FR99C0037I2 - - Google Patents
Info
- Publication number
- FR99C0037I2 FR99C0037I2 FR99C0037C FR99C0037C FR99C0037I2 FR 99C0037 I2 FR99C0037 I2 FR 99C0037I2 FR 99C0037 C FR99C0037 C FR 99C0037C FR 99C0037 C FR99C0037 C FR 99C0037C FR 99C0037 I2 FR99C0037 I2 FR 99C0037I2
- Authority
- FR
- France
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59043617A JPS60185799A (ja) | 1984-03-06 | 1984-03-06 | ヒト癌壊死因子 |
| JP59082653A JPS60232097A (ja) | 1984-04-23 | 1984-04-23 | ヒト癌壊死因子ポリペプチドの製造法 |
| JP59172307A JP2584206B2 (ja) | 1984-08-17 | 1984-08-17 | ヒト癌壊死因子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR99C0037I1 FR99C0037I1 (el) | 1999-12-10 |
| FR99C0037I2 true FR99C0037I2 (el) | 2000-10-27 |
Family
ID=27291610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR99C0037C Active FR99C0037I2 (el) | 1984-03-06 | 1999-10-12 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0155549B1 (el) |
| KR (1) | KR920010225B1 (el) |
| AU (1) | AU584608B2 (el) |
| CA (1) | CA1341240C (el) |
| DE (2) | DE3582183D1 (el) |
| DK (1) | DK172013B1 (el) |
| ES (2) | ES8802159A1 (el) |
| FR (1) | FR99C0037I2 (el) |
| HU (1) | HU202921B (el) |
| NL (1) | NL990034I2 (el) |
| PH (1) | PH22108A (el) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60112718A (ja) * | 1983-11-21 | 1985-06-19 | Kyorin Pharmaceut Co Ltd | 抗腫瘍作用を示す蛋白性物質及びその製造方法 |
| JPH0695939B2 (ja) * | 1983-12-02 | 1994-11-30 | 大日本製薬株式会社 | ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ |
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| GR851626B (el) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| DE3581730D1 (de) * | 1984-10-15 | 1991-03-14 | Cetus Corp | Menschlicher tumornekrosisfaktor. |
| US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| JP2557053B2 (ja) * | 1984-12-21 | 1996-11-27 | バイオジェン インコーポレイテッド | 腫瘍壊死因子の精製、製造および使用法 |
| JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
| JPH064675B2 (ja) * | 1985-07-29 | 1994-01-19 | 伝一 水野 | 抗腫瘍性ポリペプチド |
| US5059530A (en) * | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
| JPH0698004B2 (ja) * | 1985-09-30 | 1994-12-07 | サントリー株式会社 | Ｔｎｆ発現用新規プラスミド |
| US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
| CA1286843C (en) * | 1985-10-30 | 1991-07-23 | Leo S. Lin | Purification method for proteins |
| US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
| US5081021A (en) * | 1986-02-04 | 1992-01-14 | Mizuno Den Ichi | DNA encoding HTNF variants exhibiting enhanced activity |
| KR940005589B1 (ko) * | 1986-04-02 | 1994-06-21 | 다이닛뽄세이야꾸 가부시끼가이샤 | 핵산 또는 엔도톡신의 제거제 및 제거방법 |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| DE3750056T2 (de) * | 1986-06-20 | 1995-04-06 | Dainippon Pharmaceutical Co | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. |
| WO1988006625A2 (en) * | 1987-02-26 | 1988-09-07 | Cetus Corporation | Arginine-depleted human tumor necrosis factor |
| DE3716513A1 (de) * | 1987-05-16 | 1988-11-24 | Basf Ag | Proteine mit tnf-wirkung |
| JP2828988B2 (ja) * | 1988-04-03 | 1998-11-25 | 源一郎 杣 | 新規ｄｎａとその生産方法、それを有する新規プラスミド、新規ポリペプチドとその生産方法、及び該ポリペプチドからなる新規抗腫瘍剤 |
| GB2217325B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene for tumour necrosis factor alpha. |
| JPH0797997B2 (ja) * | 1988-04-28 | 1995-10-25 | 帝人株式会社 | 新規生理活性ポリペプチド |
| DE3843534A1 (de) * | 1988-12-23 | 1990-07-12 | Basf Ag | Neue tnf-polypeptide |
| US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
| US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
