0037I2 (el) 1984-03-06 1999-10-12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59043617A JPS60185799A (ja) 1984-03-06 1984-03-06 ヒト癌壊死因子

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63220749A Division JPH01156999A (ja) 1988-09-03 1988-09-03 ヒト癌壊死因子

Publications (2)

Publication Number Publication Date
JPS60185799A true JPS60185799A (ja) 1985-09-21
JPH0157955B2 JPH0157955B2 (el) 1989-12-08

Family

ID=12668798

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59043617A Granted JPS60185799A (ja) 1984-03-06 1984-03-06 ヒト癌壊死因子

Country Status (2)

Country Link
JP (1) JPS60185799A (el)
SU (1) SU1614765A3 (el)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60252496A (ja) * 1984-04-06 1985-12-13 Asahi Chem Ind Co Ltd 新規なヒト生理活性ポリペプチド
JPS6140221A (ja) * 1984-07-05 1986-02-26 ジエネンテク，インコ−ポレイテツド 腫瘍壊死因子
JPS62500631A (ja) * 1984-10-15 1987-03-19 カイロン　コーポレイション ヒト腫瘍壊死因子
JPS62501470A (ja) * 1984-12-21 1987-06-18 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
JPH0242986A (ja) * 1989-06-28 1990-02-13 Asahi Chem Ind Co Ltd 新規なヒト生理活性ポリペプチドをコードするｄｎａ
WO1990003395A1 (en) * 1988-09-22 1990-04-05 Teijin Limited Novel physiologically active polypeptide, recombinant plasmid, recombinant microbial cells, medicinal composition, and process for recovering purified polypeptide
US5639728A (en) * 1993-10-01 1997-06-17 Kaji; Akira Antineoplastic peptide
JP2014501508A (ja) * 2010-11-25 2014-01-23 イムナテ・ソシエテ・ア・レスポンサビリテ・リミテ 感染症、自己免疫疾患、同種因子に対する免疫応答、アレルギー性疾患、腫瘍、移植片拒絶反応、および、遺伝子療法または遺伝子ワクチン接種のために使用されるウイルスベクターに対する免疫応答の予防および／または治療における使用のための免疫原性ペプチド

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60252496A (ja) * 1984-04-06 1985-12-13 Asahi Chem Ind Co Ltd 新規なヒト生理活性ポリペプチド
JPH025760B2 (el) * 1984-04-06 1990-02-05 Asahi Chemical Ind
JPS6140221A (ja) * 1984-07-05 1986-02-26 ジエネンテク，インコ−ポレイテツド 腫瘍壊死因子
JPH07291997A (ja) * 1984-07-05 1995-11-07 Genentech Inc 腫瘍壊死因子の突然変異体
JPH0928387A (ja) * 1984-07-05 1997-02-04 Genentech Inc 腫瘍壊死因子の突然変異体をコードするｄｎａ
JPS62500631A (ja) * 1984-10-15 1987-03-19 カイロン　コーポレイション ヒト腫瘍壊死因子
JPS62501470A (ja) * 1984-12-21 1987-06-18 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
WO1990003395A1 (en) * 1988-09-22 1990-04-05 Teijin Limited Novel physiologically active polypeptide, recombinant plasmid, recombinant microbial cells, medicinal composition, and process for recovering purified polypeptide
JPH0242986A (ja) * 1989-06-28 1990-02-13 Asahi Chem Ind Co Ltd 新規なヒト生理活性ポリペプチドをコードするｄｎａ
US5639728A (en) * 1993-10-01 1997-06-17 Kaji; Akira Antineoplastic peptide
JP2014501508A (ja) * 2010-11-25 2014-01-23 イムナテ・ソシエテ・ア・レスポンサビリテ・リミテ 感染症、自己免疫疾患、同種因子に対する免疫応答、アレルギー性疾患、腫瘍、移植片拒絶反応、および、遺伝子療法または遺伝子ワクチン接種のために使用されるウイルスベクターに対する免疫応答の予防および／または治療における使用のための免疫原性ペプチド

Also Published As

Publication number Publication date
SU1614765A3 (ru) 1990-12-15
JPH0157955B2 (el) 1989-12-08

Similar Documents

Publication Publication Date Title
DK174927B1 (da) DNA, der koder for human faktor VIII:C, vektor omfattende denne DNA, transformeret vært omfattende denne DNA, og fremgangsmåde til fremstilling af human faktor VIII:C
JP5202583B2 (ja) Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子
CN102596992A (zh) 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途
DK2358745T3 (en) LEUKOLECTINES AND USES THEREOF
JP2009505637A (ja) ルピナス属の植物から抽出され又は形質転換型で製造されるタンパク質、及びその使用方法
JPH07508879A (ja) アミノペプチダーゼ酵素をコードする組換えｄｎａ分子および蠕虫感染に対するワクチンの調製におけるその用途
JP2012162567A (ja) 変えられた空間構造を備えるインターフェロン及びその応用
DK2563806T3 (en) Human leukolectiner and uses thereof
DE69133552T2 (de) Nicht-A, nicht-B Hepatitis Virus Antigen, und diagnostische Verfahren.
JPS60185799A (ja) ヒト癌壊死因子
JPS60120990A (ja) ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
JP2008502323A5 (el)
CN107987153A (zh) 高亲和力的可溶性pd-1分子
JPH05502789A (ja) ムチンヌクレオチド
CN103864938A (zh) 靶特异性双突变体融合蛋白质及其制备工艺
WO2017016430A1 (zh) 一种肿瘤抑制肽
JPS61111695A (ja) Ｂ型肝炎ビールス又はｂ型肝炎ビールス成分からのｄｎａフラグメント、ポリペプチド及びオリゴペプチド、組み換えｄｎａ分子、ｄｎａベクター、エシエリヒア・コリｋ１２変異体、ポリペプチドの製法、ｂ型肝炎ビールス疾患に対する接種物質、モノクロナール抗体ｍａ１８／７、マウス雑種細胞ｇｏ１ａ１８／７‐１並びにモノクロナール抗体ｍａ１８／７の製法
SU1607690A3 (ru) Способ стабилизации рекомбинантного фактора некроза опухоли
JPH07506969A (ja) レセプタ型チロシンキナーゼ類似の分子
CN102250239B (zh) 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用
CN106519000A (zh) 一种抗菌肽to2‑24及其应用
CN102316887A (zh) 用铜氧还蛋白预防癌症的组合物和方法
JPS60207583A (ja) ブタ・膵臓エラスタ−ゼ
CN102732524A (zh) 类HRG的七鳃鳗Lj-RGD3全RGD缺失突变体Lj-112在抗肿瘤药物中的应用
JPH06506949A (ja) カロからの抗ｈｉｖタンパク質、ｔａｐ２９、そのためのｄｎａコード化およびその治療学的使用

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term