| DK0491878T3 (da) | 1989-08-16 | 1997-06-23 | Chiron Corp | Præparater til inhibering af proteinhormondannelse og anvendelser deraf |
| US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
| WO1991017180A1 (en) * | 1990-04-27 | 1991-11-14 | Peptide Technology Ltd | Peptides derived from human tumour necrosis factor alpha and useful against intracellular malarial parasites |
| KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
| CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
| WO1995024501A1 (en) | 1994-03-07 | 1995-09-14 | Cetus Oncology Corporation | Compositions for the inhibition of tnf formation and uses thereof |
| US6395273B1 (en) | 1998-06-10 | 2002-05-28 | Promega Corporation | Prevention and treatment of inflammatory bowel disease |
| ES2151403B1 (es) * | 1998-07-13 | 2001-07-01 | Hernandez Bronchud Miguel | Linea celular transformada de rata productora de tnf-alfa humano recombinante. |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| DK2953634T3 (da) | 2013-02-07 | 2021-08-30 | Massachusetts Gen Hospital | Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler |
| US11312922B2 (en) | 2019-04-12 | 2022-04-26 | Ecolab Usa Inc. | Antimicrobial multi-purpose cleaner comprising a sulfonic acid-containing surfactant and methods of making and using the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| JPS60260522A (ja) * | 1984-06-07 | 1985-12-23 | Asahi Chem Ind Co Ltd | 遺伝子組換体が生産する生理活性物質の安定化法 |
| GR851626B (el) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| DE3581730D1 (de) * | 1984-10-15 | 1991-03-14 | Cetus Corp | Menschlicher tumornekrosisfaktor. |
| JPS61124392A (ja) * | 1984-11-22 | 1986-06-12 | Asahi Chem Ind Co Ltd | 遺伝子組換体の産生する生理活性物質の精製法 |
-
1985
- 1985-02-26 EP EP85102093A patent/EP0155549B1/en not_active Expired - Lifetime
- 1985-02-26 DE DE8585102093T patent/DE3582183D1/de not_active Expired - Lifetime
- 1985-02-26 DE DE1999175063 patent/DE19975063I2/de active Active
- 1985-03-01 AU AU39448/85A patent/AU584608B2/en not_active Expired
- 1985-03-04 PH PH31937A patent/PH22108A/en unknown
- 1985-03-04 CA CA000475653A patent/CA1341240C/en not_active Expired - Lifetime
- 1985-03-05 ES ES540939A patent/ES8802159A1/es not_active Expired
- 1985-03-05 KR KR1019850001374A patent/KR920010225B1/ko not_active IP Right Cessation
- 1985-03-05 HU HU85828A patent/HU202921B/hu unknown
- 1985-03-05 DK DK100985A patent/DK172013B1/da not_active IP Right Cessation
-
1986
- 1986-01-16 ES ES550939A patent/ES8703490A1/es not_active Expired
-
1999
- 1999-10-12 NL NL990034C patent/NL990034I2/nl unknown
- 1999-10-12 FR FR99C0037C patent/FR99C0037I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES8703490A1 (es) | 1987-02-16 |
| DE19975063I2 (de) | 2005-08-18 |
| KR920010225B1 (ko) | 1992-11-21 |
| DK172013B1 (da) | 1997-09-15 |
| DE3582183D1 (de) | 1991-04-25 |
| DK100985A (da) | 1985-09-07 |
| ES540939A0 (es) | 1988-04-01 |
| KR850006874A (ko) | 1985-10-21 |
| PH22108A (en) | 1988-06-01 |
| HU202921B (en) | 1991-04-29 |
| DE19975063I1 (de) | 2005-07-14 |
| AU584608B2 (en) | 1989-06-01 |
| DK100985D0 (da) | 1985-03-05 |
| NL990034I2 (nl) | 2000-11-01 |
| EP0155549A3 (en) | 1986-12-30 |
| EP0155549B1 (en) | 1991-03-20 |
| NL990034I1 (nl) | 1999-12-01 |
| ES8802159A1 (es) | 1988-04-01 |
| ES550939A0 (es) | 1987-02-16 |
| HUT37957A (en) | 1986-03-28 |
| CA1341240C (en) | 2001-06-05 |
| FR99C0037I1 (el) | 1999-12-10 |
| EP0155549A2 (en) | 1985-09-25 |
| AU3944885A (en) | 1985-09-12 |